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The map label for this gene is adhA [H]

Identifier: 17547849

GI number: 17547849

Start: 3376654

End: 3377679

Strand: Direct

Name: adhA [H]

Synonym: RSc3130

Alternate gene names: 17547849

Gene position: 3376654-3377679 (Clockwise)

Preceding gene: 17547848

Following gene: 17547850

Centisome position: 90.86

GC content: 70.18

Gene sequence:

>1026_bases
ATGGCCAGGTCGATGAAAGCCGCTGTCGTGCACGCGTTCGGCGAACCGCTGCGCATCGAGGACGTCCCGATCCCGACGCC
GGGCCGCGGACAGATCCTCGTCAACATCCGGGCTTCCGGGGTCTGCCACACCGACCTGCACGCCGCCGACGGCGACTGGC
CGGTCAAGCCGCGCCTGCCGTTCATCCCCGGGCACGAGGGCGTGGGCTTCGTGGCGGCGGTGGGCGAAGGCGTCACCGCC
GTCAAGGAAGGCGACCGCGTGGGCGTGCCCTGGCTCTACACCGCCTGCGGCCACTGCGAACACTGCCTGGGCGGCTGGGA
AACCCTGTGCCACGACCAGCAGAACACTGGCTACTCCGTCAACGGCGGCTACGCCGAATACGTGCTGGCCGACCCCAACT
ATGTCGGCCACCTGCCGGCGCAGGTCGGCTTCGAGGAGATCGCACCCATCCTGTGCGCGGGCGTGACGGTCTACAAGGGC
ATCCGCATGACCGACACCCGCCCCGGCCAGTGGATCGCCATCTCGGGCATCGGCGGGCTGGGGCATGTGGCGGTGCAGTA
TGCCGTCGCCATGGGGCTGCACGTGGTGGCGGTGGATGTCGCCCCCGAGAAGCTGGCGCTGGCGCGCGAACTGGGCGCCC
GGCTGAGCGTCGATGCCTCGCAGCAGGACCCGGCCGCTGTCATCCAGAAGGAGGTGGGCGGCGTGCACGGCGTGCTGGTG
ACGGCGGTCTCGCGCAGCGCCTTCGCCCAGGCCCTGGGCATGGTGCGACGCGGCGGCACCGTCTCGCTCAACGGATTGCC
GCCGGGCGACTTTCCGCTGCCGATCTTCTCGACCGTGCTCAACGGCATCACGGTGCGCGGCTCCATCGTCGGCACGCGGC
GCGATCTGCAGGAGTCGCTGCAGTTCGCCGCCGAGGGGCAGGTGCGCGCTCACATCCATCGCGACCGGCTCGACAACATC
AACCAGGTCCTCGCCGACCTGAAAGCCGGCAAGGTGGACGGCCGCATCGTCCTCTCGCTGGACTGA

Upstream 100 bases:

>100_bases
CGCAAGCACGGCATCGCCCGCCCCGGCGGTTGACGCACGTCAACCCGGCCCGGCCGCGCATCGACAAGACTGGGGGCTCC
CCAACTCCCGGAGATCCGCC

Downstream 100 bases:

>100_bases
GCAGCACGCCGTCACGGGGTGCGGGTAAGCTGTGCCGCATCACCGGCTTCCCTCACCCACCGTCATGCGCATCCTCTTCT
TCAGCAGCCACCGTTACGAC

Product: propanol-preferring alcohol dehydrogenase oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MARSMKAAVVHAFGEPLRIEDVPIPTPGRGQILVNIRASGVCHTDLHAADGDWPVKPRLPFIPGHEGVGFVAAVGEGVTA
VKEGDRVGVPWLYTACGHCEHCLGGWETLCHDQQNTGYSVNGGYAEYVLADPNYVGHLPAQVGFEEIAPILCAGVTVYKG
IRMTDTRPGQWIAISGIGGLGHVAVQYAVAMGLHVVAVDVAPEKLALARELGARLSVDASQQDPAAVIQKEVGGVHGVLV
TAVSRSAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLQFAAEGQVRAHIHRDRLDNI
NQVLADLKAGKVDGRIVLSLD

Sequences:

>Translated_341_residues
MARSMKAAVVHAFGEPLRIEDVPIPTPGRGQILVNIRASGVCHTDLHAADGDWPVKPRLPFIPGHEGVGFVAAVGEGVTA
VKEGDRVGVPWLYTACGHCEHCLGGWETLCHDQQNTGYSVNGGYAEYVLADPNYVGHLPAQVGFEEIAPILCAGVTVYKG
IRMTDTRPGQWIAISGIGGLGHVAVQYAVAMGLHVVAVDVAPEKLALARELGARLSVDASQQDPAAVIQKEVGGVHGVLV
TAVSRSAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLQFAAEGQVRAHIHRDRLDNI
NQVLADLKAGKVDGRIVLSLD
>Mature_340_residues
ARSMKAAVVHAFGEPLRIEDVPIPTPGRGQILVNIRASGVCHTDLHAADGDWPVKPRLPFIPGHEGVGFVAAVGEGVTAV
KEGDRVGVPWLYTACGHCEHCLGGWETLCHDQQNTGYSVNGGYAEYVLADPNYVGHLPAQVGFEEIAPILCAGVTVYKGI
RMTDTRPGQWIAISGIGGLGHVAVQYAVAMGLHVVAVDVAPEKLALARELGARLSVDASQQDPAAVIQKEVGGVHGVLVT
AVSRSAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESLQFAAEGQVRAHIHRDRLDNIN
QVLADLKAGKVDGRIVLSLD

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=369, Percent_Identity=29.810298102981, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=28.9972899728997, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=28.8888888888889, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI156523966, Length=368, Percent_Identity=26.6304347826087, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=26.5927977839335, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI71565154, Length=248, Percent_Identity=29.8387096774194, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71565152, Length=364, Percent_Identity=25.5494505494505, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI71743840, Length=252, Percent_Identity=26.5873015873016, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI262073058, Length=252, Percent_Identity=26.5873015873016, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI194239674, Length=270, Percent_Identity=27.4074074074074, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13236495, Length=270, Percent_Identity=27.4074074074074, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI194239676, Length=199, Percent_Identity=30.6532663316583, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87081918, Length=337, Percent_Identity=44.8071216617211, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1786518, Length=346, Percent_Identity=32.6589595375723, Blast_Score=150, Evalue=9e-38,
Organism=Escherichia coli, GI87082401, Length=311, Percent_Identity=30.5466237942122, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1790045, Length=348, Percent_Identity=27.8735632183908, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788073, Length=266, Percent_Identity=31.5789473684211, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082125, Length=204, Percent_Identity=34.8039215686275, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786552, Length=242, Percent_Identity=33.8842975206612, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI226510992, Length=296, Percent_Identity=29.3918918918919, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1788407, Length=216, Percent_Identity=31.9444444444444, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788075, Length=282, Percent_Identity=30.8510638297872, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1787863, Length=297, Percent_Identity=28.6195286195286, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790485, Length=293, Percent_Identity=26.962457337884, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790718, Length=287, Percent_Identity=24.7386759581882, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786825, Length=317, Percent_Identity=26.1829652996845, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=341, Percent_Identity=38.41642228739, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=38.2608695652174, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=33.2352941176471, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17562876, Length=336, Percent_Identity=29.1666666666667, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17562878, Length=225, Percent_Identity=34.6666666666667, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=380, Percent_Identity=24.2105263157895, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=266, Percent_Identity=28.1954887218045, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=382, Percent_Identity=24.0837696335079, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=209, Percent_Identity=26.7942583732057, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=343, Percent_Identity=38.7755102040816, Blast_Score=255, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6323961, Length=340, Percent_Identity=39.4117647058824, Blast_Score=254, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6323729, Length=340, Percent_Identity=39.1176470588235, Blast_Score=249, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=37.9411764705882, Blast_Score=245, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6319949, Length=326, Percent_Identity=27.3006134969325, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6323980, Length=286, Percent_Identity=26.2237762237762, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319955, Length=339, Percent_Identity=27.7286135693215, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=339, Percent_Identity=27.7286135693215, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=381, Percent_Identity=26.7716535433071, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=308, Percent_Identity=24.3506493506494, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137530, Length=323, Percent_Identity=29.1021671826625, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737897, Length=323, Percent_Identity=29.7213622291022, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737895, Length=237, Percent_Identity=27.8481012658228, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35963; Mature: 35831

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARSMKAAVVHAFGEPLRIEDVPIPTPGRGQILVNIRASGVCHTDLHAADGDWPVKPRLP
CCCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVAAVGEGVTAVKEGDRVGVPWLYTACGHCEHCLGGWETLCHDQQNTGYSV
CCCCCCCCEEEEECCCCCEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCEEE
NGGYAEYVLADPNYVGHLPAQVGFEEIAPILCAGVTVYKGIRMTDTRPGQWIAISGIGGL
CCCEEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCH
GHVAVQYAVAMGLHVVAVDVAPEKLALARELGARLSVDASQQDPAAVIQKEVGGVHGVLV
HHHHHHHHHHHCEEEEEEECCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCHHHHHH
TAVSRSAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESL
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHH
QFAAEGQVRAHIHRDRLDNINQVLADLKAGKVDGRIVLSLD
HHHHCCCHHEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure 
ARSMKAAVVHAFGEPLRIEDVPIPTPGRGQILVNIRASGVCHTDLHAADGDWPVKPRLP
CCCHHHHHHHHCCCCEEEECCCCCCCCCCEEEEEEECCCEEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVAAVGEGVTAVKEGDRVGVPWLYTACGHCEHCLGGWETLCHDQQNTGYSV
CCCCCCCCEEEEECCCCCEEECCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCEEE
NGGYAEYVLADPNYVGHLPAQVGFEEIAPILCAGVTVYKGIRMTDTRPGQWIAISGIGGL
CCCEEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHHCCEEECCCCCCCEEEEECCCCH
GHVAVQYAVAMGLHVVAVDVAPEKLALARELGARLSVDASQQDPAAVIQKEVGGVHGVLV
HHHHHHHHHHHCEEEEEEECCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCHHHHHH
TAVSRSAFAQALGMVRRGGTVSLNGLPPGDFPLPIFSTVLNGITVRGSIVGTRRDLQESL
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHH
QFAAEGQVRAHIHRDRLDNINQVLADLKAGKVDGRIVLSLD
HHHHCCCHHEEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]