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The map label for this gene is maeB1 [H]

Identifier: 17546842

GI number: 17546842

Start: 2299025

End: 2301346

Strand: Reverse

Name: maeB1 [H]

Synonym: RSc2123

Alternate gene names: 17546842

Gene position: 2301346-2299025 (Counterclockwise)

Preceding gene: 17546843

Following gene: 17546835

Centisome position: 61.92

GC content: 67.79

Gene sequence:

>2322_bases
ATGAACGACAAGCTTCACGACGCCTCGCCCGATACACTCGACAAGGGGGCCGAGGCCGAACTGCGCCGCGCCGCGCTCGA
ATACCACCGCTCGCCGACGCGCGGCAAGATCGAGGTCCGCTCGACCAAGACGCTGATCAACCAGCGCGACCTGTCGCTGG
CGTATTCGCCGGGCGTGGCCTATGCGTGTACCGAGATCGAGCGCGACCCGTCGCTGGCGGCCGAGTACACCTCGCGCGCC
AACCTGGTCGGCGTGATCACCAACGGCACCGCGGTGCTCGGCCTGGGCGACATCGGCCCGCTGGCCGGCAAGCCGGTGAT
GGAAGGCAAGGGCTGCCTGTTCAAGAAGTTCGCCGGCGTGGACGTGTTCGACATCGAGCTGGCCGAGCGCGATCCGGACA
AGCTGGTCGACATCATCGCCTCGCTGGAGCCGACGCTGGGCGGCATCAACCTCGAGGACATCAAGGCGCCGGAGTGCTTC
TACATCGAGCAGAAGCTGCGCGAGCGCCTGAACATTCCCGTCTTCCACGATGACCAGCACGGCACGGCGATCATCTCGTC
GGCCGCGCTGCTCAACGGCATGAAGGTGGTCGGCAAGCAGATCGGCGAGGTCAAGGTGGCGGTGTCGGGCGCGGGCGCCG
CGGCCATCGCCTGCCTGGACCTGATGGTGAGCCTGGGCGTCAAGCGCGAGAACGTGTTCGTGGTCGACTCCAAGGGCGTC
ATCTATGCCGGCCGCGACGCCAAGATGGAGCCGAACAAGGCGCGCTACGCGCAGGACACCGCGGCCCGCACGCTGGCCGA
CATCGTGCGCGATGCGGACGTGTTCCTGGGCTGCTCGGCCGCCGGCGTGCTGACCGCCGACATGGTCAAGACCATGGCGC
CCAATCCGATCATCCTGGCGCTGGCCAACCCCGAGCCGGAGATCCGTCCCGAGATCGCCAAGGCCGCGCGTCCGGACTGC
ATCATCGCCACGGGCCGTTCGGACTACCCGAACCAGGTCAACAACGTGCTGTGCTTCCCGTACATCTTCCGCGGCGCGCT
CGATTGCGGCGCCACCAAGATCACGGAAGCAATGAAGCTGGCCTGCGTGAAGGCCATCGCCGAGCTGGCCGAAGCCGAGA
CCAACGACGCCGTGGCCCAGGCCTATGCCGGCCAGGAGCTGAACTTCGGTCCGGACTACATCATCCCGAAGCCGTTCGAT
TCGCGCCTGATCGAGAAGATCGCGCCGGCGGTGGCCAAGGCAGCGATGGAGTCCGGCGTGGCGACGCGCCCGATCGCCGA
CCTGGACGCCTACCGCCACCAGCTCAACGACTTCGTCTACCACACCGGCATGACCATGCGCCCGGTGTTCTCCGCCGCCA
AGGCCGCGCCCAAGCGCGTGGTCTACGCCGAGGGCGAAGAGGAGCGCGTGCTGCGCGCGGTGCAGACGGTGATCGACGAG
GGCCTGGCCAAGCCGATCCTGGTCGGCCGCCCGCACGTGATCGAGATGCGCATCCAGAAGGCCGGCCTGCGCCTGAAGCC
GGGCGTGGATTTCGAGCTGGTGAACCCGGAAGACGATCCGCGCTACCACCAGTACCACACCGCCTACCACGAGCTGATGG
GCCGCAACGGCGTGACGCCCGACATGGCGAAGTCGGCGCTGCGCCGCTCCAACACGCTGATCGGCGCGCTGCTGGTGCGC
CTGGGCGATGCCGACGCGATGCTGTGCGGCACGGTGGGCCGCTTCGACGCGCATCTCGAGCACGTGCGCGACGTGATCGG
CCTGGCGCCCAACGCCAAGGTGTTCGCCGCCATGAACGGCCTGATGCTGGAAAAGCACACGCTGTTCATCGCCGACACCT
TCGTCAACGAAGACCCGACGGCTGAAGAGCTGGCCGCGATCACCGAGCTGGCCGCGGAAGAAGTGCGCCGCTTCGGCCTG
GAGCCGAAGGTGGCGATGCTGTCGCACTCGATGTTCGGTTCGTCCAAGAGCAAGTCGGCGCGCAAGATGCGCGCGGCGTA
CGACCTGCTCAAGACGCAGGCGCCGAGCCTGCAGGTGGAAGGCGAGATCCAGGGCGATGCCGCGCTGGTCGAAGACATCC
GCCACCACTTCCTGCCCAAGAGCGCGTTTGCCGGCAGCGCCAACCTGCTGGTGATGCCGACGCTGGACGCGGCCAACATC
GCCTTCAACCTGCTCAAGATCACGGGCGGGCACGGCGTGACGGTGGGCCCGATCCTGCTGGGCGCGGCCAAGCCGGTGCA
CATCCTCAACCCGGCGGCCACGTCGCGGCGCATCGTCAACATGACCGCGCTGGCGGTGGCGGACGTGTCGGCGACACGCT
GA

Upstream 100 bases:

>100_bases
TTTTTCCGTTTTTTTTGCTTCTCCTCCGTACCAGGACGCCTTCGCCTGAAGCGCTCACCAGCGCTTGATCCGCGGAACGT
CCCTCCAGGATGTCATTGAT

Downstream 100 bases:

>100_bases
TCGGCGGATCGCCCCGCATGGCCGCTGCGTTGCGCGGCGGCCAGGAAAAACGAAACGGCGCCTGAAGCGATTCGGGCGCC
GTTTTCTTTTGCCGTGGATC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MNDKLHDASPDTLDKGAEAELRRAALEYHRSPTRGKIEVRSTKTLINQRDLSLAYSPGVAYACTEIERDPSLAAEYTSRA
NLVGVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECF
YIEQKLRERLNIPVFHDDQHGTAIISSAALLNGMKVVGKQIGEVKVAVSGAGAAAIACLDLMVSLGVKRENVFVVDSKGV
IYAGRDAKMEPNKARYAQDTAARTLADIVRDADVFLGCSAAGVLTADMVKTMAPNPIILALANPEPEIRPEIAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKLACVKAIAELAEAETNDAVAQAYAGQELNFGPDYIIPKPFD
SRLIEKIAPAVAKAAMESGVATRPIADLDAYRHQLNDFVYHTGMTMRPVFSAAKAAPKRVVYAEGEEERVLRAVQTVIDE
GLAKPILVGRPHVIEMRIQKAGLRLKPGVDFELVNPEDDPRYHQYHTAYHELMGRNGVTPDMAKSALRRSNTLIGALLVR
LGDADAMLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNGLMLEKHTLFIADTFVNEDPTAEELAAITELAAEEVRRFGL
EPKVAMLSHSMFGSSKSKSARKMRAAYDLLKTQAPSLQVEGEIQGDAALVEDIRHHFLPKSAFAGSANLLVMPTLDAANI
AFNLLKITGGHGVTVGPILLGAAKPVHILNPAATSRRIVNMTALAVADVSATR

Sequences:

>Translated_773_residues
MNDKLHDASPDTLDKGAEAELRRAALEYHRSPTRGKIEVRSTKTLINQRDLSLAYSPGVAYACTEIERDPSLAAEYTSRA
NLVGVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECF
YIEQKLRERLNIPVFHDDQHGTAIISSAALLNGMKVVGKQIGEVKVAVSGAGAAAIACLDLMVSLGVKRENVFVVDSKGV
IYAGRDAKMEPNKARYAQDTAARTLADIVRDADVFLGCSAAGVLTADMVKTMAPNPIILALANPEPEIRPEIAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKLACVKAIAELAEAETNDAVAQAYAGQELNFGPDYIIPKPFD
SRLIEKIAPAVAKAAMESGVATRPIADLDAYRHQLNDFVYHTGMTMRPVFSAAKAAPKRVVYAEGEEERVLRAVQTVIDE
GLAKPILVGRPHVIEMRIQKAGLRLKPGVDFELVNPEDDPRYHQYHTAYHELMGRNGVTPDMAKSALRRSNTLIGALLVR
LGDADAMLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNGLMLEKHTLFIADTFVNEDPTAEELAAITELAAEEVRRFGL
EPKVAMLSHSMFGSSKSKSARKMRAAYDLLKTQAPSLQVEGEIQGDAALVEDIRHHFLPKSAFAGSANLLVMPTLDAANI
AFNLLKITGGHGVTVGPILLGAAKPVHILNPAATSRRIVNMTALAVADVSATR
>Mature_773_residues
MNDKLHDASPDTLDKGAEAELRRAALEYHRSPTRGKIEVRSTKTLINQRDLSLAYSPGVAYACTEIERDPSLAAEYTSRA
NLVGVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGVDVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECF
YIEQKLRERLNIPVFHDDQHGTAIISSAALLNGMKVVGKQIGEVKVAVSGAGAAAIACLDLMVSLGVKRENVFVVDSKGV
IYAGRDAKMEPNKARYAQDTAARTLADIVRDADVFLGCSAAGVLTADMVKTMAPNPIILALANPEPEIRPEIAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKLACVKAIAELAEAETNDAVAQAYAGQELNFGPDYIIPKPFD
SRLIEKIAPAVAKAAMESGVATRPIADLDAYRHQLNDFVYHTGMTMRPVFSAAKAAPKRVVYAEGEEERVLRAVQTVIDE
GLAKPILVGRPHVIEMRIQKAGLRLKPGVDFELVNPEDDPRYHQYHTAYHELMGRNGVTPDMAKSALRRSNTLIGALLVR
LGDADAMLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNGLMLEKHTLFIADTFVNEDPTAEELAAITELAAEEVRRFGL
EPKVAMLSHSMFGSSKSKSARKMRAAYDLLKTQAPSLQVEGEIQGDAALVEDIRHHFLPKSAFAGSANLLVMPTLDAANI
AFNLLKITGGHGVTVGPILLGAAKPVHILNPAATSRRIVNMTALAVADVSATR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505145, Length=410, Percent_Identity=25.609756097561, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4505143, Length=397, Percent_Identity=24.9370277078086, Blast_Score=90, Evalue=8e-18,
Organism=Homo sapiens, GI270265879, Length=369, Percent_Identity=26.0162601626016, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI62420882, Length=345, Percent_Identity=27.2463768115942, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI62420880, Length=345, Percent_Identity=27.2463768115942, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI239049447, Length=345, Percent_Identity=27.2463768115942, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1788806, Length=750, Percent_Identity=63.8666666666667, Blast_Score=989, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=335, Percent_Identity=29.5522388059701, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1788800, Length=315, Percent_Identity=32.0634920634921, Blast_Score=138, Evalue=2e-33,
Organism=Escherichia coli, GI87081919, Length=475, Percent_Identity=23.3684210526316, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537199, Length=410, Percent_Identity=24.390243902439, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=275, Percent_Identity=29.0909090909091, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356279, Length=505, Percent_Identity=27.5247524752475, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362672, Length=482, Percent_Identity=27.5933609958506, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281362674, Length=482, Percent_Identity=27.5933609958506, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=29.2753623188406, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=29.2753623188406, Blast_Score=90, Evalue=7e-18,
Organism=Drosophila melanogaster, GI78707242, Length=434, Percent_Identity=24.6543778801843, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI78707238, Length=434, Percent_Identity=24.6543778801843, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83126; Mature: 83126

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKLHDASPDTLDKGAEAELRRAALEYHRSPTRGKIEVRSTKTLINQRDLSLAYSPGVA
CCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCEEEECCCCE
YACTEIERDPSLAAEYTSRANLVGVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGV
EEECCCCCCCCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
DVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECFYIEQKLRERLNIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCC
GTAIISSAALLNGMKVVGKQIGEVKVAVSGAGAAAIACLDLMVSLGVKRENVFVVDSKGV
CHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCE
IYAGRDAKMEPNKARYAQDTAARTLADIVRDADVFLGCSAAGVLTADMVKTMAPNPIILA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHCCCCCEEEE
LANPEPEIRPEIAKAARPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKL
ECCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHH
ACVKAIAELAEAETNDAVAQAYAGQELNFGPDYIIPKPFDSRLIEKIAPAVAKAAMESGV
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ATRPIADLDAYRHQLNDFVYHTGMTMRPVFSAAKAAPKRVVYAEGEEERVLRAVQTVIDE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
GLAKPILVGRPHVIEMRIQKAGLRLKPGVDFELVNPEDDPRYHQYHTAYHELMGRNGVTP
HCCCCEEECCCCEEEEEEHHCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCH
DMAKSALRRSNTLIGALLVRLGDADAMLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNG
HHHHHHHHHCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCC
LMLEKHTLFIADTFVNEDPTAEELAAITELAAEEVRRFGLEPKVAMLSHSMFGSSKSKSA
EEEECEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHH
RKMRAAYDLLKTQAPSLQVEGEIQGDAALVEDIRHHFLPKSAFAGSANLLVMPTLDAANI
HHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHCCCCCCEEEEECCCHHHH
AFNLLKITGGHGVTVGPILLGAAKPVHILNPAATSRRIVNMTALAVADVSATR
EEEEEEEECCCCCEEHHHHHCCCCCEEEECCCHHCCHHHHHHHHHEECCCCCC
>Mature Secondary Structure
MNDKLHDASPDTLDKGAEAELRRAALEYHRSPTRGKIEVRSTKTLINQRDLSLAYSPGVA
CCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCEEEECCCCE
YACTEIERDPSLAAEYTSRANLVGVITNGTAVLGLGDIGPLAGKPVMEGKGCLFKKFAGV
EEECCCCCCCCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
DVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECFYIEQKLRERLNIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCC
GTAIISSAALLNGMKVVGKQIGEVKVAVSGAGAAAIACLDLMVSLGVKRENVFVVDSKGV
CHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCE
IYAGRDAKMEPNKARYAQDTAARTLADIVRDADVFLGCSAAGVLTADMVKTMAPNPIILA
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHCCCCCEEEE
LANPEPEIRPEIAKAARPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEAMKL
ECCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHH
ACVKAIAELAEAETNDAVAQAYAGQELNFGPDYIIPKPFDSRLIEKIAPAVAKAAMESGV
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ATRPIADLDAYRHQLNDFVYHTGMTMRPVFSAAKAAPKRVVYAEGEEERVLRAVQTVIDE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHH
GLAKPILVGRPHVIEMRIQKAGLRLKPGVDFELVNPEDDPRYHQYHTAYHELMGRNGVTP
HCCCCEEECCCCEEEEEEHHCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCH
DMAKSALRRSNTLIGALLVRLGDADAMLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNG
HHHHHHHHHCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCEEEHHHCC
LMLEKHTLFIADTFVNEDPTAEELAAITELAAEEVRRFGLEPKVAMLSHSMFGSSKSKSA
EEEECEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHH
RKMRAAYDLLKTQAPSLQVEGEIQGDAALVEDIRHHFLPKSAFAGSANLLVMPTLDAANI
HHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCCCCHHCCCCCCEEEEECCCHHHH
AFNLLKITGGHGVTVGPILLGAAKPVHILNPAATSRRIVNMTALAVADVSATR
EEEEEEEECCCCCEEHHHHHCCCCCEEEECCCHHCCHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]