Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 17547619

GI number: 17547619

Start: 3127050

End: 3128357

Strand: Direct

Name: hemA

Synonym: RSc2900

Alternate gene names: 17547619

Gene position: 3127050-3128357 (Clockwise)

Preceding gene: 17547617

Following gene: 17547620

Centisome position: 84.14

GC content: 69.72

Gene sequence:

>1308_bases
ATGCAGTTGCTCACCCTCGGAATCAACCACCATACGGCGCCGCTTTCCCTGCGCGAGAAGGTGGCGTTTCCGCTCGAGCA
GCTCAAGCCCGCGCTGGGCACGCTGCGCCAGCATCTGCCGCACCGCAAGAGCACGGCCGAGGCCGCCATCCTCTCCACCT
GCAACCGCACCGAGCTCTACTGCGCGACCGACGGCAACCTGCCCGAAGACACCGCCCACGAGCACGCCATCCGCTGGCTG
GCCCACCACCACAACATCGACGCCGGCGAACTGGCGCCCCACGTGTATGCGCTGGGGCAGTCGCAGGCCGTGCGCCACGC
CTTCCGCGTGGCCAGCGGGCTCGATTCCATGGTGCTGGGCGAGACGCAGATCCTCGGCCAGATGAAAGACGCGGTGCGTA
CCGCCACCGAAGCCGGCGCGCTGGGCACGTACCTGAATCAGCTGTTCCAGCGCACCTTCGCGGTCGCCAAGGAGGTACGC
GGCACCACCGAGATCGGCGCGCATTCCGTGTCGATGGCCGCGGCGGCGGTGCGGCTGGCGCAACGCATCTTCGAATCGAT
CGCCGAGCAGCGCGTGCTCTTCATCGGTGCCGGCGAGATGATCGAACTGTGCGCCACCCACTTCGCCGCGCAGAAGCCGC
GCGAAACGGTGGTCGCCAACCGCACGCTGGAGCGCGGCGAAAAGCTGGCCGAGGCGCTGTCGAACCAGGGCCTGAACGCC
CGCGCCGTGCGCCTGGCCGAACTGCCGGCCCGGCTCGGCGAGTTCGACATCGTCGTGTCGTGCACGGCCAGCACGCTGCC
GATCATCGGCCTGGGCGCCGTCGAGCGCGCCATCAAGCAGCGCCGCCACCGCCCGATGTTCATGGTCGACCTCGCGGTGC
CGCGCGACATCGAGCCGGAAGTCGCGCGCCTGTCCGACGTGTTCCTCTACACCGTGGACGACCTCGGCGCCATCGTGCGC
GAGGGCAACGCGCTGCGACAGGCCGCGGTGGCGCAAGCCGAAGCCATCATCGAGACGCGCGTGCAGAACTTCATGCACTG
GCTCGATGCGCGCAGCGTGGTGCCCATCATCCGCGACCTGCACGCGCACGCCGAGGCGCTGCGGCAAGGCGAACTCGAAC
GCGCGCAGCGCATGCTGGCGCGCGGCGATGACCCGGCGCTGGTGCTCGAAGCGCTGTCGCAGGCGCTCACCAAGAAATTC
CTGCACGGCCCGACCCACGCGCTCAACCACGCGCAGGGCGAGGGCCGCGAGCAGCTGATCGACCTGCTGCCGGGCCTGTT
CCGCCAGTCCAGCCACTCCGAGCGCTAG

Upstream 100 bases:

>100_bases
GCGGCCGCGTTGACCAGCGCCCTGCCGAGAACGAAGGCGGACGTTATAATTCGAAGTGCTCAAAATTCGTGCCGTTTCTC
CATCGGCCGGCAGCCCCCAC

Downstream 100 bases:

>100_bases
CGGCGCTTGCCATCGCCGTGCGCGCCGCCCGGGCGCGTGCCTTCGGCGCGGTATCATCGCCGCCCGCGTCCTGTGTTCCC
TTCCGCGACTGCCCGAATGA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MQLLTLGINHHTAPLSLREKVAFPLEQLKPALGTLRQHLPHRKSTAEAAILSTCNRTELYCATDGNLPEDTAHEHAIRWL
AHHHNIDAGELAPHVYALGQSQAVRHAFRVASGLDSMVLGETQILGQMKDAVRTATEAGALGTYLNQLFQRTFAVAKEVR
GTTEIGAHSVSMAAAAVRLAQRIFESIAEQRVLFIGAGEMIELCATHFAAQKPRETVVANRTLERGEKLAEALSNQGLNA
RAVRLAELPARLGEFDIVVSCTASTLPIIGLGAVERAIKQRRHRPMFMVDLAVPRDIEPEVARLSDVFLYTVDDLGAIVR
EGNALRQAAVAQAEAIIETRVQNFMHWLDARSVVPIIRDLHAHAEALRQGELERAQRMLARGDDPALVLEALSQALTKKF
LHGPTHALNHAQGEGREQLIDLLPGLFRQSSHSER

Sequences:

>Translated_435_residues
MQLLTLGINHHTAPLSLREKVAFPLEQLKPALGTLRQHLPHRKSTAEAAILSTCNRTELYCATDGNLPEDTAHEHAIRWL
AHHHNIDAGELAPHVYALGQSQAVRHAFRVASGLDSMVLGETQILGQMKDAVRTATEAGALGTYLNQLFQRTFAVAKEVR
GTTEIGAHSVSMAAAAVRLAQRIFESIAEQRVLFIGAGEMIELCATHFAAQKPRETVVANRTLERGEKLAEALSNQGLNA
RAVRLAELPARLGEFDIVVSCTASTLPIIGLGAVERAIKQRRHRPMFMVDLAVPRDIEPEVARLSDVFLYTVDDLGAIVR
EGNALRQAAVAQAEAIIETRVQNFMHWLDARSVVPIIRDLHAHAEALRQGELERAQRMLARGDDPALVLEALSQALTKKF
LHGPTHALNHAQGEGREQLIDLLPGLFRQSSHSER
>Mature_435_residues
MQLLTLGINHHTAPLSLREKVAFPLEQLKPALGTLRQHLPHRKSTAEAAILSTCNRTELYCATDGNLPEDTAHEHAIRWL
AHHHNIDAGELAPHVYALGQSQAVRHAFRVASGLDSMVLGETQILGQMKDAVRTATEAGALGTYLNQLFQRTFAVAKEVR
GTTEIGAHSVSMAAAAVRLAQRIFESIAEQRVLFIGAGEMIELCATHFAAQKPRETVVANRTLERGEKLAEALSNQGLNA
RAVRLAELPARLGEFDIVVSCTASTLPIIGLGAVERAIKQRRHRPMFMVDLAVPRDIEPEVARLSDVFLYTVDDLGAIVR
EGNALRQAAVAQAEAIIETRVQNFMHWLDARSVVPIIRDLHAHAEALRQGELERAQRMLARGDDPALVLEALSQALTKKF
LHGPTHALNHAQGEGREQLIDLLPGLFRQSSHSER

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=423, Percent_Identity=43.7352245862884, Blast_Score=332, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_RALSO (Q8XVD1)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_521021.1
- ProteinModelPortal:   Q8XVD1
- SMR:   Q8XVD1
- GeneID:   1221753
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2900
- NMPDR:   fig|267608.1.peg.2900
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   RSOL267608:RSC2900-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47753; Mature: 47753

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00747 GLUTR; PS00012 PHOSPHOPANTETHEINE

Important sites: ACT_SITE 54-54 BINDING 116-116 BINDING 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLLTLGINHHTAPLSLREKVAFPLEQLKPALGTLRQHLPHRKSTAEAAILSTCNRTELY
CCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
CATDGNLPEDTAHEHAIRWLAHHHNIDAGELAPHVYALGQSQAVRHAFRVASGLDSMVLG
EECCCCCCCCHHHHHHHHHHHHHCCCCHHHHCHHHHHCCHHHHHHHHHHHHHCCHHHHHH
ETQILGQMKDAVRTATEAGALGTYLNQLFQRTFAVAKEVRGTTEIGAHSVSMAAAAVRLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QRIFESIAEQRVLFIGAGEMIELCATHFAAQKPRETVVANRTLERGEKLAEALSNQGLNA
HHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
RAVRLAELPARLGEFDIVVSCTASTLPIIGLGAVERAIKQRRHRPMFMVDLAVPRDIEPE
HHHHHHHHHHHCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
VARLSDVFLYTVDDLGAIVREGNALRQAAVAQAEAIIETRVQNFMHWLDARSVVPIIRDL
HHHHHHHHHEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAHAEALRQGELERAQRMLARGDDPALVLEALSQALTKKFLHGPTHALNHAQGEGREQLI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHH
DLLPGLFRQSSHSER
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MQLLTLGINHHTAPLSLREKVAFPLEQLKPALGTLRQHLPHRKSTAEAAILSTCNRTELY
CCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEE
CATDGNLPEDTAHEHAIRWLAHHHNIDAGELAPHVYALGQSQAVRHAFRVASGLDSMVLG
EECCCCCCCCHHHHHHHHHHHHHCCCCHHHHCHHHHHCCHHHHHHHHHHHHHCCHHHHHH
ETQILGQMKDAVRTATEAGALGTYLNQLFQRTFAVAKEVRGTTEIGAHSVSMAAAAVRLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QRIFESIAEQRVLFIGAGEMIELCATHFAAQKPRETVVANRTLERGEKLAEALSNQGLNA
HHHHHHHHHCEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCH
RAVRLAELPARLGEFDIVVSCTASTLPIIGLGAVERAIKQRRHRPMFMVDLAVPRDIEPE
HHHHHHHHHHHCCCEEEEEEECCCCCCEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCHH
VARLSDVFLYTVDDLGAIVREGNALRQAAVAQAEAIIETRVQNFMHWLDARSVVPIIRDL
HHHHHHHHHEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAHAEALRQGELERAQRMLARGDDPALVLEALSQALTKKFLHGPTHALNHAQGEGREQLI
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHH
DLLPGLFRQSSHSER
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852