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The map label for this gene is era [H]

Identifier: 18310997

GI number: 18310997

Start: 2308479

End: 2309369

Strand: Reverse

Name: era [H]

Synonym: CPE2015

Alternate gene names: 18310997

Gene position: 2309369-2308479 (Counterclockwise)

Preceding gene: 18310998

Following gene: 18310996

Centisome position: 76.18

GC content: 28.62

Gene sequence:

>891_bases
ATGTTTAAATCAGGATTTATAACAATTGTTGGTAGACCAAATGTAGGTAAGTCAACATTAACAAACTTATTAATGGGAGA
AAAACTTTCAATTGTTTCTAATAAACCACAAACAACAAGAAATAATATTCAAACAATATTAACTGGAGATGACTATCAAA
TGATTTTCGTTGATACTCCAGGGATACATAAGCCTAAACATAAACTAGGTGAGTATATGGTAAATAGTGCTACAGATTCT
ATAAAAGATGTAGATTTAGTATTATTTTTAAGTAATCCATGCGAGGAAGTTGGTAGAGGAGATAAGTTTATAGTAGAGCA
GCTTAAAAATCAAAAAGCTCCTGTTATATTTGTATTAAACAAAGTTGATGAGAGTTCACCAGAAAAGGTTGCTAAAACTT
TAGAATTATTCTCAAAAGAATATGACTTTGCAGAAATGATTCCAATATCAGCTATGAAAGCTAAAAATACAGATAAACTT
TTAGAACTTATGGTCAAATATCTACCAGAGGGTCCTAAATATTATCCAGATGATATGATAACAGATGTTCAAGAAAGATT
TGTTGTAGCAGAGATAGTTAGAGAAAAAGCACTTAAAAATTTAAGCCAAGAAGTTCCTCATGGTATTGCTGTAGATGTTA
TACAAATGAAACAAGATGATAATGGTAAGTATAACATAGAAGTAGATTTAATATGTGAAAAAGCATCTCATAAAGGAATA
ATAATTGGTAAAAATGGTCAAACACTTAAGAAGATTGGTTCTACAGCTAGATATGAATTAGAAAGATTCTTAAGAGCAAA
AGTAAATATAAAAATATGGGTAAAAGTTAGAAAAGAGTGGAGAGATAATACTTCACTATTAAAGGAATTAGGTTATAAAA
AACTTAAATAG

Upstream 100 bases:

>100_bases
TATTCATAGTAAAAAGTGAAGATGATTATATAGAGACAACATTAGATGAAATTTTACCTGGATCTTTTACTAAAAAGGAT
CTAGAAAAATAGGAGGAAAT

Downstream 100 bases:

>100_bases
GAGGGATAGCTTCTGGCACTTATAGAGAGTGGTGGAGTTATCATTAAGGCTCAAGATTATAAAGAGAACGATAAATTGCT
TTGGATTTTTACCGAGAAAA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MFKSGFITIVGRPNVGKSTLTNLLMGEKLSIVSNKPQTTRNNIQTILTGDDYQMIFVDTPGIHKPKHKLGEYMVNSATDS
IKDVDLVLFLSNPCEEVGRGDKFIVEQLKNQKAPVIFVLNKVDESSPEKVAKTLELFSKEYDFAEMIPISAMKAKNTDKL
LELMVKYLPEGPKYYPDDMITDVQERFVVAEIVREKALKNLSQEVPHGIAVDVIQMKQDDNGKYNIEVDLICEKASHKGI
IIGKNGQTLKKIGSTARYELERFLRAKVNIKIWVKVRKEWRDNTSLLKELGYKKLK

Sequences:

>Translated_296_residues
MFKSGFITIVGRPNVGKSTLTNLLMGEKLSIVSNKPQTTRNNIQTILTGDDYQMIFVDTPGIHKPKHKLGEYMVNSATDS
IKDVDLVLFLSNPCEEVGRGDKFIVEQLKNQKAPVIFVLNKVDESSPEKVAKTLELFSKEYDFAEMIPISAMKAKNTDKL
LELMVKYLPEGPKYYPDDMITDVQERFVVAEIVREKALKNLSQEVPHGIAVDVIQMKQDDNGKYNIEVDLICEKASHKGI
IIGKNGQTLKKIGSTARYELERFLRAKVNIKIWVKVRKEWRDNTSLLKELGYKKLK
>Mature_296_residues
MFKSGFITIVGRPNVGKSTLTNLLMGEKLSIVSNKPQTTRNNIQTILTGDDYQMIFVDTPGIHKPKHKLGEYMVNSATDS
IKDVDLVLFLSNPCEEVGRGDKFIVEQLKNQKAPVIFVLNKVDESSPEKVAKTLELFSKEYDFAEMIPISAMKAKNTDKL
LELMVKYLPEGPKYYPDDMITDVQERFVVAEIVREKALKNLSQEVPHGIAVDVIQMKQDDNGKYNIEVDLICEKASHKGI
IIGKNGQTLKKIGSTARYELERFLRAKVNIKIWVKVRKEWRDNTSLLKELGYKKLK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=328, Percent_Identity=25.609756097561, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788919, Length=290, Percent_Identity=38.9655172413793, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082120, Length=162, Percent_Identity=31.4814814814815, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323665, Length=132, Percent_Identity=32.5757575757576, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646434, Length=306, Percent_Identity=22.5490196078431, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 33651; Mature: 33651

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKSGFITIVGRPNVGKSTLTNLLMGEKLSIVSNKPQTTRNNIQTILTGDDYQMIFVDTP
CCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCEEEEEEECC
GIHKPKHKLGEYMVNSATDSIKDVDLVLFLSNPCEEVGRGDKFIVEQLKNQKAPVIFVLN
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHCCCCCEEEEEE
KVDESSPEKVAKTLELFSKEYDFAEMIPISAMKAKNTDKLLELMVKYLPEGPKYYPDDMI
CCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHH
TDVQERFVVAEIVREKALKNLSQEVPHGIAVDVIQMKQDDNGKYNIEVDLICEKASHKGI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEEEEEECCCCCEE
IIGKNGQTLKKIGSTARYELERFLRAKVNIKIWVKVRKEWRDNTSLLKELGYKKLK
EEECCCCHHHHHCCHHHHHHHHHHHHHCCEEEEEEEEHHHCCCHHHHHHCCHHCCC
>Mature Secondary Structure
MFKSGFITIVGRPNVGKSTLTNLLMGEKLSIVSNKPQTTRNNIQTILTGDDYQMIFVDTP
CCCCCEEEEEECCCCCHHHHHHHHHCCCEEEECCCCCCCCCCEEEEEECCCEEEEEEECC
GIHKPKHKLGEYMVNSATDSIKDVDLVLFLSNPCEEVGRGDKFIVEQLKNQKAPVIFVLN
CCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHCCCCCEEEEEE
KVDESSPEKVAKTLELFSKEYDFAEMIPISAMKAKNTDKLLELMVKYLPEGPKYYPDDMI
CCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHH
TDVQERFVVAEIVREKALKNLSQEVPHGIAVDVIQMKQDDNGKYNIEVDLICEKASHKGI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCEEEEEEEEEEECCCCCEE
IIGKNGQTLKKIGSTARYELERFLRAKVNIKIWVKVRKEWRDNTSLLKELGYKKLK
EEECCCCHHHHHCCHHHHHHHHHHHHHCCEEEEEEEEHHHCCCHHHHHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA