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The map label for this gene is rfbD [C]

Identifier: 182680401

GI number: 182680401

Start: 3978532

End: 3979431

Strand: Reverse

Name: rfbD [C]

Synonym: Bind_3501

Alternate gene names: 182680401

Gene position: 3979431-3978532 (Counterclockwise)

Preceding gene: 182680402

Following gene: 182680400

Centisome position: 95.43

GC content: 61.78

Gene sequence:

>900_bases
TTGGCAAAGTCGCCTGATGCTCCGATCCTGGTCTTTGGCGCCGGCGGCCAATTGGGCCAGGAGGTTATGGCCCAAGGGTC
TGCGCGCGGCCTGCCCGTTCAGGGTGTGAAGCGCGCCGAGGCCGATATTGGTGACGCCGCCGCTGTCACAGCGGCGATCG
AGAGCCGCAAGCCGCGCCTGATCCTCAATGCCGCTGCCTTTACCGCCGTGGATAAGGCTGAAAGCGAACCCGAGGCCGCG
CATCTTGCCAATGTCGTGGGTATTGAAATCCTCGCCAAGGCGGCCGCGCGTTTCGACGTGCCGCTCGTGCATATTTCCAC
CGATTATGTTTTTGACGGCTCGAAACAAGGAGCCTATGTCGAGAGTGATCCCATAAAGCCGCTTGGTGTCTATGGTGCGA
CCAAGGCCGAGGGCGAAGCCAGGCTGCGCGCGGCGGCGCCCAAACATATCATTTTGCGGACAGCCTGGGTGTTTGGCCCC
TATGGAGCCAATTTTCTCAAAACCATGCTGCGGCTGGCGGGGGAACGCGATCTCTTGCGTGTCGTCGCCGATCAGCGCGG
CTGCCCAACCGCGACGGCCGATATTGCCGCCGCTGTCTTTGCCATTGATCAAGCGCTCGATGCTCCTGCCGCCGATCTAT
GGGGCACCTATCATTTCGCCGGCGCGGATGCGACCACATGGCATGCATTCGCCGATGCGATCGTGGAGGCGCAGACCCGC
TGGAGTGGCCGTCGTCCCAAGGTTGAGGCGATCACGACACAGGATTATCCGACGCCCGCGAAACGGCCACAGAATTCGGA
ACTCAACAGCGGCTTGTTTGCCGCGACTTTCGGCTATCGCGCCGCGCCTTTGGCGGAAAGGATCGCGGAAACCTTGGCAA
GTCTTCGCACGGCCGCATAA

Upstream 100 bases:

>100_bases
GTGCGCTGGTATCTCGATCATCCAGAATGGTGGCAACGCATACGCTCAGGCCTTTATCGCGGCGAAAGACTCGGCGCTCT
TGGTGGTGAGGGAGGCGCTA

Downstream 100 bases:

>100_bases
AATCTGACATCTATTGCGTAGCCGTGAGGAACATATTGCCCGCAATGGGTGTTTGTTCGTAGGCGAGAGCGTGGCCGATA
CCAACGTGCCTTTGACGATC

Product: dTDP-4-dehydrorhamnose reductase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MAKSPDAPILVFGAGGQLGQEVMAQGSARGLPVQGVKRAEADIGDAAAVTAAIESRKPRLILNAAAFTAVDKAESEPEAA
HLANVVGIEILAKAAARFDVPLVHISTDYVFDGSKQGAYVESDPIKPLGVYGATKAEGEARLRAAAPKHIILRTAWVFGP
YGANFLKTMLRLAGERDLLRVVADQRGCPTATADIAAAVFAIDQALDAPAADLWGTYHFAGADATTWHAFADAIVEAQTR
WSGRRPKVEAITTQDYPTPAKRPQNSELNSGLFAATFGYRAAPLAERIAETLASLRTAA

Sequences:

>Translated_299_residues
MAKSPDAPILVFGAGGQLGQEVMAQGSARGLPVQGVKRAEADIGDAAAVTAAIESRKPRLILNAAAFTAVDKAESEPEAA
HLANVVGIEILAKAAARFDVPLVHISTDYVFDGSKQGAYVESDPIKPLGVYGATKAEGEARLRAAAPKHIILRTAWVFGP
YGANFLKTMLRLAGERDLLRVVADQRGCPTATADIAAAVFAIDQALDAPAADLWGTYHFAGADATTWHAFADAIVEAQTR
WSGRRPKVEAITTQDYPTPAKRPQNSELNSGLFAATFGYRAAPLAERIAETLASLRTAA
>Mature_298_residues
AKSPDAPILVFGAGGQLGQEVMAQGSARGLPVQGVKRAEADIGDAAAVTAAIESRKPRLILNAAAFTAVDKAESEPEAAH
LANVVGIEILAKAAARFDVPLVHISTDYVFDGSKQGAYVESDPIKPLGVYGATKAEGEARLRAAAPKHIILRTAWVFGPY
GANFLKTMLRLAGERDLLRVVADQRGCPTATADIAAAVFAIDQALDAPAADLWGTYHFAGADATTWHAFADAIVEAQTRW
SGRRPKVEAITTQDYPTPAKRPQNSELNSGLFAATFGYRAAPLAERIAETLASLRTAA

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=304, Percent_Identity=30.2631578947368, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI11034825, Length=304, Percent_Identity=30.2631578947368, Blast_Score=81, Evalue=9e-16,
Organism=Escherichia coli, GI1788352, Length=277, Percent_Identity=42.5992779783394, Blast_Score=195, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31489; Mature: 31358

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKSPDAPILVFGAGGQLGQEVMAQGSARGLPVQGVKRAEADIGDAAAVTAAIESRKPRL
CCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCEE
ILNAAAFTAVDKAESEPEAAHLANVVGIEILAKAAARFDVPLVHISTDYVFDGSKQGAYV
EEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECEEECCCCCCCEE
ESDPIKPLGVYGATKAEGEARLRAAAPKHIILRTAWVFGPYGANFLKTMLRLAGERDLLR
CCCCCCCEECCCCCCCCCCHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCHHHHH
VVADQRGCPTATADIAAAVFAIDQALDAPAADLWGTYHFAGADATTWHAFADAIVEAQTR
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCHHHHHHHHHHHHHHHH
WSGRRPKVEAITTQDYPTPAKRPQNSELNSGLFAATFGYRAAPLAERIAETLASLRTAA
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKSPDAPILVFGAGGQLGQEVMAQGSARGLPVQGVKRAEADIGDAAAVTAAIESRKPRL
CCCCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCCCEE
ILNAAAFTAVDKAESEPEAAHLANVVGIEILAKAAARFDVPLVHISTDYVFDGSKQGAYV
EEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECEEECCCCCCCEE
ESDPIKPLGVYGATKAEGEARLRAAAPKHIILRTAWVFGPYGANFLKTMLRLAGERDLLR
CCCCCCCEECCCCCCCCCCHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHCCCHHHHH
VVADQRGCPTATADIAAAVFAIDQALDAPAADLWGTYHFAGADATTWHAFADAIVEAQTR
HHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCCCHHHHHHHHHHHHHHHH
WSGRRPKVEAITTQDYPTPAKRPQNSELNSGLFAATFGYRAAPLAERIAETLASLRTAA
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]