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The map label for this gene is ahpC [H]

Identifier: 18309764

GI number: 18309764

Start: 964622

End: 965191

Strand: Direct

Name: ahpC [H]

Synonym: CPE0782

Alternate gene names: 18309764

Gene position: 964622-965191 (Clockwise)

Preceding gene: 18309761

Following gene: 18309765

Centisome position: 31.82

GC content: 32.98

Gene sequence:

>570_bases
ATGCAAATGTCATTAATAAACAAAAAAGTTTTAGATTTTAAAGTGCAAGCATATCAAAATGGAGAATTTAAAGAAGTTAC
ATCAGAGGATTTAAAAGGACACTGGTCAGTATTCGTATTCTATCCAGCAGATTTTACTTTTGTTTGTCCAACTGAGTTAG
GGGAGTTAGCAGACAATTATGAAAGCTTTAAAGAAATAGGATGTGAAGTTTACTCAATATCAACAGATACTCACTTTGTT
CATAAAGCATGGGCAGATGCTTCAGATACTATAGGAAAGATTAAATATCCAATGTTAGCAGATCCAACAGGAAAATTAGC
AAGAGATTTTGAAGTTATGATAGAAGAAGAAGGATTAGCTTTAAGAGGATCTTTCGTAATTAACCCAGAAGGAGAGATAA
AAGCATATGAAATCCATGATAACGGAATTGGAAGAAATGCTGAAGAATTATTAAGAAAGGTTCAAGCAGCTCAGTTTGTT
GCAGAACATGGAGATCAAGTTTGTCCAGCTAAATGGAAACCAGGTGAAGAAACATTAGCACCAAGTTTAGATTTAATAGG
AAAACTTTAA

Upstream 100 bases:

>100_bases
TTTTCTAAAAAGTATTGACTTTTTATTAAATAATAATTATTATTGATTATAAGAAATAAATGATAAATAGAATCAATTGA
AAATAAATATCAAGGAGGAA

Downstream 100 bases:

>100_bases
TAAAAATAAATAAAAGAGTGGCTTAATTACCACTCTTTTATTAAATTAATATATAGTTTGTATAAAAATTATTTTATATT
TAGGTGTTTTATAAAATTTA

Product: alkyl hydrogen peroxide reductase

Products: NA

Alternate protein names: Alkyl hydroperoxide reductase protein C22; Peroxiredoxin; SCRP-23; Sulfate starvation-induced protein 8; SSI8; Thioredoxin peroxidase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MQMSLINKKVLDFKVQAYQNGEFKEVTSEDLKGHWSVFVFYPADFTFVCPTELGELADNYESFKEIGCEVYSISTDTHFV
HKAWADASDTIGKIKYPMLADPTGKLARDFEVMIEEEGLALRGSFVINPEGEIKAYEIHDNGIGRNAEELLRKVQAAQFV
AEHGDQVCPAKWKPGEETLAPSLDLIGKL

Sequences:

>Translated_189_residues
MQMSLINKKVLDFKVQAYQNGEFKEVTSEDLKGHWSVFVFYPADFTFVCPTELGELADNYESFKEIGCEVYSISTDTHFV
HKAWADASDTIGKIKYPMLADPTGKLARDFEVMIEEEGLALRGSFVINPEGEIKAYEIHDNGIGRNAEELLRKVQAAQFV
AEHGDQVCPAKWKPGEETLAPSLDLIGKL
>Mature_189_residues
MQMSLINKKVLDFKVQAYQNGEFKEVTSEDLKGHWSVFVFYPADFTFVCPTELGELADNYESFKEIGCEVYSISTDTHFV
HKAWADASDTIGKIKYPMLADPTGKLARDFEVMIEEEGLALRGSFVINPEGEIKAYEIHDNGIGRNAEELLRKVQAAQFV
AEHGDQVCPAKWKPGEETLAPSLDLIGKL

Specific function: Directly reduces organic hydroperoxides in its reduced dithiol form [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=182, Percent_Identity=43.956043956044, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=45.0867052023121, Blast_Score=166, Evalue=8e-42,
Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=45.0867052023121, Blast_Score=166, Evalue=9e-42,
Organism=Homo sapiens, GI4505591, Length=176, Percent_Identity=41.4772727272727, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI32455266, Length=176, Percent_Identity=41.4772727272727, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI32455264, Length=176, Percent_Identity=41.4772727272727, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI5453549, Length=187, Percent_Identity=42.2459893048128, Blast_Score=154, Evalue=4e-38,
Organism=Homo sapiens, GI33188454, Length=79, Percent_Identity=49.3670886075949, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI4758638, Length=162, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786822, Length=187, Percent_Identity=62.5668449197861, Blast_Score=260, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI32565831, Length=186, Percent_Identity=43.5483870967742, Blast_Score=164, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI193204376, Length=186, Percent_Identity=43.5483870967742, Blast_Score=164, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17554494, Length=174, Percent_Identity=40.8045977011494, Blast_Score=146, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI25153706, Length=164, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323613, Length=185, Percent_Identity=39.4594594594595, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320661, Length=181, Percent_Identity=38.6740331491713, Blast_Score=137, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6319407, Length=163, Percent_Identity=28.2208588957055, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357347, Length=182, Percent_Identity=43.956043956044, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI17738015, Length=178, Percent_Identity=41.5730337078652, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17157991, Length=181, Percent_Identity=40.8839779005525, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24641739, Length=181, Percent_Identity=40.8839779005525, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI24656348, Length=182, Percent_Identity=39.010989010989, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17864676, Length=182, Percent_Identity=39.010989010989, Blast_Score=147, Evalue=3e-36,
Organism=Drosophila melanogaster, GI17975518, Length=156, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24652434, Length=156, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24652436, Length=156, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24581278, Length=154, Percent_Identity=31.1688311688312, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR017559
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 21195; Mature: 21195

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMSLINKKVLDFKVQAYQNGEFKEVTSEDLKGHWSVFVFYPADFTFVCPTELGELADNY
CCCHHHHHHHHEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHHH
ESFKEIGCEVYSISTDTHFVHKAWADASDTIGKIKYPMLADPTGKLARDFEVMIEEEGLA
HHHHHCCCEEEEECCCCHHHHHHHCCCCCCCCEEECCEEECCCCHHHHHEEEEEECCCEE
LRGSFVINPEGEIKAYEIHDNGIGRNAEELLRKVQAAQFVAEHGDQVCPAKWKPGEETLA
EECEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHC
PSLDLIGKL
CCHHHHCCC
>Mature Secondary Structure
MQMSLINKKVLDFKVQAYQNGEFKEVTSEDLKGHWSVFVFYPADFTFVCPTELGELADNY
CCCHHHHHHHHEEEEEEECCCCCHHHHHHHCCCCEEEEEEECCCEEEECHHHHHHHHHHH
ESFKEIGCEVYSISTDTHFVHKAWADASDTIGKIKYPMLADPTGKLARDFEVMIEEEGLA
HHHHHCCCEEEEECCCCHHHHHHHCCCCCCCCEEECCEEECCCCHHHHHEEEEEECCCEE
LRGSFVINPEGEIKAYEIHDNGIGRNAEELLRKVQAAQFVAEHGDQVCPAKWKPGEETLA
EECEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHC
PSLDLIGKL
CCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]