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The map label for this gene is nupC [H]

Identifier: 18310266

GI number: 18310266

Start: 1513189

End: 1514370

Strand: Reverse

Name: nupC [H]

Synonym: CPE1284

Alternate gene names: 18310266

Gene position: 1514370-1513189 (Counterclockwise)

Preceding gene: 18310267

Following gene: 18310264

Centisome position: 49.96

GC content: 30.12

Gene sequence:

>1182_bases
ATGAAATATATTATTGGAGTTGTAGGATTAATTGTTATTTTAGCACTTGCGTGGATTGGAAGTAGTGATAAGAAGAATAT
AAAATATAAACCTGTATTTTTAATGCTTATTTTACAATTCGTATTAGGATTTATACTTTTAAATACTCAAGTAGGAAATT
ATTTAGTTGGAAGTATAGCAAATGGGTTTCAGGTTCTTCTAGATTGTGCTGGAGATGGAGTAAACTTTGTATTTGGTGGA
CTAGTTAATAATGATCAATTTTCATTCTTTATTAGTGTTCTTTTACCAATAATCTTTATTTCTGCCTTAATTGGTATTTT
ACAATACTTAAAAATACTTCCTTTTGTAATTAAATACATAGGCTTAGTTTTAAGTAAAATTAATGGCATGGGTAAATTAG
AGTCTTACAATGCTGTAGCATCAGCTATACTTGGTCAATCAGAAGTATTTATTTCTGTAAAAAAAGAACTTGGTTTATTA
CCTAAACATAGATTATATACTTTATGTGCATCAGCAATGTCAACAGTATCTATGTCTATAGTTGGTTCTTACATGGTTTT
ATTACAGCCTAGATATGTTGTAACAGCAATTGTTCTTAATTTATTTGGTGGATTCATTATAGCATCAGTTATAAATCCAT
ACTCTGTATCAGCAGAAGAGGATATTTTAGTAGTTGAGGATGAAAAGAAACAAACTTTCTTTGAAGTACTTGGTGAATAT
ATCTTAGATGGATTTAAGGTAGCAGTTATAGTAGCAGCTATGTTAGTTGGATTTGTAGCAATCATTGCTGTAATAAACAT
GATCTTTAGATCAATCTTTGGAATGAGCTTCCAAGAGATACTAGGATATGTATTCTCACCTTTTGCATTCTTAATGGGTG
TACCTTTAAATGAGTCAATACAAGCTGCCAGCGTAATGGCAACAAAGCTAGTATCTAATGAGTTTGTTGCAATGAATTTA
TTATCAAGTGGAACTTTAAATTTATCAGCAAGATCAATTGGTATTGTTTCAGTATTTTTAATTTCTTTTGCAAACTTCTC
ATCAATTGGAATTATTTCAGGAGCAGTAAAGGGGCTTAACCAAGAACAAGGAAATGTGGTTGCACGTTTCGGACTTAAAC
TACTATATGGTGCAACATTAGTAAGTATGTTAACAGCAACTATTGTTGGATTAATTATATAA

Upstream 100 bases:

>100_bases
TTTTGGGAAATATTAAAAACAATCTACTAAAAGTGTATTTATTGTACCATATGCAAAAGATAATAATATTAAACTTATGG
TATATAACAAGGAGGAGAAA

Downstream 100 bases:

>100_bases
ATAAAAGAATTAAATTTGTTTAGTTTATATAGTACAATGTAATGAGAAATGAAAACAGCAATAATATTTAAAATATTATT
GCTGTTTTTTATGTAGAAAT

Product: pyrimidine nucleoside transporter

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKYIIGVVGLIVILALAWIGSSDKKNIKYKPVFLMLILQFVLGFILLNTQVGNYLVGSIANGFQVLLDCAGDGVNFVFGG
LVNNDQFSFFISVLLPIIFISALIGILQYLKILPFVIKYIGLVLSKINGMGKLESYNAVASAILGQSEVFISVKKELGLL
PKHRLYTLCASAMSTVSMSIVGSYMVLLQPRYVVTAIVLNLFGGFIIASVINPYSVSAEEDILVVEDEKKQTFFEVLGEY
ILDGFKVAVIVAAMLVGFVAIIAVINMIFRSIFGMSFQEILGYVFSPFAFLMGVPLNESIQAASVMATKLVSNEFVAMNL
LSSGTLNLSARSIGIVSVFLISFANFSSIGIISGAVKGLNQEQGNVVARFGLKLLYGATLVSMLTATIVGLII

Sequences:

>Translated_393_residues
MKYIIGVVGLIVILALAWIGSSDKKNIKYKPVFLMLILQFVLGFILLNTQVGNYLVGSIANGFQVLLDCAGDGVNFVFGG
LVNNDQFSFFISVLLPIIFISALIGILQYLKILPFVIKYIGLVLSKINGMGKLESYNAVASAILGQSEVFISVKKELGLL
PKHRLYTLCASAMSTVSMSIVGSYMVLLQPRYVVTAIVLNLFGGFIIASVINPYSVSAEEDILVVEDEKKQTFFEVLGEY
ILDGFKVAVIVAAMLVGFVAIIAVINMIFRSIFGMSFQEILGYVFSPFAFLMGVPLNESIQAASVMATKLVSNEFVAMNL
LSSGTLNLSARSIGIVSVFLISFANFSSIGIISGAVKGLNQEQGNVVARFGLKLLYGATLVSMLTATIVGLII
>Mature_393_residues
MKYIIGVVGLIVILALAWIGSSDKKNIKYKPVFLMLILQFVLGFILLNTQVGNYLVGSIANGFQVLLDCAGDGVNFVFGG
LVNNDQFSFFISVLLPIIFISALIGILQYLKILPFVIKYIGLVLSKINGMGKLESYNAVASAILGQSEVFISVKKELGLL
PKHRLYTLCASAMSTVSMSIVGSYMVLLQPRYVVTAIVLNLFGGFIIASVINPYSVSAEEDILVVEDEKKQTFFEVLGEY
ILDGFKVAVIVAAMLVGFVAIIAVINMIFRSIFGMSFQEILGYVFSPFAFLMGVPLNESIQAASVMATKLVSNEFVAMNL
LSSGTLNLSARSIGIVSVFLISFANFSSIGIISGAVKGLNQEQGNVVARFGLKLLYGATLVSMLTATIVGLII

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=410, Percent_Identity=25.609756097561, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI42542381, Length=419, Percent_Identity=25.2983293556086, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI227116277, Length=416, Percent_Identity=23.7980769230769, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1788737, Length=393, Percent_Identity=56.7430025445293, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1788485, Length=415, Percent_Identity=32.289156626506, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI1788488, Length=416, Percent_Identity=32.6923076923077, Blast_Score=172, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17560276, Length=394, Percent_Identity=25.8883248730964, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71991794, Length=391, Percent_Identity=25.5754475703325, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45552517, Length=404, Percent_Identity=26.980198019802, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI19921868, Length=404, Percent_Identity=26.980198019802, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45552519, Length=404, Percent_Identity=26.980198019802, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281360430, Length=355, Percent_Identity=23.0985915492958, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 42351; Mature: 42351

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYIIGVVGLIVILALAWIGSSDKKNIKYKPVFLMLILQFVLGFILLNTQVGNYLVGSIA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFQVLLDCAGDGVNFVFGGLVNNDQFSFFISVLLPIIFISALIGILQYLKILPFVIKYI
HHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVLSKINGMGKLESYNAVASAILGQSEVFISVKKELGLLPKHRLYTLCASAMSTVSMSI
HHHHHHHCCCCCCHHHHHHHHHHHCCHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHH
VGSYMVLLQPRYVVTAIVLNLFGGFIIASVINPYSVSAEEDILVVEDEKKQTFFEVLGEY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHH
ILDGFKVAVIVAAMLVGFVAIIAVINMIFRSIFGMSFQEILGYVFSPFAFLMGVPLNESI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
QAASVMATKLVSNEFVAMNLLSSGTLNLSARSIGIVSVFLISFANFSSIGIISGAVKGLN
HHHHHHHHHHHHCCHHHHHHHCCCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
QEQGNVVARFGLKLLYGATLVSMLTATIVGLII
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKYIIGVVGLIVILALAWIGSSDKKNIKYKPVFLMLILQFVLGFILLNTQVGNYLVGSIA
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NGFQVLLDCAGDGVNFVFGGLVNNDQFSFFISVLLPIIFISALIGILQYLKILPFVIKYI
HHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVLSKINGMGKLESYNAVASAILGQSEVFISVKKELGLLPKHRLYTLCASAMSTVSMSI
HHHHHHHCCCCCCHHHHHHHHHHHCCHHHHEEEHHHHCCCCHHHHHHHHHHHHHHHHHHH
VGSYMVLLQPRYVVTAIVLNLFGGFIIASVINPYSVSAEEDILVVEDEKKQTFFEVLGEY
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHH
ILDGFKVAVIVAAMLVGFVAIIAVINMIFRSIFGMSFQEILGYVFSPFAFLMGVPLNESI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCH
QAASVMATKLVSNEFVAMNLLSSGTLNLSARSIGIVSVFLISFANFSSIGIISGAVKGLN
HHHHHHHHHHHHCCHHHHHHHCCCCCEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
QEQGNVVARFGLKLLYGATLVSMLTATIVGLII
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]