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The map label for this gene is hemH

Identifier: 17545293

GI number: 17545293

Start: 618408

End: 619316

Strand: Direct

Name: hemH

Synonym: RSc0574

Alternate gene names: 17545293

Gene position: 618408-619316 (Clockwise)

Preceding gene: 17545292

Following gene: 17545294

Centisome position: 16.64

GC content: 68.21

Gene sequence:

>909_bases
GTGTCTTCCGCACTCTATGAATCGTCGATCACCAGCCTGCCGCTGCTCGGCCGCGGCAAGGTGCGCGAAAACTACGCCGT
GGGCGACGACAAGCTGCTGATGGTCACCACCGACCGCCTGTCGGCCTTCGACGTGATCCTCGGCCAGCCGATTCCGGACA
AGGGCCGCGTCCTGGCGCAGATGTCGGATTTCTGGTTCCGCAAGCTGCGCCACATCGTGCCGACGCACGAGACGGGCATT
GCGCCGGAAGCGGTGGTGCAGCCCGGCGAAGCCGACCAGGTGCGCGGCCGCGCCATCGTGGTCAAGCGTCTCAAGCCGAT
CCTGGTGGAAGCCGTGGTGCGCGGCTACCTGGCCGGCAGCGGCTGGAAGGACTACCAGGCCACCGGCAAGGTCTGCGGCG
TGCAGCTCGCCCCCGGCCTGCGCAACGCCGAGAAGCTGCCCGAGCCCATCTTCACCCCCGCCGCCAAGGCCGACGTGGGC
GAGCACGACGAGAACATCTCGTTCGACGAAGTCGAGCGCCGCATCGGCCCCGAGCTGGCCGCGCAGATCCGCGACGTCAG
CATCCGCCTGTACAAGGAAGCCTCCGACTTTGCCGCCACGCGCGGCATCATCATCGCCGACACCAAGTTCGAGTTCGGCC
TGGACGAGAACGGCACGCTCACGCTGATGGACGAAGCGCTGACCGCCGATTCGTCGCGCTTCTGGCCGGCCGATTCGTAC
CAGGTGGGCACCAACCCGCCGTCGTTCGACAAGCAGTTCGTGCGCGACTGGCTGGAGGCCGTGCGCATCGACGGCCAGCC
GTGGCCGAAGACCGCGCCGGCGCCGCAGCTGCCCGCCGACATCATCGAGAAGACCGCGGACAAGTACCGCGAAGCACTGA
CCCGCCTGACCGGCGAGACGCTGCGCTGA

Upstream 100 bases:

>100_bases
CCCCGCGCCAGCCGTTTTTCATGGGGCCGGCCACGTATAATGTCGGCCTTCCACATTTTTTTCTTCCTCTTTGGGTTTCG
CCGTGTCCGCCACCCCCGCC

Downstream 100 bases:

>100_bases
GGGAGCGACGACGATGACCGCATCGCAATCCGCGCCGCTCGTCGGCGTCGTCATGGGTTCCAGCTCCGACTGGGACGTCA
TGCAGCACGCCGTGGTCCTG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQMSDFWFRKLRHIVPTHETGI
APEAVVQPGEADQVRGRAIVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGVQLAPGLRNAEKLPEPIFTPAAKADVG
EHDENISFDEVERRIGPELAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFWPADSY
QVGTNPPSFDKQFVRDWLEAVRIDGQPWPKTAPAPQLPADIIEKTADKYREALTRLTGETLR

Sequences:

>Translated_302_residues
MSSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQMSDFWFRKLRHIVPTHETGI
APEAVVQPGEADQVRGRAIVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGVQLAPGLRNAEKLPEPIFTPAAKADVG
EHDENISFDEVERRIGPELAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFWPADSY
QVGTNPPSFDKQFVRDWLEAVRIDGQPWPKTAPAPQLPADIIEKTADKYREALTRLTGETLR
>Mature_301_residues
SSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQMSDFWFRKLRHIVPTHETGIA
PEAVVQPGEADQVRGRAIVVKRLKPILVEAVVRGYLAGSGWKDYQATGKVCGVQLAPGLRNAEKLPEPIFTPAAKADVGE
HDENISFDEVERRIGPELAAQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFWPADSYQ
VGTNPPSFDKQFVRDWLEAVRIDGQPWPKTAPAPQLPADIIEKTADKYREALTRLTGETLR

Specific function: Unknown

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=296, Percent_Identity=44.5945945945946, Blast_Score=263, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PUR7_RALSO (Q8Y1W3)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518695.1
- ProteinModelPortal:   Q8Y1W3
- SMR:   Q8Y1W3
- GeneID:   1219379
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0574
- NMPDR:   fig|267608.1.peg.574
- HOGENOM:   HBG555040
- OMA:   LTLMDEV
- ProtClustDB:   PRK13961
- BioCyc:   RSOL267608:RSC0574-MONOMER
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 33375; Mature: 33244

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQ
CCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHH
MSDFWFRKLRHIVPTHETGIAPEAVVQPGEADQVRGRAIVVKRLKPILVEAVVRGYLAGS
HHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GWKDYQATGKVCGVQLAPGLRNAEKLPEPIFTPAAKADVGEHDENISFDEVERRIGPELA
CCCCHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHH
AQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFWPADSY
HHHHHHHHEEEHHHHHHHHHCCEEEEECCEEECCCCCCEEEEEEHHHCCCCCCCCCCCCE
QVGTNPPSFDKQFVRDWLEAVRIDGQPWPKTAPAPQLPADIIEKTADKYREALTRLTGET
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LR
CC
>Mature Secondary Structure 
SSALYESSITSLPLLGRGKVRENYAVGDDKLLMVTTDRLSAFDVILGQPIPDKGRVLAQ
CCHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHHH
MSDFWFRKLRHIVPTHETGIAPEAVVQPGEADQVRGRAIVVKRLKPILVEAVVRGYLAGS
HHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
GWKDYQATGKVCGVQLAPGLRNAEKLPEPIFTPAAKADVGEHDENISFDEVERRIGPELA
CCCCHHCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCHHHH
AQIRDVSIRLYKEASDFAATRGIIIADTKFEFGLDENGTLTLMDEALTADSSRFWPADSY
HHHHHHHHEEEHHHHHHHHHCCEEEEECCEEECCCCCCEEEEEEHHHCCCCCCCCCCCCE
QVGTNPPSFDKQFVRDWLEAVRIDGQPWPKTAPAPQLPADIIEKTADKYREALTRLTGET
ECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852