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The map label for this gene is trxB [H]

Identifier: 18309765

GI number: 18309765

Start: 965438

End: 967108

Strand: Direct

Name: trxB [H]

Synonym: CPE0783

Alternate gene names: 18309765

Gene position: 965438-967108 (Clockwise)

Preceding gene: 18309764

Following gene: 18309767

Centisome position: 31.85

GC content: 31.36

Gene sequence:

>1671_bases
ATGAGTAAAATATATGATTTGGTTATTATTGGGGGAGGGCCTGCAGGACTTTCAGCAGGTATATATGCCGGAAGAGCTAA
GATGAATACCTTGATAATAGAAAAGGGAGAATTAGGAGGACAAGTCAATAAAACCTTCGACATATCTAATTATCCTGGAT
CTAGAAATACAAATGGTCCTAAACTTATGAGTGAAATGAGAGCTCAGGCAGAGGATTTTAAAGTTAAGTTTATGAATGGA
GAAGTCCTTGAAGTAAGTTTAGAGGGAGATATTAAGGAAATAAAAACTGACAAAGGTTTAGTTCAGGGAAGATCTGTAAT
AATTGCTACTGGGGCAGCACCTAGACAACTTGGATTTAAAGGGGAAGAAGAATTTACAGGAAGAGGAGTTGCATATTGTG
CAACTTGTGATGGTCAGTTTTTTGAAGGATTAGAGGTATTTGTAATAGGAGCTGGTTTTGCAGCGGCTGAGGAAGCAATA
TTCTTAACTAGATTTGCATCAAAGGTAACTGTAATAGCTAGAGAACCAGAATTTACTTGTGCAAAATCTATAGCAGATAA
GGTTCTTTCTAACCCTAAAATTGAGGTGAAATTTAATACTGAAATAATTGAAGCTAAGGGCAAAGACATGGTAAACTATG
CTAAGTTCAAGAATAATGTAACAGGAGAAATTTTTGAATACAGAGCAAAAAAAGAGGATGGAGCCTTTGGAATATTTGTA
TTCGTTGGTTATGCCCCTAAAAGTGAATTGTTTAAAGATATTTTAGAGTTAGACAAGCAAGGATATATTATAACTAATGA
AGATATGGAAACTAATATTAATGGGGTTTATGTTGCTGGAGATTTACGTCCAAAATCTTTAAGACAAATAGTTACAGCTG
TATCAGATGGAGCTATTGCTGCCACTACAGCAGAGAGATACGTTAAAGAGCTAAAAGAAAAGCTTGGTATAGAAGATGAA
TATTTAGAAGAAGAGGAAAATATCCAAGAAGAAAAAAATAGTGATGAAAATAATGATTTGGGAAATATATCAAGAAAAAG
TTCCCTATTAAATGATGTATTAAGAGCTCAGCTAAAAGGAATTTTAAGCAAAATAGAAAATGAAGTAACTTTAGTTTCTA
TAGTTGATAGAAGTAATACAAAATCTATAGAACTTAGAGACTTAGTATTAGATATATCAGATTTAGGAGAAAAAATTAAT
GCTAAGATATTTAATAGAGGCGAAAATAAAGAGGTTGAAGAGAAGATAAATGCTGATAAATATCCAATAGTTGCACTTTT
AGACGAAAATGAAAATTATAGTGGAATTAAGTTTCATGGTGTTCCAGGAGGACATGAGTTAAATTCATTTATTTTAGCTA
TATATAACTTAGGTGGTCCAGGTCAAGGTATTGATGAAGGAGTACTTGATGAAATAAAGAAATTAGATAAAAAGACTAAT
ATTAAGGTTTGTGTATCACTATCATGTCATTTATGCCCTGATGTTGTAGTTAGTGCACAAAGAATAGCAAAAGAAAATAA
AAATATAGAAGCTGAAATGATTGATTTAGCTAATTTTAAAGATATAAAAGATGAATTTAAAATAATGAGTGTACCAGCTC
TAATAGTAAACAATAAAGATGTTTACTTTGGAAGCAAAAAAATAGAAGAAATTTTAGAGATAATAAAATAA

Upstream 100 bases:

>100_bases
TTTAGTTAATTAATTGAAATTAAAACATTTTTAAGTTATTTCAAAGTAGATAGTTTAAAAATATTTTGAATAGTAAGGAC
TAAGGAGGAGACGTAAATTT

Downstream 100 bases:

>100_bases
TTTTATTATAAAACACCACAAAATAACCTTAACAATTTAATTTTGTTAAGGTTATTTTTATAGATTTAAGTTAATAGTTC
TGCTTTAAGTGAATATTTGT

Product: thioredoxin reductase

Products: NA

Alternate protein names: TRXR [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MSKIYDLVIIGGGPAGLSAGIYAGRAKMNTLIIEKGELGGQVNKTFDISNYPGSRNTNGPKLMSEMRAQAEDFKVKFMNG
EVLEVSLEGDIKEIKTDKGLVQGRSVIIATGAAPRQLGFKGEEEFTGRGVAYCATCDGQFFEGLEVFVIGAGFAAAEEAI
FLTRFASKVTVIAREPEFTCAKSIADKVLSNPKIEVKFNTEIIEAKGKDMVNYAKFKNNVTGEIFEYRAKKEDGAFGIFV
FVGYAPKSELFKDILELDKQGYIITNEDMETNINGVYVAGDLRPKSLRQIVTAVSDGAIAATTAERYVKELKEKLGIEDE
YLEEEENIQEEKNSDENNDLGNISRKSSLLNDVLRAQLKGILSKIENEVTLVSIVDRSNTKSIELRDLVLDISDLGEKIN
AKIFNRGENKEVEEKINADKYPIVALLDENENYSGIKFHGVPGGHELNSFILAIYNLGGPGQGIDEGVLDEIKKLDKKTN
IKVCVSLSCHLCPDVVVSAQRIAKENKNIEAEMIDLANFKDIKDEFKIMSVPALIVNNKDVYFGSKKIEEILEIIK

Sequences:

>Translated_556_residues
MSKIYDLVIIGGGPAGLSAGIYAGRAKMNTLIIEKGELGGQVNKTFDISNYPGSRNTNGPKLMSEMRAQAEDFKVKFMNG
EVLEVSLEGDIKEIKTDKGLVQGRSVIIATGAAPRQLGFKGEEEFTGRGVAYCATCDGQFFEGLEVFVIGAGFAAAEEAI
FLTRFASKVTVIAREPEFTCAKSIADKVLSNPKIEVKFNTEIIEAKGKDMVNYAKFKNNVTGEIFEYRAKKEDGAFGIFV
FVGYAPKSELFKDILELDKQGYIITNEDMETNINGVYVAGDLRPKSLRQIVTAVSDGAIAATTAERYVKELKEKLGIEDE
YLEEEENIQEEKNSDENNDLGNISRKSSLLNDVLRAQLKGILSKIENEVTLVSIVDRSNTKSIELRDLVLDISDLGEKIN
AKIFNRGENKEVEEKINADKYPIVALLDENENYSGIKFHGVPGGHELNSFILAIYNLGGPGQGIDEGVLDEIKKLDKKTN
IKVCVSLSCHLCPDVVVSAQRIAKENKNIEAEMIDLANFKDIKDEFKIMSVPALIVNNKDVYFGSKKIEEILEIIK
>Mature_555_residues
SKIYDLVIIGGGPAGLSAGIYAGRAKMNTLIIEKGELGGQVNKTFDISNYPGSRNTNGPKLMSEMRAQAEDFKVKFMNGE
VLEVSLEGDIKEIKTDKGLVQGRSVIIATGAAPRQLGFKGEEEFTGRGVAYCATCDGQFFEGLEVFVIGAGFAAAEEAIF
LTRFASKVTVIAREPEFTCAKSIADKVLSNPKIEVKFNTEIIEAKGKDMVNYAKFKNNVTGEIFEYRAKKEDGAFGIFVF
VGYAPKSELFKDILELDKQGYIITNEDMETNINGVYVAGDLRPKSLRQIVTAVSDGAIAATTAERYVKELKEKLGIEDEY
LEEEENIQEEKNSDENNDLGNISRKSSLLNDVLRAQLKGILSKIENEVTLVSIVDRSNTKSIELRDLVLDISDLGEKINA
KIFNRGENKEVEEKINADKYPIVALLDENENYSGIKFHGVPGGHELNSFILAIYNLGGPGQGIDEGVLDEIKKLDKKTNI
KVCVSLSCHLCPDVVVSAQRIAKENKNIEAEMIDLANFKDIKDEFKIMSVPALIVNNKDVYFGSKKIEEILEIIK

Specific function: Unknown

COG id: COG0492

COG function: function code O; Thioredoxin reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787114, Length=322, Percent_Identity=35.7142857142857, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI87081763, Length=314, Percent_Identity=32.484076433121, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6321898, Length=319, Percent_Identity=33.8557993730408, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320560, Length=321, Percent_Identity=31.7757009345794, Blast_Score=155, Evalue=2e-38,

Paralogues:

None

Copy number: 808 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR008255
- InterPro:   IPR001327
- InterPro:   IPR000103
- InterPro:   IPR005982 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.8.1.9 [H]

Molecular weight: Translated: 61312; Mature: 61181

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIYDLVIIGGGPAGLSAGIYAGRAKMNTLIIEKGELGGQVNKTFDISNYPGSRNTNGP
CCCEEEEEEECCCCCCCCCCEEECCCEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCH
KLMSEMRAQAEDFKVKFMNGEVLEVSLEGDIKEIKTDKGLVQGRSVIIATGAAPRQLGFK
HHHHHHHCCCCCEEEEEECCEEEEEEECCCHHHHHCCCCCCCCCEEEEECCCCCHHCCCC
GEEEFTGRGVAYCATCDGQFFEGLEVFVIGAGFAAAEEAIFLTRFASKVTVIAREPEFTC
CCCCCCCCCEEEEEECCCHHHCCEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCHHH
AKSIADKVLSNPKIEVKFNTEIIEAKGKDMVNYAKFKNNVTGEIFEYRAKKEDGAFGIFV
HHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCEEEEE
FVGYAPKSELFKDILELDKQGYIITNEDMETNINGVYVAGDLRPKSLRQIVTAVSDGAIA
EEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEE
ATTAERYVKELKEKLGIEDEYLEEEENIQEEKNSDENNDLGNISRKSSLLNDVLRAQLKG
EHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ILSKIENEVTLVSIVDRSNTKSIELRDLVLDISDLGEKINAKIFNRGENKEVEEKINADK
HHHHHCCCEEEEEEEECCCCCCEEHHHHEEEHHHHCCHHCHHEECCCCCCCHHHHCCCCC
YPIVALLDENENYSGIKFHGVPGGHELNSFILAIYNLGGPGQGIDEGVLDEIKKLDKKTN
CCEEEEEECCCCCCCEEEECCCCCCHHCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
IKVCVSLSCHLCPDVVVSAQRIAKENKNIEAEMIDLANFKDIKDEFKIMSVPALIVNNKD
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHEEEEECEEEECCCE
VYFGSKKIEEILEIIK
EEECHHHHHHHHHHHC
>Mature Secondary Structure 
SKIYDLVIIGGGPAGLSAGIYAGRAKMNTLIIEKGELGGQVNKTFDISNYPGSRNTNGP
CCEEEEEEECCCCCCCCCCEEECCCEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCCH
KLMSEMRAQAEDFKVKFMNGEVLEVSLEGDIKEIKTDKGLVQGRSVIIATGAAPRQLGFK
HHHHHHHCCCCCEEEEEECCEEEEEEECCCHHHHHCCCCCCCCCEEEEECCCCCHHCCCC
GEEEFTGRGVAYCATCDGQFFEGLEVFVIGAGFAAAEEAIFLTRFASKVTVIAREPEFTC
CCCCCCCCCEEEEEECCCHHHCCEEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCHHH
AKSIADKVLSNPKIEVKFNTEIIEAKGKDMVNYAKFKNNVTGEIFEYRAKKEDGAFGIFV
HHHHHHHHHCCCCEEEEECCEEEECCCCCHHHHHHHCCCCCCHHHHHHCCCCCCCEEEEE
FVGYAPKSELFKDILELDKQGYIITNEDMETNINGVYVAGDLRPKSLRQIVTAVSDGAIA
EEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCEE
ATTAERYVKELKEKLGIEDEYLEEEENIQEEKNSDENNDLGNISRKSSLLNDVLRAQLKG
EHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ILSKIENEVTLVSIVDRSNTKSIELRDLVLDISDLGEKINAKIFNRGENKEVEEKINADK
HHHHHCCCEEEEEEEECCCCCCEEHHHHEEEHHHHCCHHCHHEECCCCCCCHHHHCCCCC
YPIVALLDENENYSGIKFHGVPGGHELNSFILAIYNLGGPGQGIDEGVLDEIKKLDKKTN
CCEEEEEECCCCCCCEEEECCCCCCHHCEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
IKVCVSLSCHLCPDVVVSAQRIAKENKNIEAEMIDLANFKDIKDEFKIMSVPALIVNNKD
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHEEEEECEEEECCCE
VYFGSKKIEEILEIIK
EEECHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223622; 2537814 [H]