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The map label for this gene is bioF [H]

Identifier: 182679917

GI number: 182679917

Start: 3426476

End: 3427702

Strand: Reverse

Name: bioF [H]

Synonym: Bind_3012

Alternate gene names: 182679917

Gene position: 3427702-3426476 (Counterclockwise)

Preceding gene: 182679920

Following gene: 182679916

Centisome position: 82.2

GC content: 58.84

Gene sequence:

>1227_bases
GTGTCGAAATTCAACAGCCTCGCCGATTTTGCCACGAAGCGTTTCAGGCTTGCGGGAAAAGCCTATCTTGAAAACGGCGA
CCCTTTCTTCGCGCCCATAGACCGCCTGCGACACGAGGCGGAGGCCCGGGGCGATTATTTCGTCAGTTTCGCGAATTACG
ATTATCTTGGTCTTTCGACCCATCCGGCCATCAAATCCGCCTGTGCCGATGCGCTTGAGACCACGGGGGTCGGAGCTTTG
GCCTCACGGCTCGTCGGCGGTGAACGGGCGGCTCATCATATTCTCGAGCAATCCCTGGCGGACTTTCTGCGGACCGACGC
CGCGCTGACCTTGGTCAGCGGCTATCTGACCAATGTGACGACGATCGCCCATGTCATGGGGACTCGCGATGCGATCTTTA
TCGATGAATTGTCGCATAATAGCATCGTCAGCGGCGCCAAGAGCGCGGTCGCCGAAACCATCATTTTCCGCCACAATGAT
CTCGATCATCTCGATCACCTCCTGACGGAGAAGCGGGGGCAGTTTCGCAATGTCATGGTCATTGCGGAAAGTCTCTACAG
CATGGACGGCGATATCGTCGATCTGCCGGCCCTGGTCGCCCTCAAGCGGAAACATAATGCTTGGCTTCTGATCGATGAAG
CCCATTCGATCGGCGTGCTGGGCGCCGAGGGCCGTGGCATTTGCGAATATAGCGGCGTGGATCCCAACGAGATCGATCTC
ATCATCGGGACCTTGTCCAAGACGCTTGCCTCCTGTGGTGGCTTCATCGCCGGCAAGCAGGCGGTCATCGAATGGCTGCG
TTATACATTGCCGGGCTTCGTCTATAGTGTCGGCTTGTCTCCGGTCATTTCAGCCGCCGCCCATATGGCCTTGCAATTGG
TGCAAAAGGAAACGTGGCGCCTGGAAAGGTTGCGGCGCAACGCCGAGCTTTTCGTCGAGCTCGCGCATGAAGCCGGCCTC
GATACGGGCCCGGCGATTGGGCGCGGCGTCATTCCGATCATGTTCCGTGACAGCCACGAAACTCTGGCCGCTTCCGCCTA
TCTCATGGAAAACGGCTTCTATGTGCCGCCGATCATCCAGATCGGTGTGCCGAAAGACCAGCCGCGCTTGCGCTTCTTCC
TGTCCGCTTCGCATAGCGAGGCGGAGATTCGCGGCGTGATCTCCTTGCTCGGCCAGAACCTACCTGCGCAGGCTCCCGCC
ACTCATCCCATCAGCGCCGCTGGCTAA

Upstream 100 bases:

>100_bases
CCGATGGCCGCAACATTGTTAATGGAATGCTTAAACTTCTCTGAGCTGATAGAGACCGTTCATCGAAGCCCTCGCGACCT
CATTTCCGGACTGCCCATAC

Downstream 100 bases:

>100_bases
AACCATCAGATCGGCGATGGGTGTCTTGTTCGCAACCGAGTTTGCGCGCCATAACGTTCTCGCCATCCGCCGAAAGATGT
GGGTATGATCGAGATCCTTC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MSKFNSLADFATKRFRLAGKAYLENGDPFFAPIDRLRHEAEARGDYFVSFANYDYLGLSTHPAIKSACADALETTGVGAL
ASRLVGGERAAHHILEQSLADFLRTDAALTLVSGYLTNVTTIAHVMGTRDAIFIDELSHNSIVSGAKSAVAETIIFRHND
LDHLDHLLTEKRGQFRNVMVIAESLYSMDGDIVDLPALVALKRKHNAWLLIDEAHSIGVLGAEGRGICEYSGVDPNEIDL
IIGTLSKTLASCGGFIAGKQAVIEWLRYTLPGFVYSVGLSPVISAAAHMALQLVQKETWRLERLRRNAELFVELAHEAGL
DTGPAIGRGVIPIMFRDSHETLAASAYLMENGFYVPPIIQIGVPKDQPRLRFFLSASHSEAEIRGVISLLGQNLPAQAPA
THPISAAG

Sequences:

>Translated_408_residues
MSKFNSLADFATKRFRLAGKAYLENGDPFFAPIDRLRHEAEARGDYFVSFANYDYLGLSTHPAIKSACADALETTGVGAL
ASRLVGGERAAHHILEQSLADFLRTDAALTLVSGYLTNVTTIAHVMGTRDAIFIDELSHNSIVSGAKSAVAETIIFRHND
LDHLDHLLTEKRGQFRNVMVIAESLYSMDGDIVDLPALVALKRKHNAWLLIDEAHSIGVLGAEGRGICEYSGVDPNEIDL
IIGTLSKTLASCGGFIAGKQAVIEWLRYTLPGFVYSVGLSPVISAAAHMALQLVQKETWRLERLRRNAELFVELAHEAGL
DTGPAIGRGVIPIMFRDSHETLAASAYLMENGFYVPPIIQIGVPKDQPRLRFFLSASHSEAEIRGVISLLGQNLPAQAPA
THPISAAG
>Mature_407_residues
SKFNSLADFATKRFRLAGKAYLENGDPFFAPIDRLRHEAEARGDYFVSFANYDYLGLSTHPAIKSACADALETTGVGALA
SRLVGGERAAHHILEQSLADFLRTDAALTLVSGYLTNVTTIAHVMGTRDAIFIDELSHNSIVSGAKSAVAETIIFRHNDL
DHLDHLLTEKRGQFRNVMVIAESLYSMDGDIVDLPALVALKRKHNAWLLIDEAHSIGVLGAEGRGICEYSGVDPNEIDLI
IGTLSKTLASCGGFIAGKQAVIEWLRYTLPGFVYSVGLSPVISAAAHMALQLVQKETWRLERLRRNAELFVELAHEAGLD
TGPAIGRGVIPIMFRDSHETLAASAYLMENGFYVPPIIQIGVPKDQPRLRFFLSASHSEAEIRGVISLLGQNLPAQAPAT
HPISAAG

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=360, Percent_Identity=31.1111111111111, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI4758668, Length=357, Percent_Identity=32.4929971988796, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI83977442, Length=347, Percent_Identity=29.971181556196, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI83977440, Length=347, Percent_Identity=29.971181556196, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI83977444, Length=347, Percent_Identity=29.971181556196, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI284448556, Length=338, Percent_Identity=29.8816568047337, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI7657118, Length=338, Percent_Identity=29.8816568047337, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI5454084, Length=253, Percent_Identity=32.4110671936759, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4502025, Length=337, Percent_Identity=31.1572700296736, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI40316939, Length=337, Percent_Identity=31.1572700296736, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1790046, Length=344, Percent_Identity=32.8488372093023, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786993, Length=352, Percent_Identity=30.9659090909091, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=30.5785123966942, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17560912, Length=394, Percent_Identity=26.9035532994924, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=394, Percent_Identity=26.9035532994924, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=343, Percent_Identity=31.1953352769679, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71982625, Length=270, Percent_Identity=27.7777777777778, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=283, Percent_Identity=26.8551236749117, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320267, Length=382, Percent_Identity=30.8900523560209, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6320438, Length=392, Percent_Identity=27.8061224489796, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323954, Length=279, Percent_Identity=24.7311827956989, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17136286, Length=362, Percent_Identity=29.2817679558011, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24662918, Length=342, Percent_Identity=30.4093567251462, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=30.6590257879656, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24653280, Length=280, Percent_Identity=30.7142857142857, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24653276, Length=280, Percent_Identity=30.7142857142857, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24653278, Length=280, Percent_Identity=30.7142857142857, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022834
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 44283; Mature: 44152

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFNSLADFATKRFRLAGKAYLENGDPFFAPIDRLRHEAEARGDYFVSFANYDYLGLST
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECCCC
HPAIKSACADALETTGVGALASRLVGGERAAHHILEQSLADFLRTDAALTLVSGYLTNVT
CHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIAHVMGTRDAIFIDELSHNSIVSGAKSAVAETIIFRHNDLDHLDHLLTEKRGQFRNVMV
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
IAESLYSMDGDIVDLPALVALKRKHNAWLLIDEAHSIGVLGAEGRGICEYSGVDPNEIDL
HHHHHHHCCCCEECHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCEEEECCCCCCHHHH
IIGTLSKTLASCGGFIAGKQAVIEWLRYTLPGFVYSVGLSPVISAAAHMALQLVQKETWR
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LERLRRNAELFVELAHEAGLDTGPAIGRGVIPIMFRDSHETLAASAYLMENGFYVPPIIQ
HHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEE
IGVPKDQPRLRFFLSASHSEAEIRGVISLLGQNLPAQAPATHPISAAG
ECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKFNSLADFATKRFRLAGKAYLENGDPFFAPIDRLRHEAEARGDYFVSFANYDYLGLST
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEECCCC
HPAIKSACADALETTGVGALASRLVGGERAAHHILEQSLADFLRTDAALTLVSGYLTNVT
CHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIAHVMGTRDAIFIDELSHNSIVSGAKSAVAETIIFRHNDLDHLDHLLTEKRGQFRNVMV
HHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHH
IAESLYSMDGDIVDLPALVALKRKHNAWLLIDEAHSIGVLGAEGRGICEYSGVDPNEIDL
HHHHHHHCCCCEECHHHHHHHHHCCCEEEEEECCCCCEEECCCCCCEEEECCCCCCHHHH
IIGTLSKTLASCGGFIAGKQAVIEWLRYTLPGFVYSVGLSPVISAAAHMALQLVQKETWR
HHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LERLRRNAELFVELAHEAGLDTGPAIGRGVIPIMFRDSHETLAASAYLMENGFYVPPIIQ
HHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCEEE
IGVPKDQPRLRFFLSASHSEAEIRGVISLLGQNLPAQAPATHPISAAG
ECCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA