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The map label for this gene is lpxA

Identifier: 17546135

GI number: 17546135

Start: 1516133

End: 1516948

Strand: Direct

Name: lpxA

Synonym: RSc1416

Alternate gene names: 17546135

Gene position: 1516133-1516948 (Clockwise)

Preceding gene: 17546134

Following gene: 17546136

Centisome position: 40.8

GC content: 67.16

Gene sequence:

>816_bases
ATGACGCAAGTTCAGAAGATTCACCCGACCGCGGTGATCGACCCGCAGGCCGAACTGGCCCCGGATGTCGAGGTCGGCGC
CTTTACCGTGATCGGCCCGAATGTGCGCATCGATTCGGGGACGCGCATCGGCCACCATACCGTGGTCGAGGGCTACACCA
CGCTGGGCCGCGACAACCAGATCGGCCACTTCGCGTCGGTGGGCGGGCGACCGCAGGATATGAAGTACCGCGACGAGCCG
ACCCGGCTCATCGTCGGCGACCGCAACACCATCCGCGAATTCACCACGATCCATACCGGCACCGCGCAGGATGTCGGCAT
CACGTCCATCGGCGATGACAACTGGATCATGGCCTACGTGCACATCGCGCACGATTGCCGCATCGGCAACCACACGGTGT
TCTCCAGCAACGCGCAGATCGCCGGCCACGTGGAAGTGGGCGATTGGGCAATCCTGGGCGGCATGTCGGGCGTGCACCAG
TTCGTGCGCATCGGCGCGCACGCGATGCTGGGCGGTGCCTCGGCGCTGGTGCAGGATGTGCCGCCGTTCGTGATCGCCGC
CAGCGACAAGGGCGGCAACAAGGCCGCGCCGCATGGCGTCAACGTCGTGGGCCTGCAGCGCCGCGGCTTTTCGGCCGAGC
AGATCGCCGGCCTGCGCCAGGCCTACAAGCTGCTCTACAAGAGCGACCTGAGCTTCGACCAGGCCCAGGCCGAGATCGCC
GCGCAGGTCGCGCAGACCGAAGATGCCCCGAGCCGCGAGGCGCTGCGCACCTTCGCCGACTTCATCGCCGCCACCAAGCG
CGGCATCGTGCGTTGA

Upstream 100 bases:

>100_bases
GCATGTGGAAGTTCAAGGTGTTCGCGACCGTGGACGATGAAGTCGCGGCCGAGGCTGAGATCATGTGTGCCGTGCGCGAA
GACAAGTCCAAGGGCGACGC

Downstream 100 bases:

>100_bases
CGCAGCCGCCCGCCGCGCCGGCCCGCCGCATCGGCATGGCAGCCGGCGAGGCGTCCGGCGACCTGCTGGCCTCGCTGCTG
CTCAAGGGGCTGCATGCGCG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTQVQKIHPTAVIDPQAELAPDVEVGAFTVIGPNVRIDSGTRIGHHTVVEGYTTLGRDNQIGHFASVGGRPQDMKYRDEP
TRLIVGDRNTIREFTTIHTGTAQDVGITSIGDDNWIMAYVHIAHDCRIGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQ
FVRIGAHAMLGGASALVQDVPPFVIAASDKGGNKAAPHGVNVVGLQRRGFSAEQIAGLRQAYKLLYKSDLSFDQAQAEIA
AQVAQTEDAPSREALRTFADFIAATKRGIVR

Sequences:

>Translated_271_residues
MTQVQKIHPTAVIDPQAELAPDVEVGAFTVIGPNVRIDSGTRIGHHTVVEGYTTLGRDNQIGHFASVGGRPQDMKYRDEP
TRLIVGDRNTIREFTTIHTGTAQDVGITSIGDDNWIMAYVHIAHDCRIGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQ
FVRIGAHAMLGGASALVQDVPPFVIAASDKGGNKAAPHGVNVVGLQRRGFSAEQIAGLRQAYKLLYKSDLSFDQAQAEIA
AQVAQTEDAPSREALRTFADFIAATKRGIVR
>Mature_270_residues
TQVQKIHPTAVIDPQAELAPDVEVGAFTVIGPNVRIDSGTRIGHHTVVEGYTTLGRDNQIGHFASVGGRPQDMKYRDEPT
RLIVGDRNTIREFTTIHTGTAQDVGITSIGDDNWIMAYVHIAHDCRIGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQF
VRIGAHAMLGGASALVQDVPPFVIAASDKGGNKAAPHGVNVVGLQRRGFSAEQIAGLRQAYKLLYKSDLSFDQAQAEIAA
QVAQTEDAPSREALRTFADFIAATKRGIVR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=265, Percent_Identity=49.4339622641509, Blast_Score=273, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_RALSO (Q8XZH9)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519537.1
- ProteinModelPortal:   Q8XZH9
- SMR:   Q8XZH9
- GeneID:   1220240
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1416
- NMPDR:   fig|267608.1.peg.1416
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BioCyc:   RSOL267608:RSC1416-MONOMER
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 29052; Mature: 28921

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQVQKIHPTAVIDPQAELAPDVEVGAFTVIGPNVRIDSGTRIGHHTVVEGYTTLGRDNQ
CCCCCCCCCCEEECCCHHCCCCCCCCEEEEECCCEEECCCCCCCCEEEECCHHHCCCCCC
IGHFASVGGRPQDMKYRDEPTRLIVGDRNTIREFTTIHTGTAQDVGITSIGDDNWIMAYV
CCHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHEEECCCCCCCCEEEECCCCEEEEEE
HIAHDCRIGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQFVRIGAHAMLGGASALVQDV
EEEEHEECCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCC
PPFVIAASDKGGNKAAPHGVNVVGLQRRGFSAEQIAGLRQAYKLLYKSDLSFDQAQAEIA
CCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQVAQTEDAPSREALRTFADFIAATKRGIVR
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQVQKIHPTAVIDPQAELAPDVEVGAFTVIGPNVRIDSGTRIGHHTVVEGYTTLGRDNQ
CCCCCCCCCEEECCCHHCCCCCCCCEEEEECCCEEECCCCCCCCEEEECCHHHCCCCCC
IGHFASVGGRPQDMKYRDEPTRLIVGDRNTIREFTTIHTGTAQDVGITSIGDDNWIMAYV
CCHHHHCCCCCCCCCCCCCCCEEEECCCHHHHHHHEEECCCCCCCCEEEECCCCEEEEEE
HIAHDCRIGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQFVRIGAHAMLGGASALVQDV
EEEEHEECCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCC
PPFVIAASDKGGNKAAPHGVNVVGLQRRGFSAEQIAGLRQAYKLLYKSDLSFDQAQAEIA
CCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
AQVAQTEDAPSREALRTFADFIAATKRGIVR
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852