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The map label for this gene is hrcA [H]

Identifier: 18311017

GI number: 18311017

Start: 2326329

End: 2327348

Strand: Reverse

Name: hrcA [H]

Synonym: CPE2035

Alternate gene names: 18311017

Gene position: 2327348-2326329 (Counterclockwise)

Preceding gene: 18311018

Following gene: 18311016

Centisome position: 76.77

GC content: 29.9

Gene sequence:

>1020_bases
GTGATAGATGATAGAAAGCTTCAAATATTAAGAGCTATAATTCAAGACTATATATCAACTGGAGAGCCCGTTGGTTCAAG
AACTATCGCTAAAAAATATAATCTTGGAGTAAGTTCAGCTACCATAAGAAATGAAATGGCTGACTTAGAGGATATGGGAT
TTTTAGAACAGCCTCATACTTCGGCAGGAAGAATTCCATCAAGCAGAGGATATAGATTATATGTTGATAGAATGATTGAA
TTCGAAAGATTATCCTCTGAAGAGGAAGGGCTTATTAGAAATTCAATAATAGATGGTACCTTGTACGAAGTTGATAAAAT
AATCAAACAAACTAGTGCTCTTCTATCGGAACTTACTAAAATGACTTGTATAGTAAAAGCACCCTCAGTACATAAGAGCT
TTGTAAAATCAATTCAGCTTTTAAAAGTTGATGATGTAAGTATTTTATGTGTTTTAGTAACTGATAATGGTGTAATAAGA
AATACAGTCATAAAAGTAAAGAGTGTTCCTATATCTGAAGAACTTATTAAAATTAGTAAGATAATAACTGAAAGGCTTAA
AAACCTTACTATTGAGCAAATAAACTTAGAGGTTATTAGCAATCTCAATAGAGCTTTAAGCGGATATGAAGATATAGTAA
ATGCAGTTTTACCTGCTCTTTATGAGAGTTTAAAAGGTGATGAAACTTCTGAGGTATTCTTAGAAGGAACAATTAATATA
TTCAATTATCCTGAATATAATAATATTCATAAGGCAAAAGAGATTTTAGAGCTTTTACATGATAAAAAAAGTATTTCAGA
ACTTATAAGTGATAGTGATGATATGACTGTAAAAATAGGTGATGAAATATTTGTACCAGAAGCAAAGGAATGTTCCATAA
TATCAGCTGGATATCATGTAGGAGATAAATCTTTAGGTACAATAGCTTTAATAGGTCCTAGAAGAATAAATTATTCTAAA
GTCTTATCAATCATGACTGAAGTTATGAAAGAGTTAAATGAAACTTTAAAGAATAAGTAA

Upstream 100 bases:

>100_bases
TGATAAAAAATGGAATTGACAAAAAACTTGGTAGGTAATATATTAATAGTGTACTAGTTAGCACTCGTTAAGAGTGAGTG
CTAATAAAGAGGTGAGATTA

Downstream 100 bases:

>100_bases
GTAAAAAAAGAGAAGAGGTGTGGCTGCTTTATGGTGGATAATAAAGATTTTAACGAAGAGTTAAAGGAAAATATCCAAGA
AGAATTAGATAACGAAACAA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MIDDRKLQILRAIIQDYISTGEPVGSRTIAKKYNLGVSSATIRNEMADLEDMGFLEQPHTSAGRIPSSRGYRLYVDRMIE
FERLSSEEEGLIRNSIIDGTLYEVDKIIKQTSALLSELTKMTCIVKAPSVHKSFVKSIQLLKVDDVSILCVLVTDNGVIR
NTVIKVKSVPISEELIKISKIITERLKNLTIEQINLEVISNLNRALSGYEDIVNAVLPALYESLKGDETSEVFLEGTINI
FNYPEYNNIHKAKEILELLHDKKSISELISDSDDMTVKIGDEIFVPEAKECSIISAGYHVGDKSLGTIALIGPRRINYSK
VLSIMTEVMKELNETLKNK

Sequences:

>Translated_339_residues
MIDDRKLQILRAIIQDYISTGEPVGSRTIAKKYNLGVSSATIRNEMADLEDMGFLEQPHTSAGRIPSSRGYRLYVDRMIE
FERLSSEEEGLIRNSIIDGTLYEVDKIIKQTSALLSELTKMTCIVKAPSVHKSFVKSIQLLKVDDVSILCVLVTDNGVIR
NTVIKVKSVPISEELIKISKIITERLKNLTIEQINLEVISNLNRALSGYEDIVNAVLPALYESLKGDETSEVFLEGTINI
FNYPEYNNIHKAKEILELLHDKKSISELISDSDDMTVKIGDEIFVPEAKECSIISAGYHVGDKSLGTIALIGPRRINYSK
VLSIMTEVMKELNETLKNK
>Mature_339_residues
MIDDRKLQILRAIIQDYISTGEPVGSRTIAKKYNLGVSSATIRNEMADLEDMGFLEQPHTSAGRIPSSRGYRLYVDRMIE
FERLSSEEEGLIRNSIIDGTLYEVDKIIKQTSALLSELTKMTCIVKAPSVHKSFVKSIQLLKVDDVSILCVLVTDNGVIR
NTVIKVKSVPISEELIKISKIITERLKNLTIEQINLEVISNLNRALSGYEDIVNAVLPALYESLKGDETSEVFLEGTINI
FNYPEYNNIHKAKEILELLHDKKSISELISDSDDMTVKIGDEIFVPEAKECSIISAGYHVGDKSLGTIALIGPRRINYSK
VLSIMTEVMKELNETLKNK

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 37980; Mature: 37980

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDDRKLQILRAIIQDYISTGEPVGSRTIAKKYNLGVSSATIRNEMADLEDMGFLEQPHT
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
SAGRIPSSRGYRLYVDRMIEFERLSSEEEGLIRNSIIDGTLYEVDKIIKQTSALLSELTK
CCCCCCCCCCCEEHHHHHHHHHHCCCHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
MTCIVKAPSVHKSFVKSIQLLKVDDVSILCVLVTDNGVIRNTVIKVKSVPISEELIKISK
HHHEEECCHHHHHHHHHHHHEEECCCEEEEEEEECCCEEEHHEEEEECCCCHHHHHHHHH
IITERLKNLTIEQINLEVISNLNRALSGYEDIVNAVLPALYESLKGDETSEVFLEGTINI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
FNYPEYNNIHKAKEILELLHDKKSISELISDSDDMTVKIGDEIFVPEAKECSIISAGYHV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCEEECCCCC
GDKSLGTIALIGPRRINYSKVLSIMTEVMKELNETLKNK
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDDRKLQILRAIIQDYISTGEPVGSRTIAKKYNLGVSSATIRNEMADLEDMGFLEQPHT
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
SAGRIPSSRGYRLYVDRMIEFERLSSEEEGLIRNSIIDGTLYEVDKIIKQTSALLSELTK
CCCCCCCCCCCEEHHHHHHHHHHCCCHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
MTCIVKAPSVHKSFVKSIQLLKVDDVSILCVLVTDNGVIRNTVIKVKSVPISEELIKISK
HHHEEECCHHHHHHHHHHHHEEECCCEEEEEEEECCCEEEHHEEEEECCCCHHHHHHHHH
IITERLKNLTIEQINLEVISNLNRALSGYEDIVNAVLPALYESLKGDETSEVFLEGTINI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
FNYPEYNNIHKAKEILELLHDKKSISELISDSDDMTVKIGDEIFVPEAKECSIISAGYHV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCEEECCCCC
GDKSLGTIALIGPRRINYSKVLSIMTEVMKELNETLKNK
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA