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The map label for this gene is lpxB

Identifier: 17546136

GI number: 17546136

Start: 1516945

End: 1518117

Strand: Direct

Name: lpxB

Synonym: RSc1417

Alternate gene names: 17546136

Gene position: 1516945-1518117 (Clockwise)

Preceding gene: 17546135

Following gene: 17546137

Centisome position: 40.82

GC content: 69.39

Gene sequence:

>1173_bases
TTGACGCAGCCGCCCGCCGCGCCGGCCCGCCGCATCGGCATGGCAGCCGGCGAGGCGTCCGGCGACCTGCTGGCCTCGCT
GCTGCTCAAGGGGCTGCATGCGCGGCTGCCGCGGGATGTCGCCTACGAGGGCATCGGCGGCGCGCGCATGGCGGAGCAGG
GCTTCGCATCGCATTGGCCGATGCACAAGCTGTCGGTCAACGGTTATGTCGAGGTGCTCGGCCAGCTGCGCGAGATTCTC
GCCATCCGGCGCGAACTGAAGCAGAACCTGCTGGCCGATCCGCCGATGGCCTTCATCGGCGTGGACGCCCCCGATTTCAA
TTTCAACGTCGAGATCGCCATGCGGCGCGCGGGCGTGCCGGTGGTGCACTTCGTCAGCCCGTCGATCTGGGCATGGCGCG
CCGGGCGCATCAAGACGATCGCGCGCGCGGTCGACCACATCCTCTGCCTGTTCCCGTTCGAGCCTGAGATCTACGCCAGG
GCCGGGATTCCAGCCACCTACGTCGGCCATCCGCTGGCCGACGAGATTCCGCTGGAGCCGGACGTGGAGGGCGCGCGCAG
CCGTCTCGGACTGCCGCTCGGCCGCAAGGTGGTGGCGGTGCTGCCGGGCAGCCGCAACTCCGAGGTCAAGCTGCTCGGGC
CGACGCTGTTCGCCGCGATGGCGCGCATGCAGGCCGTCGAGCCGGACCTCGCCTTTGTGCTGCCGGCGGCCAACGCCATG
CTGCGCGAACGGATCGACGCGATGCGCGCGGAGCACCCCGGCCTGCACCTGTGGGTGGTCGACGGGCAGTCGCACGCCGC
GATGGAAGCGGCCGACGTGATCCTGCTCGCCAGCGGCACCGCGACGTTGGAGGCCGCGCTGTACAAGAAGCCGATGGTGA
TCACCTACAAGGTGCCCTGGCTGACCGCGCAGATCATGAAGCGCAAGGGCTACCTGCCGTACGTGGGCCTGCCGAACATC
CTGTCGGGCCGCTTTGTCGTGCCCGAACTGCTGCAGGACGATGCGACACCCGAGGCGCTCGCTCGCGAGACGCTGCTGCA
GCTCAGCGACCACGCCAACGCGGCGTTCCTGCGCGAGCACTTCACGCAGATGCACCTGACGCTCAAGCAGAACATGGCCG
ACATCGGCGCCCAGGTGGTGGTGGACCTGCTGCGCGGCCGCGGCAAACTCTGA

Upstream 100 bases:

>100_bases
AGATCGCCGCGCAGGTCGCGCAGACCGAAGATGCCCCGAGCCGCGAGGCGCTGCGCACCTTCGCCGACTTCATCGCCGCC
ACCAAGCGCGGCATCGTGCG

Downstream 100 bases:

>100_bases
GACCATGACGGCCGATTCCACCGAGATTCCGCAACTCGCGCTCCCGCTGTCGCAGTCGCCGGCGGCGGGCAAGCGCGCGC
GCCGCATCCTGTGCGGCGTC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTQPPAAPARRIGMAAGEASGDLLASLLLKGLHARLPRDVAYEGIGGARMAEQGFASHWPMHKLSVNGYVEVLGQLREIL
AIRRELKQNLLADPPMAFIGVDAPDFNFNVEIAMRRAGVPVVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYAR
AGIPATYVGHPLADEIPLEPDVEGARSRLGLPLGRKVVAVLPGSRNSEVKLLGPTLFAAMARMQAVEPDLAFVLPAANAM
LRERIDAMRAEHPGLHLWVVDGQSHAAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLPYVGLPNI
LSGRFVVPELLQDDATPEALARETLLQLSDHANAAFLREHFTQMHLTLKQNMADIGAQVVVDLLRGRGKL

Sequences:

>Translated_390_residues
MTQPPAAPARRIGMAAGEASGDLLASLLLKGLHARLPRDVAYEGIGGARMAEQGFASHWPMHKLSVNGYVEVLGQLREIL
AIRRELKQNLLADPPMAFIGVDAPDFNFNVEIAMRRAGVPVVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYAR
AGIPATYVGHPLADEIPLEPDVEGARSRLGLPLGRKVVAVLPGSRNSEVKLLGPTLFAAMARMQAVEPDLAFVLPAANAM
LRERIDAMRAEHPGLHLWVVDGQSHAAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLPYVGLPNI
LSGRFVVPELLQDDATPEALARETLLQLSDHANAAFLREHFTQMHLTLKQNMADIGAQVVVDLLRGRGKL
>Mature_389_residues
TQPPAAPARRIGMAAGEASGDLLASLLLKGLHARLPRDVAYEGIGGARMAEQGFASHWPMHKLSVNGYVEVLGQLREILA
IRRELKQNLLADPPMAFIGVDAPDFNFNVEIAMRRAGVPVVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYARA
GIPATYVGHPLADEIPLEPDVEGARSRLGLPLGRKVVAVLPGSRNSEVKLLGPTLFAAMARMQAVEPDLAFVLPAANAML
RERIDAMRAEHPGLHLWVVDGQSHAAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLPYVGLPNIL
SGRFVVPELLQDDATPEALARETLLQLSDHANAAFLREHFTQMHLTLKQNMADIGAQVVVDLLRGRGKL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=373, Percent_Identity=39.142091152815, Blast_Score=276, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_RALSO (Q8XZH8)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_519538.1
- ProteinModelPortal:   Q8XZH8
- GeneID:   1220241
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc1417
- NMPDR:   fig|267608.1.peg.1417
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- ProtClustDB:   PRK00025
- BioCyc:   RSOL267608:RSC1417-MONOMER
- BRENDA:   2.4.1.182
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 42549; Mature: 42418

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPPAAPARRIGMAAGEASGDLLASLLLKGLHARLPRDVAYEGIGGARMAEQGFASHWP
CCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHCHHHCCC
MHKLSVNGYVEVLGQLREILAIRRELKQNLLADPPMAFIGVDAPDFNFNVEIAMRRAGVP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEEECCCCC
VVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYARAGIPATYVGHPLADEIPLEP
EEEECCCCCEEECCCHHHHHHHHHHHEEEECCCCCCHHEECCCCHHHCCCCCCCCCCCCC
DVEGARSRLGLPLGRKVVAVLPGSRNSEVKLLGPTLFAAMARMQAVEPDLAFVLPAANAM
CCHHHHHHCCCCCCCEEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEHHHHHH
LRERIDAMRAEHPGLHLWVVDGQSHAAMEAADVILLASGTATLEAALYKKPMVITYKVPW
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEECCH
LTAQIMKRKGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLSDHANAAFLREH
HHHHHHHHCCCCCCCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
FTQMHLTLKQNMADIGAQVVVDLLRGRGKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQPPAAPARRIGMAAGEASGDLLASLLLKGLHARLPRDVAYEGIGGARMAEQGFASHWP
CCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHCHHHCCC
MHKLSVNGYVEVLGQLREILAIRRELKQNLLADPPMAFIGVDAPDFNFNVEIAMRRAGVP
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEEECCCCC
VVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYARAGIPATYVGHPLADEIPLEP
EEEECCCCCEEECCCHHHHHHHHHHHEEEECCCCCCHHEECCCCHHHCCCCCCCCCCCCC
DVEGARSRLGLPLGRKVVAVLPGSRNSEVKLLGPTLFAAMARMQAVEPDLAFVLPAANAM
CCHHHHHHCCCCCCCEEEEEECCCCCCCEEEECHHHHHHHHHHHHCCCCCEEEEHHHHHH
LRERIDAMRAEHPGLHLWVVDGQSHAAMEAADVILLASGTATLEAALYKKPMVITYKVPW
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCEEEEECCCHHHHHHHHCCCEEEEEECCH
LTAQIMKRKGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLSDHANAAFLREH
HHHHHHHHCCCCCCCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
FTQMHLTLKQNMADIGAQVVVDLLRGRGKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852