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The map label for this gene is hemN [H]

Identifier: 18311018

GI number: 18311018

Start: 2327545

End: 2328678

Strand: Reverse

Name: hemN [H]

Synonym: CPE2036

Alternate gene names: 18311018

Gene position: 2328678-2327545 (Counterclockwise)

Preceding gene: 18311019

Following gene: 18311017

Centisome position: 76.82

GC content: 28.31

Gene sequence:

>1134_bases
ATGGACAAAATTTCTTTATATATACACATTCCTTTTTGTGCACAAAAGTGTCTTTATTGTGATTTTCCTTCTTTTGCTAG
GAAAGATCATTTAAGAAAGGCCTACATAGAAGCTTTAAATAAGGAAATAATAAGTTTAAGAGAGAAACATAATAATCTAG
AAATAAACACTATATTTATTGGAGGGGGAACACCAAGTGTTTTAGAGGCTGATGAGTTAGAATGTTTATTAAAAGAAGTA
GCTAAACTTAATATGGCGAAAGATATAGAGTACTCTATGGAGTGTAATCCAGGAAACTTAACAGAAGAAAAGCTAGAAGT
CATGAAAAAGTATGGTGTAAATAGAATCAGCATGGGGCTTCAAGCTAAGCAGGATAATCTTCTTAAAGGACTGGGAAGAA
TACATAACTATAAAACCTTTAAAGAAAATTTTTTATTAGCCAAAAAGGTTGGTTTTAATAACATAAATGTTGATTTAATG
TTTGGATTACCAAATCAGAGATTAAATGAATGGGAAGAGACTTTAAGAGAGATAATATCTTTAGAGCCAGCACATATATC
AGCATATAGTCTAATTATAGAAGAAGGAACTGCTTTTTATAATTTATATGAAAATGATAAGTTAAAGCTACCAACAGAAG
AAGAAGAGAGAAAAATGTACCACCTAGCAAAGAAAATTTTAGAGGAAAATGGATTTAATCAATATGAGATTTCTAATTAT
GCTAAAGAGGGAAAAGAATGTAGACATAATTTAGCATATTGGAATATGGATAACTGGATAGGAGTAGGGTCAGCAGCAGC
TTCTTATATTAATGGGAAAAGAATTAAAAACATAAGTAGTGTTGAGAAATATATAAATTCTATTAATGAGAAGAGAGAAG
CCGTAGAAGAAATAATAAATAATTCAAAAAATGATAATATGGAAGAATTTATGTTTATGGGACTTAGAAAAATTAATGGA
ATAGATGAAAATGAATTTAAAAATAGATTTAGCATGAATATAAATGATGTTTATGGAGAAATACTAAATAAGTATATAGA
TGAAGGGCTTTTAATAAGGGAGTCAGGAAGGATATTTCTAAGTGAAAAAGGCATAGAAATATCAAATATAATAATGGCTG
ATTTTTTATTATAA

Upstream 100 bases:

>100_bases
ATATGAAAGAAAGACTCATAACTAATAAATTATATTTAATTTAAAAATTTATTTTATATTAGTTAAAAAGTTTATTTATT
TTACATGGAGGTAAGTAACT

Downstream 100 bases:

>100_bases
AATTTAAAATAGGTTATGGTATAAATTGAAGCAAATAAAAGAAAAATAAAGATATTAAAGAATAAATAAGGCAAAATTCA
AAATTTTCATTTGAAATGAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDKISLYIHIPFCAQKCLYCDFPSFARKDHLRKAYIEALNKEIISLREKHNNLEINTIFIGGGTPSVLEADELECLLKEV
AKLNMAKDIEYSMECNPGNLTEEKLEVMKKYGVNRISMGLQAKQDNLLKGLGRIHNYKTFKENFLLAKKVGFNNINVDLM
FGLPNQRLNEWEETLREIISLEPAHISAYSLIIEEGTAFYNLYENDKLKLPTEEEERKMYHLAKKILEENGFNQYEISNY
AKEGKECRHNLAYWNMDNWIGVGSAAASYINGKRIKNISSVEKYINSINEKREAVEEIINNSKNDNMEEFMFMGLRKING
IDENEFKNRFSMNINDVYGEILNKYIDEGLLIRESGRIFLSEKGIEISNIIMADFLL

Sequences:

>Translated_377_residues
MDKISLYIHIPFCAQKCLYCDFPSFARKDHLRKAYIEALNKEIISLREKHNNLEINTIFIGGGTPSVLEADELECLLKEV
AKLNMAKDIEYSMECNPGNLTEEKLEVMKKYGVNRISMGLQAKQDNLLKGLGRIHNYKTFKENFLLAKKVGFNNINVDLM
FGLPNQRLNEWEETLREIISLEPAHISAYSLIIEEGTAFYNLYENDKLKLPTEEEERKMYHLAKKILEENGFNQYEISNY
AKEGKECRHNLAYWNMDNWIGVGSAAASYINGKRIKNISSVEKYINSINEKREAVEEIINNSKNDNMEEFMFMGLRKING
IDENEFKNRFSMNINDVYGEILNKYIDEGLLIRESGRIFLSEKGIEISNIIMADFLL
>Mature_377_residues
MDKISLYIHIPFCAQKCLYCDFPSFARKDHLRKAYIEALNKEIISLREKHNNLEINTIFIGGGTPSVLEADELECLLKEV
AKLNMAKDIEYSMECNPGNLTEEKLEVMKKYGVNRISMGLQAKQDNLLKGLGRIHNYKTFKENFLLAKKVGFNNINVDLM
FGLPNQRLNEWEETLREIISLEPAHISAYSLIIEEGTAFYNLYENDKLKLPTEEEERKMYHLAKKILEENGFNQYEISNY
AKEGKECRHNLAYWNMDNWIGVGSAAASYINGKRIKNISSVEKYINSINEKREAVEEIINNSKNDNMEEFMFMGLRKING
IDENEFKNRFSMNINDVYGEILNKYIDEGLLIRESGRIFLSEKGIEISNIIMADFLL

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=32.8301886792453, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1789325, Length=373, Percent_Identity=34.5844504021448, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI87082341, Length=384, Percent_Identity=23.1770833333333, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43714; Mature: 43714

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKISLYIHIPFCAQKCLYCDFPSFARKDHLRKAYIEALNKEIISLREKHNNLEINTIFI
CCCEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
GGGTPSVLEADELECLLKEVAKLNMAKDIEYSMECNPGNLTEEKLEVMKKYGVNRISMGL
CCCCCCCCCHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHCC
QAKQDNLLKGLGRIHNYKTFKENFLLAKKVGFNNINVDLMFGLPNQRLNEWEETLREIIS
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHC
LEPAHISAYSLIIEEGTAFYNLYENDKLKLPTEEEERKMYHLAKKILEENGFNQYEISNY
CCCCHHHHEEEEEECCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
AKEGKECRHNLAYWNMDNWIGVGSAAASYINGKRIKNISSVEKYINSINEKREAVEEIIN
HHHHHHHHHHCCEECCCCCCCCCHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
NSKNDNMEEFMFMGLRKINGIDENEFKNRFSMNINDVYGEILNKYIDEGLLIRESGRIFL
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCEEE
SEKGIEISNIIMADFLL
ECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDKISLYIHIPFCAQKCLYCDFPSFARKDHLRKAYIEALNKEIISLREKHNNLEINTIFI
CCCEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
GGGTPSVLEADELECLLKEVAKLNMAKDIEYSMECNPGNLTEEKLEVMKKYGVNRISMGL
CCCCCCCCCHHHHHHHHHHHHHCCCHHCCCEEEECCCCCCCHHHHHHHHHHCCCHHHHCC
QAKQDNLLKGLGRIHNYKTFKENFLLAKKVGFNNINVDLMFGLPNQRLNEWEETLREIIS
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHC
LEPAHISAYSLIIEEGTAFYNLYENDKLKLPTEEEERKMYHLAKKILEENGFNQYEISNY
CCCCHHHHEEEEEECCCEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
AKEGKECRHNLAYWNMDNWIGVGSAAASYINGKRIKNISSVEKYINSINEKREAVEEIIN
HHHHHHHHHHCCEECCCCCCCCCHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHC
NSKNDNMEEFMFMGLRKINGIDENEFKNRFSMNINDVYGEILNKYIDEGLLIRESGRIFL
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCEEE
SEKGIEISNIIMADFLL
ECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]