Click here to switch to the map view.

The map label for this gene is yedX [C]

Identifier: 17546835

GI number: 17546835

Start: 2292708

End: 2293061

Strand: Reverse

Name: yedX [C]

Synonym: RSc2116

Alternate gene names: 17546835

Gene position: 2293061-2292708 (Counterclockwise)

Preceding gene: 17546842

Following gene: 17546834

Centisome position: 61.7

GC content: 66.1

Gene sequence:

>354_bases
ATGGGACGCTTGACCACCCATGTGCTCGACACCGCTGCAGGCACGCCGGGCAAGGACTTGGCGATCACCCTGTTCAAGAT
TGTCAACAATCTAAGGCAGCCGATCAAAACGGTCCGCACCAATCACGATGGCCGCTGCGAGGCGCCGCTGCTGGAAGGCG
AGGCGCTGCAGGCCGGCATCTACGAGCTGGATTTCGCGGTGGGCGACTACTACCGCGCGGCCGGCGTCAGCCTCCCCGAC
CCCGCGTTCCTCGATGTGGTGACGCTGCGCTTCGGCGTGGCCGATGCCGGCGCGCACTACCACGTGCCGCTGCTGGTGTC
GCCGTGGTCGTACTCGACCTATCGCGGCAGCTGA

Upstream 100 bases:

>100_bases
GAGCAGGCCCCGGTGCCGGCCCTTGTCACACAAGGGTTTGGCGCGAGGTGCAAGTGGAGGCAGCGGCGCTTCTGATGATT
CCAACAACAGAGGAAGACAA

Downstream 100 bases:

>100_bases
GCGGGAGGCGTCATGGAAGGCTATCTCCTCGACTGGGCCAACCTGCTGCTGCGCTGGCTGCACGTGATCACGGCGATCGC
GTGGATCGGCTCGTCGTTCT

Product: transthyretin-like protein precursor

Products: NA

Alternate protein names: HIU hydrolase; HIUHase

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MGRLTTHVLDTAAGTPGKDLAITLFKIVNNLRQPIKTVRTNHDGRCEAPLLEGEALQAGIYELDFAVGDYYRAAGVSLPD
PAFLDVVTLRFGVADAGAHYHVPLLVSPWSYSTYRGS

Sequences:

>Translated_117_residues
MGRLTTHVLDTAAGTPGKDLAITLFKIVNNLRQPIKTVRTNHDGRCEAPLLEGEALQAGIYELDFAVGDYYRAAGVSLPD
PAFLDVVTLRFGVADAGAHYHVPLLVSPWSYSTYRGS
>Mature_116_residues
GRLTTHVLDTAAGTPGKDLAITLFKIVNNLRQPIKTVRTNHDGRCEAPLLEGEALQAGIYELDFAVGDYYRAAGVSLPDP
AFLDVVTLRFGVADAGAHYHVPLLVSPWSYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily

Homologues:

Organism=Escherichia coli, GI1788281, Length=114, Percent_Identity=35.0877192982456, Blast_Score=78, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115534555, Length=114, Percent_Identity=36.8421052631579, Blast_Score=71, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI115532922, Length=114, Percent_Identity=35.9649122807018, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI115532920, Length=114, Percent_Identity=35.9649122807018, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24652571, Length=117, Percent_Identity=35.042735042735, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIUH_RALSO (Q8XXJ7)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_520237.1
- ProteinModelPortal:   Q8XXJ7
- SMR:   Q8XXJ7
- GeneID:   1220957
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc2116
- NMPDR:   fig|267608.1.peg.2116
- HOGENOM:   HBG445217
- OMA:   RCDQPLL
- ProtClustDB:   CLSK897221
- BioCyc:   RSOL267608:RSC2116-MONOMER
- GO:   GO:0006810
- InterPro:   IPR014306
- InterPro:   IPR000895
- Gene3D:   G3DSA:2.60.40.180
- PRINTS:   PR00189
- SMART:   SM00095
- TIGRFAMs:   TIGR02962

Pfam domain/function: PF00576 Transthyretin; SSF49472 Transthyretin

EC number: =3.5.2.17

Molecular weight: Translated: 12674; Mature: 12542

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00768 TRANSTHYRETIN_1; PS00769 TRANSTHYRETIN_2

Important sites: BINDING 7-7 BINDING 45-45 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRLTTHVLDTAAGTPGKDLAITLFKIVNNLRQPIKTVRTNHDGRCEAPLLEGEALQAGI
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCC
YELDFAVGDYYRAAGVSLPDPAFLDVVTLRFGVADAGAHYHVPLLVSPWSYSTYRGS
EEEEHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
GRLTTHVLDTAAGTPGKDLAITLFKIVNNLRQPIKTVRTNHDGRCEAPLLEGEALQAGI
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCC
YELDFAVGDYYRAAGVSLPDPAFLDVVTLRFGVADAGAHYHVPLLVSPWSYSTYRGS
EEEEHHHCCHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852