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The map label for this gene is holA [H]

Identifier: 17547461

GI number: 17547461

Start: 2951677

End: 2952753

Strand: Reverse

Name: holA [H]

Synonym: RSc2742

Alternate gene names: 17547461

Gene position: 2952753-2951677 (Counterclockwise)

Preceding gene: 17547462

Following gene: 17547460

Centisome position: 79.45

GC content: 71.31

Gene sequence:

>1077_bases
ATGCAACTGCGGCTCGATGCGCTGGAAGGCCACCTGAAGCAGGCCGGGTCCAAGGGCCTGGCGCCGCTGTACGTGGTGCA
CGGCGACGAGCACCTGCTCGTGCTGGAGGCCGTCGATGCGCTGCGCCAGGCGGCGCGCGCGCAGGGCTTCTCCGAGCGCG
AGGTGATGACGGTCGAGCGCGGCTTTTCGTGGTCGCGCGTGACGGAGGCGCAGCAGTCGATGTCGCTGTTCGGCGACCGC
AAGATCGTTGAGCTGCGGATTCCTTCCGGCAAGCCCGGCAAGGACGGCGGCGAGGCGCTGCGCGCGCTGGCGGCGGGCAC
GCCATCGGGGCCGGCTGCCGACACCGTCACGCTGATCACGTTGCCGCGGCTGGACTTTGCCACCGCCAAGTCGGCGTGGT
TCGCGGCGCTGGAGGGCGCGGGCGTGTCGATCAAGGTCGATTCGGTGGACCGCGCCAAGCTGCCCGGCTGGATCGGCGAG
CGCTTGGCCCGCCAGCAGCAGCGCGTGGAAGCGGGCGAGTCCGGCCGCCGCGCGCTGCAGTTCATCGCCGACCGCGTGGA
AGGCAACTTGCTGGCCGCGCACCAGGAAATCCAGAAGCTCGGCCTGCTGCATCCGCCCGGCGTGCTGTCCTTCGATGCCG
TGCACGACGCGGTGCTCAACGTGGCGCGCTACGACGTCTTCAAGCTGTCCGAGGCGATGCTGTCGGGCGACGTGCCGCGC
CTGGTGCGCATGCTCGAAGGCCTGCGCGGCGAGGGCGAAGCCACCGTGCTGGTGCTGTGGACGCTGACCGAGGAAATTCG
CGTATTATCGAAAATCGCCTCGGGCGCGGCCCAGGGCAAGCCGATGGCCTCGATGCTGCGCGAGCTGCGGGTCTGGGGCC
CACGCGAGCGGCTGGTGCCGCAGGCGGTGCAGCGGCTGTCGCAGCCAGAGCTGGAGGCGGCGCTGCAGATGGCGGCCAGG
CTGGACCGGCAGGTCAAGGGCCTGCGCGAGCCGTCGCTGCCCGCCGAGCCATGGGACGGCCTGCTGCAGCTGGCCATGCG
CATCGCGCGGCCGCACAGCCTGCCGGTTCCCGTGTAG

Upstream 100 bases:

>100_bases
GCTCTACCGCGACATGCAGGGCGACATCGTCAATCAGCTGGTGCGGCGGCTTGCCTCCGTCAGGCTGCCGTCGTAAGCCA
CTCGGGACGGTGCGATCGCC

Downstream 100 bases:

>100_bases
CCGCCCGCATTCACCGGCCGCGAGGCCCCGATTTGTCCTCACCCTGAATTGCCGGCGTCCCGCCGGTCGCGATCATCATG
AAGCAGTTCGACGTCAACGA

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MQLRLDALEGHLKQAGSKGLAPLYVVHGDEHLLVLEAVDALRQAARAQGFSEREVMTVERGFSWSRVTEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRALAAGTPSGPAADTVTLITLPRLDFATAKSAWFAALEGAGVSIKVDSVDRAKLPGWIGE
RLARQQQRVEAGESGRRALQFIADRVEGNLLAAHQEIQKLGLLHPPGVLSFDAVHDAVLNVARYDVFKLSEAMLSGDVPR
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPMASMLRELRVWGPRERLVPQAVQRLSQPELEAALQMAAR
LDRQVKGLREPSLPAEPWDGLLQLAMRIARPHSLPVPV

Sequences:

>Translated_358_residues
MQLRLDALEGHLKQAGSKGLAPLYVVHGDEHLLVLEAVDALRQAARAQGFSEREVMTVERGFSWSRVTEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRALAAGTPSGPAADTVTLITLPRLDFATAKSAWFAALEGAGVSIKVDSVDRAKLPGWIGE
RLARQQQRVEAGESGRRALQFIADRVEGNLLAAHQEIQKLGLLHPPGVLSFDAVHDAVLNVARYDVFKLSEAMLSGDVPR
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPMASMLRELRVWGPRERLVPQAVQRLSQPELEAALQMAAR
LDRQVKGLREPSLPAEPWDGLLQLAMRIARPHSLPVPV
>Mature_358_residues
MQLRLDALEGHLKQAGSKGLAPLYVVHGDEHLLVLEAVDALRQAARAQGFSEREVMTVERGFSWSRVTEAQQSMSLFGDR
KIVELRIPSGKPGKDGGEALRALAAGTPSGPAADTVTLITLPRLDFATAKSAWFAALEGAGVSIKVDSVDRAKLPGWIGE
RLARQQQRVEAGESGRRALQFIADRVEGNLLAAHQEIQKLGLLHPPGVLSFDAVHDAVLNVARYDVFKLSEAMLSGDVPR
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPMASMLRELRVWGPRERLVPQAVQRLSQPELEAALQMAAR
LDRQVKGLREPSLPAEPWDGLLQLAMRIARPHSLPVPV

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=292, Percent_Identity=31.8493150684932, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38948; Mature: 38948

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEGHLKQAGSKGLAPLYVVHGDEHLLVLEAVDALRQAARAQGFSEREVMTVER
CCEEHHHHHHHHHHCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCEEEHHC
GFSWSRVTEAQQSMSLFGDRKIVELRIPSGKPGKDGGEALRALAAGTPSGPAADTVTLIT
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEE
LPRLDFATAKSAWFAALEGAGVSIKVDSVDRAKLPGWIGERLARQQQRVEAGESGRRALQ
ECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHHH
FIADRVEGNLLAAHQEIQKLGLLHPPGVLSFDAVHDAVLNVARYDVFKLSEAMLSGDVPR
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPMASMLRELRVWGPRERLVP
HHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHH
QAVQRLSQPELEAALQMAARLDRQVKGLREPSLPAEPWDGLLQLAMRIARPHSLPVPV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQLRLDALEGHLKQAGSKGLAPLYVVHGDEHLLVLEAVDALRQAARAQGFSEREVMTVER
CCEEHHHHHHHHHHCCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCEEEHHC
GFSWSRVTEAQQSMSLFGDRKIVELRIPSGKPGKDGGEALRALAAGTPSGPAADTVTLIT
CCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEE
LPRLDFATAKSAWFAALEGAGVSIKVDSVDRAKLPGWIGERLARQQQRVEAGESGRRALQ
ECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHCCHHHHHHHHHHHHHHHCCHHHHHHHH
FIADRVEGNLLAAHQEIQKLGLLHPPGVLSFDAVHDAVLNVARYDVFKLSEAMLSGDVPR
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LVRMLEGLRGEGEATVLVLWTLTEEIRVLSKIASGAAQGKPMASMLRELRVWGPRERLVP
HHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHH
QAVQRLSQPELEAALQMAARLDRQVKGLREPSLPAEPWDGLLQLAMRIARPHSLPVPV
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]