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The map label for this gene is cytR [H]

Identifier: 182679432

GI number: 182679432

Start: 2833752

End: 2834765

Strand: Reverse

Name: cytR [H]

Synonym: Bind_2481

Alternate gene names: 182679432

Gene position: 2834765-2833752 (Counterclockwise)

Preceding gene: 182679437

Following gene: 182679422

Centisome position: 67.98

GC content: 55.52

Gene sequence:

>1014_bases
ATGGCTAAAATCAGAAGTATGGAAGAATTTGCAGCGGCCAGCGGTATCTCGCGGCCAACGCTGTCAAAATATTTCAGCGA
TCCCTCAAGCGTGCGAAAGTCGACGCGACAGCGGATCGAAACAGCGCTTGTTGAACACGAATATCGTCCGAATATCTTTG
CGATCAGTCAGAACCGGAAGCGACCGATGAACGTCGGCATTCTGATTCCGCATCTGACAGATCCTTACTTCGCCGAACTC
GTGCGCCACATCGAAGCTCGATGCGCATCCATGGGCTTCTGGGCCATCATATTGAGTTCTCATGGTGATCCGGATCTGGA
GGAAAGGGCCCTTCGTACGCTTCTTTCGCTCAAGCTGGCTGGCGCGATTGTCGCGCCGCTCGGCACCCGTTCCAACTGCG
ACACCTTCAAGGCTTTGTGCAAAGAACTTCCGATTGTTTTTCTCGACAGCCGGATCGACCTTGAGGTGCCTTTTGTTGGC
ACGGACAACCGCGCCAGTATCGAACTCCTCGTCGAATACCTTGTGCGCACCGGCGAGCCACCCTGTTTCCTCGACATGCC
CCACGTCAACCAAAACGCGCTGGAAAGGCGCCAAGCGTTCGAAGAGGCGGCTCGAAAGGCGAAGTTTGAGCCGCATGTCA
TTCCCGCGCGGACATTGGACTGGAACTTCGAGCAGATCGGATTCGATGTCGTTACAGCCTATCTCCGCGGCTCAGGTCTG
CCGTCCAGAACATTGCTTTGCGCGAATGATCGGCTTGCTTTCGGCGCGCTCGCGGCGGCGTACAAGAGTGGTTTGAAGGT
TGGTCGAGAAGACAATGCAGATCTGCGAATTGCCGGCCATGATGATCATCCGCTTAGCCGCTTCGCGTGTCCATCGTTGA
CGACCATCGCCCAGGATTATGAGGGACTGGCAAGCTCTGCGTTCGATATCTTGGTCGGTCGTCTCGATGGCGAGGAAAAT
ATGCCGACTTCGGAATTGCTTTCGAGCCGGTTGGTGATGCGTGATTCCGCCTGA

Upstream 100 bases:

>100_bases
ACGCTACGGGAGTAAATAAATAAATTTACTCGAGTAAAATTTAATAAACTTGCGTCAAGATGCAATCGAAGCCACATTTG
GAGGTCGTGGAAGGAGAAAG

Downstream 100 bases:

>100_bases
CGGAGCGTTGGCTCTCAGCGCCTCCGCCTGTGCCGGAGTCTGTTCTTCCTCTACCCTACAGCCCTGCCGCCTTGGTGAGA
TTGATGCGGAAGCGGTCGCG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAKIRSMEEFAAASGISRPTLSKYFSDPSSVRKSTRQRIETALVEHEYRPNIFAISQNRKRPMNVGILIPHLTDPYFAEL
VRHIEARCASMGFWAIILSSHGDPDLEERALRTLLSLKLAGAIVAPLGTRSNCDTFKALCKELPIVFLDSRIDLEVPFVG
TDNRASIELLVEYLVRTGEPPCFLDMPHVNQNALERRQAFEEAARKAKFEPHVIPARTLDWNFEQIGFDVVTAYLRGSGL
PSRTLLCANDRLAFGALAAAYKSGLKVGREDNADLRIAGHDDHPLSRFACPSLTTIAQDYEGLASSAFDILVGRLDGEEN
MPTSELLSSRLVMRDSA

Sequences:

>Translated_337_residues
MAKIRSMEEFAAASGISRPTLSKYFSDPSSVRKSTRQRIETALVEHEYRPNIFAISQNRKRPMNVGILIPHLTDPYFAEL
VRHIEARCASMGFWAIILSSHGDPDLEERALRTLLSLKLAGAIVAPLGTRSNCDTFKALCKELPIVFLDSRIDLEVPFVG
TDNRASIELLVEYLVRTGEPPCFLDMPHVNQNALERRQAFEEAARKAKFEPHVIPARTLDWNFEQIGFDVVTAYLRGSGL
PSRTLLCANDRLAFGALAAAYKSGLKVGREDNADLRIAGHDDHPLSRFACPSLTTIAQDYEGLASSAFDILVGRLDGEEN
MPTSELLSSRLVMRDSA
>Mature_336_residues
AKIRSMEEFAAASGISRPTLSKYFSDPSSVRKSTRQRIETALVEHEYRPNIFAISQNRKRPMNVGILIPHLTDPYFAELV
RHIEARCASMGFWAIILSSHGDPDLEERALRTLLSLKLAGAIVAPLGTRSNCDTFKALCKELPIVFLDSRIDLEVPFVGT
DNRASIELLVEYLVRTGEPPCFLDMPHVNQNALERRQAFEEAARKAKFEPHVIPARTLDWNFEQIGFDVVTAYLRGSGLP
SRTLLCANDRLAFGALAAAYKSGLKVGREDNADLRIAGHDDHPLSRFACPSLTTIAQDYEGLASSAFDILVGRLDGEENM
PTSELLSSRLVMRDSA

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=340, Percent_Identity=27.9411764705882, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1786540, Length=338, Percent_Identity=26.6272189349112, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790194, Length=313, Percent_Identity=25.8785942492013, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI48994940, Length=325, Percent_Identity=24.9230769230769, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789202, Length=302, Percent_Identity=24.1721854304636, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788474, Length=339, Percent_Identity=23.0088495575221, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790715, Length=330, Percent_Identity=24.5454545454545, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786268, Length=326, Percent_Identity=25.1533742331288, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789068, Length=339, Percent_Identity=22.7138643067847, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787906, Length=279, Percent_Identity=25.4480286738351, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37433; Mature: 37302

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIRSMEEFAAASGISRPTLSKYFSDPSSVRKSTRQRIETALVEHEYRPNIFAISQNRK
CCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
RPMNVGILIPHLTDPYFAELVRHIEARCASMGFWAIILSSHGDPDLEERALRTLLSLKLA
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
GAIVAPLGTRSNCDTFKALCKELPIVFLDSRIDLEVPFVGTDNRASIELLVEYLVRTGEP
HHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCC
PCFLDMPHVNQNALERRQAFEEAARKAKFEPHVIPARTLDWNFEQIGFDVVTAYLRGSGL
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
PSRTLLCANDRLAFGALAAAYKSGLKVGREDNADLRIAGHDDHPLSRFACPSLTTIAQDY
CCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHCCCCHHHHHHHH
EGLASSAFDILVGRLDGEENMPTSELLSSRLVMRDSA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKIRSMEEFAAASGISRPTLSKYFSDPSSVRKSTRQRIETALVEHEYRPNIFAISQNRK
CCCHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
RPMNVGILIPHLTDPYFAELVRHIEARCASMGFWAIILSSHGDPDLEERALRTLLSLKLA
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
GAIVAPLGTRSNCDTFKALCKELPIVFLDSRIDLEVPFVGTDNRASIELLVEYLVRTGEP
HHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCCC
PCFLDMPHVNQNALERRQAFEEAARKAKFEPHVIPARTLDWNFEQIGFDVVTAYLRGSGL
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
PSRTLLCANDRLAFGALAAAYKSGLKVGREDNADLRIAGHDDHPLSRFACPSLTTIAQDY
CCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHHHCCCCHHHHHHHH
EGLASSAFDILVGRLDGEENMPTSELLSSRLVMRDSA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]