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The map label for this gene is coaE

Identifier: 18310975

GI number: 18310975

Start: 2282533

End: 2283132

Strand: Reverse

Name: coaE

Synonym: CPE1993

Alternate gene names: 18310975

Gene position: 2283132-2282533 (Counterclockwise)

Preceding gene: 18310976

Following gene: 18310974

Centisome position: 75.32

GC content: 29.5

Gene sequence:

>600_bases
ATGATTAAAGTAGGCCTTACAGGAGGAATATGCTCAGGTAAAAGCACTATTTCTTCTATGATAAAAGAGGCAGGAATCCC
AGTTATAGATGCAGATATTATTGCAAGAGAAGTATTAGAAAAATACCCAGATATACTTTTAAGGGTAAGAGCTACTTTTG
GAGGTCATTTCTTTGATTGGAGAGGTGATTTTAGAAGAAGAGAGTTTGGAAACCATATTTTTAGATTTCCAAAGGAAAGA
ATAAAGTATGAAGAAATCATAATGCCTTATATAAAAGAGGAAATAGAGATTAAACTTAAAGAATATGAAAAAATAAATAC
TAAGCTTGTAGTTGTAGATGGGGCAACCTTAATAGAAAATGATATGCATAAGGATATGGATATGGTTGTTCTAGTTTGGG
TAGATAAAAGTAGCCAAATAGAAAGAATGGGATTTAGAGATAAGCTTAGTAAAGGGGAAGCTATAAATAGAATAAATTCT
CAATTAAGTCTTGAAAGAAAAAAAGATTATGCTAACATAATAATTGATAATAGCGGTAATTTAATTAAAACAAAGGAACA
AATTGATGATTTGTTAGAATTTTTTACTTTATACCAGTAG

Upstream 100 bases:

>100_bases
GAGGAAATGGAAAATACAATTAAATTAAGTGTACCATTAGATGTTGATGTTAATGTTGGAGAAGATTGGTATAGGTTAAA
ATAAGGAGGGTACTGATTCT

Downstream 100 bases:

>100_bases
GAGAGTTATATGAAGAAAATTATAAGGCTAGTTATAATTGTTTTAGCCATATATTTACTATTTTTAGGGAGTGGATATAT
ATTAAAAAATGTTATATTTC

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase

Number of amino acids: Translated: 199; Mature: 199

Protein sequence:

>199_residues
MIKVGLTGGICSGKSTISSMIKEAGIPVIDADIIAREVLEKYPDILLRVRATFGGHFFDWRGDFRRREFGNHIFRFPKER
IKYEEIIMPYIKEEIEIKLKEYEKINTKLVVVDGATLIENDMHKDMDMVVLVWVDKSSQIERMGFRDKLSKGEAINRINS
QLSLERKKDYANIIIDNSGNLIKTKEQIDDLLEFFTLYQ

Sequences:

>Translated_199_residues
MIKVGLTGGICSGKSTISSMIKEAGIPVIDADIIAREVLEKYPDILLRVRATFGGHFFDWRGDFRRREFGNHIFRFPKER
IKYEEIIMPYIKEEIEIKLKEYEKINTKLVVVDGATLIENDMHKDMDMVVLVWVDKSSQIERMGFRDKLSKGEAINRINS
QLSLERKKDYANIIIDNSGNLIKTKEQIDDLLEFFTLYQ
>Mature_199_residues
MIKVGLTGGICSGKSTISSMIKEAGIPVIDADIIAREVLEKYPDILLRVRATFGGHFFDWRGDFRRREFGNHIFRFPKER
IKYEEIIMPYIKEEIEIKLKEYEKINTKLVVVDGATLIENDMHKDMDMVVLVWVDKSSQIERMGFRDKLSKGEAINRINS
QLSLERKKDYANIIIDNSGNLIKTKEQIDDLLEFFTLYQ

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

Homologues:

Organism=Homo sapiens, GI191252797, Length=189, Percent_Identity=34.3915343915344, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI191252795, Length=189, Percent_Identity=34.3915343915344, Blast_Score=104, Evalue=6e-23,
Organism=Escherichia coli, GI1786292, Length=176, Percent_Identity=32.3863636363636, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17554944, Length=194, Percent_Identity=36.0824742268041, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25143409, Length=194, Percent_Identity=28.3505154639175, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320402, Length=199, Percent_Identity=29.6482412060301, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644728, Length=182, Percent_Identity=34.6153846153846, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAE_CLOPE (Q8XIX0)

Other databases:

- EMBL:   BA000016
- RefSeq:   NP_562909.1
- ProteinModelPortal:   Q8XIX0
- SMR:   Q8XIX0
- GeneID:   990308
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE1993
- NMPDR:   fig|195102.1.peg.2056
- HOGENOM:   HBG650290
- OMA:   LSAKVVH
- PhylomeDB:   Q8XIX0
- ProtClustDB:   PRK00081
- BioCyc:   CPER195102:CPE1993-MONOMER
- BRENDA:   2.7.1.24
- GO:   GO:0005737
- HAMAP:   MF_00376
- InterPro:   IPR001977
- TIGRFAMs:   TIGR00152

Pfam domain/function: PF01121 CoaE

EC number: =2.7.1.24

Molecular weight: Translated: 23152; Mature: 23152

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS51219 DPCK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVGLTGGICSGKSTISSMIKEAGIPVIDADIIAREVLEKYPDILLRVRATFGGHFFDW
CEEECCCCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
RGDFRRREFGNHIFRFPKERIKYEEIIMPYIKEEIEIKLKEYEKINTKLVVVDGATLIEN
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
DMHKDMDMVVLVWVDKSSQIERMGFRDKLSKGEAINRINSQLSLERKKDYANIIIDNSGN
HHCCCCCEEEEEEECCCCHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCC
LIKTKEQIDDLLEFFTLYQ
EEECHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIKVGLTGGICSGKSTISSMIKEAGIPVIDADIIAREVLEKYPDILLRVRATFGGHFFDW
CEEECCCCCCCCCHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCEEECC
RGDFRRREFGNHIFRFPKERIKYEEIIMPYIKEEIEIKLKEYEKINTKLVVVDGATLIEN
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHH
DMHKDMDMVVLVWVDKSSQIERMGFRDKLSKGEAINRINSQLSLERKKDYANIIIDNSGN
HHCCCCCEEEEEEECCCCHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCC
LIKTKEQIDDLLEFFTLYQ
EEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842