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The map label for this gene is htrA [H]

Identifier: 17547859

GI number: 17547859

Start: 3390088

End: 3391005

Strand: Reverse

Name: htrA [H]

Synonym: RSc3140

Alternate gene names: 17547859

Gene position: 3391005-3390088 (Counterclockwise)

Preceding gene: 17547860

Following gene: 17547857

Centisome position: 91.24

GC content: 70.04

Gene sequence:

>918_bases
GTGGCGCTGGAGCCCGCCGAGATTTTCGAGAAAGTGTCGCCCAGCGTCTGGGAGGTCCGGGTGATCGGGCCCGACGGCAA
GGGGCTGTCGATGGGCAGCGCCGTGGTGATCGGCGATGGCGTGGTCATCACCAACTGCCACGTGCTGCGCGGCGGCAAGC
AGGTCTGGCTCAAGCGCGGCAATGCCAATTTCGGCGCGCGCTTGCAGTATCCGGACGTGGAGCGCGATCTGTGCCAGCTG
CGCGTGGCCGATTTCCACTATCCTCCCGTGACCCTGGCGCCGGGCAGCGCGCTGGTGACGGGCCAGAAGGTGTACGCGAT
CGGCAATCCGCTCGGGCTGGAGCTGACCATCAGCGAAGGGCTGATCTCGTCGCTGCGCACCGACGATGACGGCCGCCTGA
AGAGCGTGCAGACCTCGGCCGCCATCTCGCGGGGCTCCAGCGGCGGCGGGCTGTTCGATGCCAACGGCCGCCTGATCGGC
ATCACGGACCACCAGGTCGTCCTGACGCTGGGCCAGAACCTGAACTTCGCCATTCCCGCCGACTGGATCGCCGACGTGCC
GGCACGGGCGCAGAAGGCGCTGGCTGCGCGCGCCGCCGCGGCCTCGGCCGTGGTCGCGTCCACGCCGGCGCCCCAGAGCG
CGGCGCCCACACCGGCTCCCGCGCCGGCGCCCCGCCACCAGGGGGAACTCGGCCCCAACCAGCAGACCGGGTTCTCCGTC
TACCTGCAGAAGACGTGGCCCAAGGCGTTCGTCGCCGCGGACGGTGACCATTACTACTACTGGACCGGGAAGAACGCCGA
GCTCTATGCCCTGTCGGCCTGCCAGGAGCGCTGGCAGAACTGCAGCGTCTACGCCCGCAACAACACGGTCGTCGAGCCCG
TGGAGGGAACCGGCGAGCGTCCGGGCGCCGCCCGGTAA

Upstream 100 bases:

>100_bases
CGGTCCGTGTTTTCCATCTGAGGGCGCCGCCAGGCCTGTTCTCCGATCCGCTCTCCGTCTGGCCGTTGCGGCCGTCTGCG
GCCTGGCTGCCGCGCAGGCC

Downstream 100 bases:

>100_bases
TCCGCTGCCCGTCGCCGGCCGGACGCGCGGTAACGCGGGCTGGGGGCTGCCCGTATCGGGCGTGATGAATCGGGCGAAGT
CCTGCGTCGGCGCCCTGCGC

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 304

Protein sequence:

>305_residues
MALEPAEIFEKVSPSVWEVRVIGPDGKGLSMGSAVVIGDGVVITNCHVLRGGKQVWLKRGNANFGARLQYPDVERDLCQL
RVADFHYPPVTLAPGSALVTGQKVYAIGNPLGLELTISEGLISSLRTDDDGRLKSVQTSAAISRGSSGGGLFDANGRLIG
ITDHQVVLTLGQNLNFAIPADWIADVPARAQKALAARAAAASAVVASTPAPQSAAPTPAPAPAPRHQGELGPNQQTGFSV
YLQKTWPKAFVAADGDHYYYWTGKNAELYALSACQERWQNCSVYARNNTVVEPVEGTGERPGAAR

Sequences:

>Translated_305_residues
MALEPAEIFEKVSPSVWEVRVIGPDGKGLSMGSAVVIGDGVVITNCHVLRGGKQVWLKRGNANFGARLQYPDVERDLCQL
RVADFHYPPVTLAPGSALVTGQKVYAIGNPLGLELTISEGLISSLRTDDDGRLKSVQTSAAISRGSSGGGLFDANGRLIG
ITDHQVVLTLGQNLNFAIPADWIADVPARAQKALAARAAAASAVVASTPAPQSAAPTPAPAPAPRHQGELGPNQQTGFSV
YLQKTWPKAFVAADGDHYYYWTGKNAELYALSACQERWQNCSVYARNNTVVEPVEGTGERPGAAR
>Mature_304_residues
ALEPAEIFEKVSPSVWEVRVIGPDGKGLSMGSAVVIGDGVVITNCHVLRGGKQVWLKRGNANFGARLQYPDVERDLCQLR
VADFHYPPVTLAPGSALVTGQKVYAIGNPLGLELTISEGLISSLRTDDDGRLKSVQTSAAISRGSSGGGLFDANGRLIGI
TDHQVVLTLGQNLNFAIPADWIADVPARAQKALAARAAAASAVVASTPAPQSAAPTPAPAPAPRHQGELGPNQQTGFSVY
LQKTWPKAFVAADGDHYYYWTGKNAELYALSACQERWQNCSVYARNNTVVEPVEGTGERPGAAR

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=195, Percent_Identity=29.7435897435897, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI24308541, Length=194, Percent_Identity=30.4123711340206, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI22129776, Length=199, Percent_Identity=30.1507537688442, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786356, Length=172, Percent_Identity=31.3953488372093, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789629, Length=210, Percent_Identity=30.4761904761905, Blast_Score=75, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24646839, Length=175, Percent_Identity=34.8571428571429, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 32270; Mature: 32138

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALEPAEIFEKVSPSVWEVRVIGPDGKGLSMGSAVVIGDGVVITNCHVLRGGKQVWLKRG
CCCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEECCEEEEEEEEEECCCEEEEEEC
NANFGARLQYPDVERDLCQLRVADFHYPPVTLAPGSALVTGQKVYAIGNPLGLELTISEG
CCCCCCEEECCCHHHHHHHEEHHCCCCCCEEECCCCEEEECCEEEEECCCCEEEEEECHH
LISSLRTDDDGRLKSVQTSAAISRGSSGGGLFDANGRLIGITDHQVVLTLGQNLNFAIPA
HHHHHCCCCCCCEEEEEHHHHHHCCCCCCCEEECCCEEEEECCCEEEEEECCCCCEEECH
DWIADVPARAQKALAARAAAASAVVASTPAPQSAAPTPAPAPAPRHQGELGPNQQTGFSV
HHHHCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
YLQKTWPKAFVAADGDHYYYWTGKNAELYALSACQERWQNCSVYARNNTVVEPVEGTGER
EEEECCCEEEEEECCCEEEEEECCCCEEEEHHHHHHHHCCCEEEECCCEEEECCCCCCCC
PGAAR
CCCCC
>Mature Secondary Structure 
ALEPAEIFEKVSPSVWEVRVIGPDGKGLSMGSAVVIGDGVVITNCHVLRGGKQVWLKRG
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEECCEEEEEEEEEECCCEEEEEEC
NANFGARLQYPDVERDLCQLRVADFHYPPVTLAPGSALVTGQKVYAIGNPLGLELTISEG
CCCCCCEEECCCHHHHHHHEEHHCCCCCCEEECCCCEEEECCEEEEECCCCEEEEEECHH
LISSLRTDDDGRLKSVQTSAAISRGSSGGGLFDANGRLIGITDHQVVLTLGQNLNFAIPA
HHHHHCCCCCCCEEEEEHHHHHHCCCCCCCEEECCCEEEEECCCEEEEEECCCCCEEECH
DWIADVPARAQKALAARAAAASAVVASTPAPQSAAPTPAPAPAPRHQGELGPNQQTGFSV
HHHHCCCHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
YLQKTWPKAFVAADGDHYYYWTGKNAELYALSACQERWQNCSVYARNNTVVEPVEGTGER
EEEECCCEEEEEECCCEEEEEECCCCEEEEHHHHHHHHCCCEEEECCCEEEECCCCCCCC
PGAAR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]