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The map label for this gene is proA [H]

Identifier: 17547460

GI number: 17547460

Start: 2950319

End: 2951599

Strand: Reverse

Name: proA [H]

Synonym: RSc2741

Alternate gene names: 17547460

Gene position: 2951599-2950319 (Counterclockwise)

Preceding gene: 17547461

Following gene: 17547459

Centisome position: 79.42

GC content: 67.84

Gene sequence:

>1281_bases
ATGAAGCAGTTCGACGTCAACGAATACATGGCGCTGGTCGGCCGCCAGGCACGTGCCGCCTCGCGCGGCATGGCTCGCGC
AGGCACCGCGCAGAAGAACCGTGCGCTGCTGCATCTTGCCGCCGCCATCCGCCGCGACGCGGCCCGCCTGAAGGACGTCA
ACGCGCGCGACGTCGAGCGTGCCCGCGCCAATGGCCAGGATGCCGCTTTCATTGATCGCCTGACGCTGACCGACCGCGCC
ATCGAGACCATGGCGGCCGGCCTCGAGCAGATCGCCGCGCTGCCGGACCCGATCGGCGAGATTAGCAACGTCAAGTTCCG
CCCGACCGGCATCCAGGTCGGCCAGATGCGTGTGCCGCTGGGCGTGATCGGCATCATCTACGAGTCGCGCCCGAACGTGA
CGGTCGATGCGGCGGCGCTGTGCATCAAATCGGGCAACGCCACCATCCTGCGCGGCGGCTCGGAGGCGATCGAATCCAAC
GGCGCGCTGGCGGCGCTGATCGAGGAAGGGCTGGCGGACGCCGGCCTGCCCGCCACTGCGGTGCAGGTGGTGGCGACCCC
CGATCGCGCGGCGGTCGGCAAGCTGATCACCATGACGGAATACGTCGACGTGATCGTGCCGCGCGGCGGCAAGAGCCTGA
TCGCGCGGCTGATGGAAGAAGCGCGCGTGCCGATGATCAAGCACCTCGACGGCATCTGCCACGTCTATATCGACGTGGAC
GCCGACATCGACAAGGCCGTGCGCATCTGCGACAACGCCAAGACGCAGCGCTACGCGCCCTGCAACACGATGGAAACGCT
GCTGGTGGCGCGCGAGGTCGCCGCGCGTGCGCTGACGCCGCTGGCCAGGATCTACCAGGACAAGGGCGTCGAGCTGCGCG
TCTGTCCGGACACGCGCGCCACGCTCGAGGCCGCCGGCTTCAGCGGGCTCAAGGACGCCACCGAGGCCGACTGGCATACC
GAATACCTGGCGCCGATCCTGTCGATCCGCACCGTCGACGGCGTGGACGCCGCCATCGAGCACATCAACACCTACGGTTC
GGCGCACACCGATTCGATCGTCACCGAGAACTACTCGACCGGCATGCGTTTCCTGCGCGAAGTCGATTCGGCCAGCGTGA
TGATCAACGCCTCCACGCGCTTTGCCGACGGCTTCGAGTACGGCCTGGGCGCGGAAATCGGCATCTCCAACGACAAGCTG
CACGCACGCGGGCCGGTCGGGCTGGAGGGGCTGACGTCGCTCAAGTACGTGGTGTTCGGGCACGGCGAGATCCGCACCTG
A

Upstream 100 bases:

>100_bases
ACAGCCTGCCGGTTCCCGTGTAGCCGCCCGCATTCACCGGCCGCGAGGCCCCGATTTGTCCTCACCCTGAATTGCCGGCG
TCCCGCCGGTCGCGATCATC

Downstream 100 bases:

>100_bases
TACCGTCGCGCACGCTGCGCGGGCAGCGTGCGCCATGTCCACAACGCTTTCTCCTCACAAGGATCGCCGCATGCTCTGGG
TCAAGGCCTTTCACATCGTC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKQFDVNEYMALVGRQARAASRGMARAGTAQKNRALLHLAAAIRRDAARLKDVNARDVERARANGQDAAFIDRLTLTDRA
IETMAAGLEQIAALPDPIGEISNVKFRPTGIQVGQMRVPLGVIGIIYESRPNVTVDAAALCIKSGNATILRGGSEAIESN
GALAALIEEGLADAGLPATAVQVVATPDRAAVGKLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDVD
ADIDKAVRICDNAKTQRYAPCNTMETLLVAREVAARALTPLARIYQDKGVELRVCPDTRATLEAAGFSGLKDATEADWHT
EYLAPILSIRTVDGVDAAIEHINTYGSAHTDSIVTENYSTGMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKL
HARGPVGLEGLTSLKYVVFGHGEIRT

Sequences:

>Translated_426_residues
MKQFDVNEYMALVGRQARAASRGMARAGTAQKNRALLHLAAAIRRDAARLKDVNARDVERARANGQDAAFIDRLTLTDRA
IETMAAGLEQIAALPDPIGEISNVKFRPTGIQVGQMRVPLGVIGIIYESRPNVTVDAAALCIKSGNATILRGGSEAIESN
GALAALIEEGLADAGLPATAVQVVATPDRAAVGKLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDVD
ADIDKAVRICDNAKTQRYAPCNTMETLLVAREVAARALTPLARIYQDKGVELRVCPDTRATLEAAGFSGLKDATEADWHT
EYLAPILSIRTVDGVDAAIEHINTYGSAHTDSIVTENYSTGMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKL
HARGPVGLEGLTSLKYVVFGHGEIRT
>Mature_426_residues
MKQFDVNEYMALVGRQARAASRGMARAGTAQKNRALLHLAAAIRRDAARLKDVNARDVERARANGQDAAFIDRLTLTDRA
IETMAAGLEQIAALPDPIGEISNVKFRPTGIQVGQMRVPLGVIGIIYESRPNVTVDAAALCIKSGNATILRGGSEAIESN
GALAALIEEGLADAGLPATAVQVVATPDRAAVGKLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDVD
ADIDKAVRICDNAKTQRYAPCNTMETLLVAREVAARALTPLARIYQDKGVELRVCPDTRATLEAAGFSGLKDATEADWHT
EYLAPILSIRTVDGVDAAIEHINTYGSAHTDSIVTENYSTGMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKL
HARGPVGLEGLTSLKYVVFGHGEIRT

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=414, Percent_Identity=38.4057971014493, Blast_Score=259, Evalue=5e-69,
Organism=Homo sapiens, GI62912457, Length=415, Percent_Identity=38.7951807228916, Blast_Score=258, Evalue=5e-69,
Organism=Escherichia coli, GI1786438, Length=413, Percent_Identity=41.4043583535109, Blast_Score=333, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17569967, Length=416, Percent_Identity=36.5384615384615, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17569969, Length=416, Percent_Identity=36.5384615384615, Blast_Score=264, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6324899, Length=432, Percent_Identity=36.1111111111111, Blast_Score=283, Evalue=3e-77,
Organism=Drosophila melanogaster, GI21357643, Length=415, Percent_Identity=38.0722891566265, Blast_Score=269, Evalue=3e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45694; Mature: 45694

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFDVNEYMALVGRQARAASRGMARAGTAQKNRALLHLAAAIRRDAARLKDVNARDVER
CCCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ARANGQDAAFIDRLTLTDRAIETMAAGLEQIAALPDPIGEISNVKFRPTGIQVGQMRVPL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEECCCEEECCEECCE
GVIGIIYESRPNVTVDAAALCIKSGNATILRGGSEAIESNGALAALIEEGLADAGLPATA
EEEEEEEECCCCEEEEHEEEEEECCCEEEEECCHHHHHCCCCCHHHHHHCCCCCCCCHHE
VQVVATPDRAAVGKLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDVD
EEEEECCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEEEC
ADIDKAVRICDNAKTQRYAPCNTMETLLVAREVAARALTPLARIYQDKGVELRVCPDTRA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
TLEAAGFSGLKDATEADWHTEYLAPILSIRTVDGVDAAIEHINTYGSAHTDSIVTENYST
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHCCHHH
GMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFG
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEE
HGEIRT
CCCCCC
>Mature Secondary Structure
MKQFDVNEYMALVGRQARAASRGMARAGTAQKNRALLHLAAAIRRDAARLKDVNARDVER
CCCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ARANGQDAAFIDRLTLTDRAIETMAAGLEQIAALPDPIGEISNVKFRPTGIQVGQMRVPL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEECCCEEECCEECCE
GVIGIIYESRPNVTVDAAALCIKSGNATILRGGSEAIESNGALAALIEEGLADAGLPATA
EEEEEEEECCCCEEEEHEEEEEECCCEEEEECCHHHHHCCCCCHHHHHHCCCCCCCCHHE
VQVVATPDRAAVGKLITMTEYVDVIVPRGGKSLIARLMEEARVPMIKHLDGICHVYIDVD
EEEEECCCHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHCCCHHHHCCCEEEEEEEEC
ADIDKAVRICDNAKTQRYAPCNTMETLLVAREVAARALTPLARIYQDKGVELRVCPDTRA
CCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
TLEAAGFSGLKDATEADWHTEYLAPILSIRTVDGVDAAIEHINTYGSAHTDSIVTENYST
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHCCHHH
GMRFLREVDSASVMINASTRFADGFEYGLGAEIGISNDKLHARGPVGLEGLTSLKYVVFG
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCHHHHEEEEEEE
HGEIRT
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA