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The map label for this gene is strK [H]

Identifier: 17544816

GI number: 17544816

Start: 109053

End: 110504

Strand: Direct

Name: strK [H]

Synonym: RSc0097

Alternate gene names: 17544816

Gene position: 109053-110504 (Clockwise)

Preceding gene: 17544815

Following gene: 17544817

Centisome position: 2.93

GC content: 69.7

Gene sequence:

>1452_bases
ATGCACCGACTTTCCCTTCTGTCCGTCGCCGCGCTGGCCGCGCTTGCCCTCGTGGCATGCGGCAGCGACGGCACTTCCAC
CGGCGTTGCCACGCCGGATGCCGGCGCGATCACCACCGGCCCGACCAGGAACGTGGTGTTCTTCCTCGGCGACGGCATGG
GCCTGGCCACCATGACCGCCGCGCGCATCTACAAGGTGGGCGAGGACGGCGAGCTGACCATGGATACGCTGCCCGAGACC
GGCTTCGTGCGGACCTTCTCCAACAACGCGCAGGTGACCGACTCCGCGCCGTCGATGTCGGCCTACATGACCGGCGTGAA
GATGAACAACGAGGTCATTTCCATGTCGTCGGACACGGCGGCGTTCGATGCGGGCGGCAAGGACTACGTGTCCGGCGCCG
ACAGCACCTGCCCGGCCGGCGGCAACGGCAAGCCGGTGACGACGCTGCTGGAGTTGATGAAGGCCGCGGGCTACGGCACG
GGCGTGGTCACCACCACGCGCGTCACGCATGCCACGCCGGCGGCCACCTACGCGCACATCTGCCACCGCGACGGCGAGAA
CACCATCGCCGCGCAGCTGGTGCCGGCCGGCGCGGGCTACAACGCCGCGCTGGGCGATGGCGTGGACGTGGTGTTCGGCG
GCGGCCGCAAGCACTTCCAGCCGTCCGCCGCGGGCGGCGCGCGCACCGACGGCCGCGACCTGGTGGCCGAGCTGAAGGCG
GCCGGCTACCGCTACGCCGGCAACAAGGCCGAGTTCGATACGCTGTCGGCCGGCGACAGCAAGGTGGTGGGCCTGTTCAC
CAGCAGCCACATGGCCTATGACCTGGACCGCGATGCGGCCAAGGAGCCGAGCCTGGTCGAGATGACCACCAAGGCCATCG
ACGTGCTGGCCGCCAAGAAGAAGGGCTTTTTCCTGATGGTGGAAGGCGGCCGCATCGACCACGCGCTGCACGAGACCACG
GCGCGCAAGGCCCTGCAGGACACGGTGGCGTTCGATGCCGCCATTCGCGGCGCGCTGGACAAGCTCAGCACGATCGACCC
GGGCCTGAAGAACACGCTCGTCGTCGTCACCGCCGACCACGACCACACGCTGGTGCTCAACGGCTACGCCAAGCGCACCG
GCCCCACCAGCGACAGCAATCCGGGCGTTCTCGGCCTGCTCAAGAGCTACGTGAACGGCGCCACCGCCACCGACGTGGGC
GGCAATCCGTACACCATCCTCGGCTTCGGCACCGGCGAGAACCGCCCGGCCGCGCGCACCGCGCTCACCGACGCGGCCGT
CTACGACAAGGCCTACCACCAGGAAGCCGTGATCCCGACGTCGGCGGGCGGCGAGACGCACGGCGGCACCGATGTCTTTG
TCGGCGCGCGCGGCCTGGGCGCGGAGCGCTTCACGGGCGTGATGGACAACACCGAGGTCTTCGGCCTCATCAAGCAGGCC
GTCGGCCTGTGA

Upstream 100 bases:

>100_bases
CCGCGCAGACCTTTCGATCCGGTTAGGAAGCGGCGAACCACCATCACGGTGGTGCCACATGCATTGACCACAGTGGCGCC
CATTGCAACGGGAGCCAACG

Downstream 100 bases:

>100_bases
CACTCGACGGAACACTGCCATGACCAAGCAATCGAACCGCATCCTCCGCGCCGGCGCGCTCGCGCTGGCGGCGGCCGCAG
CGTTGCCCGTGCTCCCGGCC

Product: alkaline phosphatase lipoprotein transmembrane

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MHRLSLLSVAALAALALVACGSDGTSTGVATPDAGAITTGPTRNVVFFLGDGMGLATMTAARIYKVGEDGELTMDTLPET
GFVRTFSNNAQVTDSAPSMSAYMTGVKMNNEVISMSSDTAAFDAGGKDYVSGADSTCPAGGNGKPVTTLLELMKAAGYGT
GVVTTTRVTHATPAATYAHICHRDGENTIAAQLVPAGAGYNAALGDGVDVVFGGGRKHFQPSAAGGARTDGRDLVAELKA
AGYRYAGNKAEFDTLSAGDSKVVGLFTSSHMAYDLDRDAAKEPSLVEMTTKAIDVLAAKKKGFFLMVEGGRIDHALHETT
ARKALQDTVAFDAAIRGALDKLSTIDPGLKNTLVVVTADHDHTLVLNGYAKRTGPTSDSNPGVLGLLKSYVNGATATDVG
GNPYTILGFGTGENRPAARTALTDAAVYDKAYHQEAVIPTSAGGETHGGTDVFVGARGLGAERFTGVMDNTEVFGLIKQA
VGL

Sequences:

>Translated_483_residues
MHRLSLLSVAALAALALVACGSDGTSTGVATPDAGAITTGPTRNVVFFLGDGMGLATMTAARIYKVGEDGELTMDTLPET
GFVRTFSNNAQVTDSAPSMSAYMTGVKMNNEVISMSSDTAAFDAGGKDYVSGADSTCPAGGNGKPVTTLLELMKAAGYGT
GVVTTTRVTHATPAATYAHICHRDGENTIAAQLVPAGAGYNAALGDGVDVVFGGGRKHFQPSAAGGARTDGRDLVAELKA
AGYRYAGNKAEFDTLSAGDSKVVGLFTSSHMAYDLDRDAAKEPSLVEMTTKAIDVLAAKKKGFFLMVEGGRIDHALHETT
ARKALQDTVAFDAAIRGALDKLSTIDPGLKNTLVVVTADHDHTLVLNGYAKRTGPTSDSNPGVLGLLKSYVNGATATDVG
GNPYTILGFGTGENRPAARTALTDAAVYDKAYHQEAVIPTSAGGETHGGTDVFVGARGLGAERFTGVMDNTEVFGLIKQA
VGL
>Mature_483_residues
MHRLSLLSVAALAALALVACGSDGTSTGVATPDAGAITTGPTRNVVFFLGDGMGLATMTAARIYKVGEDGELTMDTLPET
GFVRTFSNNAQVTDSAPSMSAYMTGVKMNNEVISMSSDTAAFDAGGKDYVSGADSTCPAGGNGKPVTTLLELMKAAGYGT
GVVTTTRVTHATPAATYAHICHRDGENTIAAQLVPAGAGYNAALGDGVDVVFGGGRKHFQPSAAGGARTDGRDLVAELKA
AGYRYAGNKAEFDTLSAGDSKVVGLFTSSHMAYDLDRDAAKEPSLVEMTTKAIDVLAAKKKGFFLMVEGGRIDHALHETT
ARKALQDTVAFDAAIRGALDKLSTIDPGLKNTLVVVTADHDHTLVLNGYAKRTGPTSDSNPGVLGLLKSYVNGATATDVG
GNPYTILGFGTGENRPAARTALTDAAVYDKAYHQEAVIPTSAGGETHGGTDVFVGARGLGAERFTGVMDNTEVFGLIKQA
VGL

Specific function: Specifically cleaves both streptomycin-6-phosphate and, more slowly, streptomycin-3''-phosphate during the biosynthesis of streptomycin [H]

COG id: COG1785

COG function: function code P; Alkaline phosphatase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alkaline phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI116734717, Length=469, Percent_Identity=35.6076759061834, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI157266296, Length=463, Percent_Identity=35.6371490280778, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI94721246, Length=461, Percent_Identity=35.5748373101952, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI294660770, Length=459, Percent_Identity=35.9477124183007, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI157266292, Length=469, Percent_Identity=34.5415778251599, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI294660772, Length=415, Percent_Identity=34.6987951807229, Blast_Score=189, Evalue=4e-48,
Organism=Escherichia coli, GI48994877, Length=497, Percent_Identity=27.5653923541247, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6320689, Length=358, Percent_Identity=34.3575418994413, Blast_Score=163, Evalue=6e-41,
Organism=Drosophila melanogaster, GI85725200, Length=464, Percent_Identity=35.7758620689655, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI85815833, Length=464, Percent_Identity=35.7758620689655, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19921912, Length=485, Percent_Identity=34.639175257732, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI21355151, Length=465, Percent_Identity=34.8387096774194, Blast_Score=225, Evalue=5e-59,
Organism=Drosophila melanogaster, GI24585213, Length=486, Percent_Identity=33.7448559670782, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21358067, Length=479, Percent_Identity=35.0730688935282, Blast_Score=214, Evalue=7e-56,
Organism=Drosophila melanogaster, GI18859923, Length=443, Percent_Identity=34.5372460496614, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI21355981, Length=463, Percent_Identity=35.85313174946, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21355149, Length=473, Percent_Identity=31.0782241014799, Blast_Score=198, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24651554, Length=490, Percent_Identity=33.8775510204082, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24657827, Length=477, Percent_Identity=33.7526205450734, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24657842, Length=473, Percent_Identity=32.9809725158562, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24657835, Length=474, Percent_Identity=32.0675105485232, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24651556, Length=480, Percent_Identity=33.3333333333333, Blast_Score=178, Evalue=9e-45,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR001952
- InterPro:   IPR018299
- InterPro:   IPR017850 [H]

Pfam domain/function: PF00245 Alk_phosphatase [H]

EC number: =3.1.3.39 [H]

Molecular weight: Translated: 49601; Mature: 49601

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRLSLLSVAALAALALVACGSDGTSTGVATPDAGAITTGPTRNVVFFLGDGMGLATMTA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEEEECCCCHHHHHH
ARIYKVGEDGELTMDTLPETGFVRTFSNNAQVTDSAPSMSAYMTGVKMNNEVISMSSDTA
HHHEEECCCCCEEHCCCCCCCEEEEECCCCEEECCCCCCCHHEEEEEECCEEEEECCCCC
AFDAGGKDYVSGADSTCPAGGNGKPVTTLLELMKAAGYGTGVVTTTRVTHATPAATYAHI
EECCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHH
CHRDGENTIAAQLVPAGAGYNAALGDGVDVVFGGGRKHFQPSAAGGARTDGRDLVAELKA
HHCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
AGYRYAGNKAEFDTLSAGDSKVVGLFTSSHMAYDLDRDAAKEPSLVEMTTKAIDVLAAKK
CCEEECCCCCCCCEECCCCCEEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
KGFFLMVEGGRIDHALHETTARKALQDTVAFDAAIRGALDKLSTIDPGLKNTLVVVTADH
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
DHTLVLNGYAKRTGPTSDSNPGVLGLLKSYVNGATATDVGGNPYTILGFGTGENRPAART
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCCCHHHH
ALTDAAVYDKAYHQEAVIPTSAGGETHGGTDVFVGARGLGAERFTGVMDNTEVFGLIKQA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCHHHHHHHHHH
VGL
HCC
>Mature Secondary Structure
MHRLSLLSVAALAALALVACGSDGTSTGVATPDAGAITTGPTRNVVFFLGDGMGLATMTA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCCCEEEEEECCCCHHHHHH
ARIYKVGEDGELTMDTLPETGFVRTFSNNAQVTDSAPSMSAYMTGVKMNNEVISMSSDTA
HHHEEECCCCCEEHCCCCCCCEEEEECCCCEEECCCCCCCHHEEEEEECCEEEEECCCCC
AFDAGGKDYVSGADSTCPAGGNGKPVTTLLELMKAAGYGTGVVTTTRVTHATPAATYAHI
EECCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHH
CHRDGENTIAAQLVPAGAGYNAALGDGVDVVFGGGRKHFQPSAAGGARTDGRDLVAELKA
HHCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
AGYRYAGNKAEFDTLSAGDSKVVGLFTSSHMAYDLDRDAAKEPSLVEMTTKAIDVLAAKK
CCEEECCCCCCCCEECCCCCEEEEEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
KGFFLMVEGGRIDHALHETTARKALQDTVAFDAAIRGALDKLSTIDPGLKNTLVVVTADH
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
DHTLVLNGYAKRTGPTSDSNPGVLGLLKSYVNGATATDVGGNPYTILGFGTGENRPAART
CCEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCEEECCCCCCEEEEEECCCCCCCHHHH
ALTDAAVYDKAYHQEAVIPTSAGGETHGGTDVFVGARGLGAERFTGVMDNTEVFGLIKQA
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCHHHHHHHHHH
VGL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1654502 [H]