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The map label for this gene is holB [H]

Identifier: 18311431

GI number: 18311431

Start: 2796703

End: 2797626

Strand: Reverse

Name: holB [H]

Synonym: CPE2449

Alternate gene names: 18311431

Gene position: 2797626-2796703 (Counterclockwise)

Preceding gene: 18311432

Following gene: 18311430

Centisome position: 92.29

GC content: 26.84

Gene sequence:

>924_bases
ATGATAGGTCACAATAAAGTTAGAGATAGATTTAGTAAAAGTGTAAGTAAAAATGCACTTTCCCATGCTCATTTAATTAT
TGGTGAGGATGGAATAGGAAAAAGTCTTTTAGCAGATGAATTTGCTTATAAGATTTTAGGAATACCATCACAGAGAGAAC
ATGTAGATATTGTTCATTATAAATCTGAAAAGGCCTCTTTTGGTGTTGATTTAGTAAGAAATATTATAGCTGAGGCAAAT
AAAAAACCTTATGAATGTGATAGAAAGGTTATAATAATTCATAATGGAGAAAAGCTTACAGTTGCAGCACAAAATGCTTT
ATTAAAGACCATAGAAGAACCTCTTACAGGTATTTTTATAATAATTTTAAGTAGTAATATTGATTCTATATTAGAAACTA
TAAGATCTAGATGTCAAATACATAGGTTAGCACCTCTTAGTAAAGAGGAAATTAATTTATATATATCTAAAAAGTATAAT
GGAATAGATGATGAATTAAATAGAACTCTTATATCTTTTAGTGAAGGTATCCCAGGAAGAGTTGATAAATTCATGAATGA
TGATATTTTTAAGGATATAAGAAATACAGTTATAGAGATGTTAAAAGATATTGGGCATGGGAAAATAGAAGTTCCTATAA
AATATTCTGATAAATTTTATAGCATGAAGGGTAATGAAGAGGAAATCTTAGAGACCATAACTATTTTTGCCAGAGACTCA
ATTATATTTAAGGAAATAGAAAACAACTTGTCCATAATAAATGGAGATAAAATAGATGATATTAGAGAAATAGCTAGTAA
TTTATCCTATAATAAATTAAATAGGATAATAAAAGTAGTTAATGAGGCCAGAAATAATTTAAAAAGTAATACTAATTTAT
GGCTAACTTTAGATAGTATGCTGATTAGTATATTGGAGGAATAA

Upstream 100 bases:

>100_bases
TATACCATATCCTATGGAAGTGCAGGTTGGAGGAGCTACAATATTTGTTGTTGATGTAGATAAATTTATAAAGATTTAAA
ATAGAAAGGAAAGTGCATAA

Downstream 100 bases:

>100_bases
AAATGATAGAAGTAATAGGAGTCAGATTTAAAAAAGCTGGTAAAATATATTACTTTGGTCCTAATGGTATAGAGATAAAG
AAGGGTCAAAACGTAATTGT

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MIGHNKVRDRFSKSVSKNALSHAHLIIGEDGIGKSLLADEFAYKILGIPSQREHVDIVHYKSEKASFGVDLVRNIIAEAN
KKPYECDRKVIIIHNGEKLTVAAQNALLKTIEEPLTGIFIIILSSNIDSILETIRSRCQIHRLAPLSKEEINLYISKKYN
GIDDELNRTLISFSEGIPGRVDKFMNDDIFKDIRNTVIEMLKDIGHGKIEVPIKYSDKFYSMKGNEEEILETITIFARDS
IIFKEIENNLSIINGDKIDDIREIASNLSYNKLNRIIKVVNEARNNLKSNTNLWLTLDSMLISILEE

Sequences:

>Translated_307_residues
MIGHNKVRDRFSKSVSKNALSHAHLIIGEDGIGKSLLADEFAYKILGIPSQREHVDIVHYKSEKASFGVDLVRNIIAEAN
KKPYECDRKVIIIHNGEKLTVAAQNALLKTIEEPLTGIFIIILSSNIDSILETIRSRCQIHRLAPLSKEEINLYISKKYN
GIDDELNRTLISFSEGIPGRVDKFMNDDIFKDIRNTVIEMLKDIGHGKIEVPIKYSDKFYSMKGNEEEILETITIFARDS
IIFKEIENNLSIINGDKIDDIREIASNLSYNKLNRIIKVVNEARNNLKSNTNLWLTLDSMLISILEE
>Mature_307_residues
MIGHNKVRDRFSKSVSKNALSHAHLIIGEDGIGKSLLADEFAYKILGIPSQREHVDIVHYKSEKASFGVDLVRNIIAEAN
KKPYECDRKVIIIHNGEKLTVAAQNALLKTIEEPLTGIFIIILSSNIDSILETIRSRCQIHRLAPLSKEEINLYISKKYN
GIDDELNRTLISFSEGIPGRVDKFMNDDIFKDIRNTVIEMLKDIGHGKIEVPIKYSDKFYSMKGNEEEILETITIFARDS
IIFKEIENNLSIINGDKIDDIREIASNLSYNKLNRIIKVVNEARNNLKSNTNLWLTLDSMLISILEE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787341, Length=247, Percent_Identity=27.1255060728745, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 34924; Mature: 34924

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGHNKVRDRFSKSVSKNALSHAHLIIGEDGIGKSLLADEFAYKILGIPSQREHVDIVHY
CCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEE
KSEKASFGVDLVRNIIAEANKKPYECDRKVIIIHNGEKLTVAAQNALLKTIEEPLTGIFI
CCCCHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHEEEE
IILSSNIDSILETIRSRCQIHRLAPLSKEEINLYISKKYNGIDDELNRTLISFSEGIPGR
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHH
VDKFMNDDIFKDIRNTVIEMLKDIGHGKIEVPIKYSDKFYSMKGNEEEILETITIFARDS
HHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHH
IIFKEIENNLSIINGDKIDDIREIASNLSYNKLNRIIKVVNEARNNLKSNTNLWLTLDSM
HHHHHHHCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
LISILEE
HHHHHCC
>Mature Secondary Structure
MIGHNKVRDRFSKSVSKNALSHAHLIIGEDGIGKSLLADEFAYKILGIPSQREHVDIVHY
CCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEE
KSEKASFGVDLVRNIIAEANKKPYECDRKVIIIHNGEKLTVAAQNALLKTIEEPLTGIFI
CCCCHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEHHHHHHHHHHHHHHHEEEE
IILSSNIDSILETIRSRCQIHRLAPLSKEEINLYISKKYNGIDDELNRTLISFSEGIPGR
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHH
VDKFMNDDIFKDIRNTVIEMLKDIGHGKIEVPIKYSDKFYSMKGNEEEILETITIFARDS
HHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHH
IIFKEIENNLSIINGDKIDDIREIASNLSYNKLNRIIKVVNEARNNLKSNTNLWLTLDSM
HHHHHHHCCCEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHH
LISILEE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]