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The map label for this gene is yisK [H]

Identifier: 17546543

GI number: 17546543

Start: 1992677

End: 1993636

Strand: Reverse

Name: yisK [H]

Synonym: RSc1824

Alternate gene names: 17546543

Gene position: 1993636-1992677 (Counterclockwise)

Preceding gene: 17546544

Following gene: 17546542

Centisome position: 53.64

GC content: 68.75

Gene sequence:

>960_bases
ATGCGACTCGTAACCTTCCGCGCCCACGTGAATGCGGCCGCCCGCCTCGGCGCCATCGTGGACAATCTCGTCGTCGACCT
GGAGCGCTTCGGCGAGCATGTCGGCTGCGACCTGCCCGCCGACATGCTGGCGTTCATCGACCTTGGGCCCCACGCGGTCG
CGGCAACCACCGCGCTGCTCGACGAATACCGCGACAACTGGCCGCTGGGCACCGCCGTGCCGCTGGCCAACGTCAAGCTG
CTCGCGCCGATTCCCCGGCCGCGCAAGAACATCTTCGGCATCGGCCTCAACTACGTCGAACACGTGGCCGAGTCGAGCCG
CACGCTGGACACCGCGAAGGAACTGCCCAAGCAGCCCGTCATTTTCAGCAAGCCGCCGACCACGGTGATCGGCCCGGGCG
ATGCCATCGAGCACAACGCCGCCATCACCCGGCAACTGGACTGGGAAGTGGAGCTGGCCGTCATCATCGGCACGCGCGCC
AAGCGGGTCGGCGAGGCCGACGCGCTCGCCCACGTGTTCGGCTACAGCCTGCTGATCGACATGAGCGCGCGCGACTGCCG
GCGCGCCGGCCAGTGGATCTATTCCAAGGGGCAGGATACGTACGCCCCCTTCGGCCCCGTCATCGTCACGGCCGATGAGA
TTCCCGATCCGCACAACCTGGACCTGAGCCTGAAGGTGAACGGCGTGACCAAGCAGGATTCCAACACGCGCCACATGCTG
TTCAAGGTGCCGGCGCTGATCGCCGACATCAGCGCCGGCATCACGCTGGAGCCGGGCGACATCATCGCGACCGGCACGCC
GGAAGGCGTGGGCGCCGGCCGCGATCCGCAGGAATGGGTCTGGCCCGGCGACATCATCGAGGCGCAGCTGGAAAAGATCG
GGGCGCTGCGCCACCCCGTGGTCGCGGTCGGCGACAGCGCGCAGGTCGAGGCCGGCCAGCCGGTGCGGCGCGTGGCCTGA

Upstream 100 bases:

>100_bases
GGCCGACAACGATGGACACCAGCCGCTGCCTGGTCCCGCAGCGAAGTAAGCCGGCGGCGGCTGGCCCGCGCCACATTGAA
CATTCCTTGGAGAAGACACC

Downstream 100 bases:

>100_bases
CCGAAACAGGGGCGGCAGGCGGATGTCGGCCTGCGCCCTGCCACCGCCCGGGCGCCCAAACCTGTGCCCGGGCTGTCGAA
CCCCCGCTCTGCCCGCCGCG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MRLVTFRAHVNAAARLGAIVDNLVVDLERFGEHVGCDLPADMLAFIDLGPHAVAATTALLDEYRDNWPLGTAVPLANVKL
LAPIPRPRKNIFGIGLNYVEHVAESSRTLDTAKELPKQPVIFSKPPTTVIGPGDAIEHNAAITRQLDWEVELAVIIGTRA
KRVGEADALAHVFGYSLLIDMSARDCRRAGQWIYSKGQDTYAPFGPVIVTADEIPDPHNLDLSLKVNGVTKQDSNTRHML
FKVPALIADISAGITLEPGDIIATGTPEGVGAGRDPQEWVWPGDIIEAQLEKIGALRHPVVAVGDSAQVEAGQPVRRVA

Sequences:

>Translated_319_residues
MRLVTFRAHVNAAARLGAIVDNLVVDLERFGEHVGCDLPADMLAFIDLGPHAVAATTALLDEYRDNWPLGTAVPLANVKL
LAPIPRPRKNIFGIGLNYVEHVAESSRTLDTAKELPKQPVIFSKPPTTVIGPGDAIEHNAAITRQLDWEVELAVIIGTRA
KRVGEADALAHVFGYSLLIDMSARDCRRAGQWIYSKGQDTYAPFGPVIVTADEIPDPHNLDLSLKVNGVTKQDSNTRHML
FKVPALIADISAGITLEPGDIIATGTPEGVGAGRDPQEWVWPGDIIEAQLEKIGALRHPVVAVGDSAQVEAGQPVRRVA
>Mature_319_residues
MRLVTFRAHVNAAARLGAIVDNLVVDLERFGEHVGCDLPADMLAFIDLGPHAVAATTALLDEYRDNWPLGTAVPLANVKL
LAPIPRPRKNIFGIGLNYVEHVAESSRTLDTAKELPKQPVIFSKPPTTVIGPGDAIEHNAAITRQLDWEVELAVIIGTRA
KRVGEADALAHVFGYSLLIDMSARDCRRAGQWIYSKGQDTYAPFGPVIVTADEIPDPHNLDLSLKVNGVTKQDSNTRHML
FKVPALIADISAGITLEPGDIIATGTPEGVGAGRDPQEWVWPGDIIEAQLEKIGALRHPVVAVGDSAQVEAGQPVRRVA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=307, Percent_Identity=38.7622149837134, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI40786394, Length=307, Percent_Identity=38.7622149837134, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI66348062, Length=195, Percent_Identity=41.5384615384615, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI215422413, Length=195, Percent_Identity=41.5384615384615, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI13654274, Length=195, Percent_Identity=41.5384615384615, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1787428, Length=193, Percent_Identity=34.1968911917098, Blast_Score=101, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17557057, Length=205, Percent_Identity=34.1463414634146, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6324161, Length=237, Percent_Identity=27.8481012658228, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28572127, Length=310, Percent_Identity=37.741935483871, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24663695, Length=306, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28571789, Length=220, Percent_Identity=37.2727272727273, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 34359; Mature: 34359

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVTFRAHVNAAARLGAIVDNLVVDLERFGEHVGCDLPADMLAFIDLGPHAVAATTALL
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHH
DEYRDNWPLGTAVPLANVKLLAPIPRPRKNIFGIGLNYVEHVAESSRTLDTAKELPKQPV
HHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCE
IFSKPPTTVIGPGDAIEHNAAITRQLDWEVELAVIIGTRAKRVGEADALAHVFGYSLLID
EECCCCCEEECCCCCCCCCCCEEEEECCEEEEEEEEECCHHHCCHHHHHHHHHHHHEEEE
MSARDCRRAGQWIYSKGQDTYAPFGPVIVTADEIPDPHNLDLSLKVNGVTKQDSNTRHML
CCHHHHHHHCHHHHCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCEECCCCCCEEEE
FKVPALIADISAGITLEPGDIIATGTPEGVGAGRDPQEWVWPGDIIEAQLEKIGALRHPV
EEHHHHHHHHCCCCEECCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
VAVGDSAQVEAGQPVRRVA
EEECCCCCCCCCCCHHHCC
>Mature Secondary Structure
MRLVTFRAHVNAAARLGAIVDNLVVDLERFGEHVGCDLPADMLAFIDLGPHAVAATTALL
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHH
DEYRDNWPLGTAVPLANVKLLAPIPRPRKNIFGIGLNYVEHVAESSRTLDTAKELPKQPV
HHHHCCCCCCCCCCCCCEEEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCE
IFSKPPTTVIGPGDAIEHNAAITRQLDWEVELAVIIGTRAKRVGEADALAHVFGYSLLID
EECCCCCEEECCCCCCCCCCCEEEEECCEEEEEEEEECCHHHCCHHHHHHHHHHHHEEEE
MSARDCRRAGQWIYSKGQDTYAPFGPVIVTADEIPDPHNLDLSLKVNGVTKQDSNTRHML
CCHHHHHHHCHHHHCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCEECCCCCCEEEE
FKVPALIADISAGITLEPGDIIATGTPEGVGAGRDPQEWVWPGDIIEAQLEKIGALRHPV
EEHHHHHHHHCCCCEECCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCE
VAVGDSAQVEAGQPVRRVA
EEECCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]