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The map label for this gene is ycbL [H]

Identifier: 18310918

GI number: 18310918

Start: 2218379

End: 2218999

Strand: Reverse

Name: ycbL [H]

Synonym: CPE1936

Alternate gene names: 18310918

Gene position: 2218999-2218379 (Counterclockwise)

Preceding gene: 18310919

Following gene: 18310917

Centisome position: 73.2

GC content: 30.27

Gene sequence:

>621_bases
ATGTTAATAAAAACAATTCCAGTAGGAATGTATCAAGCTAATTGTTATGTTGTTATAGATGAAGAAACTAAGGATTGTAT
AATGGTAGATCCAGGTGAAGAAGCATCAAGAATTGAAAATGTAATAGAATCTTTAGATGCAAAACCAAAAATGATATTAT
TAACTCATGGACATTTTGATCATGTTGGAGCTGTGCAAAAACTTGCAGAAAAATATAAAATACCTTTTTATATAGATAAA
AAAGATGAAGATATGATAGAAAGAAATGTTGATGTTTTTGGAAAACTTCCAAAGGCAGATGGATATTTAAAAGATGGAGA
TACTCTTAAGTTCTCAGATAATTATGAAATAAAATGTCTAGAGACACCAGGACATACACCAGGAGGATTATGCTTCTTAA
TAGATAATTGTCTTTTTACAGGAGATACTCTATTTAGAGAATCAATTGGAAGAAGTGATTTTGAAGGGGGTAATCATGCT
ACTCTTCTTAAGAGTATAAATGATAAACTGGTACCATTAGGTGATGATATAGTAGTATATCCAGGACACGGACCAAGTTC
AACTATTAAACACGAAAGACAAAGAAACCCATTTTTAGCAGGAGATTTTTATGTATATTAA

Upstream 100 bases:

>100_bases
AAACATTGAAAGTTTTTATAGGAGTTTAGCTTAATAAGTTAGACTCCTATAAATTCGGTTAAAAATATAAATTAAACTTC
ATTTTTTAGGAGGGATTGAT

Downstream 100 bases:

>100_bases
AATATATCTTAATGACTTAAAGTATAGATATGACGTTTATCAAATGTTTAATATATTCTATACTTTTAAGGAATTAAAGT
TTGTAAATGAAGATGAAGAG

Product: metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MLIKTIPVGMYQANCYVVIDEETKDCIMVDPGEEASRIENVIESLDAKPKMILLTHGHFDHVGAVQKLAEKYKIPFYIDK
KDEDMIERNVDVFGKLPKADGYLKDGDTLKFSDNYEIKCLETPGHTPGGLCFLIDNCLFTGDTLFRESIGRSDFEGGNHA
TLLKSINDKLVPLGDDIVVYPGHGPSSTIKHERQRNPFLAGDFYVY

Sequences:

>Translated_206_residues
MLIKTIPVGMYQANCYVVIDEETKDCIMVDPGEEASRIENVIESLDAKPKMILLTHGHFDHVGAVQKLAEKYKIPFYIDK
KDEDMIERNVDVFGKLPKADGYLKDGDTLKFSDNYEIKCLETPGHTPGGLCFLIDNCLFTGDTLFRESIGRSDFEGGNHA
TLLKSINDKLVPLGDDIVVYPGHGPSSTIKHERQRNPFLAGDFYVY
>Mature_206_residues
MLIKTIPVGMYQANCYVVIDEETKDCIMVDPGEEASRIENVIESLDAKPKMILLTHGHFDHVGAVQKLAEKYKIPFYIDK
KDEDMIERNVDVFGKLPKADGYLKDGDTLKFSDNYEIKCLETPGHTPGGLCFLIDNCLFTGDTLFRESIGRSDFEGGNHA
TLLKSINDKLVPLGDDIVVYPGHGPSSTIKHERQRNPFLAGDFYVY

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=193, Percent_Identity=29.5336787564767, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI116642887, Length=193, Percent_Identity=31.6062176165803, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI21703352, Length=193, Percent_Identity=31.6062176165803, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI94538320, Length=178, Percent_Identity=29.2134831460674, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI94538322, Length=178, Percent_Identity=29.2134831460674, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1787158, Length=216, Percent_Identity=37.962962962963, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1786406, Length=184, Percent_Identity=35.3260869565217, Blast_Score=75, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538952, Length=193, Percent_Identity=29.5336787564767, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17536925, Length=144, Percent_Identity=31.25, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193205216, Length=191, Percent_Identity=30.3664921465969, Blast_Score=63, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320478, Length=186, Percent_Identity=28.494623655914, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330176, Length=197, Percent_Identity=29.4416243654822, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24667703, Length=193, Percent_Identity=30.0518134715026, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356335, Length=193, Percent_Identity=30.0518134715026, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24667711, Length=193, Percent_Identity=30.0518134715026, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 23121; Mature: 23121

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKTIPVGMYQANCYVVIDEETKDCIMVDPGEEASRIENVIESLDAKPKMILLTHGHFD
CEEEEECCCEEECEEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCH
HVGAVQKLAEKYKIPFYIDKKDEDMIERNVDVFGKLPKADGYLKDGDTLKFSDNYEIKCL
HHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHEECCCCCCCEECCCCEEEECCCCEEEEE
ETPGHTPGGLCFLIDNCLFTGDTLFRESIGRSDFEGGNHATLLKSINDKLVPLGDDIVVY
CCCCCCCCCEEEEEECCEECCCHHHHHHCCCCCCCCCCCCCEEECCCCCEEECCCCEEEE
PGHGPSSTIKHERQRNPFLAGDFYVY
CCCCCCHHHHHHHHCCCEEECEEEEC
>Mature Secondary Structure
MLIKTIPVGMYQANCYVVIDEETKDCIMVDPGEEASRIENVIESLDAKPKMILLTHGHFD
CEEEEECCCEEECEEEEEEECCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEECCCCH
HVGAVQKLAEKYKIPFYIDKKDEDMIERNVDVFGKLPKADGYLKDGDTLKFSDNYEIKCL
HHHHHHHHHHHCCCCEEECCCCHHHHHCCHHHEECCCCCCCEECCCCEEEECCCCEEEEE
ETPGHTPGGLCFLIDNCLFTGDTLFRESIGRSDFEGGNHATLLKSINDKLVPLGDDIVVY
CCCCCCCCCEEEEEECCEECCCHHHHHHCCCCCCCCCCCCCEEECCCCCEEECCCCEEEE
PGHGPSSTIKHERQRNPFLAGDFYVY
CCCCCCHHHHHHHHCCCEEECEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]