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The map label for this gene is gltX [H]

Identifier: 18309980

GI number: 18309980

Start: 1202355

End: 1203995

Strand: Direct

Name: gltX [H]

Synonym: CPE0998

Alternate gene names: 18309980

Gene position: 1202355-1203995 (Clockwise)

Preceding gene: 18309979

Following gene: 18309981

Centisome position: 39.66

GC content: 31.08

Gene sequence:

>1641_bases
ATGAGTTATGAAAATTTAGCTAATTTAATATTCCCAAACATAGATAAAACACCGGAATATTATTTTGAAAAGTATCCAAA
GAGAGATTTAAAAGAAGGGGCTAAAGTATTAAGATATGCACCAAGTCCAACTGGATTTCAACATATAGGAGGAGTTTTTG
CTTCATTAATAAATGAAAGATTAGCTCACCAAAGTGGTGGAATATTCTACTTAAGAATAGAAGATACTGATCAAAAGAGA
GAAGTTGAAGGTGCTATAGATGATACTATAAAAACTATGCATAACTTTGGAATGGATTTTGATGAAGGAATAACTGGTGA
AAACTCAGAAAAAGGAGCTTATGCACCATATAAACAAAGTCAAAGAGCTGATATATACAGAGCTTTTGTTAAGGATCTTT
TAAGAAAGGGATTAGCTTATCCATGCTTTATGACTTCTGAAGAATTAGAAGCTTTAAGAGAAAAACAAATTGCAGAAAAA
TTAACTCCAGGATGTTATGGAGAGTTTGCTAAATATAGAGATTTATCACCAGAAGAGGCTATAAAGAGAATTGAAGCTGG
TGAAAGTTATGTTATAAGAATGAAGTCACCTGGAAATCCTGAAAAGAGAGTTGTTGCTCATGACATGATAAAAGGAGAGG
TTTCATTCCCAGAAAATCTTCAAGATGTAGTAATAATAAAAGGTGATGGTCTTCCAACTTATCACTTTGCTCATGCAATA
GATGATACATTAATGAGAACTACTCATGTTATAAGAGGAGAAGAATGGTTATCATCACTTCCAATACATCTTCAAATGTT
TGAAGTTTTAGGAGTAGAAGCACCTAAATATGCTCATATTCCAACAATAATGAAAATGGATGGAAGTTCAAAAAGAAAAT
TATCAAAGAGAAAAGATCCAGAAAGTGCAGTAAGTTATTACAGTGAAAAAGGATATCCATCTCAATCAGTTATTGAATAT
CTTTTAAATATAATAAACTCAGCTTTCGAAGAGTGGAGAGCAGAAAATCCAGATGCTGATTATCATGATTACAAAGTTGA
ACTAGATAAAATGAGTAAGAGTGGAGCTTTATTTGATTTAGTTAAATTAAATGATGTAAGTAAAGATGTTATCTGTAAAA
TGAAACCAGAAGTTGTTTATGATTTATATACAAACTGGGCTAAAGAGTATGATAAAGAAATGTATGATTTAGTTACTTCT
AAAGAAGCTATGATGAAAGAAGTATTCAATATAGATAAAGAAGGTCCAAAGCCAAGAAAAGACTTTGCTAAATGGGATGA
AGTTAGAGAAAAAATATTCTACTTCTTTGATGAGTTATTTGATAAGGAAACAGCTAATGATGTTGAATTACCAAAAACTT
TAGAATTAGAAGAAGCTAAGAGAATAATAGAAGCTTACGAAAAAGCATATAACTTTAATACAGATAAGGATACTTGGTTC
TCAGATTTAAAAGAAGTTGCTGTAGAATTAGGATATGCTACTGATAGAAAGAAATATAAAAAGAACCCAGAAGAATACAA
AGGAATGGTTTCTGATGTTGCAGGAGCTGTAAGAGCAGCTTTAACTCACAGAGCTAATACTCCAGACCTTTATACAATAA
TGCAAATTATGGGAGAAGAAGCAGTAAGAGAAAGAATTTAA

Upstream 100 bases:

>100_bases
AACTAATTTAGGTGGTAACGCGGAAGTTAAGTCTTTCGTCCTAATTTTTAGGACGAGGGACTTTTTTTATTACATAAATT
TAGAAAGGAAAGTGAAAAGA

Downstream 100 bases:

>100_bases
AAAATTCTTAGCTCTATAATTTGATTTTAAGAAGTTTTAACACAATGATAATAAAAAGCTTGCAATGTTAATTTTTTAGT
GGTATAATTAGAACATAACA

Product: glutamyl-tRNA synthetase

Products: NA

Alternate protein names: Glutamate--tRNA ligase; GluRS [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MSYENLANLIFPNIDKTPEYYFEKYPKRDLKEGAKVLRYAPSPTGFQHIGGVFASLINERLAHQSGGIFYLRIEDTDQKR
EVEGAIDDTIKTMHNFGMDFDEGITGENSEKGAYAPYKQSQRADIYRAFVKDLLRKGLAYPCFMTSEELEALREKQIAEK
LTPGCYGEFAKYRDLSPEEAIKRIEAGESYVIRMKSPGNPEKRVVAHDMIKGEVSFPENLQDVVIIKGDGLPTYHFAHAI
DDTLMRTTHVIRGEEWLSSLPIHLQMFEVLGVEAPKYAHIPTIMKMDGSSKRKLSKRKDPESAVSYYSEKGYPSQSVIEY
LLNIINSAFEEWRAENPDADYHDYKVELDKMSKSGALFDLVKLNDVSKDVICKMKPEVVYDLYTNWAKEYDKEMYDLVTS
KEAMMKEVFNIDKEGPKPRKDFAKWDEVREKIFYFFDELFDKETANDVELPKTLELEEAKRIIEAYEKAYNFNTDKDTWF
SDLKEVAVELGYATDRKKYKKNPEEYKGMVSDVAGAVRAALTHRANTPDLYTIMQIMGEEAVRERI

Sequences:

>Translated_546_residues
MSYENLANLIFPNIDKTPEYYFEKYPKRDLKEGAKVLRYAPSPTGFQHIGGVFASLINERLAHQSGGIFYLRIEDTDQKR
EVEGAIDDTIKTMHNFGMDFDEGITGENSEKGAYAPYKQSQRADIYRAFVKDLLRKGLAYPCFMTSEELEALREKQIAEK
LTPGCYGEFAKYRDLSPEEAIKRIEAGESYVIRMKSPGNPEKRVVAHDMIKGEVSFPENLQDVVIIKGDGLPTYHFAHAI
DDTLMRTTHVIRGEEWLSSLPIHLQMFEVLGVEAPKYAHIPTIMKMDGSSKRKLSKRKDPESAVSYYSEKGYPSQSVIEY
LLNIINSAFEEWRAENPDADYHDYKVELDKMSKSGALFDLVKLNDVSKDVICKMKPEVVYDLYTNWAKEYDKEMYDLVTS
KEAMMKEVFNIDKEGPKPRKDFAKWDEVREKIFYFFDELFDKETANDVELPKTLELEEAKRIIEAYEKAYNFNTDKDTWF
SDLKEVAVELGYATDRKKYKKNPEEYKGMVSDVAGAVRAALTHRANTPDLYTIMQIMGEEAVRERI
>Mature_545_residues
SYENLANLIFPNIDKTPEYYFEKYPKRDLKEGAKVLRYAPSPTGFQHIGGVFASLINERLAHQSGGIFYLRIEDTDQKRE
VEGAIDDTIKTMHNFGMDFDEGITGENSEKGAYAPYKQSQRADIYRAFVKDLLRKGLAYPCFMTSEELEALREKQIAEKL
TPGCYGEFAKYRDLSPEEAIKRIEAGESYVIRMKSPGNPEKRVVAHDMIKGEVSFPENLQDVVIIKGDGLPTYHFAHAID
DTLMRTTHVIRGEEWLSSLPIHLQMFEVLGVEAPKYAHIPTIMKMDGSSKRKLSKRKDPESAVSYYSEKGYPSQSVIEYL
LNIINSAFEEWRAENPDADYHDYKVELDKMSKSGALFDLVKLNDVSKDVICKMKPEVVYDLYTNWAKEYDKEMYDLVTSK
EAMMKEVFNIDKEGPKPRKDFAKWDEVREKIFYFFDELFDKETANDVELPKTLELEEAKRIIEAYEKAYNFNTDKDTWFS
DLKEVAVELGYATDRKKYKKNPEEYKGMVSDVAGAVRAALTHRANTPDLYTIMQIMGEEAVRERI

Specific function: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) [H]

COG id: COG0008

COG function: function code J; Glutamyl- and glutaminyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI134288884, Length=530, Percent_Identity=27.9245283018868, Blast_Score=179, Evalue=7e-45,
Organism=Escherichia coli, GI1788743, Length=515, Percent_Identity=28.3495145631068, Blast_Score=172, Evalue=7e-44,
Organism=Escherichia coli, GI226510925, Length=332, Percent_Identity=25, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71993394, Length=298, Percent_Identity=39.9328859060403, Blast_Score=186, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324540, Length=462, Percent_Identity=30.0865800865801, Blast_Score=184, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324742, Length=244, Percent_Identity=26.6393442622951, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24665321, Length=289, Percent_Identity=38.0622837370242, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: 1,800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008925
- InterPro:   IPR020751
- InterPro:   IPR004527
- InterPro:   IPR000924
- InterPro:   IPR020061
- InterPro:   IPR020058
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00749 tRNA-synt_1c [H]

EC number: =6.1.1.17 [H]

Molecular weight: Translated: 62999; Mature: 62868

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYENLANLIFPNIDKTPEYYFEKYPKRDLKEGAKVLRYAPSPTGFQHIGGVFASLINER
CCHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LAHQSGGIFYLRIEDTDQKREVEGAIDDTIKTMHNFGMDFDEGITGENSEKGAYAPYKQS
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
QRADIYRAFVKDLLRKGLAYPCFMTSEELEALREKQIAEKLTPGCYGEFAKYRDLSPEEA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
IKRIEAGESYVIRMKSPGNPEKRVVAHDMIKGEVSFPENLQDVVIIKGDGLPTYHFAHAI
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHH
DDTLMRTTHVIRGEEWLSSLPIHLQMFEVLGVEAPKYAHIPTIMKMDGSSKRKLSKRKDP
HHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHCCCH
ESAVSYYSEKGYPSQSVIEYLLNIINSAFEEWRAENPDADYHDYKVELDKMSKSGALFDL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHHHCCCCCEEEE
VKLNDVSKDVICKMKPEVVYDLYTNWAKEYDKEMYDLVTSKEAMMKEVFNIDKEGPKPRK
HHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DFAKWDEVREKIFYFFDELFDKETANDVELPKTLELEEAKRIIEAYEKAYNFNTDKDTWF
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
SDLKEVAVELGYATDRKKYKKNPEEYKGMVSDVAGAVRAALTHRANTPDLYTIMQIMGEE
HHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AVRERI
HHHHCC
>Mature Secondary Structure 
SYENLANLIFPNIDKTPEYYFEKYPKRDLKEGAKVLRYAPSPTGFQHIGGVFASLINER
CHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
LAHQSGGIFYLRIEDTDQKREVEGAIDDTIKTMHNFGMDFDEGITGENSEKGAYAPYKQS
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
QRADIYRAFVKDLLRKGLAYPCFMTSEELEALREKQIAEKLTPGCYGEFAKYRDLSPEEA
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
IKRIEAGESYVIRMKSPGNPEKRVVAHDMIKGEVSFPENLQDVVIIKGDGLPTYHFAHAI
HHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCHHHHHHHH
DDTLMRTTHVIRGEEWLSSLPIHLQMFEVLGVEAPKYAHIPTIMKMDGSSKRKLSKRKDP
HHHHHHHHHHHCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHCCCH
ESAVSYYSEKGYPSQSVIEYLLNIINSAFEEWRAENPDADYHDYKVELDKMSKSGALFDL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEHHHHCCCCCEEEE
VKLNDVSKDVICKMKPEVVYDLYTNWAKEYDKEMYDLVTSKEAMMKEVFNIDKEGPKPRK
HHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
DFAKWDEVREKIFYFFDELFDKETANDVELPKTLELEEAKRIIEAYEKAYNFNTDKDTWF
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHH
SDLKEVAVELGYATDRKKYKKNPEEYKGMVSDVAGAVRAALTHRANTPDLYTIMQIMGEE
HHHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
AVRERI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA