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The map label for this gene is trpC

Identifier: 182678399

GI number: 182678399

Start: 1628945

End: 1629781

Strand: Direct

Name: trpC

Synonym: Bind_1416

Alternate gene names: 182678399

Gene position: 1628945-1629781 (Clockwise)

Preceding gene: 182678398

Following gene: 182678400

Centisome position: 39.06

GC content: 60.45

Gene sequence:

>837_bases
ATGGCCGATATTCTGAAGCGGATCGAAGCCTATAAAAGGCAGGAAATTGCTCAGGCAAAACAAAGTGTGAGCCTCGATGC
TTTGCGGCGCCAATGCGAAAGCGTGGAAAAGCCGCGTGGTTTCATCAAAGCGCTCGCTGCCAAACAGGCCGAGGGGCGCA
TGGCGCTCATCGCTGAAATCAAGAAGGCCAGCCCATCCAAAGGCCTGATCCGGGCCGATTTCGATCCGCCGGCCTTGGCG
CGGGCCTATGAGGAAGGTGGCGCCGCCTGTCTCTCCGTTCTCACCGATACGCCATCCTTTCAGGGCTCTCCTGAATTTCT
CACGATCGCGCGGCAGGCCGTGAGCCTGCCAGCCTTGCGCAAGGATTTCCTCTTCGATCCTTATCAGGTCTTCGAGGCGC
GGGCCTGGGGTGCCGATTGCATCTTGATCATCATGGCTTGCGTCGATGATGAGCTCGCTGGCGCCCTGCGTGATGCCGCG
CGGGAGCTTGGCATGGATTGCCTCGTCGAGGTGCATGACGAGGCGGAACTTATCCGCGCCCTCCGTCTTGAAACCCCGCT
GATCGGCATCAATAATCGCGATTTGCGCACCTTTAATGTCTCGCTCGAAACCAGCGAGCGGCTCGCCGCCAAAATTCCGG
ATGATCGCATGATCGTCGGCGAAAGCGGCATTTTCACCGCGCAGGATTGCGCGCGGCTCAAGGCCCATCGCATTGGGACC
GTGCTCGTTGGCGAAAGCCTGATGCGGGAGCAAGATGTGACGGCGGCGACACGCCGGCTGCTCGATCTGCCGCCGGAGGC
CGTGACGGGCCCGGTCCATGCCGTTTTGGAGTCATGA

Upstream 100 bases:

>100_bases
AAAGACTCATCCATAATCAGGAAGTCAGAGAGCCCTTCAGGGATGGTTTCGCCGCTCTTTTCCTCTTAAATGAAGAGGGA
ACTCTTAAAGAGACGAAGGC

Downstream 100 bases:

>100_bases
GGGGCGCTTCATGAGTTCCTTGACCCATCTGACGAGCCATGGCGAAGCCGTCATGGTCGATGTCTCCGATAAGGCAGAGA
CCGAGCGGGTCGCGATCGCC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 278; Mature: 277

Protein sequence:

>278_residues
MADILKRIEAYKRQEIAQAKQSVSLDALRRQCESVEKPRGFIKALAAKQAEGRMALIAEIKKASPSKGLIRADFDPPALA
RAYEEGGAACLSVLTDTPSFQGSPEFLTIARQAVSLPALRKDFLFDPYQVFEARAWGADCILIIMACVDDELAGALRDAA
RELGMDCLVEVHDEAELIRALRLETPLIGINNRDLRTFNVSLETSERLAAKIPDDRMIVGESGIFTAQDCARLKAHRIGT
VLVGESLMREQDVTAATRRLLDLPPEAVTGPVHAVLES

Sequences:

>Translated_278_residues
MADILKRIEAYKRQEIAQAKQSVSLDALRRQCESVEKPRGFIKALAAKQAEGRMALIAEIKKASPSKGLIRADFDPPALA
RAYEEGGAACLSVLTDTPSFQGSPEFLTIARQAVSLPALRKDFLFDPYQVFEARAWGADCILIIMACVDDELAGALRDAA
RELGMDCLVEVHDEAELIRALRLETPLIGINNRDLRTFNVSLETSERLAAKIPDDRMIVGESGIFTAQDCARLKAHRIGT
VLVGESLMREQDVTAATRRLLDLPPEAVTGPVHAVLES
>Mature_277_residues
ADILKRIEAYKRQEIAQAKQSVSLDALRRQCESVEKPRGFIKALAAKQAEGRMALIAEIKKASPSKGLIRADFDPPALAR
AYEEGGAACLSVLTDTPSFQGSPEFLTIARQAVSLPALRKDFLFDPYQVFEARAWGADCILIIMACVDDELAGALRDAAR
ELGMDCLVEVHDEAELIRALRLETPLIGINNRDLRTFNVSLETSERLAAKIPDDRMIVGESGIFTAQDCARLKAHRIGTV
LVGESLMREQDVTAATRRLLDLPPEAVTGPVHAVLES

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=39.463601532567, Blast_Score=163, Evalue=9e-42,
Organism=Saccharomyces cerevisiae, GI6322638, Length=219, Percent_Identity=38.3561643835616, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BEII9 (B2IKL7)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001832545.1
- GeneID:   6201560
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_1416
- HOGENOM:   HBG540956
- OMA:   SAINTNR
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 30439; Mature: 30308

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADILKRIEAYKRQEIAQAKQSVSLDALRRQCESVEKPRGFIKALAAKQAEGRMALIAEI
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KKASPSKGLIRADFDPPALARAYEEGGAACLSVLTDTPSFQGSPEFLTIARQAVSLPALR
HHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
KDFLFDPYQVFEARAWGADCILIIMACVDDELAGALRDAARELGMDCLVEVHDEAELIRA
HHHCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LRLETPLIGINNRDLRTFNVSLETSERLAAKIPDDRMIVGESGIFTAQDCARLKAHRIGT
HHHCCCEECCCCCCEEEEEEEECCHHHHHHCCCCCCEEECCCCCEEHHHHHHHHHHHHHH
VLVGESLMREQDVTAATRRLLDLPPEAVTGPVHAVLES
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHCC
>Mature Secondary Structure 
ADILKRIEAYKRQEIAQAKQSVSLDALRRQCESVEKPRGFIKALAAKQAEGRMALIAEI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KKASPSKGLIRADFDPPALARAYEEGGAACLSVLTDTPSFQGSPEFLTIARQAVSLPALR
HHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
KDFLFDPYQVFEARAWGADCILIIMACVDDELAGALRDAARELGMDCLVEVHDEAELIRA
HHHCCCHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LRLETPLIGINNRDLRTFNVSLETSERLAAKIPDDRMIVGESGIFTAQDCARLKAHRIGT
HHHCCCEECCCCCCEEEEEEEECCHHHHHHCCCCCCEEECCCCCEEHHHHHHHHHHHHHH
VLVGESLMREQDVTAATRRLLDLPPEAVTGPVHAVLES
HHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA