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The map label for this gene is hisK [H]

Identifier: 18309786

GI number: 18309786

Start: 985945

End: 987819

Strand: Direct

Name: hisK [H]

Synonym: CPE0804

Alternate gene names: 18309786

Gene position: 985945-987819 (Clockwise)

Preceding gene: 18309785

Following gene: 18309787

Centisome position: 32.52

GC content: 26.51

Gene sequence:

>1875_bases
ATGAAAAACTACTATTTAGAAGAGGTTGTGGATGAAATTTACTATAAAGAAGGCAAAGAAAATAGAGAATTAAAAATGGA
TATCTTAAGTATTAAGATAGAAAATGAATTGAAGATTATAGAAAATTTATGTGGCAATTGTAAAAGAAAAAATACCCTAT
ATGAGGCTATAAAGAATATAAAAAGCTTATTAAAACAATATTATATAGTTTTTAATGGAACTCAAGATGCATTATTTTTA
GTTGAAATGCTTAAAGATGGAAATTTTAAATATGTAAGAAATAACAATGCATATCTTCATGAATTTGGACTTAAAGGAGA
GGAGATTATAAATAAAACTCCAAAGGATGTGTTTGGGGAAGAGCTTGGGAAAAGATTCTGTAATTATTATAAAAATTGTA
TAGAAGGTAAAAGAGTAGTTGTATTTGAAGATGACTTGTTTTTAAATGGGAAGAAAAGAGTGTTCTTAACGAAACTACTT
CCTATTGTTGATGAAGATGATGGAGTTTTCATAGTAGGTTCAAGAGAAGATATTACAAAGAGAAAAGAAATGGAAATAGA
GTTAGACAGAATGGCTAATTATGATGAATTAACTAATATTCCTAATATGAGATTATTTTTTAAATCTTTCAGAAATACTA
TAAATGAAAGCAAAAAGATGGACAAGAAGTTTGCAGTTCTTTTTATAGATTTAGATTGGTTTAAGGAAATAAATGATAAT
TATGGACATAATGTAGGGGATGAAGTTTTAGTTTGTGCAGTTAAAAGAATATACAAATGTTTAAGAAAGGGCGATATTCT
AGGAAGAATAGGTGGAGATGAATTCGCAGCTATATTAAAGGATATAAGTGATAGAGAAGAAATTGAAAAAATAGTTAAAG
ATATTCAAAACTCCTTAAGAAAAAGAATAAAAATAGGAGATGTTACATGTAATATTGACTCATCCATAGGTATAACAATA
TTTCCAGAGGATGGAGAAAAAATAGAAGTACTTATGAGAAATTCTGATAAGGCTATGTATAAAGTAAAAAATAGAGAAAA
GGGAGGATATAGATTTTTTAATAATATGATTAGAGAATATAACTTTAAAAATAAAGATGGTCATGTCCATACAAAATATT
GCCCTCATGGTAGTGATGATAATATTGAAGATTATATTGAAGAAGCTATAAAATATAAGTTAGATGAAATAAGTTTTACT
GAGCACCTTCCTCTTCCTGAAAATTTTATTGATCCTTCGCCTTTGAAAGATAGTGCTATGAAATTAGAAGAAATGGAATC
CTATTTAAAAGAGGGACATGAGTTACAGGAAAAATATAAGGATAAGATAAAAGTAAATATTGGAGTAGAAGTAGACTATA
TAGAAGGTTACGAGATTGAAACAGAATTGCTTTTAAATAAATATGGCAAATACTTAAATGATGGGATTTTATCCGTTCAT
ATGATAAAAGGAAATAAAAGATATTATTGTATAGATTTTAGCGAAAAGGAATTTAAAAAAATCATAAATGATTTAGGTTC
TTTAGAGGAATTATATAATAAATATTACGATACATTAATTATGGCTTTAAAAAGTGATTTAGGACCATACAAACCAAAAA
GAATAGGACACTTAAATCTAGTAAGAAGGTTTAATAAGGAATTTCCATATAACTACGAAAAACATATTTCAAAGATAGAG
GAAATACTAGATCTTATAAAAGAAAAAGGATATGAACTTGATTTTAACATTGCAGGTTTAAGAAAAAAAGAGTGTAATGA
ATTCTATATAGAAGGAAAAGTTCTAGAAATGGCAATTGAGAAAGGCATACCTATGGTTTTAGGAAGTGATTCTCATTCTG
CTAAATATATAAAATGTATAAAAGAATTCTTATAA

Upstream 100 bases:

>100_bases
TTATATACTGTATATGGATAAAATGTTAATTTTTTATTGAAACATTAAAATTTATTTAATATTATTATTAAATAACATAC
TTCACAAGTGAGGGTAAGAT

Downstream 100 bases:

>100_bases
ATAAGATATGATTTAAAGTAGTGTTTGGTTTAGATAGTAATTATATATCTAAACTAAACACTTACCTAAAACAAAATCTT
ATAGTAATTTTTAATTTCAT

Product: sensory box protein/histidinol phosphate phosphatase family protein

Products: NA

Alternate protein names: HolPase [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MKNYYLEEVVDEIYYKEGKENRELKMDILSIKIENELKIIENLCGNCKRKNTLYEAIKNIKSLLKQYYIVFNGTQDALFL
VEMLKDGNFKYVRNNNAYLHEFGLKGEEIINKTPKDVFGEELGKRFCNYYKNCIEGKRVVVFEDDLFLNGKKRVFLTKLL
PIVDEDDGVFIVGSREDITKRKEMEIELDRMANYDELTNIPNMRLFFKSFRNTINESKKMDKKFAVLFIDLDWFKEINDN
YGHNVGDEVLVCAVKRIYKCLRKGDILGRIGGDEFAAILKDISDREEIEKIVKDIQNSLRKRIKIGDVTCNIDSSIGITI
FPEDGEKIEVLMRNSDKAMYKVKNREKGGYRFFNNMIREYNFKNKDGHVHTKYCPHGSDDNIEDYIEEAIKYKLDEISFT
EHLPLPENFIDPSPLKDSAMKLEEMESYLKEGHELQEKYKDKIKVNIGVEVDYIEGYEIETELLLNKYGKYLNDGILSVH
MIKGNKRYYCIDFSEKEFKKIINDLGSLEELYNKYYDTLIMALKSDLGPYKPKRIGHLNLVRRFNKEFPYNYEKHISKIE
EILDLIKEKGYELDFNIAGLRKKECNEFYIEGKVLEMAIEKGIPMVLGSDSHSAKYIKCIKEFL

Sequences:

>Translated_624_residues
MKNYYLEEVVDEIYYKEGKENRELKMDILSIKIENELKIIENLCGNCKRKNTLYEAIKNIKSLLKQYYIVFNGTQDALFL
VEMLKDGNFKYVRNNNAYLHEFGLKGEEIINKTPKDVFGEELGKRFCNYYKNCIEGKRVVVFEDDLFLNGKKRVFLTKLL
PIVDEDDGVFIVGSREDITKRKEMEIELDRMANYDELTNIPNMRLFFKSFRNTINESKKMDKKFAVLFIDLDWFKEINDN
YGHNVGDEVLVCAVKRIYKCLRKGDILGRIGGDEFAAILKDISDREEIEKIVKDIQNSLRKRIKIGDVTCNIDSSIGITI
FPEDGEKIEVLMRNSDKAMYKVKNREKGGYRFFNNMIREYNFKNKDGHVHTKYCPHGSDDNIEDYIEEAIKYKLDEISFT
EHLPLPENFIDPSPLKDSAMKLEEMESYLKEGHELQEKYKDKIKVNIGVEVDYIEGYEIETELLLNKYGKYLNDGILSVH
MIKGNKRYYCIDFSEKEFKKIINDLGSLEELYNKYYDTLIMALKSDLGPYKPKRIGHLNLVRRFNKEFPYNYEKHISKIE
EILDLIKEKGYELDFNIAGLRKKECNEFYIEGKVLEMAIEKGIPMVLGSDSHSAKYIKCIKEFL
>Mature_624_residues
MKNYYLEEVVDEIYYKEGKENRELKMDILSIKIENELKIIENLCGNCKRKNTLYEAIKNIKSLLKQYYIVFNGTQDALFL
VEMLKDGNFKYVRNNNAYLHEFGLKGEEIINKTPKDVFGEELGKRFCNYYKNCIEGKRVVVFEDDLFLNGKKRVFLTKLL
PIVDEDDGVFIVGSREDITKRKEMEIELDRMANYDELTNIPNMRLFFKSFRNTINESKKMDKKFAVLFIDLDWFKEINDN
YGHNVGDEVLVCAVKRIYKCLRKGDILGRIGGDEFAAILKDISDREEIEKIVKDIQNSLRKRIKIGDVTCNIDSSIGITI
FPEDGEKIEVLMRNSDKAMYKVKNREKGGYRFFNNMIREYNFKNKDGHVHTKYCPHGSDDNIEDYIEEAIKYKLDEISFT
EHLPLPENFIDPSPLKDSAMKLEEMESYLKEGHELQEKYKDKIKVNIGVEVDYIEGYEIETELLLNKYGKYLNDGILSVH
MIKGNKRYYCIDFSEKEFKKIINDLGSLEELYNKYYDTLIMALKSDLGPYKPKRIGHLNLVRRFNKEFPYNYEKHISKIE
EILDLIKEKGYELDFNIAGLRKKECNEFYIEGKVLEMAIEKGIPMVLGSDSHSAKYIKCIKEFL

Specific function: Unknown

COG id: COG1387

COG function: function code ER; Histidinol phosphatase and related hydrolases of the PHP family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PHP hydrolase family. HisK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=186, Percent_Identity=32.258064516129, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI87081881, Length=288, Percent_Identity=28.8194444444444, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1786584, Length=186, Percent_Identity=31.7204301075269, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788381, Length=176, Percent_Identity=31.8181818181818, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87081977, Length=171, Percent_Identity=29.2397660818713, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788085, Length=175, Percent_Identity=32, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI87082007, Length=173, Percent_Identity=32.3699421965318, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1787262, Length=158, Percent_Identity=32.2784810126582, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI145693134, Length=173, Percent_Identity=33.5260115606936, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788956, Length=164, Percent_Identity=32.9268292682927, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787816, Length=164, Percent_Identity=29.2682926829268, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1787802, Length=126, Percent_Identity=30.1587301587302, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010140
- InterPro:   IPR004013
- InterPro:   IPR016195 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 73390; Mature: 73390

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYYLEEVVDEIYYKEGKENRELKMDILSIKIENELKIIENLCGNCKRKNTLYEAIKNI
CCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHH
KSLLKQYYIVFNGTQDALFLVEMLKDGNFKYVRNNNAYLHEFGLKGEEIINKTPKDVFGE
HHHHHHEEEEEECCCHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHCCCCHHHHHH
ELGKRFCNYYKNCIEGKRVVVFEDDLFLNGKKRVFLTKLLPIVDEDDGVFIVGSREDITK
HHHHHHHHHHHHHHCCCEEEEEECCEEECCCCEEHHHHHCCCEECCCCEEEEECCHHHHH
RKEMEIELDRMANYDELTNIPNMRLFFKSFRNTINESKKMDKKFAVLFIDLDWFKEINDN
HHHHCEEHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHCCC
YGHNVGDEVLVCAVKRIYKCLRKGDILGRIGGDEFAAILKDISDREEIEKIVKDIQNSLR
CCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KRIKIGDVTCNIDSSIGITIFPEDGEKIEVLMRNSDKAMYKVKNREKGGYRFFNNMIREY
HHEEECCEEEEECCCCCEEEECCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHC
NFKNKDGHVHTKYCPHGSDDNIEDYIEEAIKYKLDEISFTEHLPLPENFIDPSPLKDSAM
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
KLEEMESYLKEGHELQEKYKDKIKVNIGVEVDYIEGYEIETELLLNKYGKYLNDGILSVH
HHHHHHHHHHCCHHHHHHHHCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEE
MIKGNKRYYCIDFSEKEFKKIINDLGSLEELYNKYYDTLIMALKSDLGPYKPKRIGHLNL
EEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VRRFNKEFPYNYEKHISKIEEILDLIKEKGYELDFNIAGLRKKECNEFYIEGKVLEMAIE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCEEECCHHHHHHHH
KGIPMVLGSDSHSAKYIKCIKEFL
CCCCEEECCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MKNYYLEEVVDEIYYKEGKENRELKMDILSIKIENELKIIENLCGNCKRKNTLYEAIKNI
CCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHH
KSLLKQYYIVFNGTQDALFLVEMLKDGNFKYVRNNNAYLHEFGLKGEEIINKTPKDVFGE
HHHHHHEEEEEECCCHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHCCCCHHHHHH
ELGKRFCNYYKNCIEGKRVVVFEDDLFLNGKKRVFLTKLLPIVDEDDGVFIVGSREDITK
HHHHHHHHHHHHHHCCCEEEEEECCEEECCCCEEHHHHHCCCEECCCCEEEEECCHHHHH
RKEMEIELDRMANYDELTNIPNMRLFFKSFRNTINESKKMDKKFAVLFIDLDWFKEINDN
HHHHCEEHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEHHHHHHHCCC
YGHNVGDEVLVCAVKRIYKCLRKGDILGRIGGDEFAAILKDISDREEIEKIVKDIQNSLR
CCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
KRIKIGDVTCNIDSSIGITIFPEDGEKIEVLMRNSDKAMYKVKNREKGGYRFFNNMIREY
HHEEECCEEEEECCCCCEEEECCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHC
NFKNKDGHVHTKYCPHGSDDNIEDYIEEAIKYKLDEISFTEHLPLPENFIDPSPLKDSAM
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHH
KLEEMESYLKEGHELQEKYKDKIKVNIGVEVDYIEGYEIETELLLNKYGKYLNDGILSVH
HHHHHHHHHHCCHHHHHHHHCCEEEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEE
MIKGNKRYYCIDFSEKEFKKIINDLGSLEELYNKYYDTLIMALKSDLGPYKPKRIGHLNL
EEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
VRRFNKEFPYNYEKHISKIEEILDLIKEKGYELDFNIAGLRKKECNEFYIEGKVLEMAIE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHCCCCEEECCHHHHHHHH
KGIPMVLGSDSHSAKYIKCIKEFL
CCCCEEECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 10322033 [H]