Click here to switch to the map view.

The map label for this gene is trpA [H]

Identifier: 17546700

GI number: 17546700

Start: 2155704

End: 2156501

Strand: Reverse

Name: trpA [H]

Synonym: RSc1981

Alternate gene names: 17546700

Gene position: 2156501-2155704 (Counterclockwise)

Preceding gene: 17546701

Following gene: 17546699

Centisome position: 58.03

GC content: 67.92

Gene sequence:

>798_bases
ATGTCCCGCATTGCTCAAACTTTTTCGCAATTGTCCGCGCAGGGCCGCAAGGGCCTGATTCCGTTCATCACGGCGGGCGA
CCCGTATCCCGAGTTGACCGTCGACCTGATGCATGCGCTGGTCAAGGGCGGCGCCAACGTCATCGAACTGGGCGTGCCGT
TTTCCGACCCGATGGCCGACGGCCCGGTCATCCAGCGTGCGTCGGAGCGCGCACTCGCCAAGAAAATCGGCCTGCGCACC
GTGCTGGACTACGTGCGTGCGTTCCGCGCCACCGACAAGACCACGCCCGTGGTGCTGATGGGCTACGCCAACCCGATCGA
GCGCATGGGCATCGACGCCTTCGCCAAGGCCGCGTCGGAAGCCGGCGTGGACGGCGTGCTGGTGGTGGACTACCCGCCCG
AGGAGTGCGAGGCGTTCGCCAAGACCATGCGGGCCGCGGGCATCGACCCGATCTTCCTGCTGGCGCCCACGTCGACCGAA
GCGCGCATGGCGCAGATCGCCCGCGTGGCGAGCGGCTACATCTACTACGTCTCGCTCAAGGGCGTGACGGGTGCGGCGAC
GCTCGACCTCGACAGCGTGGCCGCGCGCATCCCGCAGATCCGCCAGCACGCGCGGCTGCCGGTGGGGGTCGGCTTCGGCA
TCCGCGATGCGGCGACGGCGCGCGCGATCGGCGGCGTGGCCGATGCGGTGGTGATCGGATCCCGCATTGTGCAATTGCTG
GAGGAGGCGTCCCGCGAACAAGCGGTACAATGTCTGACTGATTTCATCGCGGACATCCGCCAGGCGCTCGACGCCTGA

Upstream 100 bases:

>100_bases
TGGCGCGCGAGCGGGTGGCCGCCGTCACGCCGCTTGGACCCCAATCGACTGATTCCCAGGTGCCCGACACCGTCAGGGTC
GCCTGAAACCTCTTCAATCC

Downstream 100 bases:

>100_bases
GCCACATGACCCGCGCGAGCGCATTCAAGGAGTACGCATGAGCTGGCTGGACAAACTGCTTCCGCCCAAGATCCAACAGA
CCGATCCGTCGCAACGCAAG

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MSRIAQTFSQLSAQGRKGLIPFITAGDPYPELTVDLMHALVKGGANVIELGVPFSDPMADGPVIQRASERALAKKIGLRT
VLDYVRAFRATDKTTPVVLMGYANPIERMGIDAFAKAASEAGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLLAPTSTE
ARMAQIARVASGYIYYVSLKGVTGAATLDLDSVAARIPQIRQHARLPVGVGFGIRDAATARAIGGVADAVVIGSRIVQLL
EEASREQAVQCLTDFIADIRQALDA

Sequences:

>Translated_265_residues
MSRIAQTFSQLSAQGRKGLIPFITAGDPYPELTVDLMHALVKGGANVIELGVPFSDPMADGPVIQRASERALAKKIGLRT
VLDYVRAFRATDKTTPVVLMGYANPIERMGIDAFAKAASEAGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLLAPTSTE
ARMAQIARVASGYIYYVSLKGVTGAATLDLDSVAARIPQIRQHARLPVGVGFGIRDAATARAIGGVADAVVIGSRIVQLL
EEASREQAVQCLTDFIADIRQALDA
>Mature_264_residues
SRIAQTFSQLSAQGRKGLIPFITAGDPYPELTVDLMHALVKGGANVIELGVPFSDPMADGPVIQRASERALAKKIGLRTV
LDYVRAFRATDKTTPVVLMGYANPIERMGIDAFAKAASEAGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLLAPTSTEA
RMAQIARVASGYIYYVSLKGVTGAATLDLDSVAARIPQIRQHARLPVGVGFGIRDAATARAIGGVADAVVIGSRIVQLLE
EASREQAVQCLTDFIADIRQALDA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=250, Percent_Identity=35.6, Blast_Score=144, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6321412, Length=261, Percent_Identity=36.0153256704981, Blast_Score=172, Evalue=4e-44,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28100; Mature: 27969

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIAQTFSQLSAQGRKGLIPFITAGDPYPELTVDLMHALVKGGANVIELGVPFSDPMAD
CCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQRASERALAKKIGLRTVLDYVRAFRATDKTTPVVLMGYANPIERMGIDAFAKAASE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHCHHHHHHHHHH
AGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLLAPTSTEARMAQIARVASGYIYYVSLK
CCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEEC
GVTGAATLDLDSVAARIPQIRQHARLPVGVGFGIRDAATARAIGGVADAVVIGSRIVQLL
CCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EEASREQAVQCLTDFIADIRQALDA
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SRIAQTFSQLSAQGRKGLIPFITAGDPYPELTVDLMHALVKGGANVIELGVPFSDPMAD
CHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
GPVIQRASERALAKKIGLRTVLDYVRAFRATDKTTPVVLMGYANPIERMGIDAFAKAASE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHCHHHHHHHHHH
AGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLLAPTSTEARMAQIARVASGYIYYVSLK
CCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEEEC
GVTGAATLDLDSVAARIPQIRQHARLPVGVGFGIRDAATARAIGGVADAVVIGSRIVQLL
CCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
EEASREQAVQCLTDFIADIRQALDA
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA