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The map label for this gene is fis [C]

Identifier: 17545224

GI number: 17545224

Start: 539551

End: 539784

Strand: Reverse

Name: fis [C]

Synonym: RSc0505

Alternate gene names: 17545224

Gene position: 539784-539551 (Counterclockwise)

Preceding gene: 17545225

Following gene: 17545223

Centisome position: 14.52

GC content: 61.54

Gene sequence:

>234_bases
ATGAGCCGCAACCCCATCGAACGCTGCATCCGGGACAGCCTGGATACGTACTACCGCGACCTGGACGGCGAGAACCCGTC
CAACGTCTACGACATGGTGCTGCAGGCCATCGAGCGACCGCTGCTGGAGACCGTGATGGAATGGGCCTCCAACAACCAGT
CGCTGGCCGCCGATTATCTCGGCATCAACCGCAACACGCTGCGCAAGAAACTGCAGCAGCACGGACTGCTCTGA

Upstream 100 bases:

>100_bases
GCGCGCTGTCCGACCGCCTGGTCTACACGGACCAGGACGATGCCGCGGGCGGCCCTCCCACGACGGGCAACAACAACGAC
AACAAGGAACTGCTTGCCGC

Downstream 100 bases:

>100_bases
GGCGGCCCGGCACCGTGCCCCGCCGCATCCCGATGTTCCTTTCCTGACGGCGCCTCGCCGCGCCCCATCCGCCTGACGGC
GTTTCCACCATGATCCAGCA

Product: DNA-binding protein Fis

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 77; Mature: 76

Protein sequence:

>77_residues
MSRNPIERCIRDSLDTYYRDLDGENPSNVYDMVLQAIERPLLETVMEWASNNQSLAADYLGINRNTLRKKLQQHGLL

Sequences:

>Translated_77_residues
MSRNPIERCIRDSLDTYYRDLDGENPSNVYDMVLQAIERPLLETVMEWASNNQSLAADYLGINRNTLRKKLQQHGLL
>Mature_76_residues
SRNPIERCIRDSLDTYYRDLDGENPSNVYDMVLQAIERPLLETVMEWASNNQSLAADYLGINRNTLRKKLQQHGLL

Specific function: Activates Ribosomal RNA Transcription. Plays A Direct Role In Upstream Activation Of rRNA Promoters. Binds To A Recombinational Enhancer Sequence That Is Required To Stimulate Hin-Mediated DNA Inversion. Prevents Initiation Of DNA Replication From Oric.

COG id: COG2901

COG function: function code KL; Factor for inversion stimulation Fis, transcriptional activator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transcriptional regulatory fis family

Homologues:

Organism=Escherichia coli, GI1789661, Length=76, Percent_Identity=38.1578947368421, Blast_Score=72, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FISL_RALSO (Q8Y231)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518626.1
- ProteinModelPortal:   Q8Y231
- SMR:   Q8Y231
- GeneID:   1219309
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0505
- NMPDR:   fig|267608.1.peg.505
- HOGENOM:   HBG509520
- OMA:   EMVLCEV
- ProtClustDB:   PRK01905
- BioCyc:   RSOL267608:RSC0505-MONOMER
- HAMAP:   MF_00166
- InterPro:   IPR005412
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- PIRSF:   PIRSF002097
- PRINTS:   PR01591
- PRINTS:   PR01590

Pfam domain/function: PF02954 HTH_8; SSF46689 Homeodomain_like

EC number: NA

Molecular weight: Translated: 8968; Mature: 8837

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRNPIERCIRDSLDTYYRDLDGENPSNVYDMVLQAIERPLLETVMEWASNNQSLAADYL
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GINRNTLRKKLQQHGLL
CCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SRNPIERCIRDSLDTYYRDLDGENPSNVYDMVLQAIERPLLETVMEWASNNQSLAADYL
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GINRNTLRKKLQQHGLL
CCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852