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The map label for this gene is aceK [H]

Identifier: 17544997

GI number: 17544997

Start: 310322

End: 312148

Strand: Reverse

Name: aceK [H]

Synonym: RSc0278

Alternate gene names: 17544997

Gene position: 312148-310322 (Counterclockwise)

Preceding gene: 17544998

Following gene: 17544996

Centisome position: 8.4

GC content: 63.77

Gene sequence:

>1827_bases
ATGTCCCATTTTCCCAAGCTTCTCTCTTCGCAGATCGCCTTCGACGTCGCCCGCACGATGCTCGACGGGTTCGACAAGCA
CTACCGCTTGTTCCGCGAGGTGAGCGTGCGGGCCAAGGCGCTGTTCGAGGCCGGCGACTGGCAGGGCCTGCAGCAGCTGC
AGCGCGACCGCATCGCCTACTACGACGAGCGTGTGCGCGAGGCGTCGGTCATCCTGGAAGACGAGTACGACGCCGAGAAC
ATCGACGACGAAATCTGGCGCCAGATCAAGCTGCACTTCATCGGCCTGCTGACCAACCATCACCAGCCCGAGTGCGCCGA
GACCTTCTTCAACTCGGTGTGCACGCGCATCCTGCATCGCTCGTACTTCAACAACGATTTCATCTTCCTGCGGCCGGCCA
TCTCGACGGAGTACATCGAGAACGAGGAGTCGCCCACCAAGCCGACCTACCGCGCCTACTACCCCGGCTCGCGCGAGGGC
CTGGGCGGCTGCCTCGAGCGCATCGTGCACAATTTCCAGCTCGACGCGCCGTTCGAAGACCTGCCGCGCGACATCGGCTA
CGTGGTGCGCGCCGTGGGCGAGCATTTCGGCGATTTCCGCATCGCGCCGAATTTCCAGATCCACGTGCTGTCGTCGCTGT
TCTTCCGCAACACCGCGGCGTACATCATCGGGCGCGTGATCAACGGCGACAAGACGTACCCGCTGGCGGTACCGATCATG
CGCGGCGCCGATGGCCAGCTGCGGCTCGATACCGTGCTGCTGCGGCCGGAACAGCTGCTGATCCTGTTCTCGTTCACGCA
CTCGTATTTCATGGTGGACATGGAGATCCCGTCCGCCTACGTGACCTTCCTGCGCGACCTGATGCCACGCAAGCCGCGCG
CCGAGATCTACACCTCGCTCGGCCTGCAGAAGCAGGGCAAGAACCTGTTCTACCGCGACTTCCTCCACCACCTGCAGCAC
TCGTCGGACAAGTTCATCATCGCGCCCGGCATCAAGGGGCTGGTGATGCTGGTGTTCACGCTGCCGTCGTACCCGTACGT
GTTCAAGGTCATCAAGGACTATTTCCCGCCGCCGAAGGAAACCACGCGCGAGCTGATCAAGAGCAAGTACCAGTTGGTGA
AGCAGCACGACCGCGTGGGCCGCATGGCCGATACGCTGGAGTATTCCGACGTGGCCTTCCCGCTCTCGCGCTTCGACGAC
GCGCTGATCAAGGAGCTGGAAAAGCACGCGCCGTCGATGGTCGAATACCAGCGCGGCGCCGACGGCAGCGACGAGATCGT
GATCCGCCACGTCTACATCGAGCGCCGCATGACGCCGCTGAACATCTGGCTGCACGAAGGCACCGACGCGCAGGTCGAGC
ACGGCATCATCGAATACGGCAATGCCATCAAGGAACTGATCGCCGCGAACATCTTCCCCGGCGACATGCTGTACAAGAAC
TTCGGCGTGACGCGCCACGGCCGCGTGGTCTTCTACGACTACGACGAGATCGAGTACCTGACCGACTGCAACGTCCGCGA
CGTGCCGCAGCCGCGCAACGAAGAGGAAGAGATGTCGGGCGAGGTCTGGTACAGCGTCGGCCCGCACGACATCTTCCCGC
AGACGTACGGGACCTTCCTGCTGGGCGATCCGCGCGTGCGCGAGGCCTTCCTCAGGCACCATGCGGACTTCTTCGACCCG
GCCATGTGGCAGGCGCACAAGGCGCGCCTGCTGTCCGGGCAGACCCACGATTTCTACGCGTACGACGCGAGCGAACGCTT
CGTCAACCGCTACGGCGACAGCGCGCCGGGAAACGCAGCGACACCGCTGCGGCGCGCCGCTGCCTGA

Upstream 100 bases:

>100_bases
CGTGGCCGCCATAGGCGAAACGGATAAGGCGCCGATGCAGGACGGCGAAGCCCATACAATCTACCCATTGCGGCCCCCGC
CCTGCCCGAGCGCGCACGCC

Downstream 100 bases:

>100_bases
ACCCCGCAACAACAAGACGGAAACACATGCCACATCGCATCAAGGAACTCTTCGAGAACAACCGCAAGTGGGTCGAGCGC
GTCAATGCCGAAGACCCGGC

Product: bifunctional isocitrate dehydrogenase kinase/phosphatase

Products: NA

Alternate protein names: IDH kinase/phosphatase; IDHK/P [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MSHFPKLLSSQIAFDVARTMLDGFDKHYRLFREVSVRAKALFEAGDWQGLQQLQRDRIAYYDERVREASVILEDEYDAEN
IDDEIWRQIKLHFIGLLTNHHQPECAETFFNSVCTRILHRSYFNNDFIFLRPAISTEYIENEESPTKPTYRAYYPGSREG
LGGCLERIVHNFQLDAPFEDLPRDIGYVVRAVGEHFGDFRIAPNFQIHVLSSLFFRNTAAYIIGRVINGDKTYPLAVPIM
RGADGQLRLDTVLLRPEQLLILFSFTHSYFMVDMEIPSAYVTFLRDLMPRKPRAEIYTSLGLQKQGKNLFYRDFLHHLQH
SSDKFIIAPGIKGLVMLVFTLPSYPYVFKVIKDYFPPPKETTRELIKSKYQLVKQHDRVGRMADTLEYSDVAFPLSRFDD
ALIKELEKHAPSMVEYQRGADGSDEIVIRHVYIERRMTPLNIWLHEGTDAQVEHGIIEYGNAIKELIAANIFPGDMLYKN
FGVTRHGRVVFYDYDEIEYLTDCNVRDVPQPRNEEEEMSGEVWYSVGPHDIFPQTYGTFLLGDPRVREAFLRHHADFFDP
AMWQAHKARLLSGQTHDFYAYDASERFVNRYGDSAPGNAATPLRRAAA

Sequences:

>Translated_608_residues
MSHFPKLLSSQIAFDVARTMLDGFDKHYRLFREVSVRAKALFEAGDWQGLQQLQRDRIAYYDERVREASVILEDEYDAEN
IDDEIWRQIKLHFIGLLTNHHQPECAETFFNSVCTRILHRSYFNNDFIFLRPAISTEYIENEESPTKPTYRAYYPGSREG
LGGCLERIVHNFQLDAPFEDLPRDIGYVVRAVGEHFGDFRIAPNFQIHVLSSLFFRNTAAYIIGRVINGDKTYPLAVPIM
RGADGQLRLDTVLLRPEQLLILFSFTHSYFMVDMEIPSAYVTFLRDLMPRKPRAEIYTSLGLQKQGKNLFYRDFLHHLQH
SSDKFIIAPGIKGLVMLVFTLPSYPYVFKVIKDYFPPPKETTRELIKSKYQLVKQHDRVGRMADTLEYSDVAFPLSRFDD
ALIKELEKHAPSMVEYQRGADGSDEIVIRHVYIERRMTPLNIWLHEGTDAQVEHGIIEYGNAIKELIAANIFPGDMLYKN
FGVTRHGRVVFYDYDEIEYLTDCNVRDVPQPRNEEEEMSGEVWYSVGPHDIFPQTYGTFLLGDPRVREAFLRHHADFFDP
AMWQAHKARLLSGQTHDFYAYDASERFVNRYGDSAPGNAATPLRRAAA
>Mature_607_residues
SHFPKLLSSQIAFDVARTMLDGFDKHYRLFREVSVRAKALFEAGDWQGLQQLQRDRIAYYDERVREASVILEDEYDAENI
DDEIWRQIKLHFIGLLTNHHQPECAETFFNSVCTRILHRSYFNNDFIFLRPAISTEYIENEESPTKPTYRAYYPGSREGL
GGCLERIVHNFQLDAPFEDLPRDIGYVVRAVGEHFGDFRIAPNFQIHVLSSLFFRNTAAYIIGRVINGDKTYPLAVPIMR
GADGQLRLDTVLLRPEQLLILFSFTHSYFMVDMEIPSAYVTFLRDLMPRKPRAEIYTSLGLQKQGKNLFYRDFLHHLQHS
SDKFIIAPGIKGLVMLVFTLPSYPYVFKVIKDYFPPPKETTRELIKSKYQLVKQHDRVGRMADTLEYSDVAFPLSRFDDA
LIKELEKHAPSMVEYQRGADGSDEIVIRHVYIERRMTPLNIWLHEGTDAQVEHGIIEYGNAIKELIAANIFPGDMLYKNF
GVTRHGRVVFYDYDEIEYLTDCNVRDVPQPRNEEEEMSGEVWYSVGPHDIFPQTYGTFLLGDPRVREAFLRHHADFFDPA
MWQAHKARLLSGQTHDFYAYDASERFVNRYGDSAPGNAATPLRRAAA

Specific function: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source

COG id: COG4579

COG function: function code T; Isocitrate dehydrogenase kinase/phosphatase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AceK family [H]

Homologues:

Organism=Escherichia coli, GI1790446, Length=578, Percent_Identity=41.8685121107266, Blast_Score=457, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010452
- ProDom:   PD043552 [H]

Pfam domain/function: PF06315 AceK [H]

EC number: =2.7.11.5 [H]

Molecular weight: Translated: 70554; Mature: 70423

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHFPKLLSSQIAFDVARTMLDGFDKHYRLFREVSVRAKALFEAGDWQGLQQLQRDRIAY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YDERVREASVILEDEYDAENIDDEIWRQIKLHFIGLLTNHHQPECAETFFNSVCTRILHR
HHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SYFNNDFIFLRPAISTEYIENEESPTKPTYRAYYPGSREGLGGCLERIVHNFQLDAPFED
HHCCCCEEEEECCCCHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCHHH
LPRDIGYVVRAVGEHFGDFRIAPNFQIHVLSSLFFRNTAAYIIGRVINGDKTYPLAVPIM
HHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
RGADGQLRLDTVLLRPEQLLILFSFTHSYFMVDMEIPSAYVTFLRDLMPRKPRAEIYTSL
ECCCCCEEEEEEEECCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHH
GLQKQGKNLFYRDFLHHLQHSSDKFIIAPGIKGLVMLVFTLPSYPYVFKVIKDYFPPPKE
CCHHCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
TTRELIKSKYQLVKQHDRVGRMADTLEYSDVAFPLSRFDDALIKELEKHAPSMVEYQRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCC
DGSDEIVIRHVYIERRMTPLNIWLHEGTDAQVEHGIIEYGNAIKELIAANIFPGDMLYKN
CCCCCEEEEEEEHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FGVTRHGRVVFYDYDEIEYLTDCNVRDVPQPRNEEEEMSGEVWYSVGPHDIFPQTYGTFL
CCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCCCCEE
LGDPRVREAFLRHHADFFDPAMWQAHKARLLSGQTHDFYAYDASERFVNRYGDSAPGNAA
ECCHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCC
TPLRRAAA
CCHHHHCC
>Mature Secondary Structure 
SHFPKLLSSQIAFDVARTMLDGFDKHYRLFREVSVRAKALFEAGDWQGLQQLQRDRIAY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YDERVREASVILEDEYDAENIDDEIWRQIKLHFIGLLTNHHQPECAETFFNSVCTRILHR
HHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SYFNNDFIFLRPAISTEYIENEESPTKPTYRAYYPGSREGLGGCLERIVHNFQLDAPFED
HHCCCCEEEEECCCCHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCHHH
LPRDIGYVVRAVGEHFGDFRIAPNFQIHVLSSLFFRNTAAYIIGRVINGDKTYPLAVPIM
HHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEE
RGADGQLRLDTVLLRPEQLLILFSFTHSYFMVDMEIPSAYVTFLRDLMPRKPRAEIYTSL
ECCCCCEEEEEEEECCCCEEEEEEECCCEEEEEEECCHHHHHHHHHHCCCCCHHHHHHHH
GLQKQGKNLFYRDFLHHLQHSSDKFIIAPGIKGLVMLVFTLPSYPYVFKVIKDYFPPPKE
CCHHCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCHH
TTRELIKSKYQLVKQHDRVGRMADTLEYSDVAFPLSRFDDALIKELEKHAPSMVEYQRGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHCCC
DGSDEIVIRHVYIERRMTPLNIWLHEGTDAQVEHGIIEYGNAIKELIAANIFPGDMLYKN
CCCCCEEEEEEEHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
FGVTRHGRVVFYDYDEIEYLTDCNVRDVPQPRNEEEEMSGEVWYSVGPHDIFPQTYGTFL
CCCCCCCEEEEEECCCHHHHCCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCCCCCEE
LGDPRVREAFLRHHADFFDPAMWQAHKARLLSGQTHDFYAYDASERFVNRYGDSAPGNAA
ECCHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCCCCCC
TPLRRAAA
CCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA