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The map label for this gene is fbaA [H]

Identifier: 17545292

GI number: 17545292

Start: 617215

End: 618279

Strand: Direct

Name: fbaA [H]

Synonym: RSc0573

Alternate gene names: 17545292

Gene position: 617215-618279 (Clockwise)

Preceding gene: 17545291

Following gene: 17545293

Centisome position: 16.61

GC content: 65.26

Gene sequence:

>1065_bases
ATGCCACTCGTCTCGATGCGCCAACTGCTCGACCATGCCGCTGAAAACGGCTACGGCCTGCCAGCGTTCAACGTCAACAA
CCTGGAGCAGGTCCAGGCCGTGATGGAAGCTGCCAAGGAAACCGGCGCGCCGGTGATCCTGCAGGCCAGCGCGGGCGCCC
GCAAGTACGCCGGCGAGTCCTTCATCAAGCACCTGATCCAGGCCGCTGTTGAAGCCTATCCGGAAATCCCGCTGGTCATG
CACCAGGATCACGGTCAGAGCCCGGCAATCTGCCAGGGCGCGATCGACCTGGGCTTCGGCTCGGTCATGATGGACGGCTC
GCTGCACGAGGATGGCAAGACCCCGGCCTCGTTCGACTACAACGTCGACGTCACGCGCCGCGTGGTCGACATGGCGCACA
AGGTTGGCGTGACGGTCGAGGGCGAGCTCGGCTGCCTGGGCTCGCTGGAAACCGGCGAGGCGGGCGAGGAAGATGGCCAC
GGCGCCGTCGGCAAGCTCGACCATTCGGCCCTGCTGACCGACCCCGAGGAAGCCGCGCAGTTCGTCAAGGCCACCCAGCT
CGACGCCCTGGCCATCGCCATCGGCACCAGCCACGGCGCCTACAAGTTCTCGCGCAAGCCCACCGGCGACATCCTGGCGA
TCAGCCGCGTCAAGGAAATTCACGCGCGCATCCCGAATACCCACCTGGTGATGCACGGCTCGTCGAGCGTGCCGCAGGAG
CTGCTGGCCATCATCAACCAGTACGGCGGCAAGATGAAGGAAACCTACGGCGTGCCGGTCGAGGAAATCCAGGAGGCCAT
CAAGTACGGCGTGCGCAAGATCAACATCGACACCGACATCCGCCTGGCGATGACCGGCGCGGTGCGCAAGTTCCTGGCCG
AAAACCCCGAGAAGTTCGACGCCCGCGAATGGCTCAAGCCCGCGCGCGAGGCTGCCAAGGCGGTTTGCAAGGCACGCTAC
ATCGAGTTCGGTTGCGAAGGCCAGGCCGGCAAGATCAAGCCGATCGGCCTGTCGGTCATCGCTTCGCAGTACCAGAGCGG
CGCGCTGGCGCAAGTGGTGCAGTAA

Upstream 100 bases:

>100_bases
CAAGATCGTGCGCGTCGGCATGCACTGACGCGCCACCGGGAATGCCGGTTGCTACCGGCATCCGTGAGACCGAATACAGA
TCGACCCATAGGAGAAAACC

Downstream 100 bases:

>100_bases
GCCGCATTCCGCCCGCAAGAACGGCTGGCCCCGCGCCAGCCGTTTTTCATGGGGCCGGCCACGTATAATGTCGGCCTTCC
ACATTTTTTTCTTCCTCTTT

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKETGAPVILQASAGARKYAGESFIKHLIQAAVEAYPEIPLVM
HQDHGQSPAICQGAIDLGFGSVMMDGSLHEDGKTPASFDYNVDVTRRVVDMAHKVGVTVEGELGCLGSLETGEAGEEDGH
GAVGKLDHSALLTDPEEAAQFVKATQLDALAIAIGTSHGAYKFSRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPEKFDAREWLKPAREAAKAVCKARY
IEFGCEGQAGKIKPIGLSVIASQYQSGALAQVVQ

Sequences:

>Translated_354_residues
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKETGAPVILQASAGARKYAGESFIKHLIQAAVEAYPEIPLVM
HQDHGQSPAICQGAIDLGFGSVMMDGSLHEDGKTPASFDYNVDVTRRVVDMAHKVGVTVEGELGCLGSLETGEAGEEDGH
GAVGKLDHSALLTDPEEAAQFVKATQLDALAIAIGTSHGAYKFSRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPEKFDAREWLKPAREAAKAVCKARY
IEFGCEGQAGKIKPIGLSVIASQYQSGALAQVVQ
>Mature_353_residues
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKETGAPVILQASAGARKYAGESFIKHLIQAAVEAYPEIPLVMH
QDHGQSPAICQGAIDLGFGSVMMDGSLHEDGKTPASFDYNVDVTRRVVDMAHKVGVTVEGELGCLGSLETGEAGEEDGHG
AVGKLDHSALLTDPEEAAQFVKATQLDALAIAIGTSHGAYKFSRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQEL
LAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPEKFDAREWLKPAREAAKAVCKARYI
EFGCEGQAGKIKPIGLSVIASQYQSGALAQVVQ

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=319, Percent_Identity=33.8557993730408, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI87082041, Length=329, Percent_Identity=34.6504559270517, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1788072, Length=332, Percent_Identity=31.0240963855422, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789293, Length=369, Percent_Identity=25.4742547425474, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322790, Length=351, Percent_Identity=26.2108262108262, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 37954; Mature: 37823

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKETGAPVILQASAGARKYAGES
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLIQAAVEAYPEIPLVMHQDHGQSPAICQGAIDLGFGSVMMDGSLHEDGKTPASFDY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
NVDVTRRVVDMAHKVGVTVEGELGCLGSLETGEAGEEDGHGAVGKLDHSALLTDPEEAAQ
CCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHH
FVKATQLDALAIAIGTSHGAYKFSRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPEKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
AREWLKPAREAAKAVCKARYIEFGCEGQAGKIKPIGLSVIASQYQSGALAQVVQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure 
PLVSMRQLLDHAAENGYGLPAFNVNNLEQVQAVMEAAKETGAPVILQASAGARKYAGES
CHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FIKHLIQAAVEAYPEIPLVMHQDHGQSPAICQGAIDLGFGSVMMDGSLHEDGKTPASFDY
HHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCCC
NVDVTRRVVDMAHKVGVTVEGELGCLGSLETGEAGEEDGHGAVGKLDHSALLTDPEEAAQ
CCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHHHH
FVKATQLDALAIAIGTSHGAYKFSRKPTGDILAISRVKEIHARIPNTHLVMHGSSSVPQE
HHHHHHHCEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LLAIINQYGGKMKETYGVPVEEIQEAIKYGVRKINIDTDIRLAMTGAVRKFLAENPEKFD
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHCCCCCCC
AREWLKPAREAAKAVCKARYIEFGCEGQAGKIKPIGLSVIASQYQSGALAQVVQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550527 [H]