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The map label for this gene is hit [H]

Identifier: 182678640

GI number: 182678640

Start: 1884961

End: 1885389

Strand: Direct

Name: hit [H]

Synonym: Bind_1666

Alternate gene names: 182678640

Gene position: 1884961-1885389 (Clockwise)

Preceding gene: 182678639

Following gene: 182678644

Centisome position: 45.2

GC content: 58.04

Gene sequence:

>429_bases
ATGAGCACTCCGGCCTACGACGAGAACAATATTTTCGCCAAAATTCTGCGCGGCGAAATGCCGTGCACCAAGGTCTATGA
GGATGACGTAGCACTCGCCTTCATGGACATCATGCCGCGCGCCGACGGCCATGTGCTGGTCATCCCCAAGAAAGCTGGCC
GCAATCTTCTCGATATAGACGCCGAGGCCCTCGCCCAATTGATGCCACGTGTGCAGAAAGTGGCGCGCGCCGTCAAAAAG
GCCGTCGCCGCGGATGGCATCACGCTGCATCAATATAATGAAAGCGCGGGCGGACAGGTCATTTTCCACCTGCATTTCCA
TATTCTGCCACGCTGGGCAGGCGTGGAATTGCGGCCGCATACAGGAGAAATGGCCAAGCCAGAGGCTTTGGCGGCGCTTG
CGGAAAAGATCATCGCCGCGCTGGCCTGA

Upstream 100 bases:

>100_bases
CATAGAGCAATATGGCGAACAGACCCCCTTCAAGAAGGGACCTTGACCCTCATCCATTCCTGGCCGATGTCTTTCCATCA
TCGACCATGCGAGGAAGCGG

Downstream 100 bases:

>100_bases
ACAAGCGTGCCCAGATGGATGCCTAAAAATACAAAGCCGGCGCTTGCCTGAGCAAGCGCCGGCTTTGTTTGTCCGCGAGC
TCCCCTTAAGGAAGCCCGCG

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MSTPAYDENNIFAKILRGEMPCTKVYEDDVALAFMDIMPRADGHVLVIPKKAGRNLLDIDAEALAQLMPRVQKVARAVKK
AVAADGITLHQYNESAGGQVIFHLHFHILPRWAGVELRPHTGEMAKPEALAALAEKIIAALA

Sequences:

>Translated_142_residues
MSTPAYDENNIFAKILRGEMPCTKVYEDDVALAFMDIMPRADGHVLVIPKKAGRNLLDIDAEALAQLMPRVQKVARAVKK
AVAADGITLHQYNESAGGQVIFHLHFHILPRWAGVELRPHTGEMAKPEALAALAEKIIAALA
>Mature_141_residues
STPAYDENNIFAKILRGEMPCTKVYEDDVALAFMDIMPRADGHVLVIPKKAGRNLLDIDAEALAQLMPRVQKVARAVKKA
VAADGITLHQYNESAGGQVIFHLHFHILPRWAGVELRPHTGEMAKPEALAALAEKIIAALA

Specific function: Unknown

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Homo sapiens, GI4885413, Length=109, Percent_Identity=39.4495412844037, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI1787346, Length=105, Percent_Identity=38.0952380952381, Blast_Score=67, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17506713, Length=105, Percent_Identity=40.9523809523809, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320078, Length=112, Percent_Identity=40.1785714285714, Blast_Score=81, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574010, Length=110, Percent_Identity=43.6363636363636, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24581222, Length=111, Percent_Identity=42.3423423423423, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR019808
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: NA

Molecular weight: Translated: 15519; Mature: 15388

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPAYDENNIFAKILRGEMPCTKVYEDDVALAFMDIMPRADGHVLVIPKKAGRNLLDID
CCCCCCCCCCHHHHHHHCCCCCCHHHHCHHHHHHHHHCCCCCCCEEEEECCCCCCEEECC
AEALAQLMPRVQKVARAVKKAVAADGITLHQYNESAGGQVIFHLHFHILPRWAGVELRPH
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEEEECCCCCCEECCC
TGEMAKPEALAALAEKIIAALA
CCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STPAYDENNIFAKILRGEMPCTKVYEDDVALAFMDIMPRADGHVLVIPKKAGRNLLDID
CCCCCCCCCHHHHHHHCCCCCCHHHHCHHHHHHHHHCCCCCCCEEEEECCCCCCEEECC
AEALAQLMPRVQKVARAVKKAVAADGITLHQYNESAGGQVIFHLHFHILPRWAGVELRPH
HHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEEEECCCCCCEECCC
TGEMAKPEALAALAEKIIAALA
CCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]