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The map label for this gene is pabB [H]

Identifier: 18309999

GI number: 18309999

Start: 1220406

End: 1221752

Strand: Direct

Name: pabB [H]

Synonym: CPE1017

Alternate gene names: 18309999

Gene position: 1220406-1221752 (Clockwise)

Preceding gene: 18309998

Following gene: 18310000

Centisome position: 40.26

GC content: 27.32

Gene sequence:

>1347_bases
TTGAATTTTGAAATTAAGGAAATAGAAAATAAGCTTAAGCCACATGAAGTATATTTTTTATTTAAAGATGAAATAAACAG
TATATTTTTAGATAGTTCAAAGGAAGATAGCGAATTTTCTTTATATTCATTCATAGGATTAAATCCTTTTAAAAAGTTTA
TCTCTAAGGGAAATGAGATTTTTATAGATGAAAAACTAGTCTTAGGAGATCCTTTTAAAAAATTAGAAGAGCTTATTTTA
GAATATAAAATAAATTATAATAGTGAGATACCTTTTTTAGGAGGTGCTATGGGATATTTTTCTTATGATATAGGAAGAGT
TATTGAAGATATGCCTAAAAGTGCTAAGGATGATGTGTGTATTCCAGATAGTTATTTTTTATTTTATGATAATGTAATAA
TATTTGATTTGAGAAATCAAAAAACATATATAACAGCCCTAGGAATTAAGGAAGAGTCAGAAAAAAGTATAGCTAATATT
TATGAGAGGATAAAAGATAAGGATATAAATTTAAATATCAGCTTAGATAAAAATACTGAGTTTAGTTCAAATTTTTCAAG
AGAAGAATACATAAATTCAGTAAAAAAGGTTAAAGAGTACATAAAAGAAGGGCATACATATATTGCAAACCTAACACAGA
GATTTTCCTGTGATTTTAATTCTGATCCTTTTGATACATATATAAGTTTGAGAAGTATAAATAAAGCCCCTTTTTCCTGT
TATTTAAATTTAGATGGTTTTCAAATTATAAGTTCTTCTCCAGAGAGGTTTTTAAAAGTGTTTAATAATAAGGTTGAAAC
AAGACCAATTAAAGGCACAAGACCAAGAGGAAAAGATAAATTAGAAGATGAAAAGAATAAAAAAGAACTTTTAAATAGTG
AAAAGGATAAGTCAGAGCTTTTAATGATTGTTGATTTAGAGAGAAATGATTTAAGTAAGGTATGCAAACCTTTTTCTGTG
AAGGTTACAGAATTATTTAAATTAGAGGAATATGCTACAGTATTTCACTTAGTTTCCACAGTTATAGGAGAACTAAAGGA
AGATGTTAGTTCTGTAAAATGTATAAGAGAATGTTTTCCAGGAGGTTCTATAACAGGCGCTCCTAAAATAAGAAGTATGG
AGATAATAGAGGAACTAGAAGGCATTAGAAGAGGGATATATACTGGGTCCATAGGTTATTTTGATTTAAGAGGAAATTGT
GATTTTAATATAGTAATAAGAACTATATTAGCAAAAGATAATAAGGCTTATTTTGGAGTAGGTGGAGGCATAACTATTGA
ATCAGAAGAAGAGATGGAATATGAGGAAACTTTAGATAAGGCAAAGGCTTTAATGAGAGTATTATAA

Upstream 100 bases:

>100_bases
AGTTTCATCCAGAGGCTGTTTTAACTGAATATGGCCATGAAATGCTTAAAAATTTTATTGATAATGCTAGGAAATTTAAT
ATTATAGAAAGGTGAGTAAT

Downstream 100 bases:

>100_bases
TTAGGTTGTGATATAAAGTGATTTATATAGGAGAAAATAAAAGAGGTTATAGTATGGTTAAGAAAGATTTACTTATCATA
GATTCTTCTGTTTTTTTTGG

Product: para-aminobenzoate synthase, component I

Products: NA

Alternate protein names: ADC synthase; Para-aminobenzoate synthase component I [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNFEIKEIENKLKPHEVYFLFKDEINSIFLDSSKEDSEFSLYSFIGLNPFKKFISKGNEIFIDEKLVLGDPFKKLEELIL
EYKINYNSEIPFLGGAMGYFSYDIGRVIEDMPKSAKDDVCIPDSYFLFYDNVIIFDLRNQKTYITALGIKEESEKSIANI
YERIKDKDINLNISLDKNTEFSSNFSREEYINSVKKVKEYIKEGHTYIANLTQRFSCDFNSDPFDTYISLRSINKAPFSC
YLNLDGFQIISSSPERFLKVFNNKVETRPIKGTRPRGKDKLEDEKNKKELLNSEKDKSELLMIVDLERNDLSKVCKPFSV
KVTELFKLEEYATVFHLVSTVIGELKEDVSSVKCIRECFPGGSITGAPKIRSMEIIEELEGIRRGIYTGSIGYFDLRGNC
DFNIVIRTILAKDNKAYFGVGGGITIESEEEMEYEETLDKAKALMRVL

Sequences:

>Translated_448_residues
MNFEIKEIENKLKPHEVYFLFKDEINSIFLDSSKEDSEFSLYSFIGLNPFKKFISKGNEIFIDEKLVLGDPFKKLEELIL
EYKINYNSEIPFLGGAMGYFSYDIGRVIEDMPKSAKDDVCIPDSYFLFYDNVIIFDLRNQKTYITALGIKEESEKSIANI
YERIKDKDINLNISLDKNTEFSSNFSREEYINSVKKVKEYIKEGHTYIANLTQRFSCDFNSDPFDTYISLRSINKAPFSC
YLNLDGFQIISSSPERFLKVFNNKVETRPIKGTRPRGKDKLEDEKNKKELLNSEKDKSELLMIVDLERNDLSKVCKPFSV
KVTELFKLEEYATVFHLVSTVIGELKEDVSSVKCIRECFPGGSITGAPKIRSMEIIEELEGIRRGIYTGSIGYFDLRGNC
DFNIVIRTILAKDNKAYFGVGGGITIESEEEMEYEETLDKAKALMRVL
>Mature_448_residues
MNFEIKEIENKLKPHEVYFLFKDEINSIFLDSSKEDSEFSLYSFIGLNPFKKFISKGNEIFIDEKLVLGDPFKKLEELIL
EYKINYNSEIPFLGGAMGYFSYDIGRVIEDMPKSAKDDVCIPDSYFLFYDNVIIFDLRNQKTYITALGIKEESEKSIANI
YERIKDKDINLNISLDKNTEFSSNFSREEYINSVKKVKEYIKEGHTYIANLTQRFSCDFNSDPFDTYISLRSINKAPFSC
YLNLDGFQIISSSPERFLKVFNNKVETRPIKGTRPRGKDKLEDEKNKKELLNSEKDKSELLMIVDLERNDLSKVCKPFSV
KVTELFKLEEYATVFHLVSTVIGELKEDVSSVKCIRECFPGGSITGAPKIRSMEIIEELEGIRRGIYTGSIGYFDLRGNC
DFNIVIRTILAKDNKAYFGVGGGITIESEEEMEYEETLDKAKALMRVL

Specific function: Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine [H]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1788114, Length=428, Percent_Identity=37.8504672897196, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1787518, Length=365, Percent_Identity=33.6986301369863, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786809, Length=416, Percent_Identity=22.3557692307692, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87082077, Length=219, Percent_Identity=24.2009132420091, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320935, Length=462, Percent_Identity=36.3636363636364, Blast_Score=256, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6324361, Length=401, Percent_Identity=28.1795511221945, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR015890
- InterPro:   IPR005802 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =2.6.1.85 [H]

Molecular weight: Translated: 51670; Mature: 51670

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFEIKEIENKLKPHEVYFLFKDEINSIFLDSSKEDSEFSLYSFIGLNPFKKFISKGNEI
CCCCHHHHHHCCCCEEEEEEEECCCCEEEECCCCCCCCEEEEHHHCCCHHHHHHHCCCEE
FIDEKLVLGDPFKKLEELILEYKINYNSEIPFLGGAMGYFSYDIGRVIEDMPKSAKDDVC
EEECEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEE
IPDSYFLFYDNVIIFDLRNQKTYITALGIKEESEKSIANIYERIKDKDINLNISLDKNTE
CCCCEEEEECCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
FSSNFSREEYINSVKKVKEYIKEGHTYIANLTQRFSCDFNSDPFDTYISLRSINKAPFSC
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHEEECCCCCCCEEE
YLNLDGFQIISSSPERFLKVFNNKVETRPIKGTRPRGKDKLEDEKNKKELLNSEKDKSEL
EEECCCCEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCE
LMIVDLERNDLSKVCKPFSVKVTELFKLEEYATVFHLVSTVIGELKEDVSSVKCIRECFP
EEEEECCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGSITGAPKIRSMEIIEELEGIRRGIYTGSIGYFDLRGNCDFNIVIRTILAKDNKAYFGV
CCCCCCCCCCHHHHHHHHHHHHHHCCEECCCEEEEECCCCCHHEEEEEEHHCCCCEEEEC
GGGITIESEEEMEYEETLDKAKALMRVL
CCCEEECCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFEIKEIENKLKPHEVYFLFKDEINSIFLDSSKEDSEFSLYSFIGLNPFKKFISKGNEI
CCCCHHHHHHCCCCEEEEEEEECCCCEEEECCCCCCCCEEEEHHHCCCHHHHHHHCCCEE
FIDEKLVLGDPFKKLEELILEYKINYNSEIPFLGGAMGYFSYDIGRVIEDMPKSAKDDVC
EEECEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEE
IPDSYFLFYDNVIIFDLRNQKTYITALGIKEESEKSIANIYERIKDKDINLNISLDKNTE
CCCCEEEEECCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
FSSNFSREEYINSVKKVKEYIKEGHTYIANLTQRFSCDFNSDPFDTYISLRSINKAPFSC
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHEEECCCCCCCEEE
YLNLDGFQIISSSPERFLKVFNNKVETRPIKGTRPRGKDKLEDEKNKKELLNSEKDKSEL
EEECCCCEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCE
LMIVDLERNDLSKVCKPFSVKVTELFKLEEYATVFHLVSTVIGELKEDVSSVKCIRECFP
EEEEECCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GGSITGAPKIRSMEIIEELEGIRRGIYTGSIGYFDLRGNCDFNIVIRTILAKDNKAYFGV
CCCCCCCCCCHHHHHHHHHHHHHHCCEECCCEEEEECCCCCHHEEEEEEHHCCCCEEEEC
GGGITIESEEEMEYEETLDKAKALMRVL
CCCEEECCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6330050; 9097040; 9278503; 7896119; 2251281; 7592344 [H]