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The map label for this gene is bceR [H]

Identifier: 18309822

GI number: 18309822

Start: 1028688

End: 1029356

Strand: Direct

Name: bceR [H]

Synonym: CPE0840

Alternate gene names: 18309822

Gene position: 1028688-1029356 (Clockwise)

Preceding gene: 18309821

Following gene: 18309823

Centisome position: 33.93

GC content: 28.25

Gene sequence:

>669_bases
ATGAAGAGAATTCTTATAATTGAAGACACAGATACCATAAGAGAAGAACTTACAAAACTTCTTACTAGATATGGTTATGA
AGTTTTAGCTCCAACAGATTTTGAAAATATATTAGAGTATGTTAAAGAAAATAATTCAGATTTAATCCTATTAGATATAA
ACTTACCTTATTTTGATGGATATCATATTTGTAGAGAAATAAGAAAAGATTCTAATGTGCCTATAATAATAGTTACAAGT
AGAGATAGTGATATGGATGAAATTATGAGTATGAATTTAGGAGCTGATGATTTTATAACGAAGCCTTATAATACTCAAGT
TTTATTAGCTAGAATAGCTTCACTACTTAGAAGAACCTATTCTTTATCAGAGCAAGAAGTTTTAACATATGGTGATTTAA
AGCTTAATTTATCTAATGGAACAATTTCTTGCAGAGGAAAAGAAGAAGAGTTAACTAAAAATGAACTTAAGATATTATCA
CATCTTTTAAAAAACAAAGGAAATGTTGTTTCAAGGGAAGATCTTATGGATTATATGTGGAACTCAGATATTTTTGTGGA
TGATAACACACTTTCAGTAAATGTAACTAGACTTAGAAAAAAATTAGAAGAGGTTGGAGTAAAAGGCGCTATAGAAACTA
GAAGGGGATTAGGGTATATTATGCCATGA

Upstream 100 bases:

>100_bases
GACAATAAAATCGTAATACTTTAAGAAAGCTTAATATAGCTTTAAAATTTTATCTGTTAAGAATATTATAAAATTAATTA
TAATGGAAGGACTGGTTAGT

Downstream 100 bases:

>100_bases
AACTAAGGGATTACTTTGAGGATAAAACATTCTTTTTAATTGTAAACTTTATAATTTTTGCCACTATAGGAGTTTTATTG
TTCATAGGCAATGTTGGTTC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKRILIIEDTDTIREELTKLLTRYGYEVLAPTDFENILEYVKENNSDLILLDINLPYFDGYHICREIRKDSNVPIIIVTS
RDSDMDEIMSMNLGADDFITKPYNTQVLLARIASLLRRTYSLSEQEVLTYGDLKLNLSNGTISCRGKEEELTKNELKILS
HLLKNKGNVVSREDLMDYMWNSDIFVDDNTLSVNVTRLRKKLEEVGVKGAIETRRGLGYIMP

Sequences:

>Translated_222_residues
MKRILIIEDTDTIREELTKLLTRYGYEVLAPTDFENILEYVKENNSDLILLDINLPYFDGYHICREIRKDSNVPIIIVTS
RDSDMDEIMSMNLGADDFITKPYNTQVLLARIASLLRRTYSLSEQEVLTYGDLKLNLSNGTISCRGKEEELTKNELKILS
HLLKNKGNVVSREDLMDYMWNSDIFVDDNTLSVNVTRLRKKLEEVGVKGAIETRRGLGYIMP
>Mature_222_residues
MKRILIIEDTDTIREELTKLLTRYGYEVLAPTDFENILEYVKENNSDLILLDINLPYFDGYHICREIRKDSNVPIIIVTS
RDSDMDEIMSMNLGADDFITKPYNTQVLLARIASLLRRTYSLSEQEVLTYGDLKLNLSNGTISCRGKEEELTKNELKILS
HLLKNKGNVVSREDLMDYMWNSDIFVDDNTLSVNVTRLRKKLEEVGVKGAIETRRGLGYIMP

Specific function: Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up-regulates the expression of these two genes [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=31.6742081447964, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=34.703196347032, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.5991189427313, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=32.8888888888889, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=30.1369863013699, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=31.3636363636364, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=31.3364055299539, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.981981981982, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=31.8181818181818, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=31.5555555555556, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=30.1310043668122, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=29.0598290598291, Blast_Score=91, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25605; Mature: 25605

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRILIIEDTDTIREELTKLLTRYGYEVLAPTDFENILEYVKENNSDLILLDINLPYFDG
CCEEEEEECCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCH
YHICREIRKDSNVPIIIVTSRDSDMDEIMSMNLGADDFITKPYNTQVLLARIASLLRRTY
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SLSEQEVLTYGDLKLNLSNGTISCRGKEEELTKNELKILSHLLKNKGNVVSREDLMDYMW
CCCCHHEEEECCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
NSDIFVDDNTLSVNVTRLRKKLEEVGVKGAIETRRGLGYIMP
CCCEEEECCEEEEEHHHHHHHHHHCCCCCCHHHHCCCCCCCC
>Mature Secondary Structure
MKRILIIEDTDTIREELTKLLTRYGYEVLAPTDFENILEYVKENNSDLILLDINLPYFDG
CCEEEEEECCHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCH
YHICREIRKDSNVPIIIVTSRDSDMDEIMSMNLGADDFITKPYNTQVLLARIASLLRRTY
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SLSEQEVLTYGDLKLNLSNGTISCRGKEEELTKNELKILSHLLKNKGNVVSREDLMDYMW
CCCCHHEEEECCEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
NSDIFVDDNTLSVNVTRLRKKLEEVGVKGAIETRRGLGYIMP
CCCEEEECCEEEEEHHHHHHHHHHCCCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]