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The map label for this gene is pabA [H]

Identifier: 18309998

GI number: 18309998

Start: 1219810

End: 1220400

Strand: Direct

Name: pabA [H]

Synonym: CPE1016

Alternate gene names: 18309998

Gene position: 1219810-1220400 (Clockwise)

Preceding gene: 18309995

Following gene: 18309999

Centisome position: 40.24

GC content: 29.44

Gene sequence:

>591_bases
ATGTTTTTAATGATAGATAACTATGATTCCTTCGTGTTTAATTTACTTAGGTATTTTAAGGAATTAAATGAGGATATAAA
GATAAAGAGGAATGATAAAATAACTATAGAAGAAATAAAAAAATTGAATCCAGAGGGAATAATAATATCTCCAGGACCTA
AAGCACCTAAGGATATGAAAGAATGTTTAAATATTATAGAGGAATTTAAGGGAAAGATTCCTATTTTAGGTGTATGTCTT
GGTCACCAATGTATTGGATATTCCTTTGGGAGTAAAATAAAAAAAGGGGATTTCCCAGTCCACGGAAAAGTGAGTAAAAT
AACTCATGACGGAAAAGGGATTTTTAAGGGAATCAAAAATAATATAAATGTAACTAGATATCATTCTTTAGTAGTTGATA
GAAATTTTTTAGGAGAAGATTTAGAGATAACTGCCTTAAGTGATGATGGGGTAGTTATGGGAATAAGGCATAAAAGGTAC
AATATAGAAGGAGTACAGTTTCATCCAGAGGCTGTTTTAACTGAATATGGCCATGAAATGCTTAAAAATTTTATTGATAA
TGCTAGGAAATTTAATATTATAGAAAGGTGA

Upstream 100 bases:

>100_bases
CAATTAGAAGATTCAAATATATAAATGGTATAAAATTCATATTTTTTTTTAGGTGTTTTTGATATAATGATTTTAAACTA
AATATTTTAGAGGTGAATTA

Downstream 100 bases:

>100_bases
GTAATTTGAATTTTGAAATTAAGGAAATAGAAAATAAGCTTAAGCCACATGAAGTATATTTTTTATTTAAAGATGAAATA
AACAGTATATTTTTAGATAG

Product: anthranilate synthase component II

Products: NA

Alternate protein names: ADC synthase [H]

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MFLMIDNYDSFVFNLLRYFKELNEDIKIKRNDKITIEEIKKLNPEGIIISPGPKAPKDMKECLNIIEEFKGKIPILGVCL
GHQCIGYSFGSKIKKGDFPVHGKVSKITHDGKGIFKGIKNNINVTRYHSLVVDRNFLGEDLEITALSDDGVVMGIRHKRY
NIEGVQFHPEAVLTEYGHEMLKNFIDNARKFNIIER

Sequences:

>Translated_196_residues
MFLMIDNYDSFVFNLLRYFKELNEDIKIKRNDKITIEEIKKLNPEGIIISPGPKAPKDMKECLNIIEEFKGKIPILGVCL
GHQCIGYSFGSKIKKGDFPVHGKVSKITHDGKGIFKGIKNNINVTRYHSLVVDRNFLGEDLEITALSDDGVVMGIRHKRY
NIEGVQFHPEAVLTEYGHEMLKNFIDNARKFNIIER
>Mature_196_residues
MFLMIDNYDSFVFNLLRYFKELNEDIKIKRNDKITIEEIKKLNPEGIIISPGPKAPKDMKECLNIIEEFKGKIPILGVCL
GHQCIGYSFGSKIKKGDFPVHGKVSKITHDGKGIFKGIKNNINVTRYHSLVVDRNFLGEDLEITALSDDGVVMGIRHKRY
NIEGVQFHPEAVLTEYGHEMLKNFIDNARKFNIIER

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789760, Length=185, Percent_Identity=49.7297297297297, Blast_Score=217, Evalue=5e-58,
Organism=Escherichia coli, GI1787517, Length=191, Percent_Identity=35.6020942408377, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1786215, Length=143, Percent_Identity=31.4685314685315, Blast_Score=69, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322638, Length=185, Percent_Identity=46.4864864864865, Blast_Score=188, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324361, Length=207, Percent_Identity=28.0193236714976, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323873, Length=146, Percent_Identity=31.5068493150685, Blast_Score=68, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281365319, Length=140, Percent_Identity=35.7142857142857, Blast_Score=73, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 22483; Mature: 22483

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLMIDNYDSFVFNLLRYFKELNEDIKIKRNDKITIEEIKKLNPEGIIISPGPKAPKDMK
CEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCEEHHHHHCCCCCCEEECCCCCCHHHHH
ECLNIIEEFKGKIPILGVCLGHQCIGYSFGSKIKKGDFPVHGKVSKITHDGKGIFKGIKN
HHHHHHHHHCCCCCEEEEECCCHHHCCHHCCCCCCCCCCCCCCHHHEEECCHHHHHHHHC
NINVTRYHSLVVDRNFLGEDLEITALSDDGVVMGIRHKRYNIEGVQFHPEAVLTEYGHEM
CCCEEEEEEEEEECCCCCCCEEEEEECCCCEEEEEEECEECCCCEEECHHHHHHHHHHHH
LKNFIDNARKFNIIER
HHHHHCCHHHCCCCCC
>Mature Secondary Structure
MFLMIDNYDSFVFNLLRYFKELNEDIKIKRNDKITIEEIKKLNPEGIIISPGPKAPKDMK
CEEEEECCHHHHHHHHHHHHHCCCCCEEECCCCEEHHHHHCCCCCCEEECCCCCCHHHHH
ECLNIIEEFKGKIPILGVCLGHQCIGYSFGSKIKKGDFPVHGKVSKITHDGKGIFKGIKN
HHHHHHHHHCCCCCEEEEECCCHHHCCHHCCCCCCCCCCCCCCHHHEEECCHHHHHHHHC
NINVTRYHSLVVDRNFLGEDLEITALSDDGVVMGIRHKRYNIEGVQFHPEAVLTEYGHEM
CCCEEEEEEEEEECCCCCCCEEEEEECCCCEEEEEEECEECCCCEEECHHHHHHHHHHHH
LKNFIDNARKFNIIER
HHHHHCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3894673; 2403545; 11677609 [H]