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The map label for this gene is lysA [H]

Identifier: 17547698

GI number: 17547698

Start: 3211760

End: 3213115

Strand: Direct

Name: lysA [H]

Synonym: RSc2979

Alternate gene names: 17547698

Gene position: 3211760-3213115 (Clockwise)

Preceding gene: 17547697

Following gene: 17547707

Centisome position: 86.42

GC content: 69.25

Gene sequence:

>1356_bases
ATGCCGCCAGCGCAGTCCCGGCCAGCCGCTGATTCCGTTCTTCCGCTGTCTTTCTCAACCGGCGTCGCAGTGCGGCGCCC
TGATGGTTTCCTGTTCATGTCCGAGTCCCTGATCCGCCAGGACGGCGCCCTGATGATCGAAGGCGTCGCGCTCGAGGCGA
TTGCCGCCCGGTTCGGCACGCCCACCTACGTCTATTCGCGCGCCGCCCTGACCGCCAACTACCGCGCCTACGCGGCCGCC
TGCGAGGGCCGCAACGCGCGCGTGCAGTACGCCATGAAGGCCAACTCCAACCTGGCGGTGCTGCAGATCTTCGCGCAACT
GGGCGCCGGCTTCGACATCGTCTCGGGCGGGGAACTGCGGCGCGTGCTGGCCGCCGGAGGCAAGGCCGCCGACGTGGTGT
TCTCGGGGGTGGGCAAGACCGCCGACGAGATGCGCCTGGCGCTCGAAGCCGGTGTCGCCTGCTTCAACGTCGAATCGATC
CCCGAGCTGCACCGGCTCAACGAGGTGGCCGGCTCGCTGGGCAAGACCGCGCCGGTGTCGCTGCGCGTCAACCCGGACGT
GGATGCCAAGACCCACCCGTACATCTCCACCGGCCTGAAGGGCAACAAGTTCGGCGTCGCGTTCGATGAAGTCCTGCCGA
CCTACCGCGCGGCCGCGGCCATGCCGAACCTGCGCGTGGTCGGCATCGACTGCCATATCGGTTCGCAGATCACCGAGGTC
TCGCCGTACCTGGACGCGATCGACAAAGTGCTCGACGTGGTGGCCCGGCTCGACGCCGAAGGCATCCGCCTGTCGCACAT
CGATGTGGGCGGCGGCCTGGGCATCACCTATACCGACGAGACGCCGCCGGACATCACCGCCTTCGCCCGCACGCTGCTGG
ACCGCATCGAGCAGCGCGGCTTCGGTGACCGCACCGTGCTGTTCGAGCCCGGCCGCTCGCTGGTCGGCAATGCCGGCCTG
CTGCTGACGCGGGTCGAATTCCTCAAGCCCGGCGCGGCCAAGAACTTCTGCATCGTCGATGCGGCCATGAACGACCTGGC
CCGCCCGGCAATGTACGAGGCGTACCACCACATCGTGCCGGTGCGCGAGCGCGGCGGCGCGCCGACCGTCTACGACATCG
TCGGCCCGGTCTGCGAATCGGGCGACTGGCTCGGCCGCGACCGCGCGCTCGACGCGCAGCCGGGCGATCTGCTGGCGATC
CTGTCGGCGGGCGCCTACGGCTTCACCATGAGCTCGAACTACAACACCCGCGGCCGCGCGGCCGAAGTCATCGTCGACGG
CGACCGGGTACACGTGGCACGCGAGCGCGAGCGCTTCGAAGACCTGATCCGCGGCGAGCAGCTGCTGTCGGCCTGA

Upstream 100 bases:

>100_bases
GTGCCGCCCGCCCCGACCGCGCCCACCACGCCGGACCCGGGCATCGCAGGCCCCAACGCCGTGCCGCAATTGCCGGTGCC
GGGCACCAGGGCCGCGCCGG

Downstream 100 bases:

>100_bases
AGACGCCCCCCCCCCCAAAAAAAAGCCGCGCACGTCGCGGCTTTTTCATTGGGCCTGCCTCGGCGCATCAATCGCGTAGC
GGCACGGCCCCACCGGCAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MPPAQSRPAADSVLPLSFSTGVAVRRPDGFLFMSESLIRQDGALMIEGVALEAIAARFGTPTYVYSRAALTANYRAYAAA
CEGRNARVQYAMKANSNLAVLQIFAQLGAGFDIVSGGELRRVLAAGGKAADVVFSGVGKTADEMRLALEAGVACFNVESI
PELHRLNEVAGSLGKTAPVSLRVNPDVDAKTHPYISTGLKGNKFGVAFDEVLPTYRAAAAMPNLRVVGIDCHIGSQITEV
SPYLDAIDKVLDVVARLDAEGIRLSHIDVGGGLGITYTDETPPDITAFARTLLDRIEQRGFGDRTVLFEPGRSLVGNAGL
LLTRVEFLKPGAAKNFCIVDAAMNDLARPAMYEAYHHIVPVRERGGAPTVYDIVGPVCESGDWLGRDRALDAQPGDLLAI
LSAGAYGFTMSSNYNTRGRAAEVIVDGDRVHVARERERFEDLIRGEQLLSA

Sequences:

>Translated_451_residues
MPPAQSRPAADSVLPLSFSTGVAVRRPDGFLFMSESLIRQDGALMIEGVALEAIAARFGTPTYVYSRAALTANYRAYAAA
CEGRNARVQYAMKANSNLAVLQIFAQLGAGFDIVSGGELRRVLAAGGKAADVVFSGVGKTADEMRLALEAGVACFNVESI
PELHRLNEVAGSLGKTAPVSLRVNPDVDAKTHPYISTGLKGNKFGVAFDEVLPTYRAAAAMPNLRVVGIDCHIGSQITEV
SPYLDAIDKVLDVVARLDAEGIRLSHIDVGGGLGITYTDETPPDITAFARTLLDRIEQRGFGDRTVLFEPGRSLVGNAGL
LLTRVEFLKPGAAKNFCIVDAAMNDLARPAMYEAYHHIVPVRERGGAPTVYDIVGPVCESGDWLGRDRALDAQPGDLLAI
LSAGAYGFTMSSNYNTRGRAAEVIVDGDRVHVARERERFEDLIRGEQLLSA
>Mature_450_residues
PPAQSRPAADSVLPLSFSTGVAVRRPDGFLFMSESLIRQDGALMIEGVALEAIAARFGTPTYVYSRAALTANYRAYAAAC
EGRNARVQYAMKANSNLAVLQIFAQLGAGFDIVSGGELRRVLAAGGKAADVVFSGVGKTADEMRLALEAGVACFNVESIP
ELHRLNEVAGSLGKTAPVSLRVNPDVDAKTHPYISTGLKGNKFGVAFDEVLPTYRAAAAMPNLRVVGIDCHIGSQITEVS
PYLDAIDKVLDVVARLDAEGIRLSHIDVGGGLGITYTDETPPDITAFARTLLDRIEQRGFGDRTVLFEPGRSLVGNAGLL
LTRVEFLKPGAAKNFCIVDAAMNDLARPAMYEAYHHIVPVRERGGAPTVYDIVGPVCESGDWLGRDRALDAQPGDLLAIL
SAGAYGFTMSSNYNTRGRAAEVIVDGDRVHVARERERFEDLIRGEQLLSA

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=436, Percent_Identity=32.7981651376147, Blast_Score=165, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17562780, Length=348, Percent_Identity=25.2873563218391, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322664, Length=364, Percent_Identity=23.6263736263736, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586474, Length=340, Percent_Identity=27.9411764705882, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24586472, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48196; Mature: 48065

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPAQSRPAADSVLPLSFSTGVAVRRPDGFLFMSESLIRQDGALMIEGVALEAIAARFGT
CCCCCCCCCCCCEEEEEECCCEEEECCCCEEEECHHHHHCCCCEEEEHHHHHHHHHHCCC
PTYVYSRAALTANYRAYAAACEGRNARVQYAMKANSNLAVLQIFAQLGAGFDIVSGGELR
CHHEEECHHEEECCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEECCHHHH
RVLAAGGKAADVVFSGVGKTADEMRLALEAGVACFNVESIPELHRLNEVAGSLGKTAPVS
HHHHCCCCCHHHEEECCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
LRVNPDVDAKTHPYISTGLKGNKFGVAFDEVLPTYRAAAAMPNLRVVGIDCHIGSQITEV
EEECCCCCCCCCCCEECCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHH
SPYLDAIDKVLDVVARLDAEGIRLSHIDVGGGLGITYTDETPPDITAFARTLLDRIEQRG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
FGDRTVLFEPGRSLVGNAGLLLTRVEFLKPGAAKNFCIVDAAMNDLARPAMYEAYHHIVP
CCCEEEEECCCCHHHCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHCCHHHHHHHHHEEE
VRERGGAPTVYDIVGPVCESGDWLGRDRALDAQPGDLLAILSAGAYGFTMSSNYNTRGRA
HHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCE
AEVIVDGDRVHVARERERFEDLIRGEQLLSA
EEEEECCCEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PPAQSRPAADSVLPLSFSTGVAVRRPDGFLFMSESLIRQDGALMIEGVALEAIAARFGT
CCCCCCCCCCCEEEEEECCCEEEECCCCEEEECHHHHHCCCCEEEEHHHHHHHHHHCCC
PTYVYSRAALTANYRAYAAACEGRNARVQYAMKANSNLAVLQIFAQLGAGFDIVSGGELR
CHHEEECHHEEECCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEECCHHHH
RVLAAGGKAADVVFSGVGKTADEMRLALEAGVACFNVESIPELHRLNEVAGSLGKTAPVS
HHHHCCCCCHHHEEECCCCCHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCCCCCEEE
LRVNPDVDAKTHPYISTGLKGNKFGVAFDEVLPTYRAAAAMPNLRVVGIDCHIGSQITEV
EEECCCCCCCCCCCEECCCCCCCCCEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHH
SPYLDAIDKVLDVVARLDAEGIRLSHIDVGGGLGITYTDETPPDITAFARTLLDRIEQRG
HHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCC
FGDRTVLFEPGRSLVGNAGLLLTRVEFLKPGAAKNFCIVDAAMNDLARPAMYEAYHHIVP
CCCEEEEECCCCHHHCCCCHHHHHHHHHCCCCCCCEEEEEHHHHHHCCHHHHHHHHHEEE
VRERGGAPTVYDIVGPVCESGDWLGRDRALDAQPGDLLAILSAGAYGFTMSSNYNTRGRA
HHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCE
AEVIVDGDRVHVARERERFEDLIRGEQLLSA
EEEEECCCEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]