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The map label for this gene is goaG [H]

Identifier: 17544748

GI number: 17544748

Start: 34078

End: 35358

Strand: Reverse

Name: goaG [H]

Synonym: RSc0029

Alternate gene names: 17544748

Gene position: 35358-34078 (Counterclockwise)

Preceding gene: 17544750

Following gene: 17544747

Centisome position: 0.95

GC content: 69.24

Gene sequence:

>1281_bases
ATGAACGCCAGAGACCCCCAGCACAACGCCCAATGGAACGCCCGCCGCCTGGCCGCCACACCGCGCGGCGTCGGCGTCAT
GACCGACCGCTACGCGGAACACGCCGAGAACGCCCAGTTCTGGGACGTGGAAGGCAAGCGCTACATCGACTTCGCGGCCG
GCATCGCCGTGGTCAACACCGGCCACCGCCATCCGCGCCTGGTGCAGGCCGTGCGCGAGCAGCTCGAGCGCTTCACCCAC
ACCGCCTTCCAGATCGTGCCGTACGCCTCGTACGTCGAGCTGGCCGAGCGCCTGAACACGCTCACGCCCGGCGCGCATGC
CAAGAAGACGGCATTCTTCTCCACCGGCGCCGAAGCCGTGGAGAACGCCATCAAGATCGCGCGCGCCCACACTGGCCGCC
CCGGCGTGATCGCACTGACGGGCGCCTTCCACGGCCGCACCTTCATGGGCATGTCGCTCACCGGCAAGGTGGTGCCGTAC
AAGACCGGCTTCGGTCCGTTCCCGGGCAGCATCTATCACGTGCCGGCACCGATCGCGCTGCACGGCGTCAGCACGCAGGA
TTCGCTCGATGCGATCGGCCGCCTGTTCAAGGCCGACATCGACCCGCGCCAGGTCGCGGCCATCATCTTCGAGCCGGTGC
AGGGCGAGGGCGGCTTCTACCAGATGCCCGCCGATTTCGTGCGCGCCCTCCGCGCCCTGTGCGACGAGCACGGCATCGTG
ATGATCGCCGACGAAGTGCAGACCGGCTTTGCCCGCACCGGCAAGCTGTTCGCCATGGAGCACACCGGCGTGCTGCCCGA
CCTGGTGACGATGGCCAAGGGCCTGGCCGGCGGCCTGCCGCTGTCGGCCGTCACCGGCCGCGCCGAGATCATGGACGCGC
CCGCCCCCGGCGGCCTGGGCGGTACCTACGCCGGCAACCCGCTGGCCGTAGCCGCCGCGCACGCAGTGCTCGACATCATT
GACGAGGAAAAGCTGTGCGAGCGCTCCGCCGCGCTGGGCCGGCGCCTGGTCGATGCGCTCGACGCCGCCAAGGCCGGCCA
GCCGCGCATCGCCGAAGTGCGCGGCGTGGGCGCGATGGTTGCTATTGAATTCAACACGCCCGACGGCAAGCCCGATGCCG
ACTTCACCCGCACCGTGCAGCAGCGCGCGCTCGAAGCCGGCCTGCTGCTGCTATCGTGCGGCGTGTACGGCAACGTGATC
CGCTTCCTGTTCCCGCTCACCATCGAAGACGCGGTATTCGAAGAGGGCCTTGCCATCCTGAAACACGCACTGGAGGGCTG
A

Upstream 100 bases:

>100_bases
CGGATTGGCTCCATCAGAAAAACTCGATTGGGTCTCATTGTACGGGGCCAATGGCTGCCACACTGGCCCGCATCGCACCT
TTTTCCGACGCCCGAACGCC

Downstream 100 bases:

>100_bases
CACCATGACCCGCACCGATCTGCCACCGGCACCGATCACGCTCAACGACCCGGCGCTGTGGCGCACGCAAGCCTTCCTGG
CCGGCGCGTGGACCGATGCC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MNARDPQHNAQWNARRLAATPRGVGVMTDRYAEHAENAQFWDVEGKRYIDFAAGIAVVNTGHRHPRLVQAVREQLERFTH
TAFQIVPYASYVELAERLNTLTPGAHAKKTAFFSTGAEAVENAIKIARAHTGRPGVIALTGAFHGRTFMGMSLTGKVVPY
KTGFGPFPGSIYHVPAPIALHGVSTQDSLDAIGRLFKADIDPRQVAAIIFEPVQGEGGFYQMPADFVRALRALCDEHGIV
MIADEVQTGFARTGKLFAMEHTGVLPDLVTMAKGLAGGLPLSAVTGRAEIMDAPAPGGLGGTYAGNPLAVAAAHAVLDII
DEEKLCERSAALGRRLVDALDAAKAGQPRIAEVRGVGAMVAIEFNTPDGKPDADFTRTVQQRALEAGLLLLSCGVYGNVI
RFLFPLTIEDAVFEEGLAILKHALEG

Sequences:

>Translated_426_residues
MNARDPQHNAQWNARRLAATPRGVGVMTDRYAEHAENAQFWDVEGKRYIDFAAGIAVVNTGHRHPRLVQAVREQLERFTH
TAFQIVPYASYVELAERLNTLTPGAHAKKTAFFSTGAEAVENAIKIARAHTGRPGVIALTGAFHGRTFMGMSLTGKVVPY
KTGFGPFPGSIYHVPAPIALHGVSTQDSLDAIGRLFKADIDPRQVAAIIFEPVQGEGGFYQMPADFVRALRALCDEHGIV
MIADEVQTGFARTGKLFAMEHTGVLPDLVTMAKGLAGGLPLSAVTGRAEIMDAPAPGGLGGTYAGNPLAVAAAHAVLDII
DEEKLCERSAALGRRLVDALDAAKAGQPRIAEVRGVGAMVAIEFNTPDGKPDADFTRTVQQRALEAGLLLLSCGVYGNVI
RFLFPLTIEDAVFEEGLAILKHALEG
>Mature_426_residues
MNARDPQHNAQWNARRLAATPRGVGVMTDRYAEHAENAQFWDVEGKRYIDFAAGIAVVNTGHRHPRLVQAVREQLERFTH
TAFQIVPYASYVELAERLNTLTPGAHAKKTAFFSTGAEAVENAIKIARAHTGRPGVIALTGAFHGRTFMGMSLTGKVVPY
KTGFGPFPGSIYHVPAPIALHGVSTQDSLDAIGRLFKADIDPRQVAAIIFEPVQGEGGFYQMPADFVRALRALCDEHGIV
MIADEVQTGFARTGKLFAMEHTGVLPDLVTMAKGLAGGLPLSAVTGRAEIMDAPAPGGLGGTYAGNPLAVAAAHAVLDII
DEEKLCERSAALGRRLVDALDAAKAGQPRIAEVRGVGAMVAIEFNTPDGKPDADFTRTVQQRALEAGLLLLSCGVYGNVI
RFLFPLTIEDAVFEEGLAILKHALEG

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=403, Percent_Identity=33.7468982630273, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI13994255, Length=348, Percent_Identity=33.6206896551724, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI37574042, Length=399, Percent_Identity=31.5789473684211, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=34.2679127725857, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI226442709, Length=373, Percent_Identity=31.9034852546917, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI226442705, Length=399, Percent_Identity=30.5764411027569, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI24119277, Length=392, Percent_Identity=26.7857142857143, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI188536080, Length=410, Percent_Identity=27.8048780487805, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI38679950, Length=410, Percent_Identity=27.8048780487805, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI38679946, Length=410, Percent_Identity=27.8048780487805, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1787560, Length=418, Percent_Identity=70.0956937799043, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1789016, Length=419, Percent_Identity=54.8926014319809, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=37.9746835443038, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1788044, Length=399, Percent_Identity=36.0902255639098, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI145693181, Length=376, Percent_Identity=36.436170212766, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1786349, Length=419, Percent_Identity=31.980906921241, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786991, Length=348, Percent_Identity=31.3218390804598, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32564660, Length=403, Percent_Identity=34.2431761786601, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI25144271, Length=396, Percent_Identity=34.3434343434343, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=412, Percent_Identity=29.8543689320388, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=286, Percent_Identity=34.2657342657343, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=430, Percent_Identity=26.2790697674419, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=148, Percent_Identity=31.0810810810811, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323470, Length=410, Percent_Identity=34.1463414634146, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=31.5136476426799, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=25.796178343949, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=422, Percent_Identity=25.1184834123223, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574759, Length=436, Percent_Identity=33.0275229357798, Blast_Score=194, Evalue=8e-50,
Organism=Drosophila melanogaster, GI161085790, Length=448, Percent_Identity=32.1428571428571, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI21357415, Length=397, Percent_Identity=34.5088161209068, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=412, Percent_Identity=31.7961165048544, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI281366494, Length=364, Percent_Identity=28.021978021978, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667139, Length=364, Percent_Identity=28.021978021978, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24667143, Length=364, Percent_Identity=28.021978021978, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 45550; Mature: 45550

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNARDPQHNAQWNARRLAATPRGVGVMTDRYAEHAENAQFWDVEGKRYIDFAAGIAVVNT
CCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEHHCCEEEEEC
GHRHPRLVQAVREQLERFTHTAFQIVPYASYVELAERLNTLTPGAHAKKTAFFSTGAEAV
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
ENAIKIARAHTGRPGVIALTGAFHGRTFMGMSLTGKVVPYKTGFGPFPGSIYHVPAPIAL
HHHHHHHHHCCCCCCEEEEEECCCCCEEECCEECCCEEEECCCCCCCCCCEEECCCCEEE
HGVSTQDSLDAIGRLFKADIDPRQVAAIIFEPVQGEGGFYQMPADFVRALRALCDEHGIV
ECCCCHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEE
MIADEVQTGFARTGKLFAMEHTGVLPDLVTMAKGLAGGLPLSAVTGRAEIMDAPAPGGLG
EEECCHHCCHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHCCCHHEEECCCCCCCC
GTYAGNPLAVAAAHAVLDIIDEEKLCERSAALGRRLVDALDAAKAGQPRIAEVRGVGAMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEE
AIEFNTPDGKPDADFTRTVQQRALEAGLLLLSCGVYGNVIRFLFPLTIEDAVFEEGLAIL
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KHALEG
HHHHCC
>Mature Secondary Structure
MNARDPQHNAQWNARRLAATPRGVGVMTDRYAEHAENAQFWDVEGKRYIDFAAGIAVVNT
CCCCCCCCCCCCCCHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCEEEEHHCCEEEEEC
GHRHPRLVQAVREQLERFTHTAFQIVPYASYVELAERLNTLTPGAHAKKTAFFSTGAEAV
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
ENAIKIARAHTGRPGVIALTGAFHGRTFMGMSLTGKVVPYKTGFGPFPGSIYHVPAPIAL
HHHHHHHHHCCCCCCEEEEEECCCCCEEECCEECCCEEEECCCCCCCCCCEEECCCCEEE
HGVSTQDSLDAIGRLFKADIDPRQVAAIIFEPVQGEGGFYQMPADFVRALRALCDEHGIV
ECCCCHHHHHHHHHHHHCCCCHHHEEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEE
MIADEVQTGFARTGKLFAMEHTGVLPDLVTMAKGLAGGLPLSAVTGRAEIMDAPAPGGLG
EEECCHHCCHHHCCCEEEEECCCCCHHHHHHHHHHCCCCCHHHHCCCHHEEECCCCCCCC
GTYAGNPLAVAAAHAVLDIIDEEKLCERSAALGRRLVDALDAAKAGQPRIAEVRGVGAMV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEE
AIEFNTPDGKPDADFTRTVQQRALEAGLLLLSCGVYGNVIRFLFPLTIEDAVFEEGLAIL
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KHALEG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]