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The map label for this gene is ilvG [H]

Identifier: 17546072

GI number: 17546072

Start: 1440421

End: 1442166

Strand: Direct

Name: ilvG [H]

Synonym: RSc1353

Alternate gene names: 17546072

Gene position: 1440421-1442166 (Clockwise)

Preceding gene: 17546071

Following gene: 17546073

Centisome position: 38.76

GC content: 72.16

Gene sequence:

>1746_bases
ATGGAGACAGCCGTTGCCCGCCCGGTATCCACCGGCCCCACCGATTCCACCGATTCCGGTTCCCGTCCGGTCCCCCGGCA
CGGCGGACAGATCCTGGTCGATGCCCTGATCGCCCATGGCACGGACCTCGCCTTCGGCGTGCCGGGCGAGAGCTACCTGG
CCGTGCTGGAAGGCTTCTACCAGCGGCGCGACCGCGCGCGCTTCATCGTATGCCGGCAGGAGGGCGGGGCCGCCACCATG
GCCGACGCCCATGGCAAGCTGACCGGTCGCCCCGGCATCGTGTTCTGCACGCGCGGCCCCGGGGCGACCAACGCTAGCAT
CGGCGTGCACACCGCGTTCCAGGATTCCACGCCGCTGATCCTTTTCATTGGCCAGGTCGGCCGCGACTGCGTCGACCGCG
AAGCCTTCCAGGAGATCGACTACCGCCGCATGTTCGGCCAGATGGCCAAGTGGGTTGCGCAGATCGACAGCGTCGAGCGC
ATCCCCGAATACATCGCGCGCGCCTTCCAGACCGCGACGGCGGGGCGCCCCGGCCCGGTGGTGCTGGCGCTGCCCGAAGA
CATGCTCACCCAGGTCGCCACCGTGGCCGACGTGCCGCCGATGCCGCGCGCGATGGCGTGGCCCGCGCCGCACGATCTGG
CGCGGCTCAAGGCCCTGCTGGGCCGCGCCGAGCGCCCGCTGCTGCTGCTGGGCGGCGCCGGCTGGACGCCGCAGGCCGCC
GCGCGCCTGCAGGCCTTCGCCGAGCGCTGGCGCTTGCCGGTGGGCTGCGTGTTCCGCCGGCAGGATCTGTTCGACAACCG
CCATCCGAACTACGCCGGCGATGTCGGCATCGCCATCAACCCGAAGCTGGCGGCGCGCGTGCGCGAGGCGGACGTGGTGC
TCGCCATCGGCACGCGCCTGGGCGAGATGGCGACTTCGGGCTACACGCTGTTCGACGTGCCGCGCCCGCGGCAGACGCTG
ATCCACGTGCACGCCGGCGCCGAAGAGCTGGGCCGCGTCTACCAGGCCGATCTGATGATCCACGCGGCGATGCCCGCCAT
CGGCGAGGCGCTGGACGGCGTCGCGCCCGATGCGCCGCCGCGCTGGCAGGCCTGGACCGAGGCCGCGCATGCGGACTACC
TCGCCAACATCGCGCCGCCGCCGTTCGCCGGGCGGGGCATCGATCTGGCCCGCGCGATGCAATGGCTGCGCGAGCGCCTG
CCGCGCAACGCCATCCTGACCAACGGCGCGGGCAACTACGCCACCTGGCTGCATCGCTTCTACCAGTACGGGCCGCTGGC
CGCCGGCTCGCGCACCCAGCTCGCGCCGACCAGCGGGGCGATGGGCTATGGCGCCCCGGCGGCCGTGGCGGCCAAGATCG
CCTGTCCGCAGACGCCCGTGATCTGCCTCGCCGGCGACGGCTGCTTCCTGATGAACGGCCAGGAGCTGGCGACCGCCATG
CAGTACGACGCGCCGGTGATCTTCATCGTGGTCAACAACGGCATGTACGGCACCATTCGCATGCACCAGGAGCGCGCGTA
TCCGGAACACGTGAGCGGCACCGAGCTGCGCAACCCGGACTTCGCCGCGCTGGCGCGCGCCTACGGCGCCGAGGGCCACA
CCGTGCGTTCGCTGGAGGGCTTCCAGGCCGCGGTGGAGGCGGCGCTGGCGGTCCCGGTGGCCACCGTCATCGAAGTGCAG
ACCGATCCGGAGATCATCAGCCCGCGCGCAACCCTGCAATCGCTGCGTGCGCAGGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
GTTCCGGCAGATGTAGCGTCCCCATTCGGGGGTGTGCGCGGGCCGTCCTTCCGCTATGCTCGGTTGTATCGTCAACGAAT
CGATAGCGAGACGACCCGCC

Downstream 100 bases:

>100_bases
ACCCGTTCCATCCACGCCGACACCGCCATGACGACGATGATGATTCCCGTGACCGACCTGTGCGACGCGCACGAAGACCA
GCTCGCCAGCGGCGCCGTGC

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
METAVARPVSTGPTDSTDSGSRPVPRHGGQILVDALIAHGTDLAFGVPGESYLAVLEGFYQRRDRARFIVCRQEGGAATM
ADAHGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDCVDREAFQEIDYRRMFGQMAKWVAQIDSVER
IPEYIARAFQTATAGRPGPVVLALPEDMLTQVATVADVPPMPRAMAWPAPHDLARLKALLGRAERPLLLLGGAGWTPQAA
ARLQAFAERWRLPVGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVREADVVLAIGTRLGEMATSGYTLFDVPRPRQTL
IHVHAGAEELGRVYQADLMIHAAMPAIGEALDGVAPDAPPRWQAWTEAAHADYLANIAPPPFAGRGIDLARAMQWLRERL
PRNAILTNGAGNYATWLHRFYQYGPLAAGSRTQLAPTSGAMGYGAPAAVAAKIACPQTPVICLAGDGCFLMNGQELATAM
QYDAPVIFIVVNNGMYGTIRMHQERAYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQAAVEAALAVPVATVIEVQ
TDPEIISPRATLQSLRAQARG

Sequences:

>Translated_581_residues
METAVARPVSTGPTDSTDSGSRPVPRHGGQILVDALIAHGTDLAFGVPGESYLAVLEGFYQRRDRARFIVCRQEGGAATM
ADAHGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDCVDREAFQEIDYRRMFGQMAKWVAQIDSVER
IPEYIARAFQTATAGRPGPVVLALPEDMLTQVATVADVPPMPRAMAWPAPHDLARLKALLGRAERPLLLLGGAGWTPQAA
ARLQAFAERWRLPVGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVREADVVLAIGTRLGEMATSGYTLFDVPRPRQTL
IHVHAGAEELGRVYQADLMIHAAMPAIGEALDGVAPDAPPRWQAWTEAAHADYLANIAPPPFAGRGIDLARAMQWLRERL
PRNAILTNGAGNYATWLHRFYQYGPLAAGSRTQLAPTSGAMGYGAPAAVAAKIACPQTPVICLAGDGCFLMNGQELATAM
QYDAPVIFIVVNNGMYGTIRMHQERAYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQAAVEAALAVPVATVIEVQ
TDPEIISPRATLQSLRAQARG
>Mature_581_residues
METAVARPVSTGPTDSTDSGSRPVPRHGGQILVDALIAHGTDLAFGVPGESYLAVLEGFYQRRDRARFIVCRQEGGAATM
ADAHGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLILFIGQVGRDCVDREAFQEIDYRRMFGQMAKWVAQIDSVER
IPEYIARAFQTATAGRPGPVVLALPEDMLTQVATVADVPPMPRAMAWPAPHDLARLKALLGRAERPLLLLGGAGWTPQAA
ARLQAFAERWRLPVGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVREADVVLAIGTRLGEMATSGYTLFDVPRPRQTL
IHVHAGAEELGRVYQADLMIHAAMPAIGEALDGVAPDAPPRWQAWTEAAHADYLANIAPPPFAGRGIDLARAMQWLRERL
PRNAILTNGAGNYATWLHRFYQYGPLAAGSRTQLAPTSGAMGYGAPAAVAAKIACPQTPVICLAGDGCFLMNGQELATAM
QYDAPVIFIVVNNGMYGTIRMHQERAYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEGFQAAVEAALAVPVATVIEVQ
TDPEIISPRATLQSLRAQARG

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=569, Percent_Identity=25.6590509666081, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI21361361, Length=554, Percent_Identity=26.3537906137184, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI87081685, Length=544, Percent_Identity=27.7573529411765, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI1790104, Length=545, Percent_Identity=28.6238532110092, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786717, Length=572, Percent_Identity=26.9230769230769, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788716, Length=574, Percent_Identity=23.6933797909408, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1787096, Length=560, Percent_Identity=23.5714285714286, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17531301, Length=554, Percent_Identity=26.3537906137184, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17531299, Length=572, Percent_Identity=26.2237762237762, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17542570, Length=584, Percent_Identity=23.1164383561644, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323755, Length=575, Percent_Identity=27.304347826087, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6320816, Length=561, Percent_Identity=20.855614973262, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323073, Length=534, Percent_Identity=21.9101123595506, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922626, Length=564, Percent_Identity=26.9503546099291, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 62450; Mature: 62450

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METAVARPVSTGPTDSTDSGSRPVPRHGGQILVDALIAHGTDLAFGVPGESYLAVLEGFY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHH
QRRDRARFIVCRQEGGAATMADAHGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLI
HHCCCCEEEEEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEE
LFIGQVGRDCVDREAFQEIDYRRMFGQMAKWVAQIDSVERIPEYIARAFQTATAGRPGPV
EEECHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VLALPEDMLTQVATVADVPPMPRAMAWPAPHDLARLKALLGRAERPLLLLGGAGWTPQAA
EEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
ARLQAFAERWRLPVGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVREADVVLAIGTRL
HHHHHHHHHHCCCHHHEEEHHHHHCCCCCCCCCCEEEEECCHHHHHHHHCCEEEEECHHH
GEMATSGYTLFDVPRPRQTLIHVHAGAEELGRVYQADLMIHAAMPAIGEALDGVAPDAPP
HHHHCCCEEEEECCCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RWQAWTEAAHADYLANIAPPPFAGRGIDLARAMQWLRERLPRNAILTNGAGNYATWLHRF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
YQYGPLAAGSRTQLAPTSGAMGYGAPAAVAAKIACPQTPVICLAGDGCFLMNGQELATAM
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEECCHHHHHHH
QYDAPVIFIVVNNGMYGTIRMHQERAYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEG
HCCCCEEEEEECCCEEEEEEEECHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHH
FQAAVEAALAVPVATVIEVQTDPEIISPRATLQSLRAQARG
HHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
METAVARPVSTGPTDSTDSGSRPVPRHGGQILVDALIAHGTDLAFGVPGESYLAVLEGFY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHH
QRRDRARFIVCRQEGGAATMADAHGKLTGRPGIVFCTRGPGATNASIGVHTAFQDSTPLI
HHCCCCEEEEEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCCEE
LFIGQVGRDCVDREAFQEIDYRRMFGQMAKWVAQIDSVERIPEYIARAFQTATAGRPGPV
EEECHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VLALPEDMLTQVATVADVPPMPRAMAWPAPHDLARLKALLGRAERPLLLLGGAGWTPQAA
EEECCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
ARLQAFAERWRLPVGCVFRRQDLFDNRHPNYAGDVGIAINPKLAARVREADVVLAIGTRL
HHHHHHHHHHCCCHHHEEEHHHHHCCCCCCCCCCEEEEECCHHHHHHHHCCEEEEECHHH
GEMATSGYTLFDVPRPRQTLIHVHAGAEELGRVYQADLMIHAAMPAIGEALDGVAPDAPP
HHHHCCCEEEEECCCCHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RWQAWTEAAHADYLANIAPPPFAGRGIDLARAMQWLRERLPRNAILTNGAGNYATWLHRF
CCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
YQYGPLAAGSRTQLAPTSGAMGYGAPAAVAAKIACPQTPVICLAGDGCFLMNGQELATAM
HHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCEEEECCHHHHHHH
QYDAPVIFIVVNNGMYGTIRMHQERAYPEHVSGTELRNPDFAALARAYGAEGHTVRSLEG
HCCCCEEEEEECCCEEEEEEEECHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEHHHHH
FQAAVEAALAVPVATVIEVQTDPEIISPRATLQSLRAQARG
HHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]