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The map label for this gene is coaX

Identifier: 17545030

GI number: 17545030

Start: 342361

End: 343248

Strand: Reverse

Name: coaX

Synonym: RSc0311

Alternate gene names: 17545030

Gene position: 343248-342361 (Counterclockwise)

Preceding gene: 229259639

Following gene: 17545029

Centisome position: 9.24

GC content: 75.11

Gene sequence:

>888_bases
ATGATCCGCCTCAAGGCCCCCACCCCCGAGCGGCCGCTGCTGCTGATCGACGCCGGCAATACGCGCATCAAATGGGCCTG
GACTGCCGCCGACGTCGCCCCGCCGGCCGTCGCCCCCGGCGGCACGCCCTGGCAGCATGCCGGCGCGCGACCGCACGACC
AGTTGGCCGAACTGGTGGAAGACTGGCGCGACTGCCACGCCGGCGCGGGCATGGCACCGCCCGACGTGTGGATCAGCGTG
GTCGCCGGCCCGGCCCTGCGCGATGCGCTGTGCGCCCGCATCGCCCGCGTCTTCGATGGCGCGCGCCTGCGCATCGTCGC
CTCCGAGGCCGCCGCCGCCGGGTTGCGCAACGGCTATCGGGACCCCGCCCAGCTCGGCACCGACCGCTGGGTGGGCGCCG
TCGGGGCCCGCCACGCGTGGCCGGACACGGCGCTGCTGCTGGTCACGGCCGGCACCGCCACCACGCTCGACATCGTCGCG
CCCGACGGCCGCTTCGCCGGCGGGCTCATCCTGCCCGGACTCACGCTGATGATGCGCGCGCTGTCGCGCAACACGGCGCA
GCTGCCCGAGATCGACATCGGCTACCTGGCCGCGCGTGACGACGCCCAGGCCCCCGCCGACGTGCCGTCCTGGGCCGACA
ACACGCAGGATGCGATCGCGCTGGGCTGCGTGACCGCCCAGGCGGGCGCCATTGCCCAGACCTGGCAGGCCCTGCAGGCG
CAATACCCGGGGCCGTACCGCTGCGTGCTGAGCGGCGGCGCGCGCGCGGCACTCGCCCCGCACCTGCGCATGCCGTTCCA
GATGCACGATAATCTGGTGCTGCTCGGCCTCCAGGTGCTGGCGCACACCGGCCACGAAGGCCGCCCCGGCGCCGCGACGC
AAGCCTGA

Upstream 100 bases:

>100_bases
GCATCGATGCCCAGGGACGCCTGGCCATCGAATCCGGCGGACGCGTGCAGTGGATCCACAGCGGCGAGGTGTCCTTGCGC
GCGGCCGACGCGGAGCAGCC

Downstream 100 bases:

>100_bases
GCACCATCGCCGTTCCCGTTTCCCTGTTGTAGCCGTGTTCCTGCATTCCGCACCACCGTCCGACGCCGATTCCCGCACCA
TGACGCTTCGCCTCGCCCTG

Product: pantothenate kinase

Products: NA

Alternate protein names: PanK-III; Pantothenic acid kinase

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIRLKAPTPERPLLLIDAGNTRIKWAWTAADVAPPAVAPGGTPWQHAGARPHDQLAELVEDWRDCHAGAGMAPPDVWISV
VAGPALRDALCARIARVFDGARLRIVASEAAAAGLRNGYRDPAQLGTDRWVGAVGARHAWPDTALLLVTAGTATTLDIVA
PDGRFAGGLILPGLTLMMRALSRNTAQLPEIDIGYLAARDDAQAPADVPSWADNTQDAIALGCVTAQAGAIAQTWQALQA
QYPGPYRCVLSGGARAALAPHLRMPFQMHDNLVLLGLQVLAHTGHEGRPGAATQA

Sequences:

>Translated_295_residues
MIRLKAPTPERPLLLIDAGNTRIKWAWTAADVAPPAVAPGGTPWQHAGARPHDQLAELVEDWRDCHAGAGMAPPDVWISV
VAGPALRDALCARIARVFDGARLRIVASEAAAAGLRNGYRDPAQLGTDRWVGAVGARHAWPDTALLLVTAGTATTLDIVA
PDGRFAGGLILPGLTLMMRALSRNTAQLPEIDIGYLAARDDAQAPADVPSWADNTQDAIALGCVTAQAGAIAQTWQALQA
QYPGPYRCVLSGGARAALAPHLRMPFQMHDNLVLLGLQVLAHTGHEGRPGAATQA
>Mature_295_residues
MIRLKAPTPERPLLLIDAGNTRIKWAWTAADVAPPAVAPGGTPWQHAGARPHDQLAELVEDWRDCHAGAGMAPPDVWISV
VAGPALRDALCARIARVFDGARLRIVASEAAAAGLRNGYRDPAQLGTDRWVGAVGARHAWPDTALLLVTAGTATTLDIVA
PDGRFAGGLILPGLTLMMRALSRNTAQLPEIDIGYLAARDDAQAPADVPSWADNTQDAIALGCVTAQAGAIAQTWQALQA
QYPGPYRCVLSGGARAALAPHLRMPFQMHDNLVLLGLQVLAHTGHEGRPGAATQA

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis

COG id: COG1521

COG function: function code K; Putative transcriptional regulator, homolog of Bvg accessory factor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type III pantothenate kinase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAX_RALSO (Q8Y2M4)

Other databases:

- EMBL:   AL646052
- RefSeq:   NP_518432.1
- ProteinModelPortal:   Q8Y2M4
- SMR:   Q8Y2M4
- GeneID:   1219114
- GenomeReviews:   AL646052_GR
- KEGG:   rso:RSc0311
- NMPDR:   fig|267608.1.peg.311
- HOGENOM:   HBG634537
- OMA:   LHAMAMA
- ProtClustDB:   PRK13328
- BioCyc:   RSOL267608:RSC0311-MONOMER
- BRENDA:   2.7.1.33
- GO:   GO:0005737
- HAMAP:   MF_01274
- InterPro:   IPR004619
- TIGRFAMs:   TIGR00671

Pfam domain/function: PF03309 Bvg_acc_factor

EC number: =2.7.1.33

Molecular weight: Translated: 30991; Mature: 30991

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: ACT_SITE 128-128 BINDING 119-119 BINDING 152-152 BINDING 215-215

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLKAPTPERPLLLIDAGNTRIKWAWTAADVAPPAVAPGGTPWQHAGARPHDQLAELVE
CEEECCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
DWRDCHAGAGMAPPDVWISVVAGPALRDALCARIARVFDGARLRIVASEAAAAGLRNGYR
HHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCC
DPAQLGTDRWVGAVGARHAWPDTALLLVTAGTATTLDIVAPDGRFAGGLILPGLTLMMRA
CHHHHCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
LSRNTAQLPEIDIGYLAARDDAQAPADVPSWADNTQDAIALGCVTAQAGAIAQTWQALQA
HHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHH
QYPGPYRCVLSGGARAALAPHLRMPFQMHDNLVLLGLQVLAHTGHEGRPGAATQA
CCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIRLKAPTPERPLLLIDAGNTRIKWAWTAADVAPPAVAPGGTPWQHAGARPHDQLAELVE
CEEECCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
DWRDCHAGAGMAPPDVWISVVAGPALRDALCARIARVFDGARLRIVASEAAAAGLRNGYR
HHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCC
DPAQLGTDRWVGAVGARHAWPDTALLLVTAGTATTLDIVAPDGRFAGGLILPGLTLMMRA
CHHHHCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
LSRNTAQLPEIDIGYLAARDDAQAPADVPSWADNTQDAIALGCVTAQAGAIAQTWQALQA
HHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCHHHHHHHHHHH
QYPGPYRCVLSGGARAALAPHLRMPFQMHDNLVLLGLQVLAHTGHEGRPGAATQA
CCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852