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The map label for this gene is serS [H]

Identifier: 17547056

GI number: 17547056

Start: 2534810

End: 2536126

Strand: Reverse

Name: serS [H]

Synonym: RSc2337

Alternate gene names: 17547056

Gene position: 2536126-2534810 (Counterclockwise)

Preceding gene: 17547057

Following gene: 17547055

Centisome position: 68.24

GC content: 67.58

Gene sequence:

>1317_bases
ATGCTCGACATCCAACTGCTCCGCAAAGACATCGACGCCGTCGCCGCGCGCCTGAACGACCGCGGCTACGAACTCGACGT
GGCCGGCTTCGCCGCGCTCGAAGCGGAACGCAAGGCCATCCAGACCCGTACCGAAGAACTGCAGGCGCGCCGCAACAGCC
TGTCCAAGCAGATCGGCATGCTCAAGGGCAAGGGCGAGGACGCCTCGGCGGTGATGGCGGAAGTCGCCGGCATCGGCGAC
GAGCTCAAGGCCTCGGCCGCGCAGCTCGACGTGGTGCAGGGCAGGCTGCAGGACCTGCTGCTGTCGATCCCGAACGTGCC
GCACGAGAGCGTGCCGGCCGGCAAGAGCGAGGCCGAGAACGTCGAGGTGCGTCGCGAAGGCACGCCGCGCGCGTTCGACT
TCCCGGTCAAGGACCATGTCGATCTGGGCGCCGGGCTGGGGCTGGATTTCGACGTGGCCGCCAAGCTGAGCGGTTCGCGC
TTCGCGGTGCTCAAGGGCCCGGTGGCGCGCCTGCATCGCGCGCTCGCGCAGTTCATGCTCGACACCCACACGCAGGAGCA
CGGCTACACCGAGGCCTACGTACCCTACATCGTCAATGCCGCGTCGATGCGCGGCACCGGCCAGTTGCCGAAGTTCGAGG
AAGACCTGTTCCGCGTGCCCCGCAAGATGGGACAGGCCACTGAAGCCGAGGCCGGCGAGCACGTCGAGAATTTCTACCTG
ATCCCGACCGCCGAGGTGCCGCTGACCAACCTCGTGCGCGATGAGATCGTCGCGGGCGATGCGCTGCCGATGAAGTTCGC
CGCGCATTCGCCGTGCTTCCGCTCGGAGGCCGGCTCGTACGGCAAGGACACGCGCGGCATGATCCGCCAGCACCAGTTCG
ACAAGGTCGAGATGGTGCAGATCGTGCAGCCGGAGACGTCGTTCGAGGCGCTGGACGCCATGACGCACCATGCGGAGAAC
ATCCTGCGCAAGCTGGAGTTGCCGTTCCGCACCGTCGTGCTGTGCACCGGCGACATGGGCTTCGGCAGCACCAAGACGTA
CGACATCGAGGTGTGGATCCCCGCGCAGAACACCTATCGCGAGATCAGCTCGTGCTCCAACATGGGCGATTTCCAGGCGC
GCCGCATGCAGGCCCGCTTCCGCAATGCGCAGGGCAAGCCGGAGCTGCTGCACACGCTCAACGGCTCCGGCCTCGCCGTG
GGCCGCACGCTGGTGGCCGTGCTGGAGAACTACCAGAACGCCGATGGTTCGGTGACGGTGCCGGCGGCGCTGCGCCCGTA
CCTGGGCGGCCAAGCGGTGCTGAAACCGGCGGCCTGA

Upstream 100 bases:

>100_bases
GCAGCAGAAGAACAAATCCTCCCGCGACGACTGAGGCCGGGGCCGGTGCGATAAAATCGGCCCTTTCGATCGTTCGCCAT
CCTCGGTTTTCCTCCTCACC

Downstream 100 bases:

>100_bases
CAAAGATTGCGCGTGCCTCTTGAAACGGGGCGCGAAAGTCTGTTATAGTCGCGGTTTCGCGATACAGCGACCCAGTTACC
AGGAGAGGTGGCAGAGTGGT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MLDIQLLRKDIDAVAARLNDRGYELDVAGFAALEAERKAIQTRTEELQARRNSLSKQIGMLKGKGEDASAVMAEVAGIGD
ELKASAAQLDVVQGRLQDLLLSIPNVPHESVPAGKSEAENVEVRREGTPRAFDFPVKDHVDLGAGLGLDFDVAAKLSGSR
FAVLKGPVARLHRALAQFMLDTHTQEHGYTEAYVPYIVNAASMRGTGQLPKFEEDLFRVPRKMGQATEAEAGEHVENFYL
IPTAEVPLTNLVRDEIVAGDALPMKFAAHSPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQIVQPETSFEALDAMTHHAEN
ILRKLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREISSCSNMGDFQARRMQARFRNAQGKPELLHTLNGSGLAV
GRTLVAVLENYQNADGSVTVPAALRPYLGGQAVLKPAA

Sequences:

>Translated_438_residues
MLDIQLLRKDIDAVAARLNDRGYELDVAGFAALEAERKAIQTRTEELQARRNSLSKQIGMLKGKGEDASAVMAEVAGIGD
ELKASAAQLDVVQGRLQDLLLSIPNVPHESVPAGKSEAENVEVRREGTPRAFDFPVKDHVDLGAGLGLDFDVAAKLSGSR
FAVLKGPVARLHRALAQFMLDTHTQEHGYTEAYVPYIVNAASMRGTGQLPKFEEDLFRVPRKMGQATEAEAGEHVENFYL
IPTAEVPLTNLVRDEIVAGDALPMKFAAHSPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQIVQPETSFEALDAMTHHAEN
ILRKLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREISSCSNMGDFQARRMQARFRNAQGKPELLHTLNGSGLAV
GRTLVAVLENYQNADGSVTVPAALRPYLGGQAVLKPAA
>Mature_438_residues
MLDIQLLRKDIDAVAARLNDRGYELDVAGFAALEAERKAIQTRTEELQARRNSLSKQIGMLKGKGEDASAVMAEVAGIGD
ELKASAAQLDVVQGRLQDLLLSIPNVPHESVPAGKSEAENVEVRREGTPRAFDFPVKDHVDLGAGLGLDFDVAAKLSGSR
FAVLKGPVARLHRALAQFMLDTHTQEHGYTEAYVPYIVNAASMRGTGQLPKFEEDLFRVPRKMGQATEAEAGEHVENFYL
IPTAEVPLTNLVRDEIVAGDALPMKFAAHSPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQIVQPETSFEALDAMTHHAEN
ILRKLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREISSCSNMGDFQARRMQARFRNAQGKPELLHTLNGSGLAV
GRTLVAVLENYQNADGSVTVPAALRPYLGGQAVLKPAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=471, Percent_Identity=31.6348195329087, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI8923421, Length=451, Percent_Identity=28.3813747228381, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI225579074, Length=452, Percent_Identity=28.9823008849558, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1787120, Length=432, Percent_Identity=62.5, Blast_Score=551, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17539260, Length=420, Percent_Identity=32.1428571428571, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=332, Percent_Identity=28.9156626506024, Blast_Score=128, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6320226, Length=419, Percent_Identity=31.5035799522673, Blast_Score=200, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6321799, Length=401, Percent_Identity=29.925187032419, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24581334, Length=471, Percent_Identity=30.9978768577495, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI17737985, Length=344, Percent_Identity=31.6860465116279, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47914; Mature: 47914

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50862 AA_TRNA_LIGASE_II ; PS01039 SBP_BACTERIAL_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDIDAVAARLNDRGYELDVAGFAALEAERKAIQTRTEELQARRNSLSKQIGM
CCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDASAVMAEVAGIGDELKASAAQLDVVQGRLQDLLLSIPNVPHESVPAGKSEAEN
HCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRREGTPRAFDFPVKDHVDLGAGLGLDFDVAAKLSGSRFAVLKGPVARLHRALAQFML
EEEEECCCCCEECCCCHHCCCCCCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
DTHTQEHGYTEAYVPYIVNAASMRGTGQLPKFEEDLFRVPRKMGQATEAEAGEHVENFYL
HHCCHHCCCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHCEEE
IPTAEVPLTNLVRDEIVAGDALPMKFAAHSPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQ
EECCCCCHHHHHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCCHHHHHHHHCCCCCHHHE
IVQPETSFEALDAMTHHAENILRKLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYR
EECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHH
EISSCSNMGDFQARRMQARFRNAQGKPELLHTLNGSGLAVGRTLVAVLENYQNADGSVTV
HHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEE
PAALRPYLGGQAVLKPAA
CHHHCCCCCCCCEECCCC
>Mature Secondary Structure
MLDIQLLRKDIDAVAARLNDRGYELDVAGFAALEAERKAIQTRTEELQARRNSLSKQIGM
CCCHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDASAVMAEVAGIGDELKASAAQLDVVQGRLQDLLLSIPNVPHESVPAGKSEAEN
HCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRREGTPRAFDFPVKDHVDLGAGLGLDFDVAAKLSGSRFAVLKGPVARLHRALAQFML
EEEEECCCCCEECCCCHHCCCCCCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHH
DTHTQEHGYTEAYVPYIVNAASMRGTGQLPKFEEDLFRVPRKMGQATEAEAGEHVENFYL
HHCCHHCCCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHCEEE
IPTAEVPLTNLVRDEIVAGDALPMKFAAHSPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQ
EECCCCCHHHHHHHHHHCCCCCCCHHHCCCCCHHHCCCCCCCCHHHHHHHHCCCCCHHHE
IVQPETSFEALDAMTHHAENILRKLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYR
EECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHH
EISSCSNMGDFQARRMQARFRNAQGKPELLHTLNGSGLAVGRTLVAVLENYQNADGSVTV
HHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEE
PAALRPYLGGQAVLKPAA
CHHHCCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA