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The map label for this gene is birA [H]

Identifier: 229259639

GI number: 229259639

Start: 343245

End: 344135

Strand: Reverse

Name: birA [H]

Synonym: RSc0312

Alternate gene names: 229259639

Gene position: 344135-343245 (Counterclockwise)

Preceding gene: 17545040

Following gene: 17545030

Centisome position: 9.26

GC content: 74.86

Gene sequence:

>891_bases
GTGTTTGCCCAGCTCATGTCTTCCGCCCCCATCCCTGCGCGCTGGCGCCTGACCCGCGACCGCATCCGGCCAACCGGCAT
CGCCGCCGGCTGGCCGGTCGAGGTGGTCGAGTCCACCGGCTCCACCAATGCGGACCTGATGGCCGCCGTGCGCGACGCCG
CCTGGCCCGTGGCCGCCGGCGTGCCGGCCGGCACGGCGCCGCTGGTGGGCGGGCGTGTGCTGGCGGCGCTGCGGCAGACC
GCCGGCCGCGGCCGCCAGGGCCGCCCGTGGGATGGCGATCACGGCCTGACCTTTTCCGTCGCCTGCGCCTTTGCCGCCGA
ACCCGCGCAACTGGCTGGCCTGAGCCTGGCGGTGGGCGTGGCCGTGGCCGAAGCCGTGGCTGCCTATGCGCAGACGCACG
GCGGCAACGCGCAGGCCCTGGCGCTCAAATGGCCCAACGATGTGCAGATCGCCGGGCGCAAGCTCGCCGGCATCCTGGTC
GAGACGATGCGCGCGGCCCCCGGGCAGACCTGGGCCGTGATCGGCATCGGCCTGAACCTGGAGCGCCCGCATGCGCTGGA
GGCGGCGCTGGGCCGGTCGCTGTCGGGCGTGGAAGAACTGGTCGAGCGGCCCGAGCCGAACGCGGTGCTGGCCGCGCTGC
TGAGCGCGCTGGGCGAGCACCTGCAGCGCTTCGGCTCCCACGGCCTGGCGCCGTTCGTCGCGCCGTTCGCCGCGCGCGAT
GCCTTTGCCGGCCGGCCCGTACGGCTGTGGCAGGACGGCGCCGTGGTGCTCGAAGGCGTGGCGCACGGCATCGATGCCCA
GGGACGCCTGGCCATCGAATCCGGCGGACGCGTGCAGTGGATCCACAGCGGCGAGGTGTCCTTGCGCGCGGCCGACGCGG
AGCAGCCATGA

Upstream 100 bases:

>100_bases
TGCCGTGGCACTCTCCGCCATGAGACGTACCGGCCGCCCACTACATGCGCGGTGTCCGTGATGTCCTCGCTACAATGCGC
CATCATCCAGCCATTCCCAT

Downstream 100 bases:

>100_bases
TCCGCCTCAAGGCCCCCACCCCCGAGCGGCCGCTGCTGCTGATCGACGCCGGCAATACGCGCATCAAATGGGCCTGGACT
GCCGCCGACGTCGCCCCGCC

Product: biotin--protein ligase

Products: NA

Alternate protein names: Biotin--[acetyl-CoA-carboxylase] synthetase; Biotin--protein ligase; Type III pantothenate kinase; PanK-III; Pantothenic acid kinase [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MFAQLMSSAPIPARWRLTRDRIRPTGIAAGWPVEVVESTGSTNADLMAAVRDAAWPVAAGVPAGTAPLVGGRVLAALRQT
AGRGRQGRPWDGDHGLTFSVACAFAAEPAQLAGLSLAVGVAVAEAVAAYAQTHGGNAQALALKWPNDVQIAGRKLAGILV
ETMRAAPGQTWAVIGIGLNLERPHALEAALGRSLSGVEELVERPEPNAVLAALLSALGEHLQRFGSHGLAPFVAPFAARD
AFAGRPVRLWQDGAVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRAADAEQP

Sequences:

>Translated_296_residues
MFAQLMSSAPIPARWRLTRDRIRPTGIAAGWPVEVVESTGSTNADLMAAVRDAAWPVAAGVPAGTAPLVGGRVLAALRQT
AGRGRQGRPWDGDHGLTFSVACAFAAEPAQLAGLSLAVGVAVAEAVAAYAQTHGGNAQALALKWPNDVQIAGRKLAGILV
ETMRAAPGQTWAVIGIGLNLERPHALEAALGRSLSGVEELVERPEPNAVLAALLSALGEHLQRFGSHGLAPFVAPFAARD
AFAGRPVRLWQDGAVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRAADAEQP
>Mature_296_residues
MFAQLMSSAPIPARWRLTRDRIRPTGIAAGWPVEVVESTGSTNADLMAAVRDAAWPVAAGVPAGTAPLVGGRVLAALRQT
AGRGRQGRPWDGDHGLTFSVACAFAAEPAQLAGLSLAVGVAVAEAVAAYAQTHGGNAQALALKWPNDVQIAGRKLAGILV
ETMRAAPGQTWAVIGIGLNLERPHALEAALGRSLSGVEELVERPEPNAVLAALLSALGEHLQRFGSHGLAPFVAPFAARD
AFAGRPVRLWQDGAVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRAADAEQP

Specific function: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis [H]

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the type III pantothenate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1790408, Length=227, Percent_Identity=33.920704845815, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143
- InterPro:   IPR008988
- InterPro:   IPR004619 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB; PF03309 Bvg_acc_factor [H]

EC number: =6.3.4.15; =2.7.1.33 [H]

Molecular weight: Translated: 30648; Mature: 30648

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAQLMSSAPIPARWRLTRDRIRPTGIAAGWPVEVVESTGSTNADLMAAVRDAAWPVAAG
CCHHHHHCCCCCCEEEEHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCHHCC
VPAGTAPLVGGRVLAALRQTAGRGRQGRPWDGDHGLTFSVACAFAAEPAQLAGLSLAVGV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
AVAEAVAAYAQTHGGNAQALALKWPNDVQIAGRKLAGILVETMRAAPGQTWAVIGIGLNL
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
ERPHALEAALGRSLSGVEELVERPEPNAVLAALLSALGEHLQRFGSHGLAPFVAPFAARD
CCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AFAGRPVRLWQDGAVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRAADAEQP
HCCCCCEEEECCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCEEEEECCCCCC
>Mature Secondary Structure
MFAQLMSSAPIPARWRLTRDRIRPTGIAAGWPVEVVESTGSTNADLMAAVRDAAWPVAAG
CCHHHHHCCCCCCEEEEHHHCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCCCHHCC
VPAGTAPLVGGRVLAALRQTAGRGRQGRPWDGDHGLTFSVACAFAAEPAQLAGLSLAVGV
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHH
AVAEAVAAYAQTHGGNAQALALKWPNDVQIAGRKLAGILVETMRAAPGQTWAVIGIGLNL
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
ERPHALEAALGRSLSGVEELVERPEPNAVLAALLSALGEHLQRFGSHGLAPFVAPFAARD
CCCHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
AFAGRPVRLWQDGAVVLEGVAHGIDAQGRLAIESGGRVQWIHSGEVSLRAADAEQP
HCCCCCEEEECCCHHHHHHHHHCCCCCCEEEEECCCEEEEEECCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA