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The map label for this gene is gmk

Identifier: 17546874

GI number: 17546874

Start: 2338353

End: 2339018

Strand: Reverse

Name: gmk

Synonym: RSc2155

Alternate gene names: 17546874

Gene position: 2339018-2338353 (Counterclockwise)

Preceding gene: 17546875

Following gene: 17546873

Centisome position: 62.94

GC content: 67.72

Gene sequence:

>666_bases
ATGCCTTCTTCCCAAGCGCACTCGGCGGTCGATACGCCCATCGAGAACCATTTTCCCGGCAGCCTGTTCATGGTGGTGGC
GCCGTCCGGCGCGGGCAAGTCGACGCTGGTGAACGCGCTGCTGGCGCAGGACCCGTCGATCCGCCTGTCCGTCTCCGCCA
CCACGCGCAAGCCGCGGCCGGGCGAGCAGCATGGCCGCGAATACAATTTCATGACGGTCGACGAGTTCAAGGCCTGCCGC
GATCGCGGCGAGTTCCTCGAATGGGCCGAAGTGCACGGCAACTACTACGCGACCTCGCGCGTGTGGATCGAAGAGCAGAT
GCGCGCCGGCACCGACGTGCTGCTGGAGATCGACTGGCAGGGCGCGCAGCAGGTGCATCGCCGCTTCGCCAACGCGGTCG
AGATCTTCATCCTGCCGCCGTCGCTGACCGCGCTCGAAGACCGCCTCAAGAAGCGCGGCCAGGACGAGCCCAACGTGATC
GTGCGCCGGCTGCTCGCCGCGGGCAGCGAAATGGCGCACGCGCCCGAAGCCGACTACGTGATCATCAACGAGGTCTTCGA
GGCCGCGCTGGCCGAGCTGCGCACCGTGGTGCAGGCCGCGCGGCTGCGCTACATGGCGCAGAAGGCGCGGCACGCCGAGC
TCTTCGTCGAGCTGGGCATTCACTGA

Upstream 100 bases:

>100_bases
AGAGCTGGCCGATGCCTCGATGGAGCTCAAGCTCCTGATCGAGCAGATGCGCGAGCAGGTCCAGAATCTCGAATAACCAC
GCACCACGCAGAACAACAAC

Downstream 100 bases:

>100_bases
GCGTCGCCGCGCGTTTTCCGGCGCGCAAGCGAAAGTGTGGTAGGCCCCGCGCCGACGAGGCGTCCGGGGCAGGCGCCGCG
CTGCTGCTAAAATACCGGCA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MPSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDPSIRLSVSATTRKPRPGEQHGREYNFMTVDEFKACR
DRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQGAQQVHRRFANAVEIFILPPSLTALEDRLKKRGQDEPNVI
VRRLLAAGSEMAHAPEADYVIINEVFEAALAELRTVVQAARLRYMAQKARHAELFVELGIH

Sequences:

>Translated_221_residues
MPSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDPSIRLSVSATTRKPRPGEQHGREYNFMTVDEFKACR
DRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQGAQQVHRRFANAVEIFILPPSLTALEDRLKKRGQDEPNVI
VRRLLAAGSEMAHAPEADYVIINEVFEAALAELRTVVQAARLRYMAQKARHAELFVELGIH
>Mature_220_residues
PSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDPSIRLSVSATTRKPRPGEQHGREYNFMTVDEFKACRD
RGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQGAQQVHRRFANAVEIFILPPSLTALEDRLKKRGQDEPNVIV
RRLLAAGSEMAHAPEADYVIINEVFEAALAELRTVVQAARLRYMAQKARHAELFVELGIH

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=38.8571428571429, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=38.8571428571429, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=38.8571428571429, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI21361598, Length=196, Percent_Identity=24.4897959183673, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI262118259, Length=139, Percent_Identity=28.0575539568345, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI4505237, Length=139, Percent_Identity=28.0575539568345, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI262118255, Length=139, Percent_Identity=28.0575539568345, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=52.2388059701493, Blast_Score=211, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI193203132, Length=190, Percent_Identity=33.6842105263158, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=33.8888888888889, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=41.2087912087912, Blast_Score=142, Evalue=6e-35,
Organism=Drosophila melanogaster, GI21356141, Length=179, Percent_Identity=40.2234636871508, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_RALSO (Q8XXF9)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520276.1
- ProteinModelPortal:   Q8XXF9
- GeneID:   1220998
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2155
- NMPDR:   fig|267608.1.peg.2155
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   RSOL267608:RSC2155-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR003593
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00382
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24747; Mature: 24616

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDPSIRLSVSATTRKPRP
CCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCC
GEQHGREYNFMTVDEFKACRDRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQ
CHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCC
GAQQVHRRFANAVEIFILPPSLTALEDRLKKRGQDEPNVIVRRLLAAGSEMAHAPEADYV
CHHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEE
IINEVFEAALAELRTVVQAARLRYMAQKARHAELFVELGIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
PSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDPSIRLSVSATTRKPRP
CCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCC
GEQHGREYNFMTVDEFKACRDRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQ
CHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCC
GAQQVHRRFANAVEIFILPPSLTALEDRLKKRGQDEPNVIVRRLLAAGSEMAHAPEADYV
CHHHHHHHHHCEEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEE
IINEVFEAALAELRTVVQAARLRYMAQKARHAELFVELGIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852