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The map label for this gene is deoA [H]

Identifier: 18310789

GI number: 18310789

Start: 2086621

End: 2087922

Strand: Reverse

Name: deoA [H]

Synonym: CPE1807

Alternate gene names: 18310789

Gene position: 2087922-2086621 (Counterclockwise)

Preceding gene: 18310790

Following gene: 18310788

Centisome position: 68.88

GC content: 32.03

Gene sequence:

>1302_bases
ATGAGAATGTATGATTTAATATTAAAAAAGAGAAATGGTGGGGAATTAAGCACTGAAGAAATAAACTTTTTTGTTGATAA
ATATACAAATGGTGAAATACCAGATTATCAAGTAGCAGCCTTATTAATGGCTATATATTTCCAAAAAATGAATAAGAGAG
AAACTTCAGATTTAACTATGGCTATGGTTAATTCAGGAGATATATTAGATTTAAGTGAAATACACGGTATAAAAGTAGAT
AAGCATTCAACTGGTGGGGTTGGTGATACTACTACTTTAGTTTTAGGACCTATGGTTGCAGCTTTAGGAATTCCTGTAGC
TAAAATGTCAGGAAGAGGTCTTGGACATACTGGTGGAACAATAGATAAATTAGAAAGTTTTGATGGATTCTCAGTAGAAA
TGACTAAGGATCAATTTATAAATAATGTTAATAATATAAAATTAGCAGTTGGTGGACAAACAGGAGATTTAGCTCCAGCT
GATAAAAAACTTTATGCTTTAAGAGATGTTACTGGAACTGTTGATAATGTATCATTAATAGCTTCAAGTATTATGAGTAA
AAAAATTGCTGCAGGCGCTGATGCCATAGTATTAGACGTTAAGGTTGGAGATGGAGCATTTATGAAAACTCCAGAGGCAG
CTAGAGAACTTGCAACTGAAATGGTTGGAATAGGTAAACATGTTGGAAGAAATACTGTTGCCATAATTTCAGATATGGAT
CAACCTTTAGGATTTGCTATAGGTAATGCATTAGAAGTTAAAGAAGCCATAGAAACTTTAAGAGGAAATGGTCCTAAGGA
TCTTTTAGAGCTTTGCTTAACACTTGGAAGCAACATGGTTGTTTTAGCAGGTGCTGCTAAAGATACTGATGAAGCAAGAA
AAATGTTAATGGAAACAATAACTTCAGGAAAAGCAATTGAAAAATTAAAAGAATTTGTAAAAGCTCAAGGTGGAGATGCA
TCAGTTATTGATGATATATCAAACTTCCATAATGCTAAATATGTAATTCCAGTTAAAGCTACTAAATCAGGAGTTGTAAG
CAAAATACATGCTGAAAACATAGGATTAGTTGCTATGGAACTTGGAGCAGGAAGAGCTACTAAAGAAAGTATTATAGATT
TAGCTGTTGGTATTGTTCTTCAAAAGAAAAGAGGAGACAAAGTTAATGAAGGAGATATAATAGCATATATTCATGCTGAT
GATGAAGAAAAAGGTAAGAAAGCAGTAGATGGAATATTAGCTAATTACGAAATATCAGATTCAGTAAAAGATATTCCATT
AATATATGATATAGTTAAATAG

Upstream 100 bases:

>100_bases
TATTTTATAGGGTGAAAGTACTTGTAAATAAGGAATCTCTCTGATAAAATGAATTTATGAAAAGGTTATCACAAATTGAT
AGTGTGGAGGAAAGAAACTT

Downstream 100 bases:

>100_bases
TTTTAAAAAATGCTTTAAAGCTGGTTGGATTCTTGTCAGGTATAGCTAAGATTTATAGTTATGCATCGTAATCTTTGAAT
AACCATATCTAACAAGGAAC

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MRMYDLILKKRNGGELSTEEINFFVDKYTNGEIPDYQVAALLMAIYFQKMNKRETSDLTMAMVNSGDILDLSEIHGIKVD
KHSTGGVGDTTTLVLGPMVAALGIPVAKMSGRGLGHTGGTIDKLESFDGFSVEMTKDQFINNVNNIKLAVGGQTGDLAPA
DKKLYALRDVTGTVDNVSLIASSIMSKKIAAGADAIVLDVKVGDGAFMKTPEAARELATEMVGIGKHVGRNTVAIISDMD
QPLGFAIGNALEVKEAIETLRGNGPKDLLELCLTLGSNMVVLAGAAKDTDEARKMLMETITSGKAIEKLKEFVKAQGGDA
SVIDDISNFHNAKYVIPVKATKSGVVSKIHAENIGLVAMELGAGRATKESIIDLAVGIVLQKKRGDKVNEGDIIAYIHAD
DEEKGKKAVDGILANYEISDSVKDIPLIYDIVK

Sequences:

>Translated_433_residues
MRMYDLILKKRNGGELSTEEINFFVDKYTNGEIPDYQVAALLMAIYFQKMNKRETSDLTMAMVNSGDILDLSEIHGIKVD
KHSTGGVGDTTTLVLGPMVAALGIPVAKMSGRGLGHTGGTIDKLESFDGFSVEMTKDQFINNVNNIKLAVGGQTGDLAPA
DKKLYALRDVTGTVDNVSLIASSIMSKKIAAGADAIVLDVKVGDGAFMKTPEAARELATEMVGIGKHVGRNTVAIISDMD
QPLGFAIGNALEVKEAIETLRGNGPKDLLELCLTLGSNMVVLAGAAKDTDEARKMLMETITSGKAIEKLKEFVKAQGGDA
SVIDDISNFHNAKYVIPVKATKSGVVSKIHAENIGLVAMELGAGRATKESIIDLAVGIVLQKKRGDKVNEGDIIAYIHAD
DEEKGKKAVDGILANYEISDSVKDIPLIYDIVK
>Mature_433_residues
MRMYDLILKKRNGGELSTEEINFFVDKYTNGEIPDYQVAALLMAIYFQKMNKRETSDLTMAMVNSGDILDLSEIHGIKVD
KHSTGGVGDTTTLVLGPMVAALGIPVAKMSGRGLGHTGGTIDKLESFDGFSVEMTKDQFINNVNNIKLAVGGQTGDLAPA
DKKLYALRDVTGTVDNVSLIASSIMSKKIAAGADAIVLDVKVGDGAFMKTPEAARELATEMVGIGKHVGRNTVAIISDMD
QPLGFAIGNALEVKEAIETLRGNGPKDLLELCLTLGSNMVVLAGAAKDTDEARKMLMETITSGKAIEKLKEFVKAQGGDA
SVIDDISNFHNAKYVIPVKATKSGVVSKIHAENIGLVAMELGAGRATKESIIDLAVGIVLQKKRGDKVNEGDIIAYIHAD
DEEKGKKAVDGILANYEISDSVKDIPLIYDIVK

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=409, Percent_Identity=39.8533007334963, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4503445, Length=409, Percent_Identity=39.8533007334963, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI166158922, Length=409, Percent_Identity=39.8533007334963, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1790842, Length=408, Percent_Identity=42.8921568627451, Blast_Score=312, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46187; Mature: 46187

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMYDLILKKRNGGELSTEEINFFVDKYTNGEIPDYQVAALLMAIYFQKMNKRETSDLTM
CCHHHHHEECCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEE
AMVNSGDILDLSEIHGIKVDKHSTGGVGDTTTLVLGPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFDGFSVEMTKDQFINNVNNIKLAVGGQTGDLAPADKKLYALRDVTGTVDNVSLI
HHHHHCCCCCEEEECHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEHHCCCCHHHHHHH
ASSIMSKKIAAGADAIVLDVKVGDGAFMKTPEAARELATEMVGIGKHVGRNTVAIISDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
QPLGFAIGNALEVKEAIETLRGNGPKDLLELCLTLGSNMVVLAGAAKDTDEARKMLMETI
CCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
TSGKAIEKLKEFVKAQGGDASVIDDISNFHNAKYVIPVKATKSGVVSKIHAENIGLVAME
HCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCEEEEE
LGAGRATKESIIDLAVGIVLQKKRGDKVNEGDIIAYIHADDEEKGKKAVDGILANYEISD
CCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCC
SVKDIPLIYDIVK
CCCCCCHHHEECC
>Mature Secondary Structure
MRMYDLILKKRNGGELSTEEINFFVDKYTNGEIPDYQVAALLMAIYFQKMNKRETSDLTM
CCHHHHHEECCCCCCCCHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEE
AMVNSGDILDLSEIHGIKVDKHSTGGVGDTTTLVLGPMVAALGIPVAKMSGRGLGHTGGT
EEECCCCEEEHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
IDKLESFDGFSVEMTKDQFINNVNNIKLAVGGQTGDLAPADKKLYALRDVTGTVDNVSLI
HHHHHCCCCCEEEECHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEHHCCCCHHHHHHH
ASSIMSKKIAAGADAIVLDVKVGDGAFMKTPEAARELATEMVGIGKHVGRNTVAIISDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
QPLGFAIGNALEVKEAIETLRGNGPKDLLELCLTLGSNMVVLAGAAKDTDEARKMLMETI
CCHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHH
TSGKAIEKLKEFVKAQGGDASVIDDISNFHNAKYVIPVKATKSGVVSKIHAENIGLVAME
HCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCCEEEEE
LGAGRATKESIIDLAVGIVLQKKRGDKVNEGDIIAYIHADDEEKGKKAVDGILANYEISD
CCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCC
SVKDIPLIYDIVK
CCCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]