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The map label for this gene is ilvD [H]

Identifier: 182679985

GI number: 182679985

Start: 3518691

End: 3520427

Strand: Reverse

Name: ilvD [H]

Synonym: Bind_3081

Alternate gene names: 182679985

Gene position: 3520427-3518691 (Counterclockwise)

Preceding gene: 182679986

Following gene: 182679984

Centisome position: 84.42

GC content: 62.35

Gene sequence:

>1737_bases
ATGAAAGACGACATTCCCCACAAGCCTCTGCGCAGTCAGGCCTGGTTCGGTCGGCAGGATAAAATGGGCTTCTATTACCG
CTCCTTTCTGAAGAATAGCGGCTTCCCGCAGGACCAGTTCGACGGGCGCCCGGTCATCGGCATCTGCAACACCTGGTCCG
AGCTCACACCCTGCAATGCCCATTTCCGCACCATTGCGGAGCATGTGCGCTACGGCGTGTTGGAAGCGGGTGGCTTTCCG
CTGGAATTCCCGGTTTCCTCGCTCGGCGAAGTGACCATGCGCCCGACCGCAATGTTGTTCCGCAATCTTGCGTCAATGGA
TGTCGAGGAGGCGATCCGCGCGCATCCGCTTGACGGCGTCGTGCTGTTGATGGGTTGCGACAAAACCACCCCCGCGCTGC
TGATGGGTGCCGCCTCGGCGGACATTCCGACCATTGGGGTTTCGGGCGGACCGCAGCTGCGCGGCGTCTATCGCGGTGAG
ATCATCGGCTCTGGAACTAACATCATTTCCATGAGCGAGCAGCTGCGGGCTGGCGAGATCACCCTCGCCGAGTTCCATGA
AGCCGAAGCCGCGATGAACCGCTCTGCGGGCAGCTGCATGACCATGGGAACCGCCTCCACTATGGCCTCCATGGTGGAAG
CTCTCGGCATCGGACTGCCCGAGAATGCCGCCATTCCCGCCGCCGACGCCCGCCGTAACCTCATCGCTCGCATGGCGGGA
CGGCGCATCGTTGACATGGTGCATGAGGATCTGAAGCCTTCGGACATCCTTACCCGTGCCGCCTTCGAGAACGCGATCCG
AACGCTCGCTGCTATCGGCGGCTCCACCAATGCAGTGGTTCACCTCCTTGCTATTGCCGGGCGCATCGGCGTCGAGCTCA
CGCTCGATGATTTCGACCAGCTGGGTCGTGGCATTCACTGCCTCGTGGATCTCATGCCGTCCGGCCGTTTTCTGATGGAG
GATTTCTATTATGCGGGTGGCCTGCCGGCCGTGCTGCGCACGCTGGGCGAGCGTGGCCTCCTCCATCGTGATGCACGGAC
GGTCAATGGGCAAAGCATTTGGGAGAATGTCGCGAATGCGCCCTGTTGGAACAATGAGGTGATCACACCCTTCGACAAAG
CGTTCAAGGCTGACGCAGGCATCGCCATCCTCAAGGGTAACCTTGCGCCCGACGGAGCGGTGATCAAGCCTTCCGCTGCC
TCCCCCGAACTGATGAGCCACACCGGCCGCGCCGTGGTTTTTGAGAATGTGGAAGAGATGCATCATGCGGTGAACGACGA
GACGCTCGACATCGACGCCTCCTGCATTATGGTGCTCAAGAACTGCGGACCGAAGGGCTATCCAGGCATGGCCGAGGTCG
GCAACATGCCGCTGCCGGCCAAGCTGCTGCGTCAAGGTGTGCGCGATATGATCCGTATCTCGGATGCGCGTATGTCGGGC
ACTGCTTATGGCACAGTAGTGTTGCATGTCGCACCGGAGGCCACGGCCGGCGGCCCCTTGGCCTTGGTCCGCAACGGCGA
TCTGATCACCCTCGACGTACCGGCTCGCTCGCTCCACCTGCATGTGAGCCAGGAAGAGCTCGCCGCGCGCCGCGCCGTGT
GGAAGCCACCCGTTCCTCACGCCGATCGCGGCTACGCCCGCCTCTATATCGACCACGTGCTGCAGGCCGATCGCGGCGCC
GATTTCGATTTCCTCGTCGGGCGTTCCGGCGCGCCCGTGCCGCGCGACAATCATTGA

Upstream 100 bases:

>100_bases
GCTGAAAAGAATTCCGAGTCGGCAGCGGCTGCGATGACCAATGTCATTTTCTCAGGCCAGCGCCGCCACCGGGCAGCGGA
CTGAAGCAAACGGAAACAAC

Downstream 100 bases:

>100_bases
GGGTCATCAATGTCCACCTCTCCCTTGAAGCGCCCCCATCGCGGTGTCTTTCCCGTCGCTCCGACAGTGTTCGACGCCAA
TGGAGCTCTCGATCTCGATG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MKDDIPHKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPCNAHFRTIAEHVRYGVLEAGGFP
LEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADIPTIGVSGGPQLRGVYRGE
IIGSGTNIISMSEQLRAGEITLAEFHEAEAAMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLIARMAG
RRIVDMVHEDLKPSDILTRAAFENAIRTLAAIGGSTNAVVHLLAIAGRIGVELTLDDFDQLGRGIHCLVDLMPSGRFLME
DFYYAGGLPAVLRTLGERGLLHRDARTVNGQSIWENVANAPCWNNEVITPFDKAFKADAGIAILKGNLAPDGAVIKPSAA
SPELMSHTGRAVVFENVEEMHHAVNDETLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKLLRQGVRDMIRISDARMSG
TAYGTVVLHVAPEATAGGPLALVRNGDLITLDVPARSLHLHVSQEELAARRAVWKPPVPHADRGYARLYIDHVLQADRGA
DFDFLVGRSGAPVPRDNH

Sequences:

>Translated_578_residues
MKDDIPHKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPCNAHFRTIAEHVRYGVLEAGGFP
LEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADIPTIGVSGGPQLRGVYRGE
IIGSGTNIISMSEQLRAGEITLAEFHEAEAAMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLIARMAG
RRIVDMVHEDLKPSDILTRAAFENAIRTLAAIGGSTNAVVHLLAIAGRIGVELTLDDFDQLGRGIHCLVDLMPSGRFLME
DFYYAGGLPAVLRTLGERGLLHRDARTVNGQSIWENVANAPCWNNEVITPFDKAFKADAGIAILKGNLAPDGAVIKPSAA
SPELMSHTGRAVVFENVEEMHHAVNDETLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKLLRQGVRDMIRISDARMSG
TAYGTVVLHVAPEATAGGPLALVRNGDLITLDVPARSLHLHVSQEELAARRAVWKPPVPHADRGYARLYIDHVLQADRGA
DFDFLVGRSGAPVPRDNH
>Mature_578_residues
MKDDIPHKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPCNAHFRTIAEHVRYGVLEAGGFP
LEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADIPTIGVSGGPQLRGVYRGE
IIGSGTNIISMSEQLRAGEITLAEFHEAEAAMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLIARMAG
RRIVDMVHEDLKPSDILTRAAFENAIRTLAAIGGSTNAVVHLLAIAGRIGVELTLDDFDQLGRGIHCLVDLMPSGRFLME
DFYYAGGLPAVLRTLGERGLLHRDARTVNGQSIWENVANAPCWNNEVITPFDKAFKADAGIAILKGNLAPDGAVIKPSAA
SPELMSHTGRAVVFENVEEMHHAVNDETLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKLLRQGVRDMIRISDARMSG
TAYGTVVLHVAPEATAGGPLALVRNGDLITLDVPARSLHLHVSQEELAARRAVWKPPVPHADRGYARLYIDHVLQADRGA
DFDFLVGRSGAPVPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=597, Percent_Identity=30.9882747068677, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788157, Length=525, Percent_Identity=30.0952380952381, Blast_Score=182, Evalue=4e-47,
Organism=Escherichia coli, GI2367371, Length=458, Percent_Identity=32.0960698689956, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1786464, Length=452, Percent_Identity=32.9646017699115, Blast_Score=173, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=572, Percent_Identity=31.4685314685315, Blast_Score=263, Evalue=6e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62277; Mature: 62277

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDDIPHKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPCNA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCH
HFRTIAEHVRYGVLEAGGFPLEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGV
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCE
VLLMGCDKTTPALLMGAASADIPTIGVSGGPQLRGVYRGEIIGSGTNIISMSEQLRAGEI
EEEEECCCCCHHHEEECCCCCCCEEECCCCCCCCEEEECEEEECCCCEEEHHHHHCCCCE
TLAEFHEAEAAMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLIARMAG
EHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
RRIVDMVHEDLKPSDILTRAAFENAIRTLAAIGGSTNAVVHLLAIAGRIGVELTLDDFDQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEHHHHH
LGRGIHCLVDLMPSGRFLMEDFYYAGGLPAVLRTLGERGLLHRDARTVNGQSIWENVANA
HCCHHEEEHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHCCC
PCWNNEVITPFDKAFKADAGIAILKGNLAPDGAVIKPSAASPELMSHTGRAVVFENVEEM
CCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCEECCCCCCCHHHHCCCCEEEHHHHHHH
HHAVNDETLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKLLRQGVRDMIRISDARMSG
HHHCCCCEEECCHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
TAYGTVVLHVAPEATAGGPLALVRNGDLITLDVPARSLHLHVSQEELAARRAVWKPPVPH
CEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCCCC
ADRGYARLYIDHVLQADRGADFDFLVGRSGAPVPRDNH
CCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKDDIPHKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPCNA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCCH
HFRTIAEHVRYGVLEAGGFPLEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGV
HHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCCE
VLLMGCDKTTPALLMGAASADIPTIGVSGGPQLRGVYRGEIIGSGTNIISMSEQLRAGEI
EEEEECCCCCHHHEEECCCCCCCEEECCCCCCCCEEEECEEEECCCCEEEHHHHHCCCCE
TLAEFHEAEAAMNRSAGSCMTMGTASTMASMVEALGIGLPENAAIPAADARRNLIARMAG
EHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
RRIVDMVHEDLKPSDILTRAAFENAIRTLAAIGGSTNAVVHLLAIAGRIGVELTLDDFDQ
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEHHHHH
LGRGIHCLVDLMPSGRFLMEDFYYAGGLPAVLRTLGERGLLHRDARTVNGQSIWENVANA
HCCHHEEEHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCEECCCCCCCHHHHHHHHCCC
PCWNNEVITPFDKAFKADAGIAILKGNLAPDGAVIKPSAASPELMSHTGRAVVFENVEEM
CCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCCEECCCCCCCHHHHCCCCEEEHHHHHHH
HHAVNDETLDIDASCIMVLKNCGPKGYPGMAEVGNMPLPAKLLRQGVRDMIRISDARMSG
HHHCCCCEEECCHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCC
TAYGTVVLHVAPEATAGGPLALVRNGDLITLDVPARSLHLHVSQEELAARRAVWKPPVPH
CEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCCCC
ADRGYARLYIDHVLQADRGADFDFLVGRSGAPVPRDNH
CCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA