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The map label for this gene is sppA [C]

Identifier: 182679840

GI number: 182679840

Start: 3340553

End: 3341527

Strand: Reverse

Name: sppA [C]

Synonym: Bind_2929

Alternate gene names: 182679840

Gene position: 3341527-3340553 (Counterclockwise)

Preceding gene: 182679841

Following gene: 182679839

Centisome position: 80.13

GC content: 58.67

Gene sequence:

>975_bases
ATGCCTCTTTCTTCTTTCTCGGACTATATGGTCGAGCGCCGTTTGCTGCGCCGCAAACTGTCCTTCTGGCGAATCGCCAC
CATGGCCCTCGTTCTGGCGGGGATCGCCAGCTTGGCCTATGTTTCGCTCGGCTTCCGGTCAGGCCAGCAACGGGCGCATA
TTGCACGGCTCTCGATTTCCGGCCTTATTACCGGTGACCGGGATACACTCCGGCTGATCAAAAGGGTTGAGGATTCGTCC
GCTCAAGCCGTACTCGTTTCGATCGAAAGTCCCGGTGGCACCACGACGGGAGCCGAACGGATCTACGAGGCCTTGCGGCG
GCTCTCCAGGAAAAAACCGACGGCGGCGGTTGTTGGCACGATGGCGGCCTCGGGGGGCTATATTGCCGCGCTCGGGACCG
ATCAGATCGTCGCACAAGGCAATTCCCTTGTCGGCTCGATCGGTGTCTTGTTCCAATATCCGAATGTTGCCAGGCTCCTC
GATACGCTGGGGGTCAAGGTTGAGGAGGTGAAATCCTCGCCGCTTAAGGCTTCGCCCAATGGATTCGAGCCGACCACGCC
GGAGGCTCGCGCGGCCCTCGTTTCGCTCATCAATGACAGCTATAGCTGGTTCAAGGGGCTCGTGAAGGAGCGCCGCGGCA
TGGATGATGCTCAATTGGCTAATGTTTCCGATGGACGGGTGTTTACCGGACGGCAAGGGATACCTTTGCATCTCGTCGAT
CGGTTAGGGGGCGAGCAAGAAGCCATAGCTTGGCTGGAGCAGCAAAAGGGGGTTGGCAAAAACCTGCCGGTGCGTGACTG
GAAACACGAGCGCGGCCTCGGACGATGGGGGATCATCAGTCTGGCGGCTGGCCTTGCTGAAAAGCTTGGTCTGGCCAGTC
TGGCGCTTGTTCTGAATGGGGAAAGTCCCTTCGCTGGCTCGCCTTTGCTTGACGGTTTGGTATCGATTTGGCAAGTTGAC
GCAGGTTCAAATTGA

Upstream 100 bases:

>100_bases
GTCGTTGCTCGAAAGGGGATGATGTCTTTGATGAGAATCAGATATCATCCTTGATGATCAGAGCCGATGAGCGGTTCTGA
CTCGTTCGGTCTGGACGGAA

Downstream 100 bases:

>100_bases
CCCAGGCCCTTGAAACGGATCGAAAATCCCGGTTCCCGAGCGGTTGATGGATTAAACGAATGATTAAATCGGAGCTCGTG
CAGCGCATTGCTGATCGCAA

Product: signal peptide peptidase SppA, 36K type

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MPLSSFSDYMVERRLLRRKLSFWRIATMALVLAGIASLAYVSLGFRSGQQRAHIARLSISGLITGDRDTLRLIKRVEDSS
AQAVLVSIESPGGTTTGAERIYEALRRLSRKKPTAAVVGTMAASGGYIAALGTDQIVAQGNSLVGSIGVLFQYPNVARLL
DTLGVKVEEVKSSPLKASPNGFEPTTPEARAALVSLINDSYSWFKGLVKERRGMDDAQLANVSDGRVFTGRQGIPLHLVD
RLGGEQEAIAWLEQQKGVGKNLPVRDWKHERGLGRWGIISLAAGLAEKLGLASLALVLNGESPFAGSPLLDGLVSIWQVD
AGSN

Sequences:

>Translated_324_residues
MPLSSFSDYMVERRLLRRKLSFWRIATMALVLAGIASLAYVSLGFRSGQQRAHIARLSISGLITGDRDTLRLIKRVEDSS
AQAVLVSIESPGGTTTGAERIYEALRRLSRKKPTAAVVGTMAASGGYIAALGTDQIVAQGNSLVGSIGVLFQYPNVARLL
DTLGVKVEEVKSSPLKASPNGFEPTTPEARAALVSLINDSYSWFKGLVKERRGMDDAQLANVSDGRVFTGRQGIPLHLVD
RLGGEQEAIAWLEQQKGVGKNLPVRDWKHERGLGRWGIISLAAGLAEKLGLASLALVLNGESPFAGSPLLDGLVSIWQVD
AGSN
>Mature_323_residues
PLSSFSDYMVERRLLRRKLSFWRIATMALVLAGIASLAYVSLGFRSGQQRAHIARLSISGLITGDRDTLRLIKRVEDSSA
QAVLVSIESPGGTTTGAERIYEALRRLSRKKPTAAVVGTMAASGGYIAALGTDQIVAQGNSLVGSIGVLFQYPNVARLLD
TLGVKVEEVKSSPLKASPNGFEPTTPEARAALVSLINDSYSWFKGLVKERRGMDDAQLANVSDGRVFTGRQGIPLHLVDR
LGGEQEAIAWLEQQKGVGKNLPVRDWKHERGLGRWGIISLAAGLAEKLGLASLALVLNGESPFAGSPLLDGLVSIWQVDA
GSN

Specific function: Digestion Of The Cleaved Signal Peptides. This Activity Is Necessary To Maintain Proper Secretion Of Mature Proteins Across The Membrane. [C]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=191, Percent_Identity=32.4607329842932, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787527, Length=167, Percent_Identity=32.9341317365269, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 34718; Mature: 34587

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSSFSDYMVERRLLRRKLSFWRIATMALVLAGIASLAYVSLGFRSGQQRAHIARLSIS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEEE
GLITGDRDTLRLIKRVEDSSAQAVLVSIESPGGTTTGAERIYEALRRLSRKKPTAAVVGT
EEEECCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
MAASGGYIAALGTDQIVAQGNSLVGSIGVLFQYPNVARLLDTLGVKVEEVKSSPLKASPN
HHCCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCCCCCCCC
GFEPTTPEARAALVSLINDSYSWFKGLVKERRGMDDAQLANVSDGRVFTGRQGIPLHLVD
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHCCCCCCCEEECCCCCCHHHHH
RLGGEQEAIAWLEQQKGVGKNLPVRDWKHERGLGRWGIISLAAGLAEKLGLASLALVLNG
HCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCHHHEEEEECC
ESPFAGSPLLDGLVSIWQVDAGSN
CCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PLSSFSDYMVERRLLRRKLSFWRIATMALVLAGIASLAYVSLGFRSGQQRAHIARLSIS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEEEE
GLITGDRDTLRLIKRVEDSSAQAVLVSIESPGGTTTGAERIYEALRRLSRKKPTAAVVGT
EEEECCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHH
MAASGGYIAALGTDQIVAQGNSLVGSIGVLFQYPNVARLLDTLGVKVEEVKSSPLKASPN
HHCCCCEEEEECCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCCCCCCCC
GFEPTTPEARAALVSLINDSYSWFKGLVKERRGMDDAQLANVSDGRVFTGRQGIPLHLVD
CCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHCCCCCCCEEECCCCCCHHHHH
RLGGEQEAIAWLEQQKGVGKNLPVRDWKHERGLGRWGIISLAAGLAEKLGLASLALVLNG
HCCCHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCHHHEEEEECC
ESPFAGSPLLDGLVSIWQVDAGSN
CCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]