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The map label for this gene is moaA [H]

Identifier: 182678756

GI number: 182678756

Start: 2023172

End: 2024227

Strand: Direct

Name: moaA [H]

Synonym: Bind_1785

Alternate gene names: 182678756

Gene position: 2023172-2024227 (Clockwise)

Preceding gene: 182678754

Following gene: 182678758

Centisome position: 48.52

GC content: 58.81

Gene sequence:

>1056_bases
ATGACGCTTATTCTGCCGCAAGACGCAAAATCCGAACCAGCCCGTCTGGAAACGGGTTTACCGCCCCTCGTCGATCCCTT
CGGCCGCCACATCAGTTATGTGCGCGTCTCCGTGACCGATCGCTGCGACATGCGTTGCACTTATTGCATGGCGGAAGATA
TGCACTTTCTGCCAAAGGAACAATTACTCACCCTCGAAGAACTCGATCGGCTCTGCTCGGCCTTCATCGCGCGTGGTGTC
AAAACCTTGCGCATCACTGGTGGCGAACCCCTGATCCGGCGTAATATTCTGAGCTTGTTCCGGGCTCTTTCGCGCCATTT
GAAATCCGGTGCCTTGTCGGAATTGACCCTGACCACCAATGGGTCGCAGCTTGCCCGCTATGCCGAGGATCTCGCGGCCT
GCGGCATCCGCCGCATTAACGTCTCGCTCGATACATTGGACGCGGATCGCTATCGTTCCGTGACCCGCTGGGGCGATCAT
GCCGAGGTTCTGAGGGGGATCGAGGCGGCCCGTGCTGCGGGTCTCAAGATCAAAATCAACATGGTTGCTCTGCAAGGCGT
CAATGAGCACGAAATCGTCCCCATGCTGGAATGGGCGCATGGCCAGGGCATGGATCTGACCCTGATCGAAGTCATGCCCA
TGGGAGTCATCGAGACGGATCGAGCCGACCAATATTTGCCCCTGACTCGTGTGCGGACCGCCCTCGAATCCCGCTTCACC
TTGCGCGATATCGCTTACAAGACCGGCGGTCCGGCCCGTTATGTCGAGGTTGGAGAAACCGGGGGACGGCTCGGCTTCAT
TACTCCTCTGACGCATAATTTCTGCGAGGGCTGCAATCGCGTCCGCGTCACCTGCACCGGCACGATTTATATGTGCCTCG
GCCAGGAAGATGCCGCCGATCTCCGCACGCCTTTACGGGCCGCTGTTTCCGACGAGCTTTTGCACCAAGCCCTCGACGAA
GCCATAGCGCGCAAGCCGAAAGGCCATGACTTCGATATTGATCGACACCATGCCATGCCCGCCGTGTCGCGCCACATGAG
CATGACCGGCGGCTAA

Upstream 100 bases:

>100_bases
GCCTCGAGTTTCTCGGCCGTGGTTCTTCACCACGGAATTCTCTCTACACGTCTTTGTTAAGCCCTTATCCGTCATGCGAT
ATTGGGCTATATGAAAGAGC

Downstream 100 bases:

>100_bases
AAAGAAAAGCGCATCCATGTGTCATACCAAAGGTCGTAAAGAAACGACCTTTGGTTCCTTTCTTGAATTTTCGCTTTTTC
AAAGCGAGAGCGAAAATTCA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTLILPQDAKSEPARLETGLPPLVDPFGRHISYVRVSVTDRCDMRCTYCMAEDMHFLPKEQLLTLEELDRLCSAFIARGV
KTLRITGGEPLIRRNILSLFRALSRHLKSGALSELTLTTNGSQLARYAEDLAACGIRRINVSLDTLDADRYRSVTRWGDH
AEVLRGIEAARAAGLKIKINMVALQGVNEHEIVPMLEWAHGQGMDLTLIEVMPMGVIETDRADQYLPLTRVRTALESRFT
LRDIAYKTGGPARYVEVGETGGRLGFITPLTHNFCEGCNRVRVTCTGTIYMCLGQEDAADLRTPLRAAVSDELLHQALDE
AIARKPKGHDFDIDRHHAMPAVSRHMSMTGG

Sequences:

>Translated_351_residues
MTLILPQDAKSEPARLETGLPPLVDPFGRHISYVRVSVTDRCDMRCTYCMAEDMHFLPKEQLLTLEELDRLCSAFIARGV
KTLRITGGEPLIRRNILSLFRALSRHLKSGALSELTLTTNGSQLARYAEDLAACGIRRINVSLDTLDADRYRSVTRWGDH
AEVLRGIEAARAAGLKIKINMVALQGVNEHEIVPMLEWAHGQGMDLTLIEVMPMGVIETDRADQYLPLTRVRTALESRFT
LRDIAYKTGGPARYVEVGETGGRLGFITPLTHNFCEGCNRVRVTCTGTIYMCLGQEDAADLRTPLRAAVSDELLHQALDE
AIARKPKGHDFDIDRHHAMPAVSRHMSMTGG
>Mature_350_residues
TLILPQDAKSEPARLETGLPPLVDPFGRHISYVRVSVTDRCDMRCTYCMAEDMHFLPKEQLLTLEELDRLCSAFIARGVK
TLRITGGEPLIRRNILSLFRALSRHLKSGALSELTLTTNGSQLARYAEDLAACGIRRINVSLDTLDADRYRSVTRWGDHA
EVLRGIEAARAAGLKIKINMVALQGVNEHEIVPMLEWAHGQGMDLTLIEVMPMGVIETDRADQYLPLTRVRTALESRFTL
RDIAYKTGGPARYVEVGETGGRLGFITPLTHNFCEGCNRVRVTCTGTIYMCLGQEDAADLRTPLRAAVSDELLHQALDEA
IARKPKGHDFDIDRHHAMPAVSRHMSMTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=324, Percent_Identity=32.4074074074074, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI22027536, Length=324, Percent_Identity=32.4074074074074, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1786999, Length=332, Percent_Identity=30.421686746988, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=364, Percent_Identity=31.8681318681319, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=359, Percent_Identity=31.7548746518106, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=343, Percent_Identity=32.3615160349854, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI28574490, Length=338, Percent_Identity=35.7988165680473, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=36.5079365079365, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39035; Mature: 38903

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLILPQDAKSEPARLETGLPPLVDPFGRHISYVRVSVTDRCDMRCTYCMAEDMHFLPKE
CEEECCCCCCCCCCHHCCCCCCHHHHHCCCEEEEEEEECCCCCCEEEEHHHHHHHCCCHH
QLLTLEELDRLCSAFIARGVKTLRITGGEPLIRRNILSLFRALSRHLKSGALSELTLTTN
HHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GSQLARYAEDLAACGIRRINVSLDTLDADRYRSVTRWGDHAEVLRGIEAARAAGLKIKIN
HHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
MVALQGVNEHEIVPMLEWAHGQGMDLTLIEVMPMGVIETDRADQYLPLTRVRTALESRFT
EEEECCCCCCCCEEEEECCCCCCCCEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCH
LRDIAYKTGGPARYVEVGETGGRLGFITPLTHNFCEGCNRVRVTCTGTIYMCLGQEDAAD
HHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHHHCCCCEEEEEEEEEEEEEECCCCHHH
LRTPLRAAVSDELLHQALDEAIARKPKGHDFDIDRHHAMPAVSRHMSMTGG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHCCCCC
>Mature Secondary Structure 
TLILPQDAKSEPARLETGLPPLVDPFGRHISYVRVSVTDRCDMRCTYCMAEDMHFLPKE
EEECCCCCCCCCCHHCCCCCCHHHHHCCCEEEEEEEECCCCCCEEEEHHHHHHHCCCHH
QLLTLEELDRLCSAFIARGVKTLRITGGEPLIRRNILSLFRALSRHLKSGALSELTLTTN
HHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECC
GSQLARYAEDLAACGIRRINVSLDTLDADRYRSVTRWGDHAEVLRGIEAARAAGLKIKIN
HHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEE
MVALQGVNEHEIVPMLEWAHGQGMDLTLIEVMPMGVIETDRADQYLPLTRVRTALESRFT
EEEECCCCCCCCEEEEECCCCCCCCEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCH
LRDIAYKTGGPARYVEVGETGGRLGFITPLTHNFCEGCNRVRVTCTGTIYMCLGQEDAAD
HHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHHHCCCCEEEEEEEEEEEEEECCCCHHH
LRTPLRAAVSDELLHQALDEAIARKPKGHDFDIDRHHAMPAVSRHMSMTGG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]