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The map label for this gene is ldcA [H]

Identifier: 17546171

GI number: 17546171

Start: 1553101

End: 1554027

Strand: Direct

Name: ldcA [H]

Synonym: RSc1452

Alternate gene names: 17546171

Gene position: 1553101-1554027 (Clockwise)

Preceding gene: 17546170

Following gene: 17546172

Centisome position: 41.79

GC content: 70.01

Gene sequence:

>927_bases
ATGACCACTGTCCGCCTGATCGCGCCCTCCGGCTATCCGAACGATTCCGCCATCGCCGAGCGTGGCGTGGCGTTCCTGCA
GGGGCAGGGCTGCGCGGTGGTCAACCAGGCATGCCTGGCGCGCCAGCACCAGCGCTTTGCCGGCGGCGAGCTGGCGCGGC
TGGCCGATCTGCACCAGATCGGCACCGGCGGCGGCCAGGAGATCGCCATGGCCATCCGCGGCGGCTACGGGCTGACGCGG
CTGCTGGACCACATCGACTTCATCGGCATCGGCCGGCGCGCGCAGGCGACCGACGCCATCATCGTCGGCCACAGCGACTT
CACCGCGTTCTCGCTGGCCTACCTGGCCGCGACCGGCGGCGTGACCTTCGCCGGCCCGCACGTGTGCTCGGACTTCGGGC
TGGAGACGGTCGATCCGTTCATGGTCGAGCACTTCTGGGGCATCCTGCGCAATCCGGCCTATACCCTGCGGGTGGACGCG
CCGCAGCCCGGCGACTGCGCGCGTCCGGGCCGCTACGCCGGCACGCTGTGGGGCGGCAACCTGGCGATGCTGTGCAGCCT
GGTCGGCACGCCGTACCTGCCGAACATCCGTGACGGCATCCTCTTCGTCGAGGACATCAACGAGCATCCCTACCGCGTCG
AGCGGATGCTGCTGCAACTGCAGCAGGCCGGCGTGCTGGAGGCGCAGCAGGCGCTGGTGCTGGGCGATTTTTCCGGCTAC
AAGACCACGCCCTACGATGCCGGCTACGACTTCGGCGCCATGTTTGCGTATCTGGCCGAGCACCTGTCGATCCCGGTGGT
CAGCGGCCTGCCGTTCGGCCATTGCCCGACCAAGGCGACGCTGCCCGTCGGTGCGCAGGCCGAGCTGGACGTGGACGCGG
AGGGCTTCACCTTGCGCCTGTCGGGCTACCCGACGCTGCCCGGCTAG

Upstream 100 bases:

>100_bases
AGGACTGCGGCGACATGCTGCGCGCCTTCTTCGCCGAGCGCCGCGCCAGCCAGCGCGCCGCGCGCATGGCCTCCGCCTCC
GACGATTCCGCTTCCGCCGC

Downstream 100 bases:

>100_bases
CCGGGCGACCATCCGCGTCACCGGCGGGTGGTAAAATTCCAGGTTTTCCAGATGGTGTCTGGCCTGTCACTGTGCCGGCG
CCGCTCACCGCTTTTTTCAT

Product: L,D-carboxypeptidase A

Products: NA

Alternate protein names: LD-carboxypeptidase A; Muramoyltetrapeptide carboxypeptidase [H]

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MTTVRLIAPSGYPNDSAIAERGVAFLQGQGCAVVNQACLARQHQRFAGGELARLADLHQIGTGGGQEIAMAIRGGYGLTR
LLDHIDFIGIGRRAQATDAIIVGHSDFTAFSLAYLAATGGVTFAGPHVCSDFGLETVDPFMVEHFWGILRNPAYTLRVDA
PQPGDCARPGRYAGTLWGGNLAMLCSLVGTPYLPNIRDGILFVEDINEHPYRVERMLLQLQQAGVLEAQQALVLGDFSGY
KTTPYDAGYDFGAMFAYLAEHLSIPVVSGLPFGHCPTKATLPVGAQAELDVDAEGFTLRLSGYPTLPG

Sequences:

>Translated_308_residues
MTTVRLIAPSGYPNDSAIAERGVAFLQGQGCAVVNQACLARQHQRFAGGELARLADLHQIGTGGGQEIAMAIRGGYGLTR
LLDHIDFIGIGRRAQATDAIIVGHSDFTAFSLAYLAATGGVTFAGPHVCSDFGLETVDPFMVEHFWGILRNPAYTLRVDA
PQPGDCARPGRYAGTLWGGNLAMLCSLVGTPYLPNIRDGILFVEDINEHPYRVERMLLQLQQAGVLEAQQALVLGDFSGY
KTTPYDAGYDFGAMFAYLAEHLSIPVVSGLPFGHCPTKATLPVGAQAELDVDAEGFTLRLSGYPTLPG
>Mature_307_residues
TTVRLIAPSGYPNDSAIAERGVAFLQGQGCAVVNQACLARQHQRFAGGELARLADLHQIGTGGGQEIAMAIRGGYGLTRL
LDHIDFIGIGRRAQATDAIIVGHSDFTAFSLAYLAATGGVTFAGPHVCSDFGLETVDPFMVEHFWGILRNPAYTLRVDAP
QPGDCARPGRYAGTLWGGNLAMLCSLVGTPYLPNIRDGILFVEDINEHPYRVERMLLQLQQAGVLEAQQALVLGDFSGYK
TTPYDAGYDFGAMFAYLAEHLSIPVVSGLPFGHCPTKATLPVGAQAELDVDAEGFTLRLSGYPTLPG

Specific function: Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. Can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc- tetrapeptide, G

COG id: COG1619

COG function: function code V; Uncharacterized proteins, homologs of microcin C7 resistance protein MccF

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S66 family [H]

Homologues:

Organism=Escherichia coli, GI1787441, Length=307, Percent_Identity=46.9055374592834, Blast_Score=268, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003507 [H]

Pfam domain/function: PF02016 Peptidase_S66 [H]

EC number: NA

Molecular weight: Translated: 32872; Mature: 32741

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVRLIAPSGYPNDSAIAERGVAFLQGQGCAVVNQACLARQHQRFAGGELARLADLHQI
CCEEEEEECCCCCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GTGGGQEIAMAIRGGYGLTRLLDHIDFIGIGRRAQATDAIIVGHSDFTAFSLAYLAATGG
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCC
VTFAGPHVCSDFGLETVDPFMVEHFWGILRNPAYTLRVDAPQPGDCARPGRYAGTLWGGN
CEECCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCC
LAMLCSLVGTPYLPNIRDGILFVEDINEHPYRVERMLLQLQQAGVLEAQQALVLGDFSGY
HHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHEEEEECCCCC
KTTPYDAGYDFGAMFAYLAEHLSIPVVSGLPFGHCPTKATLPVGAQAELDVDAEGFTLRL
CCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEE
SGYPTLPG
CCCCCCCC
>Mature Secondary Structure 
TTVRLIAPSGYPNDSAIAERGVAFLQGQGCAVVNQACLARQHQRFAGGELARLADLHQI
CEEEEEECCCCCCHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GTGGGQEIAMAIRGGYGLTRLLDHIDFIGIGRRAQATDAIIVGHSDFTAFSLAYLAATGG
CCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCC
VTFAGPHVCSDFGLETVDPFMVEHFWGILRNPAYTLRVDAPQPGDCARPGRYAGTLWGGN
CEECCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCEEEEECCC
LAMLCSLVGTPYLPNIRDGILFVEDINEHPYRVERMLLQLQQAGVLEAQQALVLGDFSGY
HHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHEEEEECCCCC
KTTPYDAGYDFGAMFAYLAEHLSIPVVSGLPFGHCPTKATLPVGAQAELDVDAEGFTLRL
CCCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEE
SGYPTLPG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]