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The map label for this gene is murC [H]

Identifier: 17547562

GI number: 17547562

Start: 3057935

End: 3059386

Strand: Reverse

Name: murC [H]

Synonym: RSc2843

Alternate gene names: 17547562

Gene position: 3059386-3057935 (Counterclockwise)

Preceding gene: 17547563

Following gene: 17547561

Centisome position: 82.32

GC content: 69.08

Gene sequence:

>1452_bases
ATGAAGCACATCGTCAAGAACATCCATTTCGTGGGCATCGGCGGCGCCGGCATGAGCGGCATCGCCGAGGTGCTGCTGAA
CCTGGGCTACCGCGTGACGGGCTCCGACCTGGGGCAGAGCGCGGCCACGCAGCGTCTGACCGCGCTTGGGGCCACGGTCA
TGCAGGGCCACGCGCCGGAGCACGTGGTCGGCGCCAACGCCGTGGTGGTGTCCACCGCCGTGCGCGGCGACAACCCCGAG
GTGCTGGCCGCGCGCGCCAAGCGCATCCCCATCGTGCCGCGCGCGGTGATGCTGGCCGAGCTGATGCGCCTGAAGCAGGG
CATCGCCATCGCCGGCACGCACGGCAAGACCACCACCACCAGCCTGGTCGCCTCCGTGCTGGCCGAGGGCGGGCTCGACC
CGACCTTCGTGATCGGCGGACGGCTCAATTCGGCCGGCGCCAATGCGCGGCTGGGCACGGGCGATTTCATCGTCGCCGAG
GCGGACGAGTCCGACGCGTCGTTCCTCAACCTGTTCCCCGTGATCGAGGTCATCACCAATATCGATGCCGATCACATGGA
CACCTACGGGCACGACTTCGCGCGGCTCAAGCAGGCGTTCATCGAGTTCACGCACCGCCTGCCGTTCTACGGCATCGCCG
TGTTGTGCGTGGACGACCCGAACGTGCGCGAGATCCTGCCGTTCGTGTCCAAACCGGTGGTGCGCTACGGCTTTGCCGAG
GATGCGCAGGTCCGCGCCGTCAACGCGCGCGCGGTGGACGGCCGCATGGAATTCACCGTGATCCGGCAGCTCAACGGCCA
CGCCGAGCCGCCGCTGTCGATCACGCTCAACCTGCCCGGCATGCACAACGTGCAGAACGCGCTGGCCGCCATCGCCATTG
CCACCGAGCTGGAGGTGCCCGACGAAGCCATCGTCAAGGCGCTGGCCGAGTTCAACGGCGTCGGCCGCCGCTTCCAGCGC
TACGGCGAGGTGCCTACCGCCGACGGCCAGGGCCGCTTCACGCTGATCGACGACTACGGCCACCATCCGGTCGAGATGGC
GGCCACGCTCGCCGCCGCGCGCGGCGCGTTCCCGGGTCGCCGCCTGGTGCTGGCCTTCCAGCCGCACCGCTTCACGCGCA
CGCGCGATTGCTTCGAAGATTTCATCAAGGTGCTCGGCACGGTCGACGCCTTGCTGCTGGCCGAGGTGTACGCGGCCGGC
GAGCCGCCCATCGTGGCGGCGGACGGGCGTGCGCTCACGCGCGCGCTGCGGGTGGCCGGCAAGATCGAGCCGGTCTTCGT
GGAACAGATTGAAGACATGCCGCAAGCCATCCTGGACGCGGCGCAGGACAACGACGTGGTCATCACCATGGGTGCGGGAT
CGATCGGGCAGGTACCTGGTCAGGTGGTTGCGCGGCAGGCGGAAGTGCGTGCTGCGAACGTGGTCGACCTCAACGGGGGC
GCCGCAGCATGA

Upstream 100 bases:

>100_bases
CCGATATGGCGGCCAAAGCACGCGAGCAGGCGCGGCCGGAAGCGGCCGAGCGTGTCGCCGACATCTGTGTCGCGGCGGCA
AGGGCATAGGGAACCGATTT

Downstream 100 bases:

>100_bases
CGACCGGTCCGTTCGTCCCCCATCCGACGCTCGATCCGAAGTCCCTCGGCAAGGTGGGCGTGATCCTCGGCGGTCGCTCG
GCCGAGCGCGAGATCTCGCT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGQSAATQRLTALGATVMQGHAPEHVVGANAVVVSTAVRGDNPE
VLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTHRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGMHNVQNALAAIAIATELEVPDEAIVKALAEFNGVGRRFQR
YGEVPTADGQGRFTLIDDYGHHPVEMAATLAAARGAFPGRRLVLAFQPHRFTRTRDCFEDFIKVLGTVDALLLAEVYAAG
EPPIVAADGRALTRALRVAGKIEPVFVEQIEDMPQAILDAAQDNDVVITMGAGSIGQVPGQVVARQAEVRAANVVDLNGG
AAA

Sequences:

>Translated_483_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGQSAATQRLTALGATVMQGHAPEHVVGANAVVVSTAVRGDNPE
VLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTHRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGMHNVQNALAAIAIATELEVPDEAIVKALAEFNGVGRRFQR
YGEVPTADGQGRFTLIDDYGHHPVEMAATLAAARGAFPGRRLVLAFQPHRFTRTRDCFEDFIKVLGTVDALLLAEVYAAG
EPPIVAADGRALTRALRVAGKIEPVFVEQIEDMPQAILDAAQDNDVVITMGAGSIGQVPGQVVARQAEVRAANVVDLNGG
AAA
>Mature_483_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGQSAATQRLTALGATVMQGHAPEHVVGANAVVVSTAVRGDNPE
VLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTHRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGMHNVQNALAAIAIATELEVPDEAIVKALAEFNGVGRRFQR
YGEVPTADGQGRFTLIDDYGHHPVEMAATLAAARGAFPGRRLVLAFQPHRFTRTRDCFEDFIKVLGTVDALLLAEVYAAG
EPPIVAADGRALTRALRVAGKIEPVFVEQIEDMPQAILDAAQDNDVVITMGAGSIGQVPGQVVARQAEVRAANVVDLNGG
AAA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=457, Percent_Identity=54.4857768052516, Blast_Score=448, Evalue=1e-127,
Organism=Escherichia coli, GI1790680, Length=479, Percent_Identity=29.6450939457203, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51201; Mature: 51201

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGQSAATQRLTALGATVMQGHAPE
CCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCHHCHHHHHHHHHHHHHHHHCCCCCC
HVVGANAVVVSTAVRGDNPEVLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTT
CEECCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAEADESDASFLNLFPVIEVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTHRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCC
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGMHNVQNALAAIAIATELEVP
CCEEEEEEEEEECCCEEEEEEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
DEAIVKALAEFNGVGRRFQRYGEVPTADGQGRFTLIDDYGHHPVEMAATLAAARGAFPGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
RLVLAFQPHRFTRTRDCFEDFIKVLGTVDALLLAEVYAAGEPPIVAADGRALTRALRVAG
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHC
KIEPVFVEQIEDMPQAILDAAQDNDVVITMGAGSIGQVPGQVVARQAEVRAANVVDLNGG
CCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCEEEEEECCCC
AAA
CCC
>Mature Secondary Structure
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGQSAATQRLTALGATVMQGHAPE
CCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCHHCHHHHHHHHHHHHHHHHCCCCCC
HVVGANAVVVSTAVRGDNPEVLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTT
CEECCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAEADESDASFLNLFPVIEVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTHRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCC
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGMHNVQNALAAIAIATELEVP
CCEEEEEEEEEECCCEEEEEEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
DEAIVKALAEFNGVGRRFQRYGEVPTADGQGRFTLIDDYGHHPVEMAATLAAARGAFPGR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
RLVLAFQPHRFTRTRDCFEDFIKVLGTVDALLLAEVYAAGEPPIVAADGRALTRALRVAG
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHC
KIEPVFVEQIEDMPQAILDAAQDNDVVITMGAGSIGQVPGQVVARQAEVRAANVVDLNGG
CCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCEEEEEECCCC
AAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA