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The map label for this gene is nuoF [H]

Identifier: 17546776

GI number: 17546776

Start: 2231315

End: 2232610

Strand: Reverse

Name: nuoF [H]

Synonym: RSc2057

Alternate gene names: 17546776

Gene position: 2232610-2231315 (Counterclockwise)

Preceding gene: 17546777

Following gene: 17546775

Centisome position: 60.07

GC content: 64.12

Gene sequence:

>1296_bases
ATGACCTCCCTGCACGATCGACACATCCAGCCGCTGATTCTCGCCGGCCTGAACGGCGACAACTGGCACCTCGAAGACTA
TGTCAAGCGCGGCGGTTACCAGCAGCTCAAGCGCATCCTGACGGAAAAGATTTCGCCTGAACAGATCATCGCCGACGTGA
AGGCCTCGGGCCTGCGCGGCCGTGGCGGCGCGGGCTTCCCGACCGGCCTGAAGTGGAGCTTCATGCCGCGCCAGTTCCCG
GGCCAGAAGTACCTGGTCTGCAACACGGACGAGGGCGAGCCCGGCACGTTCAAGGATCGCGACATCATCCGCTACAACCC
GCACGCCTTGATCGAAGGCATGGCCATCGGCGGCTACGCGATGGGCATCACCGTGGGCTACAACTACATCCACGGCGAGA
TCTGGAACGAGTACAAGCTCTTCGAGCAGGCGCTCGAAGAGGCGCGTGCCGCAGGTTTGCTGGGCGACAACATTCTCGGC
TCCGGCTTCAACTTCCAGCTGCATGCGCACCATGGCTATGGCGCGTACATCTGCGGCGAGGAAACCGCGCTGCTCGAATC
GCTGGAAGGCAAGAAGGGCCAGCCGCGCTTCAAGCCGCCGTTCCCGGCCAGCTTCGGCCTGTACGGCAAGCCGACCACCA
TCAACAACACCGAAACCTTTGCCGCGGTGCCGTTCCTGCTGTCCATCGGTCCGGACAACTACCTGAAGATGGGCAAGCCG
AACAACGGCGGCTCGAAGATCTTCTCGGTGTCCGGCGACGTGGAGCGCCCGGGCAACTACGAGATTCCGCTCGGCACGCC
GTTCTCCAAGCTGCTGGAACTGGCCGGCGGCATGCGTGGCGGCAAGAAGCTCAAGGCGGTCATCCCGGGTGGCTCGTCGG
CGCCGGTGGTGCCGGCCGACCTGATGATGGCCTCCGACATGGACTACGACTCGATCGCCAAGGCCGGCTCGATGCTGGGT
TCGGGCGCCGTGATCGTGATGGACGAGACGCGCTGCATGGTGAAGTCGCTGCTGCGCCTGTCGTACTTCTACTTCGAGGA
GTCGTGCGGCCAGTGCACGCCGTGCCGTGAGGGCACCGGCTGGCTGTACCGCGTGGTCGATCGCATCGAGCACGGCAAGG
GCCGCCAGGAAGATCTGGACCTGCTCAACAACGTGGCCGAGAACATCATGGGCCGGACCATCTGCGCGCTGGGCGATGCC
GCCGCGATGCCGGTCCGCGGCATGCTCAAGCACTACTGGGACGAGTTCGCGTATCACGTCGAGCACAAGCAGTGCATGGT
GCCCACCTACATCTAA

Upstream 100 bases:

>100_bases
CAACAACACCCATATGTGCAGCTTCATGAGCAACGAGAAGCTCGACGCGCTGATCGCCGACCTGAAGGCGAAGGCGCCCG
CCAATGGAGCAGGCAAGTAA

Downstream 100 bases:

>100_bases
GCGTGGCAGAACATGGTTGAAATCGAAATCGATGGCAAGAAGGTCGAGGTTGCCGAAGGCAGCCTGGTGATGGAGGCCGC
CCGTCAGGCGGGCACCTATA

Product: NADH dehydrogenase I chain F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKISPEQIIADVKASGLRGRGGAGFPTGLKWSFMPRQFP
GQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYAMGITVGYNYIHGEIWNEYKLFEQALEEARAAGLLGDNILG
SGFNFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLSIGPDNYLKMGKP
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPADLMMASDMDYDSIAKAGSMLG
SGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTGWLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDA
AAMPVRGMLKHYWDEFAYHVEHKQCMVPTYI

Sequences:

>Translated_431_residues
MTSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKISPEQIIADVKASGLRGRGGAGFPTGLKWSFMPRQFP
GQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYAMGITVGYNYIHGEIWNEYKLFEQALEEARAAGLLGDNILG
SGFNFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLSIGPDNYLKMGKP
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPADLMMASDMDYDSIAKAGSMLG
SGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTGWLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDA
AAMPVRGMLKHYWDEFAYHVEHKQCMVPTYI
>Mature_430_residues
TSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKISPEQIIADVKASGLRGRGGAGFPTGLKWSFMPRQFPG
QKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYAMGITVGYNYIHGEIWNEYKLFEQALEEARAAGLLGDNILGS
GFNFQLHAHHGYGAYICGEETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLSIGPDNYLKMGKPN
NGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPADLMMASDMDYDSIAKAGSMLGS
GAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTGWLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDAA
AMPVRGMLKHYWDEFAYHVEHKQCMVPTYI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=425, Percent_Identity=47.0588235294118, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI260656005, Length=425, Percent_Identity=47.0588235294118, Blast_Score=391, Evalue=1e-109,
Organism=Escherichia coli, GI1788620, Length=402, Percent_Identity=42.5373134328358, Blast_Score=331, Evalue=5e-92,
Organism=Caenorhabditis elegans, GI17531727, Length=431, Percent_Identity=47.0997679814385, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19920794, Length=424, Percent_Identity=45.7547169811321, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI45550452, Length=415, Percent_Identity=45.3012048192771, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24653819, Length=398, Percent_Identity=37.6884422110553, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24653817, Length=398, Percent_Identity=33.9195979899498, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47394; Mature: 47263

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKISPEQIIADVKASGLRG
CCCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RGGAGFPTGLKWSFMPRQFPGQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYA
CCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHEEEEECCEE
MGITVGYNYIHGEIWNEYKLFEQALEEARAAGLLGDNILGSGFNFQLHAHHGYGAYICGE
EEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEECC
ETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLSIGPDNYLKMGKP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEHEECCCCCCEECCCC
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPAD
CCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHH
LMMASDMDYDSIAKAGSMLGSGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTG
HHHCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
WLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDAAAMPVRGMLKHYWDEFAYHV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHH
EHKQCMVPTYI
CCCEEECCCCC
>Mature Secondary Structure 
TSLHDRHIQPLILAGLNGDNWHLEDYVKRGGYQQLKRILTEKISPEQIIADVKASGLRG
CCCCCCCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCC
RGGAGFPTGLKWSFMPRQFPGQKYLVCNTDEGEPGTFKDRDIIRYNPHALIEGMAIGGYA
CCCCCCCCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHEEEEECCEE
MGITVGYNYIHGEIWNEYKLFEQALEEARAAGLLGDNILGSGFNFQLHAHHGYGAYICGE
EEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEEECC
ETALLESLEGKKGQPRFKPPFPASFGLYGKPTTINNTETFAAVPFLLSIGPDNYLKMGKP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEHEECCCCCCEECCCC
NNGGSKIFSVSGDVERPGNYEIPLGTPFSKLLELAGGMRGGKKLKAVIPGGSSAPVVPAD
CCCCCEEEEECCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCHH
LMMASDMDYDSIAKAGSMLGSGAVIVMDETRCMVKSLLRLSYFYFEESCGQCTPCREGTG
HHHCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCH
WLYRVVDRIEHGKGRQEDLDLLNNVAENIMGRTICALGDAAAMPVRGMLKHYWDEFAYHV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHH
EHKQCMVPTYI
CCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]