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The map label for this gene is pcaK [H]

Identifier: 17545812

GI number: 17545812

Start: 1150277

End: 1151641

Strand: Reverse

Name: pcaK [H]

Synonym: RSc1093

Alternate gene names: 17545812

Gene position: 1151641-1150277 (Counterclockwise)

Preceding gene: 17545817

Following gene: 17545810

Centisome position: 30.99

GC content: 70.55

Gene sequence:

>1365_bases
ATGCTGCCCCCAAGTCCCGTGATTGACGTCCGCGCCTGGCTCGACCGCCAGCGCTTTTCCGCGTTCCAGTGGAGCGTGGT
GCTGTTGTGCTTCTTCGTCGTCGCCATCGACGGATTCGATACGGCATGCGTCGGCTTCATCGCGCCGGCGCTGGCGCAGG
ATTGGCACATCGGCCCCGCAGTCCTGGGCACCGTGTTCAGCGCCGGGCTGGCGGGGCTGATGGTCGGCGCGCTGATCTTC
GGCCCGCTGGCCGACCGCATCGGGCGCAAGCAGACGCTGCTGTTCACGGTCGGGGCCTTCGGCCTCGCGAGCGTGCTGTC
GGCGTTCGCGCCGTCGGTCGGCGCGCTGGTCGCGCTGCGCTTCCTCACCGGGCTCGGGCTGGGCGGGGCGATGCCGAACG
CCATCGCCCTGACCTCGGAGTACTGCCCCGAGCGCCGCCGCGCGTTCCTGACCACCGTGATGTTCTGCGGCTTCACGCTG
GGGTCGGGTTTCGGCGGCATCGTCGCGGCCCAGCTGGTGCCGGAGTTCGGCTGGCGCAGCGTGCTGCTGTTCGGCGGCGT
GATCCCGCTGTTGCTGCTGCCGGTGATGGTGTTCGCGCTGCCCGAGTCGGTCCGCTACCTGGTGGCCAAGGGCGGACAGA
GCGCCGCGGTCGGCCGGCTGCTCAACCGGATCGCGCCGGTGCAGGTCACACCGGACACGCGCTTCGTGCTCCATGAAACG
GCGGCGAAAGGCGCGCCGGGGTCGCCGGTCAGGCAGCTCTTCCTGCCCGCGTTCCGGACGGGCACGTTGCTGCTGTGGTC
GGTGTTCTTCATGAGCCTGCTGATCGTCTATCTGATGACGAACTGGCTGCCCACGCTGATCCATTCGGGCGGCGTGGCGC
TGGCCCTGGCGTCGCGCATCGCGGTGATGTACCAGCTTGGCGGGACGGTCGGCGCGCTGGTCATCGGCCGCATGATGGAC
CGGTATCCCGCCACGGTGGTGCTGTGCTGCACGTATGGGCTCGGTGCCGGCTTCCTGGTGCTGACCGGCGTGTCGCAGGG
GACGATGCTGGCCATCGCCGTCACGGGCGTGGGCTTCTGCATCAGCGGCTCGCAGATCGGCGCCAATGCGTTCGCCGCGC
AGTTCTACCCGACCGCGAGCCGCGTGACGGGGATCAGCTGGGCGCTCGGCATCGGGCGCCTCGGCTCGGTGTGCGGCGCG
CTGATCGGCGGCGTGCTGCTGGCCGCGAACATCGGGTTCCAGCTGCTGTTCCTGCTGGTCGCCGTGCCGGCCGCCATCGC
ATCGCTCGCGATCTTCCTGTGCGGCGCGCAGGCCCGGCACGTCGAGACGCAGGGCGCCCTGCCCGCCGTCACCGAAGGCG
CCTGA

Upstream 100 bases:

>100_bases
AATCCCGTGAATGGCGGGCATTCACCATCCGACTGGACTGCGCCCTGACGCGCGGGCACGCTTCGCGGCACACACCACAC
AAGAGCGTGAAGGAGACATC

Downstream 100 bases:

>100_bases
GCCATCGCATCATCGAGCCGTCGCGCGGGCAGCGCCGCCTGCGTGGCGGACTGCCCGCCGCATTTTCGCTAGATCGCAAA
GGTCTCGAACAGCAACTGCC

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MLPPSPVIDVRAWLDRQRFSAFQWSVVLLCFFVVAIDGFDTACVGFIAPALAQDWHIGPAVLGTVFSAGLAGLMVGALIF
GPLADRIGRKQTLLFTVGAFGLASVLSAFAPSVGALVALRFLTGLGLGGAMPNAIALTSEYCPERRRAFLTTVMFCGFTL
GSGFGGIVAAQLVPEFGWRSVLLFGGVIPLLLLPVMVFALPESVRYLVAKGGQSAAVGRLLNRIAPVQVTPDTRFVLHET
AAKGAPGSPVRQLFLPAFRTGTLLLWSVFFMSLLIVYLMTNWLPTLIHSGGVALALASRIAVMYQLGGTVGALVIGRMMD
RYPATVVLCCTYGLGAGFLVLTGVSQGTMLAIAVTGVGFCISGSQIGANAFAAQFYPTASRVTGISWALGIGRLGSVCGA
LIGGVLLAANIGFQLLFLLVAVPAAIASLAIFLCGAQARHVETQGALPAVTEGA

Sequences:

>Translated_454_residues
MLPPSPVIDVRAWLDRQRFSAFQWSVVLLCFFVVAIDGFDTACVGFIAPALAQDWHIGPAVLGTVFSAGLAGLMVGALIF
GPLADRIGRKQTLLFTVGAFGLASVLSAFAPSVGALVALRFLTGLGLGGAMPNAIALTSEYCPERRRAFLTTVMFCGFTL
GSGFGGIVAAQLVPEFGWRSVLLFGGVIPLLLLPVMVFALPESVRYLVAKGGQSAAVGRLLNRIAPVQVTPDTRFVLHET
AAKGAPGSPVRQLFLPAFRTGTLLLWSVFFMSLLIVYLMTNWLPTLIHSGGVALALASRIAVMYQLGGTVGALVIGRMMD
RYPATVVLCCTYGLGAGFLVLTGVSQGTMLAIAVTGVGFCISGSQIGANAFAAQFYPTASRVTGISWALGIGRLGSVCGA
LIGGVLLAANIGFQLLFLLVAVPAAIASLAIFLCGAQARHVETQGALPAVTEGA
>Mature_454_residues
MLPPSPVIDVRAWLDRQRFSAFQWSVVLLCFFVVAIDGFDTACVGFIAPALAQDWHIGPAVLGTVFSAGLAGLMVGALIF
GPLADRIGRKQTLLFTVGAFGLASVLSAFAPSVGALVALRFLTGLGLGGAMPNAIALTSEYCPERRRAFLTTVMFCGFTL
GSGFGGIVAAQLVPEFGWRSVLLFGGVIPLLLLPVMVFALPESVRYLVAKGGQSAAVGRLLNRIAPVQVTPDTRFVLHET
AAKGAPGSPVRQLFLPAFRTGTLLLWSVFFMSLLIVYLMTNWLPTLIHSGGVALALASRIAVMYQLGGTVGALVIGRMMD
RYPATVVLCCTYGLGAGFLVLTGVSQGTMLAIAVTGVGFCISGSQIGANAFAAQFYPTASRVTGISWALGIGRLGSVCGA
LIGGVLLAANIGFQLLFLLVAVPAAIASLAIFLCGAQARHVETQGALPAVTEGA

Specific function: Could Be A Transporter For 3-Phenylpropionate (Hydrocinnamic Acid). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=421, Percent_Identity=28.2660332541568, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI166064021, Length=378, Percent_Identity=28.8359788359788, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI8923870, Length=358, Percent_Identity=26.8156424581006, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI7662270, Length=318, Percent_Identity=22.9559748427673, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI216548223, Length=324, Percent_Identity=23.7654320987654, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI213021148, Length=236, Percent_Identity=26.6949152542373, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI73695465, Length=207, Percent_Identity=28.0193236714976, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI296080721, Length=157, Percent_Identity=29.9363057324841, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI296080719, Length=157, Percent_Identity=29.9363057324841, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI24497499, Length=157, Percent_Identity=29.9363057324841, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI296080734, Length=157, Percent_Identity=29.9363057324841, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI262399383, Length=260, Percent_Identity=23.8461538461538, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI20070188, Length=380, Percent_Identity=25.7894736842105, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI24497476, Length=379, Percent_Identity=25.3298153034301, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87081723, Length=418, Percent_Identity=34.688995215311, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI1788074, Length=355, Percent_Identity=24.7887323943662, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786229, Length=198, Percent_Identity=30.3030303030303, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87082159, Length=392, Percent_Identity=25.765306122449, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI87082404, Length=181, Percent_Identity=28.7292817679558, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788068, Length=451, Percent_Identity=22.3946784922395, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082231, Length=192, Percent_Identity=21.875, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=436, Percent_Identity=25, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI32565921, Length=218, Percent_Identity=30.7339449541284, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320595, Length=191, Percent_Identity=28.2722513089005, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI19922874, Length=243, Percent_Identity=27.1604938271605, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24640198, Length=229, Percent_Identity=26.2008733624454, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640196, Length=229, Percent_Identity=26.2008733624454, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24640200, Length=229, Percent_Identity=26.2008733624454, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47185; Mature: 47185

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00120 LIPASE_SER ; PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8063101 [H]